cdc2c_Dmel      FQRAEKIGEGTYGIVYKARSNSTG---QDVALKKIRLEGETEGVPSTAIREISLLKNLKH
CDK2_Mmus       FQKVEKIGEGTYGVVYKAKNKLTG---EVVALKKIRLDTETEGVPSTAIREISLLKELNH
CDC28_Scer      YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKD
CDK2_Hsap       FQKVEKIGEGTYGVVYKARNKLTG---EVVALKKIRLDTETEGVPSTAIREISLLKELNH
CDK3_Hsap       FQKVEKIGEGTYGVVYKAKNRETG---QLVALKKIRLDLEMEGVPSTAIREISLLKELKH
Cdc2_Ddis       YQKLEKLGEGTYGKVYKAKEKATG---RMVALKKIRL--EDDGVPSTALREISLLKEVPH
CDK2_Spur       FEKIEKIGEGTYGVVYKARDLKSG---KTVALKKIRLDTESEGVPSTAIREIALLKELDH
AqueK096_Aque   YERLEKIGEGTYGVVYKARQATHGN--RVVALKKIRLDAECEGVPSTAIREISILKELDH
                ::: **:****** **** .   *   . ********  * :******:***::**:: .

cdc2c_Dmel      PNVVQLFDVVISG-NNLYMIFEYLNMDLKKLMDKKKDV-F-TPQLIKSYMHQILDAVGFC
CDK2_Mmus       PNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLFQLLQGLAFC
CDC28_Scer      DNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYC
CDK2_Hsap       PNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLFQLLQGLAFC
CDK3_Hsap       PNIVRLLDVVHNE-RKLYLVFEFLSQDLKKYMDSTPGS-ELPLHLIKSYLFQLLQGVSFC
Cdc2_Ddis       PNVVSLFDVLHCQ-NRLYLVFEYLDQDLKKYMDSVPA---LCPQLIKSYLYQLLKGLAYS
CDK2_Spur       KNIVKLHDVVHSD-KKLYLVFEFMNQDLKKYMDVAPPS-GLPPGLVKSYLQQLLQGIAFC
AqueK096_Aque   VNIVSLLDVLYCD-RKLFMVFEFLDYDLKKYMDRHAPT-GIP-----TARAKLLEGVAYC
                 *:* * *::    ..*:::**::  ***: *:              .   :: ..:.:.

cdc2c_Dmel      HTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTK
CDK2_Mmus       HSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK
CDC28_Scer      HSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGK
CDK2_Hsap       HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK
CDK3_Hsap       HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK
Cdc2_Ddis       HGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSK
CDK2_Spur       HAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCR
AqueK096_Aque   HAHRVLHRDLKPQNLLISSDGRIKLADFGLARAFGVPVRTYTHEVVTLWYRSPELLLGSQ
                * :*::**********:.  * :**.*******..:*:*.****:******:**:*** :

cdc2c_Dmel      FYSTGVDIWSLGCIFSEM------------------------------------------
CDK2_Mmus       YYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTA
CDC28_Scer      QYSTGVDTWSIGCIFAEM------------------------------------------
CDK2_Hsap       YYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTA
CDK3_Hsap       FYTTAVDIWSIGCIFAEM------------------------------------------
Cdc2_Ddis       SYSVPVDMWSVGCIFGEM------------------------------------------
CDK2_Spur       YYSTAVDIWSLGCIFVEM------------------------------------------
AqueK096_Aque   YYSTPVDIWSIGCIFAEM------------------------------------------
                 *:. ** **:**** **

cdc2c_Dmel      ------IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQ
CDK2_Mmus       VSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSK
CDC28_Scer      ------CNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQ
CDK2_Hsap       VSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSK
CDK3_Hsap       ------VTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEE
Cdc2_Ddis       ------LNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNK
CDK2_Spur       ------ITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTK
AqueK096_Aque   ------VTKRPLFPGDSEIDQLFRIFRTLGTPDESVWPGISSFPDYKSSFPKWPRQNLQR
                        ::.:*.**.****:::*** :.**.:  **.:  :*::  .**.*      .

cdc2c_Dmel      --PITEHEAHELIMSMLCYDPNLRISAKDALQHAYF
CDK2_Mmus       VVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
CDC28_Scer      VVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYF
CDK2_Hsap       VVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
CDK3_Hsap       IVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
Cdc2_Ddis       IFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYF
CDK2_Spur       IVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYF
AqueK096_Aque   IVKSLDTLGINLLEQMLCYEPCKRITAINGMRHPFF
                     :  . .*: .:* *:*  **:*  .  *.:*