cdc2c_Dmel MTT--ILDNFQRAEKIGEGTYGIVYKARSNSTG---QDVALKKIRLEGETEGVPSTAIRE
CDK2_Mmus ------MENFQKVEKIGEGTYGVVYKAKNKLTG---EVVALKKIRLDTETEGVPSTAIRE
CDC28_Scer MSG--ELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIRE
CDK2_Hsap ------MENFQKVEKIGEGTYGVVYKARNKLTG---EVVALKKIRLDTETEGVPSTAIRE
CDK3_Hsap ------MDMFQKVEKIGEGTYGVVYKAKNRETG---QLVALKKIRLDLEMEGVPSTAIRE
Cdc2_Ddis MESDGGLSRYQKLEKLGEGTYGKVYKAKEKATG---RMVALKKIRL--EDDGVPSTALRE
CDK2_Spur ------MNNFEKIEKIGEGTYGVVYKARDLKSG---KTVALKKIRLDTESEGVPSTAIRE
AqueK096_Aque ------MDGYERLEKIGEGTYGVVYKARQATHGN--RVVALKKIRLDAECEGVPSTAIRE
: ::: **:****** **** . * . ******** * :******:**
cdc2c_Dmel ISLLKNLKHPNVVQLFDVVISG-NNLYMIFEYLNMDLKKLMDKKKDV--FTPQLIKSYMH
CDK2_Mmus ISLLKELNHPNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLF
CDC28_Scer ISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMM
CDK2_Hsap ISLLKELNHPNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLF
CDK3_Hsap ISLLKELKHPNIVRLLDVVHNE-RKLYLVFEFLSQDLKKYMDSTPGS-ELPLHLIKSYLF
Cdc2_Ddis ISLLKEVPHPNVVSLFDVLHCQ-NRLYLVFEYLDQDLKKYMDSVPA---LCPQLIKSYLY
CDK2_Spur IALLKELDHKNIVKLHDVVHSD-KKLYLVFEFMNQDLKKYMDVAPPS-GLPPGLVKSYLQ
AqueK096_Aque ISILKELDHVNIVSLLDVLYCD-RKLFMVFEFLDYDLKKYMDRHAPT-GIP-----TARA
*::**:: . *:* * *:: ..*:::**:: ***: *: : .
cdc2c_Dmel QILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYR
CDK2_Mmus QLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYR
CDC28_Scer QLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYR
CDK2_Hsap QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR
CDK3_Hsap QLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYR
Cdc2_Ddis QLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYR
CDK2_Spur QLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYR
AqueK096_Aque KLLEGVAYCHAHRVLHRDLKPQNLLISSDGRIKLADFGLARAFGVPVRTYTHEVVTLWYR
:: ..:.:.* :*::**********:. * :**.*******..:*:*.****:******
cdc2c_Dmel APEILLGTKFYSTGVDIWSLGCIFSEM---------------------------------
CDK2_Mmus APEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVA
CDC28_Scer APEVLLGGKQYSTGVDTWSIGCIFAEM---------------------------------
CDK2_Hsap APEILLGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVA
CDK3_Hsap APEILLGSKFYTTAVDIWSIGCIFAEM---------------------------------
Cdc2_Ddis APEVLLGSKSYSVPVDMWSVGCIFGEM---------------------------------
CDK2_Spur APEILLGCRYYSTAVDIWSLGCIFVEM---------------------------------
AqueK096_Aque SPELLLGSQYYSTPVDIWSIGCIFAEM---------------------------------
:**:*** : *:. ** **:**** **
cdc2c_Dmel ---------------IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFP
CDK2_Mmus ASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP
CDC28_Scer ---------------CNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFP
CDK2_Hsap ASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP
CDK3_Hsap ---------------VTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFP
Cdc2_Ddis ---------------LNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFP
CDK2_Spur ---------------ITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFP
AqueK096_Aque ---------------VTKRPLFPGDSEIDQLFRIFRTLGTPDESVWPGISSFPDYKSSFP
::.:*.**.****:::*** :.**.: **.: :*:: .**
cdc2c_Dmel RWEGTNMPQ--PITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPVDP
CDK2_Mmus KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK-PV-------
CDC28_Scer QWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE-------------
CDK2_Hsap KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK-PV-------
CDK3_Hsap KWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQY---
Cdc2_Ddis NWPGQPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYFGDLDTS---------
CDK2_Spur RWTPQDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYFKDVKMVPP-------
AqueK096_Aque KWPRQNLQRIVKSLDTLGINLLEQMLCYEPCKRITAINGMRHPFFS--------------
.* . : . .*: .:* *:* **:* . *.:*
cdc2c_Dmel NAGSASRLT-RLV
CDK2_Mmus --------PHLRL
CDC28_Scer ------------S
CDK2_Hsap --------PHLRL
CDK3_Hsap ------VLQRFRH
Cdc2_Ddis -----------FF
CDK2_Spur --------PRLPT
AqueK096_Aque ------------E