Kinase Subfamily RSKp90

Kinase Classification: Group AGC: Kinase Family RSK: RSKp90

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RSK are Ribosomal S6 Kinases, phosphorylating the S6 subunit of the cytoplasmic ribosome, and so controlling the rate of protein translation.

Evolution

RSKp90 genes are found in all holozaons. While RSK family genes outside of animals are often not classified to the subfamily level, none have the dual kinase domain arrangement.

Domain Structure

RSKp90 kinases have an AGC-group kinase domain followed by the PKC_Cterminal domain typical of AGC kinases, and then have a second, active kinase domain, from the CAMK group. The MSK subfamily of RSK have a similar organization.

Nomenclature

The RSKp90 human genes have a confusing nomenclature. The most common nomenclature calls them RSK1-RSK4, but the numbers are scrambled in some sources:

• The 2002 human kinome paper called RSK3 to be RSK1 and RSK1 to be RSK3.
• The HGNC 'official' human gene nomenclature calls these kinases RPS6KA#, and transposes the numbers in a different way: RSK2 is known as RPS6KA3, RSK3 is known as RPS6KA2, and RSK4 is known as RPS6KA6.