Kinase Subfamily DYRKP

Kinase Classification: Group CMGC: Family DYRK: Subfamily DYRKP

Potential plant homologues of human Dyrk1a (UniProt ID:Q13627) exhibits 31-60% sequence identity. At the same time, the similarity was 50-79% and 15% of gaps. All plant sequences are represented by proteins with unknown function (July 21-24, 2011), and have «Unreviewed» UniProt status. The Neighbor-Joining clustering of plant homologues and «Reviewed» DYRKs catalytic domains resulted in common clade. Based on common clustering the 34 plant homologues were identified, among them 18 potential plant DYRK-like kinases were represented by complete sequences (Fig).

Functions

The analysis by complete sequence STRING v.8.3 tool scanning of plant homologues in human proteome confirm their strong relationship to DYRK group. Therefore, Dyrk1A - A9U0E5 from Physcomitrella patens subsp. patens, D7MHY5 from Arabidopsis lyrata subsp. lyrata, Q8RWH3 from A. thaliana, Q00ZG2 from Ostreococcus tauri; Dyrk1B - C1MRI0 from Micromonas pusilla; Dyrk3 - A4RXI5 from O. lucimarinus, Q019C0 from O. tauri и Dyrk4 - A9RDR5 and A9TA59 from P. patens subsp. patens, C0PR87 from Picea sitchensis, B9SDF7 from Ricinus communis, D8RDP5 from Selaginella moellendorffii, A9TKQ3 from P. patens subsp. patens, D8RRY9 from S. moellendorffii).

References

KARPOV P.A., RAEVSKY A.V., ISAENKOV S.V., SPIVAC S.I., BLUME Ya.B. Identification of Plant Homologs of Dual Specificity Yak1-Related Kinase 1A. Proceedings of the International Moscow Conference on Computational Molecular Biology (MCCMB’11). 2011, Moscow, Rossia. – P.148-149. http://mccmb.belozersky.msu.ru/2011/mccmb11.pdf

RAEVSKY A.V., KARPOV P.A., KORABLYOV M.D., ISAENKOV S.V., BLUME Ya.B. Prediction and Validation of Plant DYRK1A Homologs Spatial Structure. Proceedings of the International Moscow Conference on Computational Molecular Biology (MCCMB’11). 2011, Moscow, Rossia. – P.148-149. http://mccmb.belozersky.msu.ru/2011/mccmb11.pdf