Kinase Family RSKR
From WikiKinome
Kinase Classification: Group AGC: Kinase Family RSKR
RSKR are RSK-Related kinases, first named in the human [1] and Drosophila[2] kinome papers. The family is closely related to RSK and RSKL families, and is found only in bilateral animals. All have a central kinase domain with weakly conserved flanking regions. The human RSKR, SgK494 is uncharacterized, and the Drosophila homolog Pk17E has only been characterized as part of large-scale screens, making this one of the more mysterious of kinase families.
References
- Manning G, Whyte DB, Martinez R, Hunter T, and Sudarsanam S. The protein kinase complement of the human genome. Science. 2002 Dec 6;298(5600):1912-34. DOI:10.1126/science.1075762 |
- Manning G, Plowman GD, Hunter T, and Sudarsanam S. Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci. 2002 Oct;27(10):514-20. DOI:10.1016/s0968-0004(02)02179-5 |
