p38g_Hsap YRDLQPVGSGAYGAVCSAV-DG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR
p38d_Hsap YVSPTHVGSGAYGSVCSAI-DK---RSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ
p38b_Hsap LQGLRPVGSGAYGSVCSAY-DA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK
p38a_Hsap YQNLSPVGSGAYGSVCAAF-DT---KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK
P38c_Dmel YEFVRFLGGGSFGQVAKVR-LR---GTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMN
Mpk2_Dmel YQDLQPVGSGAYGQVSKAV-VR---GTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMD
p38b_Dmel YQNLQPVGQGAYGQVCKAV-VR---GTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMD
p38g_Mmus YQDLQPVGSGAYGAVCSAV-DS---RTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMR
p38d_Mmus YLAPAHVGSGAYGAVCSAI-DK---RTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMH
p38b_Mmus LQGLRPVGSGAYGSVCSAY-DA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK
p38a_Mmus YQNLSPVGSGAYGSVCAAF-DT---KTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK
pmk-3_Cele PNSIEYLGGGSFGNVIKTSAVCRDG-LRRYVAIKKMREPFFDPHHARRIFRETKLLQLMR
pmk-2_Cele YNSLKPLGEGAYGVVCTAE-YE---PTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQ
pmk-1_Cele YINLTPIGTGAYGTVCAAE-CT---RSGTRVAIKKFNRPFQSIIHARRTYRELRLLRCMC
HOG1_Scer YNDLNPVGMGAFGLVCSAT-DT---LTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLR
p38_Spur YVRLEPVGSGAYGQVCSTE-AEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMR
AqueK129_Aque YREIASIGTGAYGTVCSAT-DT---HYNIKVALKKLARPFQNHVHAKRTYRELRLLKHMK
AqueK130_Aque YQDMSPIGIGGFSTVCCAV-DS---ETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLT
AqueK131_Aque YQELTPINSGAYGQVCSAL-DT---KYGIRVAIKKLYAPFEHRHNAKKAYREMRILSHLK
:. *.:. * . .*:*:: ** *: :** :* :
p38g_Hsap H--ENVIGLLDVFTPD---ETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQ
p38d_Hsap H--ENVIGLLDVFTPA---SSLRNFYDFYLVMPFMQTDLQKIMGM-------EFSEEKIQ
p38b_Hsap H--ENVIGLLDVFTPA---TSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQ
p38a_Hsap H--ENVIGLLDVFTPA---RSLEEFNDVYLVTHLMGADLNNIVKC------QKLTDDHVQ
P38c_Dmel H--RNVISLLNVFHPP--AHNMMEFQQVYLVTHLMDADLHRYSRS------KRMSDQEIR
Mpk2_Dmel H--ENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRM------QHLSDDHVQ
p38b_Dmel H--ENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRT------QKLSDDHVQ
p38g_Mmus H--ENVIGLLDVFTPD---ESLDDFTDFYLVMPFMGTDLGKLMKH------ETLSEDRIQ
p38d_Mmus H--ENVIGLLDVFTPA---SSLRSFHDFYLVMPFMQTDLQKIMGM-------EFSEDKVQ
p38b_Mmus H--ENVIGLLDVFTPA---TSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQ
p38a_Mmus H--ENVIGLLDVFTPA---RSLEEFNDVYLVTHLMGADLNNIVKC------QKLTDDHVQ
pmk-3_Cele H--DNIICALDIYTPD---EE-NDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIK
pmk-2_Cele H--DNVLEMIDVFTPD---PDASSLNNVYFVSVLMGSDLQNIMKI------QRLTDEQIQ
pmk-1_Cele H--ENIIDLLDVFTPN---ENVNDIEDVYFVSMLMGADLSNILKI------QRLNDDHIQ
HOG1_Scer H--ENLICLQDIFL--------SPLEDIYFVTELQGTDLHRLLQT------RPLEKQFVQ
p38_Spur H--ENVISLLDCFTPD---R--VNFSDVYMVTHLMGADLNNIIKC------QKLSDDHVQ
