CLUSTAL W (1.83) multiple sequence alignment p38g_Hsap MSSP---------------------------------P---------------------- p38d_Hsap MSLI-------------------------------------------------------- p38b_Hsap MSGP-------------------------------------------------------- p38a_Hsap MSQE-------------------------------------------------------- P38c_Dmel M----------------------------------------------------------- Mpk2_Dmel MSVS-------------------------------------------------------- p38b_Dmel MSRK-------------------------------------------------------- p38g_Mmus MSSP---------------------------------P---------------------- p38d_Mmus MSLT-------------------------------------------------------- p38b_Mmus MSGP-------------------------------------------------------- p38a_Mmus MSQE-------------------------------------------------------- pmk-3_Cele MASVPSS-SSLPVSHVRRHEDVS---------TPSAPPTKRSNNQSQPPESYEPNTWLQQ pmk-2_Cele MGMSATMGDS-----------ASIPGVFFADFGPAPPE---------------------- pmk-1_Cele MFPQTTMDH------------------------I-LHP---------------------- HOG1_Scer MTT--------------------------------------------------------- p38_Spur MSAF---------------------------------H---------------------- AqueK129_Aque MAAA--------------------------------DK---------------------- AqueK130_Aque MAAADM-SSV-----------LS---------SPRSPK---------------------- AqueK131_Aque MAKR-------------------------------------------------------- * p38g_Hsap ------------------------------------------PARSGFYRQEVTKTAWEV p38d_Hsap -------------------------------------------RKKGFYKQDVNKTAWEL p38b_Hsap --------------------------------------------RAGFYRQELNKTVWEV p38a_Hsap --------------------------------------------RPTFYRQELNKTIWEV P38c_Dmel ---------------------------------------------PEFVRVAINESLWEF Mpk2_Dmel -------------------------------------------ITKKFYKLDINRTEWEI p38b_Dmel --------------------------------------------MAKFYKLDINRTEWEI p38g_Mmus ------------------------------------------PARKGFYRQEVTKTAWEV p38d_Mmus -------------------------------------------RKRGFYKQDINKTAWEL p38b_Mmus --------------------------------------------RAGFYRQELNKTVWEV p38a_Mmus --------------------------------------------RPTFYRQELNKTIWEV pmk-3_Cele QREQEQQKKLAAENIKKQSIEATGNNEMVGEEEEDILSKPCGPHKRRFQFVMIRNITFAI pmk-2_Cele ------------------------------------------ITPEGYHEVELNKTKWVL pmk-1_Cele ------------------------------------------TPREGYYVVELNRSVWVV HOG1_Scer --------------------------------------------NEEFIRTQIFGTVFEI p38_Spur ------------------------------------------SLPEDFHHIELNKTIWEV AqueK129_Aque ------------------------------------------SLKEGFHRIELFKAEWEV AqueK130_Aque ------------------------------------------PLKPGFYRQDINRDTWIV AqueK131_Aque -------------------------------------------LPQGYYSSKINGTTWEV : : : . p38g_Hsap RAVYR----DLQPVGSGAYGAVCSAV-DG---RTGAKVAIKKLYRPFQSELFAKRAYREL p38d_Hsap PKTYV----SPTHVGSGAYGSVCSAI-DK---RSGEKVAIKKLSRPFQSEIFAKRAYREL p38b_Hsap PQRLQ----GLRPVGSGAYGSVCSAY-DA---RLRQKVAVKKLSRPFQSLIHARRTYREL p38a_Hsap PERYQ----NLSPVGSGAYGSVCAAF-DT---KTGLRVAVKKLSRPFQSIIHAKRTYREL