Kinase Family NNK1

Kinase Classification: Group CAMK: Family NNK1

NNK1 (SGD) is a yeast kinase implicated in interactions with TOR and nitrogen metabolism [1]. Up until 2011, it was classified as CAMK-Unique, but then was placed in its own family, due to the presence of orthologs in other fungi including basidiomycetes such as Coprinopsis cinerea. The protein has multiple inserts within the kinase domain, of varying length in different orthologs, making blast-based homology comparisons difficult. It may be a member of the CAMKL family, but this needs more investigation.

References

1. Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, Larsen B, Lin ZY, Breitkreutz BJ, Stark C, Liu G, Ahn J, Dewar-Darch D, Reguly T, Tang X, Almeida R, Qin ZS, Pawson T, Gingras AC, Nesvizhskii AI, and Tyers M. A global protein kinase and phosphatase interaction network in yeast. Science. 2010 May 21;328(5981):1043-6. DOI:10.1126/science.1176495 |