AqueK129_Aque H--ENIIGLLDVFTPA---ENYENFQDVYLVMHLMGSDINNILKQ------QALTDEHVQ
AqueK130_Aque RSNANVVELLDVFTPN---DSLDSFNDIYLVTCFMQSDLDNAIKI------QPITDDQVQ
AqueK131_Aque H--ENCIGLLDVFSPC---EDIEEFSDFYMVMHLMSMDLAKLLKENRT--SQILSEDHIK
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p38g_Hsap FLVYQMLKGLRY-----------------------------IHAAGIIHRDLKPGNLAVN
p38d_Hsap YLVYQMLKGLKY-----------------------------IHSAGVVHRDLKPGNLAVN
p38b_Hsap FLVYQLLRGLKY-----------------------------IHSAGIIHRDLKPSNVAVN
p38a_Hsap FLIYQILRGLKY-----------------------------IHSADIIHRDLKPSNLAVN
P38c_Dmel IILYQILRGLKY-----------------------------IHSAGVVHRDLKPCNIAVN
Mpk2_Dmel FLVYQILRGLKY-----------------------------IHSAGVIHRDLKPSNIAVN
p38b_Dmel FLVYQILRGLKY-----------------------------IHSAGVIHRDLKPSNIAVN
p38g_Mmus FLVYQMLKGLKY-----------------------------IHAAGVIHRDLKPGNLAVN
p38d_Mmus YLVYQMLKGLKY-----------------------------IHSAGIVHRDLKPGNLAVN
p38b_Mmus FLVYQLLRGLKY-----------------------------IHSAGIIHRDLKPSNVAVN
p38a_Mmus FLIYQILRGLKY-----------------------------IHSADIIHRDLKPSNLAVN
pmk-3_Cele FIIYQIIRALKY-----------------------------IHSANIIHRDLKPGNLALT
pmk-2_Cele LLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVN
pmk-1_Cele FLVYQILRGLKY-----------------------------IHSADIIHRDLKPSNIAVN
HOG1_Scer YFLYQILRGLKY-----------------------------VHSAGVIHRDLKPSNILIN
p38_Spur FLIYQVLRGLKY-----------------------------IHSAGVIHRDLKPSNIAVN
AqueK129_Aque FLVYQILRGLKY-----------------------------VHSAGIVHRDLKPSNIAVN
AqueK130_Aque LLVYQILRGLKY-----------------------------IHSAGVIHRDIKPSNIGVS
AqueK131_Aque FLLYQILCGLKY-----------------------------VHSAGIIHRDLKPSNIAVN
::**:: .*:* :*:*.::***:** *: :.
p38g_Hsap EDCEL-----------------KILDFGLARQ---ADSEMTGYVVTRWYRAPEVILN-WM
p38d_Hsap EDCEL-----------------KILDFGLARH---ADAEMTGYVVTRWYRAPEVILS-WM
p38b_Hsap EDCEL-----------------RILDFGLARQ---ADEEMTGYVATRWYRAPEIMLN-WM
p38a_Hsap EDCEL-----------------KILDFGLARH---TDDEMTGYVATRWYRAPEIMLN-WM
P38c_Dmel GNSEV-----------------RILDFGLSRM---CADKMTDHVGTMWYLAPEIIFL-RG
Mpk2_Dmel EDCEL-----------------RILDFGLARP---TENEMTGYVATRWYRAPEIMLN-WM
p38b_Dmel EDCEL-----------------RILDFGLARP---AESEMTGYVATRWYRAPEIMLN-WM
p38g_Mmus EDCEL-----------------KILDFGLARQ---ADSEMTGYVVTRWYRAPEVILN-WM
p38d_Mmus EDCEL-----------------KILDFGLARH---TDTEMTGYVVTRWYRAPEVILS-WM
p38b_Mmus EDCEL-----------------RILDFGLARQ---ADEEMTGYVATRWYRAPEIMLN-WM
p38a_Mmus EDCEL-----------------KILDFGLARH---TDDEMTGYVATRWYRAPEIMLN-WM
pmk-3_Cele DDSDL-----------------MILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKID
pmk-2_Cele ERCEVKVFLSFSQLSFLILSFFKILDFGLARA---QDAEMTGYVATRWYRAPEIMLN-WM
pmk-1_Cele EDCEL-----------------KILDFGLARQ---TDSEMTGYVATRWYRAPEIMLN-WM
HOG1_Scer ENCDL-----------------KICDFGLARI---QDPQMTGYVSTRYYRAPEIMLT-WQ
p38_Spur EDCEL-----------------RILDFGLARS---TDDEMTGYVATRWYRAPEIMLN-WM
AqueK129_Aque EDCEL-----------------RILDFGLARA---TDQEMTGYVATRYWRAPEIMLN-WM
AqueK130_Aque SDLEI-----------------KILDFGLGRK---KKGEMTGYVTTRFWRAPEVLLQ-WM