P38c_Dmel PDIYE----FVRFLGGGSFGQVAKVR-LR---GTENYFAMKRLMRPFEREEDAKGTYREI Mpk2_Dmel PDIYQ----DLQPVGSGAYGQVSKAV-VR---GTNMHVAIKKLARPFQSAVHAKRTYREL p38b_Dmel PETYQ----NLQPVGQGAYGQVCKAV-VR---GTSTKVAIKKLARPFQSAVHAKRTYREL p38g_Mmus RAVYQ----DLQPVGSGAYGAVCSAV-DS---RTGNKVAIKKLYRPFQSELFAKRAYREL p38d_Mmus PKTYL----APAHVGSGAYGAVCSAI-DK---RTGEKVAIKKLSRPFQSEIFAKRAYREL p38b_Mmus PQRLQ----GLRPVGSGAYGSVCSAY-DA---RLRQKVAVKKLSRPFQSLIHARRTYREL p38a_Mmus PERYQ----NLSPVGSGAYGSVCAAF-DT---KTGHRVAVKKLSRPFQSIIHAKRTYREL pmk-3_Cele PEGYDVEPNSIEYLGGGSFGNVIKTSAVCRDG-LRRYVAIKKMREPFFDPHHARRIFRET pmk-2_Cele PQWYN----SLKPLGEGAYGVVCTAE-YE---PTGDRVAIKKFFRPFQSTIHAKRTYREL pmk-1_Cele PNYYI----NLTPIGTGAYGTVCAAE-CT---RSGTRVAIKKFNRPFQSIIHARRTYREL HOG1_Scer TNRYN----DLNPVGMGAFGLVCSAT-DT---LTSQPVAIKKIMKPFSTAVLAKRTYREL p38_Spur PNRYV----RLEPVGSGAYGQVCSTE-AEDTRQKGLRVAIKKLSRPFQTVIHAKRTYREL AqueK129_Aque PLNYR----EIASIGTGAYGTVCSAT-DT---HYNIKVALKKLARPFQNHVHAKRTYREL AqueK130_Aque KERYQ----DMSPIGIGGFSTVCCAV-DS---ETGEKVALKKLARPFQSPVHAKRAYREI AqueK131_Aque PDRYQ----ELTPINSGAYGQVCSAL-DT---KYGIRVAIKKLYAPFEHRHNAKKAYREM :. *.:. * . .*:*:: ** *: :** p38g_Hsap RLLKHMRH--ENVIGLLDVFTPD---ETLDDFTDFYLVMPFMGTDLGKLMKH------EK p38d_Hsap LLLKHMQH--ENVIGLLDVFTPA---SSLRNFYDFYLVMPFMQTDLQKIMGM-------E p38b_Hsap RLLKHLKH--ENVIGLLDVFTPA---TSIEDFSEVYLVTTLMGADLNNIVKC------QA p38a_Hsap RLLKHMKH--ENVIGLLDVFTPA---RSLEEFNDVYLVTHLMGADLNNIVKC------QK P38c_Dmel RLLKHMNH--RNVISLLNVFHPP--AHNMMEFQQVYLVTHLMDADLHRYSRS------KR Mpk2_Dmel RLLKHMDH--ENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRM------QH p38b_Dmel RLLKHMDH--ENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRT------QK p38g_Mmus RLLKHMRH--ENVIGLLDVFTPD---ESLDDFTDFYLVMPFMGTDLGKLMKH------ET p38d_Mmus LLLKHMHH--ENVIGLLDVFTPA---SSLRSFHDFYLVMPFMQTDLQKIMGM-------E p38b_Mmus RLLKHLKH--ENVIGLLDVFTPA---TSIEDFSEVYLVTTLMGADLNNIVKC------QA p38a_Mmus RLLKHMKH--ENVIGLLDVFTPA---RSLEEFNDVYLVTHLMGADLNNIVKC------QK pmk-3_Cele KLLQLMRH--DNIICALDIYTPD---EE-NDFRDVYVVTEFAGRSLYQILKQQRDYGRRV pmk-2_Cele KLLRTLQH--DNVLEMIDVFTPD---PDASSLNNVYFVSVLMGSDLQNIMKI------QR pmk-1_Cele RLLRCMCH--ENIIDLLDVFTPN---ENVNDIEDVYFVSMLMGADLSNILKI------QR HOG1_Scer KLLKHLRH--ENLICLQDIFL--------SPLEDIYFVTELQGTDLHRLLQT------RP p38_Spur RLLKHMRH--ENVISLLDCFTPD---R--VNFSDVYMVTHLMGADLNNIIKC------QK AqueK129_Aque RLLKHMKH--ENIIGLLDVFTPA---ENYENFQDVYLVMHLMGSDINNILKQ------QA AqueK130_Aque KLLKMLTRSNANVVELLDVFTPN---DSLDSFNDIYLVTCFMQSDLDNAIKI------QP AqueK131_Aque RILSHLKH--ENCIGLLDVFSPC---EDIEEFSDFYMVMHLMSMDLAKLLKENRT--SQI :* : : * : : : : :.*.* : .: . p38g_Hsap LGEDRIQFLVYQMLKGLRY-----------------------------IHAAGIIHRDLK p38d_Hsap FSEEKIQYLVYQMLKGLKY-----------------------------IHSAGVVHRDLK p38b_Hsap LSDEHVQFLVYQLLRGLKY-----------------------------IHSAGIIHRDLK p38a_Hsap LTDDHVQFLIYQILRGLKY-----------------------------IHSADIIHRDLK P38c_Dmel MSDQEIRIILYQILRGLKY-----------------------------IHSAGVVHRDLK Mpk2_Dmel LSDDHVQFLVYQILRGLKY-----------------------------IHSAGVIHRDLK p38b_Dmel LSDDHVQFLVYQILRGLKY-----------------------------IHSAGVIHRDLK p38g_Mmus