Kinase Family PHK

Kinase Classification: Group CAMK: Family PHK

PHK, or phosphorylase kinase regulates release of glucose from glycogen stored in muscle.

Evolution

Trbl is found throughout animals. Most organisms have a single copy, mammals have two, PHKg1 ad PHKg2.

Domain Structure

All PHK have an N-terminal ePK kinase domain, followed by a shorter C-terminal region containing two calmodulin-binding domains

Functions

PHKg is the gamma subunit of the phosphorylase kinase complex, which phosphorylates and activates glycogen phosphorylase, increasing release of glucose-1-phosphate from glycogen. PHK was the first protein kinase to be purified and extensively characterized, by Krebs and Fisher [1, 2]

References

1. Fischer EH. Phosphorylase and the origin of reversible protein phosphorylation. Biol Chem. 2010 Feb-Mar;391(2-3):131-137. DOI:10.1515/bc.2010.011 |
2. KREBS EG, GRAVES DJ, and FISCHER EH. Factors affecting the activity of muscle phosphorylase b kinase. J Biol Chem. 1959 Nov;234:2867-73.