AqueK131_Aque PTCDL-----------------RILDFGLARQ---TDRDMTGYVSTRHYRAPEIMLS-WE
:: * ****.* .:* :* * : :**::
p38g_Hsap RYTQ-TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE---
p38d_Hsap HYNQ-TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA---
p38b_Hsap HYNQ-TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH---
p38a_Hsap HYNQ-TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES---
P38c_Dmel QYTK-AIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMER---
Mpk2_Dmel HYDQ-TVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSES---
p38b_Dmel HYNQ-TADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSES---
p38g_Mmus RYTQ-TVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAE---
p38d_Mmus HYNQ-TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKA---
p38b_Mmus HYNQ-TVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEH---
p38a_Mmus HYNQ-TVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHE---
pmk-3_Cele SYTN-LADMWSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSA
pmk-2_Cele HYTQ-TVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEE---
pmk-1_Cele HYTQ-TVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKISSEE---
HOG1_Scer KYDV-EVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSEN---
p38_Spur HYTE-KVDIWSVGCIMAELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASES---
AqueK129_Aque HYGKEGFDMWSVGCIMAELLTGQVLFPGSDHIDQLTKILQIVGTPDQEFVTKITSDT---
AqueK130_Aque HYDQ-KVDIWSVGCILAELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDD---
AqueK131_Aque NYGK-QVDVWSVGCIMAELLGSKVLFPGDNQIDQLHKIFEIMGTPSQSLIDKIPHQK---
* *:** *** **:: . ** * : : : : * * . :
p38g_Hsap AKNYMKGLPELEKKDFASILTNASPL--AVNLLEKMLVLDAEQRVTAGEALAHPYF
p38d_Hsap AKSYIQSLPQTPRKDFTQLFPRASPQ--AADLLEKMLELDVDKRLTAAQALTHPFF
p38b_Hsap ARTYIQSLPPMPQKDLSSIFRGANPL--AIDLLGRMLVLDSDQRVSAAEALAHAYF
p38a_Hsap ARNYIQSLTQMPKMNFANVFIGANPL--AVDLLEKMLVLDSDKRITAAQALAHAYF
P38c_Dmel SRNYLEGYPLRQRCDFHHLFMGYDVQ--AIDLMEKMLEMVPEKRITAAEAMLHPYL
Mpk2_Dmel ARSYIQSLPPMKGRSFKNVFKNANPL--AIDLLEKMLELDAEKRITAEEALSHPYL
p38b_Dmel ARNYIRSLPVMPRRNFRDIFRGANPL--AIDLLEKMLELDADKRITAEQALAHPYM
p38g_Mmus AKNYMEGLPELEKKDFASVLTNASPQ--AVNLLERMLVLDAEQRVTAAEALTHPYF
p38d_Mmus AKSYIQSLPQSPKKDFTQLFPRASPQ--AADLLDKMLELDVDKRLTAAQALAHPFF
p38b_Mmus ARTYIQSLPPMPQKDLSSVFHGANPL--AIDLLGRMLVLDSDQRVSAAEALAHAYF
p38a_Mmus ARNYIQSLAQMPKMNFANVFIGANPL--AVDLLEKMLVLDSDKRITAAQALAHAYF
pmk-3_Cele IKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQHPYL
pmk-2_Cele ARNYIKNRSPIIRQDFVTLFPMASPY--ALELLEMMLILDPDRRISVSSALRHDYL
pmk-1_Cele ARNYIRNLPKMTRRDFKRLFAQATPQ--AIDLLEKMLHLDPDRRPTAKEAMEHEYL
HOG1_Scer TLKFVTSLPHRDPIPFSERFKTVEPD--AVDLLEKMLVFDPKKRITAADALAHPYS
p38_Spur AKTYLMSMAAYPKRDFSTIFLGASRK--AVDLLEKMLQLDEDRRLSAEQALQHPYL
AqueK129_Aque ARSYIESLPKYPKKDFHTFFQGANPL--AIDLLQMLLTIDPDKRITAEQALLHPYM
AqueK130_Aque ARTYIRSLPTFAKKNFKEYFTGANPL--AVDLLEKLLHLDPDRRPSAAEALEHPYF
AqueK131_Aque TKLYLQSLKVIKPKNLKNLLEIHNND--ALDLLKKLLTLDPERRITVEEALSHPYL
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