LSEDRIQFLVYQMLKGLKY-----------------------------IHAAGVIHRDLK p38d_Mmus FSEDKVQYLVYQMLKGLKY-----------------------------IHSAGIVHRDLK p38b_Mmus LSDEHVQFLVYQLLRGLKY-----------------------------IHSAGIIHRDLK p38a_Mmus LTDDHVQFLIYQILRGLKY-----------------------------IHSADIIHRDLK pmk-3_Cele LTDEHIKFIIYQIIRALKY-----------------------------IHSANIIHRDLK pmk-2_Cele LTDEQIQLLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLK pmk-1_Cele LNDDHIQFLVYQILRGLKY-----------------------------IHSADIIHRDLK HOG1_Scer LEKQFVQYFLYQILRGLKY-----------------------------VHSAGVIHRDLK p38_Spur LSDDHVQFLIYQVLRGLKY-----------------------------IHSAGVIHRDLK AqueK129_Aque LTDEHVQFLVYQILRGLKY-----------------------------VHSAGIVHRDLK AqueK130_Aque ITDDQVQLLVYQILRGLKY-----------------------------IHSAGVIHRDIK AqueK131_Aque LSEDHIKFLLYQILCGLKY-----------------------------VHSAGIIHRDLK : .: :: ::**:: .*:* :*:*.::***:* p38g_Hsap PGNLAVNEDCEL-----------------KILDFGLARQ---ADSEMTGYVVTRWYRAPE p38d_Hsap PGNLAVNEDCEL-----------------KILDFGLARH---ADAEMTGYVVTRWYRAPE p38b_Hsap PSNVAVNEDCEL-----------------RILDFGLARQ---ADEEMTGYVATRWYRAPE p38a_Hsap PSNLAVNEDCEL-----------------KILDFGLARH---TDDEMTGYVATRWYRAPE P38c_Dmel PCNIAVNGNSEV-----------------RILDFGLSRM---CADKMTDHVGTMWYLAPE Mpk2_Dmel PSNIAVNEDCEL-----------------RILDFGLARP---TENEMTGYVATRWYRAPE p38b_Dmel PSNIAVNEDCEL-----------------RILDFGLARP---AESEMTGYVATRWYRAPE p38g_Mmus PGNLAVNEDCEL-----------------KILDFGLARQ---ADSEMTGYVVTRWYRAPE p38d_Mmus PGNLAVNEDCEL-----------------KILDFGLARH---TDTEMTGYVVTRWYRAPE p38b_Mmus PSNVAVNEDCEL-----------------RILDFGLARQ---ADEEMTGYVATRWYRAPE p38a_Mmus PSNLAVNEDCEL-----------------KILDFGLARH---TDDEMTGYVATRWYRAPE pmk-3_Cele PGNLALTDDSDL-----------------MILDFGLARSLEKKDTSLTQYVQTRWYRSPE pmk-2_Cele PSNIAVNERCEVKVFLSFSQLSFLILSFFKILDFGLARA---QDAEMTGYVATRWYRAPE pmk-1_Cele PSNIAVNEDCEL-----------------KILDFGLARQ---TDSEMTGYVATRWYRAPE HOG1_Scer PSNILINENCDL-----------------KICDFGLARI---QDPQMTGYVSTRYYRAPE p38_Spur PSNIAVNEDCEL-----------------RILDFGLARS---TDDEMTGYVATRWYRAPE AqueK129_Aque PSNIAVNEDCEL-----------------RILDFGLARA---TDQEMTGYVATRYWRAPE AqueK130_Aque PSNIGVSSDLEI-----------------KILDFGLGRK---KKGEMTGYVTTRFWRAPE AqueK131_Aque PSNIAVNPTCDL-----------------RILDFGLARQ---TDRDMTGYVSTRHYRAPE * *: :. :: * ****.* .:* :* * : :** p38g_Hsap VILN-WMRYTQ-TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL p38d_Hsap VILS-WMHYNQ-TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL p38b_Hsap IMLN-WMHYNQ-TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI p38a_Hsap IMLN-WMHYNQ-TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI P38c_Dmel IIFL-RGQYTK-AIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGI Mpk2_Dmel IMLN-WMHYDQ-TVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKI p38b_Dmel IMLN-WMHYNQ-TADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRI p38g_Mmus VILN-WMRYTQ-TVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKL p38d_Mmus VILS-WMHYNQ-TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKL p38b_Mmus IMLN-WMHYNQ-TVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKI p38a_Mmus IMLN-WMHYNQ-TVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRM pmk-3_Cele VIYWKIDSYTN-LADMWSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKI pmk-2_Cele IMLN-WMHYTQ-TVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKI pmk-1_Cele IMLN-WMHYTQ-TVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKI HOG1_Scer IMLT-WQKYDV-EVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTI p38_Spur IMLN-WMHYTE-KVDIWSVGCIMAELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKI AqueK129_Aque IMLN-WMHYGKEGFDMWSVGCIMAELLTGQVLFPGSDHIDQLTKILQIVGTPDQEFVTKI AqueK130_Aque VLLQ-WMHYDQ-KVDIWSVGCILAELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKI AqueK131_Aque IMLS-WENYGK-QVDVWSVGCIMAELLGSKVLFPGDNQIDQLHKIFEIMGTPSQSLIDKI :: * *:** *** **:: . ** * : : : : * * . : p38g_Hsap QSDE---AKNYMKGLPELEKKDFASILTNASPL--AVNLLEKMLVLDAEQRVTAGEALAH p38d_Hsap NDKA---AKSYIQSLPQTPRKDFTQLFPRASPQ--AADLLEKMLELDVDKRLTAAQALTH p38b_Hsap SSEH---ARTYIQSLPPMPQKDLSSIFRGANPL--AIDLLGRMLVLDSDQRVSAAEALAH p38a_Hsap SSES---ARNYIQSLTQMPKMNFANVFIGANPL--AVDLLEKMLVLDSDKRITAAQALAH P38c_Dmel SMER---SRNYLEGYPLRQRCDFHHLFMGYDVQ--AIDLMEKMLEMVPEKRITAAEAMLH Mpk2_Dmel SSES---ARSYIQSLPPMKGRSFKNVFKNANPL--AIDLLEKMLELDAEKRITAEEALSH p38b_Dmel SSES---ARNYIRSLPVMPRRNFRDIFRGANPL--AIDLLEKMLELDADKRITAEQALAH p38g_Mmus QSAE---AKNYMEGLPELEKKDFASVLTNASPQ--AVNLLERMLVLDAEQRVTAAEALTH p38d_Mmus KDKA---AKSYIQSLPQSPKKDFTQLFPRASPQ--AADLLDKMLELDVDKRLTAAQALAH p38b_Mmus SSEH---ARTYIQSLPPMPQKDLSSVFHGANPL--AIDLLGRMLVLDSDQRVSAAEALAH p38a_Mmus PSHE---ARNYIQSLAQMPKMNFANVFIGANPL--AVDLLEKMLVLDSDKRITAAQALAH pmk-3_Cele ENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQH pmk-2_Cele QSEE---ARNYIKNRSPIIRQDFVTLFPMASPY--ALELLEMMLILDPDRRISVSSALRH pmk-1_Cele SSEE---ARNYIRNLPKMTRRDFKRLFAQATPQ--AIDLLEKMLHLDPDRRPTAKEAMEH HOG1_Scer CSEN---TLKFVTSLPHRDPIPFSERFKTVEPD--AVDLLEKMLVFDPKKRITAADALAH p38_Spur ASES---AKTYLMSMAAYPKRDFSTIFLGASRK--AVDLLEKMLQLDEDRRLSAEQALQH AqueK129_Aque TSDT---ARSYIESLPKYPKKDFHTFFQGANPL--AIDLLQMLLTIDPDKRITAEQALLH AqueK130_Aque DSDD---ARTYIRSLPTFAKKNFKEYFTGANPL--AVDLLEKLLHLDPDRRPSAAEALEH AqueK131_Aque PHQK---TKLYLQSLKVIKPKNLKNLLEIHNND--ALDLLKKLLTLDPERRITVEEALSH : . : : :*: :* : .:* :. .*: * p38g_Hsap PYFESLHDTED--EPQVQ-KY-------DDSFDDVDRTLDEWKRVTYKEVL--------- p38d_Hsap PFFEPFRDPEE--ETEAQQPF-------DDSLEHEKLTVDEWKQHIYKEIV--------- p38b_Hsap AYFSQYHDPED--EPEAE-PY-------DESVEAKERTLEEWKELTYQEVL--------- p38a_Hsap AYFAQYHDPDD--EPVAD-PY-------DQSFESRDLLIDEWKSLTYDEVI--------- P38c_Dmel PYLRDLIEPHHHAEDTAP-VY-------DQNFENMVLPVKCWKELVSHEIR--------- Mpk2_Dmel PYLEKYAEPSV--EQTSP-PY-------DHSFEDMDLPVDKWKELIYKEVT--------- p38b_Dmel PYMEKYHDPTD--EQTAA-LY-------DQSFEENELPVEKWREMVFSEVT--------- p38g_Mmus PYFESLRDTED--EPKAQ-KY-------DDSFDDVDRTLEEWKRVTYKEVL--------- p38d_Mmus PFFEPFRDPEE--ETEAQQPF-------DDALEHEKLSVDEWKQHIYKEIS--------- p38b_Mmus AYFSQYHDPDD--EPEAE-PY-------DESVEAKERTLEEWKELTYQEVL--------- p38a_Mmus AYFAQYHDPDD--EPVAD-PY-------DQSFESRDLLIDEWKSLTYDEVI--------- pmk-3_Cele PYLAEFSLPED--EPRAD-HI-------FDLDDSQARTRFEWRDAVWKEIM--------- pmk-2_Cele