PKL

Kinase Glossary: PKL

PKL (Protein Kinase-Like) is a protein structure fold shared by most protein kinases. These also share a similar catalytic mechanism. A variety of PKL classes have been found in prokaryotes and eukaryotes [1], and their structural and sequence relationships explored [2]. All catalytically active PKLs act as kinases, though not all are protein kinases. For instance, PI3Ks phosphorylate phosphoinositides, and CAKs phosphorylate various small molecules. ePKs are a major class of protein-specific kinases within PKL and account for the majority of human kinases. Within the kinase classification scheme, the PKL group consists of all PKL kinases that are not in one of the 8 ePK groups.

See also: Protein Kinase Evolution, Standard Kinase Classification Scheme

References

1. Kannan N, Taylor SS, Zhai Y, Venter JC, and Manning G. Structural and functional diversity of the microbial kinome. PLoS Biol. 2007 Mar;5(3):e17. DOI:10.1371/journal.pbio.0050017 |
2. Scheeff ED and Bourne PE. Structural evolution of the protein kinase-like superfamily. PLoS Comput Biol. 2005 Oct;1(5):e49. DOI:10.1371/journal.pcbi.0010049 |