E91

Kinase Glossary: E91

E91 is a key conserved residue in ePK and most PKL kinases. It forms a salt bridge with K72. It is found in the C helix, though it is not part of a larger motif, making it difficult to detect in some remote kinases. The number 91 is based on the position of this residue in the first PKA kinase crystal [1]. It is a D in some PKL kinases.

1. Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, and Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. DOI:10.1107/S0907444993000423 |