DYLREYSVPND--EPVAM-DTVINSIVTIDPAEERATTLSDWRELIWNEIR--------- pmk-1_Cele EYLAAYHDETD--EPIAE-EM-------DLNDDVRADTIDEWKKIIWEEIS--------- HOG1_Scer PYSAPYHDPTD--EPVADAKF-------DWHFNDADLPVDTWRVMMYSEIL--------- p38_Spur PYLSKYHDPDD--EPIAA-MF-------DDSQENSDIVIDEWRQRVLKEVT--------- AqueK129_Aque PYMANYSDPDD--EPIAP-PY-------DDSFEKLELDAEGWRKMVWDEIQ--------- AqueK130_Aque PYFSWLHRSDD--EPICDQQY-------TDETEDKDLDTEAWKRETFEDIPVTDLEVTLG AqueK131_Aque PYLSDYADPVY--ETTAL-PY-------SDDYEELELEASCWKGLVWKQIQ--------- : * : *: :: p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque EFLDVSLKALEGDCKITLPETDSDLIDTQDFHVFSVDKSEEFSLSTQLKNISYISTASLK AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque DPPTLFLESSIFRSAIEVDIDSRIKRRRETIGSSVKNSAPYPPVRSLSLSSKGMSSEHMI AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque FLAGRKEYDNNMSQRMYGSTDVMSLSEGTSSLNLPEESLQRVFSNSMSMIDETGSIQSYG AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque SEASEVLSRKLGGKDGLHDSDAFSHGGESSQESEVQHPPRVYIRHSTCDEEQETVVKTSG AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque VDDNNLLPTCEENTPPDTPAKQSSALRSRKVKLSSRRASAMATLSPLPVNDDTVLNLPSP AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque LLNAQGSFNRTTFRAKRNGSTVISPQHTKVYGSIKLFVVDFDIVVANIILTMDIRGDNTV AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque TQIKQSLWRLLRDEGHVTQECDSLWDPEKFTLTYEMNSSVYELYDEQQIFQTTTVAQLWR AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque QEKRQKGQLSVVTKRAESKEEKTLNMAISSMIGIGLYQLQFANNDELDITRRKMVAERQK AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque AVQQRDPAMYSMEVEVQFTPLPPHVKAMIGEENKLLVKVYYESGASQTFQVDVNTVADDF AqueK131_Aque ------------------------------------------------------------ p38g_Hsap --------------------------------------------SFKPPRQ--------- p38d_Hsap --------------------------------------------NFSPIAR--------- p38b_Hsap --------------------------------------------SFKPPEP--------- p38a_Hsap --------------------------------------------SFVPPPL--------- P38c_Dmel --------------------------------------------NFRPDQ---------- Mpk2_Dmel --------------------------------------------NFKPPPS--------- p38b_Dmel --------------------------------------------AFKPTAA--------- p38g_Mmus --------------------------------------------SFKPPRQ--------- p38d_Mmus --------------------------------------------NFSPIAR--------- p38b_Mmus --------------------------------------------SFKPLEP--------- p38a_Mmus --------------------------------------------SFVPPPL--------- pmk-3_Cele --------------------------------------------NYKRLSS--------- pmk-2_Cele --------------------------------------------LFQNSAR--------- pmk-1_Cele --------------------------------------------DFQKNVA--------- HOG1_Scer --------------------------------------------DFHKIGG--------- p38_Spur --------------------------------------------EFVADPA--------- AqueK129_Aque --------------------------------------------LFQKDPS--------- AqueK130_Aque LPTVFPTEPHKRKRLGLPEHCNISDYVLKVAGRSSFIHGNFELIDFSPIVKALSKRRDIV AqueK131_Aque --------------------------------------------TFTPDPA--------- : p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque