Kinase Family TKL-Sp1
Kinase Classification: Group TKL: Family TKL-Sp1
TKL-Sp1
An uncharacterized TKL family with an unusual evolutionary range, first described a specific to the sea urchin, Strongylocentrotus purpuratus [1] (hence the 'Sp' part of the name), but now seen to be in several animal phyla.
Evolution
TKL-Sp1 genes are found in fish (generally one per genome), some chordates (several in Saccoglossus, one in Branchiostoma), another expansion in the sea urchin, and with likely orthologs also found in the wasp Nasonia, and the sea anemone, Nematostella. The family is quite divergent, but the orthology between the members seems clear.
Domain Structure
Most members have an N-terminal kinase domain and a short C-terminal extension. Several urchin homologs have upstream ankyrin repeats.
Function
No function is known for any TKL-Sp1 kinase. They are very poorly represented in EST databases, suggesting very low or restricted expression. All appear to be catalytically active.
Details
A draft sequence analysis is available on the TKL-Sp1 Draft Analysis page.
References
- Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, and Manning G. The sea urchin kinome: a first look. Dev Biol. 2006 Dec 1;300(1):180-93. DOI:10.1016/j.ydbio.2006.08.074 |
