Kinase Subfamily PI3K3

Kinase Classification: Group PKL: Family PIK: Subfamily PI3K3

Class 3 Phosphatidyl Inositol Kinases

Evolution

A single PI3K3 is found in most or all eukaryotes [1]. The human gene is PIK3C3 and the yeast is Vps34. Its regulatory partner, Vps15, is also pan-eukaryotic.

Domain Structure

PI3K3 have a N-terminal C2 domain followed by PI3Ka (accessory domain), and then a PKL kinase domain.

Functions

PI3K3 has a conserved role in membrane trafficking and autophagy, in yeast and mammals, as well as endocytosis and insulin signaling in mammals.

References

1. Philippon H, Brochier-Armanet C, and Perrière G. Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns. BMC Evol Biol. 2015 Oct 19;15:226. DOI:10.1186/s12862-015-0498-7 |