LALVRRSDPKDDLPQHFPDWDLIDESTGLTGTHEELSALGKEHSQVFTMSMWDLQHKFRV AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque RILGLDNLRDCSPDFDVIYVDVAVFHGGEELCRTLSTHEITACKYPRWNQWLVFNIAVKN AqueK131_Aque ------------------------------------------------------------ p38g_Hsap -----------------LGA---------------------------------------- p38d_Hsap -----------------KDS---------------------------------------- p38b_Hsap -----------------PKP---------------------------------------- p38a_Hsap -----------------D------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel -----------------YAQ---------------------------------------- p38b_Dmel -----------------FAE---------------------------------------- p38g_Mmus -----------------LGA---------------------------------------- p38d_Mmus -----------------KDS---------------------------------------- p38b_Mmus -----------------SQL---------------------------------------- p38a_Mmus -----------------D------------------------------------------ pmk-3_Cele -----------------SP----------------------------------------- pmk-2_Cele -----------------RLSFVS------------------------------------- pmk-1_Cele -----------------FAD---------------------------------------- HOG1_Scer -----------------SDGQIDISATFDDQVAAATAAAAQAQAQAQAQVQLNMAAHSHN p38_Spur -----------------P------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque LPKAARLCFAVSGGVRRNDS---------------------------------------- AqueK131_Aque -----------------M------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ---------------------------------CT------------------------- pmk-1_Cele ----------------------------------E------------------------- HOG1_Scer GAGTTGNDHSDIAGGNKVSDHVAANDTITDYGNQA------------------------- p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque ----------------------------------RKRSSTWSKKDFVKQNTLRGDNIQAD AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque RPLHWVNMQILDHRALLRQGVLRLNLWPYSTSGGEGRWGGMSPVGSTAVNPDGNTAAVLF AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque IELDTYLHPVACPTEGWGDEEIRYLRSEMDSPQFSQRFGILLEAFLKGCGKNIFIELQKQ AqueK131_Aque ------------------------------------------------------------ p38g_Hsap --------------------------------------------R-V------------- p38d_Hsap --------------------------------------------R-R------------- p38b_Hsap --------------------------------------------P-G------------- p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus --------------------------------------------R-V------------- p38d_Mmus --------------------------------------------R-R------------- p38b_Mmus --------------------------------------------P-G------------- p38a_Mmus ------------------------------------------------------------ pmk-3_Cele --------------------------------------------L-I------------- pmk-2_Cele --------------------------------------------D-T------------- pmk-1_Cele --------------------------------------------E-E------------- HOG1_Scer --------------------------------------------I-Q------------- p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque HQAVQDIMSIASGLKKHMEKHKGSATDYAKADLSQQNLPEYFAPPFDPSLRMGNLQVEKC AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque RVMDSKKTPLWLEFMNMDPSSTTQKPIKVIAKHGDDLRQDMLTLQMLTIMDSLWQSEGLD AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque LYIIPYGCVATGNEMGMIEVVQDAETVAKIQLHHGGSFSTLKDEPLYEWLKKKNPNPKHF AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque EQAIERFVYSCAGYCVATYVLGIGDRHNDNIMLTVSGNLFHIDFGHFLGNTKAFLGVNRD AqueK131_Aque ------------------------------------------------------------ p38g_Hsap ------------------------------------------------------------ p38d_Hsap ------------------------------------------------------------ p38b_Hsap ------------------------------------------------------------ p38a_Hsap ------------------------------------------------------------ P38c_Dmel ------------------------------------------------------------ Mpk2_Dmel ------------------------------------------------------------ p38b_Dmel ------------------------------------------------------------ p38g_Mmus ------------------------------------------------------------ p38d_Mmus ------------------------------------------------------------ p38b_Mmus ------------------------------------------------------------ p38a_Mmus ------------------------------------------------------------ pmk-3_Cele ------------------------------------------------------------ pmk-2_Cele ------------------------------------------------------------ pmk-1_Cele ------------------------------------------------------------ HOG1_Scer ------------------------------------------------------------ p38_Spur ------------------------------------------------------------ AqueK129_Aque ------------------------------------------------------------ AqueK130_Aque RAPFVLTPDFEYVLGKRTSENFKKFEEIAVRAYLIIRKNANLFINLFSMMKCTGIPELRS AqueK131_Aque ------------------------------------------------------------ p38g_Hsap --------------------------------------------SKETPL p38d_Hsap --------------------------------------------RSGMKL p38b_Hsap --------------------------------------------SLEIEQ p38a_Hsap --------------------------------------------QEEMES P38c_Dmel ---------------------------------------------LDLHF Mpk2_Dmel --------------------------------------------VLKDVK p38b_Dmel --------------------------------------------LLPKEQ p38g_Mmus --------------------------------------------PKETAL p38d_Mmus -------------------------------------------RSGMKLQ p38b_Mmus --------------------------------------------THEIEQ p38a_Mmus --------------------------------------------QEEMES pmk-3_Cele --------------------------------------------PGEADR pmk-2_Cele -------------------------------------------EEEPMKI pmk-1_Cele -------------------------------------------DEEKMES HOG1_Scer -------------------------------------------YANEFQQ p38_Spur ------------------------------------------------MD AqueK129_Aque -----------------------------------------------LYQ AqueK130_Aque VEDLDYLKSVLVLGKNEEQAADHFRQQIQKCLRLQWSTQLSWLAHNWVHR AqueK131_Aque ---------------------------------------------YLLDD