Shk1_Ddis MATQQQQQ-----------------QQQQQQQQ---------------------------
Shk2_Ddis MNDKISKL---------ESSILQLTEEVKQLESKQASKELEIRTLVDNAINSQNPAQERE
Shk3_Ddis MDSGLGS-----------------------------------------------------
Shk4_Ddis MKRFFSNL---------FKRKQDQNSHIKQINGPTTSTPTTTPTTPTTPTTTQTPTPQNN
Shk5_Ddis MDINLIKQYINSSLPNDKESLIQYYGQLKQILNALSDKEQQQ-LLNNNGKISE--QQQLS
* .
Shk1_Ddis ------------------------IK----A--R---------KDI--------------
Shk2_Ddis -----LINKLFTESLIDLKLKAEKIQTLERYRQEIITNLLVE------------------
Shk3_Ddis ------------------------------------------------------------
Shk4_Ddis NTNNNTNNNNNTNSNNSNQQKKEQAQ----A--SPSTNQTQTPSNNTISTSPTVTTQPSF
Shk5_Ddis IEN-------NYKVIGS-I--EEKMK----SIEHLFNNLDVS------------------
Shk1_Ddis ------------------------------------------------------------
Shk2_Ddis ------------------------------------------------------------
Shk3_Ddis ------------------------------------------------------------
Shk4_Ddis TPGVISTSKLTTSPPESPRPPTSTTNTTQPSTTTTTATNSTNTNTASAPTKTASPSSPSA
Shk5_Ddis ------------------------------------------------------------
Shk1_Ddis ------------------------------------------------------------
Shk2_Ddis ---Q-KQPNDTSI-----------------------------ISAWEQLKISSFRINPNN
Shk3_Ddis ------------------------------------------------------------
Shk4_Ddis TASPNNNSNNTTTTAATTTTTTTTTTTTNANQTASVNHTSSDQSLNAQN-VTQTNNNNNN
Shk5_Ddis ---DSNNNNST-----------------------SP----VFISLDNQNTVNNNNNNNNN
Shk1_Ddis ------------------------------------------------------------
Shk2_Ddis NNNNSNNTNSSDSNQNYSS--VILNGSLTEDSTSTISPDSTKN-----------------
Shk3_Ddis ------------------------------------------------------------
Shk4_Ddis NNNNNNNNNANNTKPINPNDYIPLDFV---DST----P----------------------
Shk5_Ddis NNNNNNNNNNNNNNSLAPT--VILDNNDNKKTAEIILPDHHNNTPQQQPEQQVQQQQVQQ
Shk1_Ddis ----QIQQA-----------------------------------QSASDILGPPEISETE
Shk2_Ddis --------------------------------------------RDEE-EIIRWEIDRNE
Shk3_Ddis --------S-----------------------------------YPE-ERSGPPEIRPEE
Shk4_Ddis ----KVDNN-----------------------------------QPKRKASGPPEILPEE
Shk5_Ddis QQQVQQQQQQPEQQQQHLTEEQIQKQQQSQASIQQAIANMGEKKRSSSRHSGPPEIPPEE
** *
Shk1_Ddis ITT---ESILGDGSFGTVYKGRCRLKDVAVKVMLKQV-DQKTLTDFRKEVAIMSKIFHPN
Shk2_Ddis ISYN-REAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPH
Shk3_Ddis INF---EELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPN
Shk4_Ddis IDR---TDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPN
Shk5_Ddis IKFDVKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPN
* :* *::*.***. * : **:* : . :. *::** :* :: :*:
Shk1_Ddis IVLFLGACTSTPGKLMICTELM-KGNLESLLLDPMVK--LPLITR-MRMAKDAALGVLWL
Shk2_Ddis LLLFMGACTA-PEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWL
Shk3_Ddis ICLFMGACTI-PGRCVIVTELVPKGNLETLLHDQKIQ--LPLYLR-MRMARDAALGINWL
Shk4_Ddis VVLFLGACTQ-SGKMQIVTELC-QTDLEKLLHNDRTKKEFSLFRR-MQMAKDAALGMNWL
Shk5_Ddis VVLCLGACTK-PGKVMIVSELM-QTDLEKLIHSSEVEP-PPLYER-MKMCLDAALGINWL
: * :**** . * :** : .:..*: * : :. *:.**: **
Shk1_Ddis HSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEV
Shk2_Ddis HASN--ILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDS--KDKLLGQAGSPLYMAPEM
Shk3_Ddis HESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKD-QSSAKGTPLYMAPEV
Shk4_Ddis HGITR-IVHNDLKTANLLVDINLRVKVTDFGFSQIKE-GEEFQD--KAAKGTPLWMAPEV
Shk5_Ddis HGICN-IIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSD-QKGPKGTALYMAPEV
* ::* *:* :**::. : **: ***:* : .* . *:.*:****:
Shk1_Ddis LQGRLFNEKADVYSFGLVLWQIFTRQELFPE-FDNFFKFVAAICEKQLRPSIPDDCPKSL
Shk2_Ddis LVNQPYDGKVDVFSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRL
Shk3_Ddis MMFKEFNESSDVYSFGIVLWEILTRKEPFSH-HRELEKFREAVCVKHERPPIPNDCLDSL
Shk4_Ddis MMGNPYNEKADVYSFGIILWEILTKEAPYSH-HKDYDIFFNAICNEKERPPIPADTLPSL
Shk5_Ddis MMKHEFNEKADVYSFGLILYEMATCEELFPE-YSEIDPFYDAICNKKLRPPIPDSFPKSL
: . :: . **:**.::*::: * : : . . . : .: :: ** ** *
Shk1_Ddis KELIQKCWDPNPEVRPSFEGIVSE--LEEIIIDCCIPDEYGAILWKNHFKH-----ENEA
Shk2_Ddis KDLLARCWDHYPSRRPSFAEISKQRILETILIDGLILDSSARQFWSQYYMG-----KEEV
Shk3_Ddis RRLIEKCWDKEPISRPSFKEIISA--LDHVIIDAAISDLNGRDFWKKSFLT-----EQEV
Shk4_Ddis RHLIQTCWDHNPQNRPSFSEILFR--LNEILIDCAIDFDDGRKYWKEHFLVPKQELQEEV
Shk5_Ddis KTLIQKCWDHDPNKRPSFNEVTQR--MNEVLTDTAISGLDAAMFWKYNFIKPE---SESV
: *: *** * **** : :: :: * * . *. : .:..
Shk1_Ddis NWKDFINVFSNFVGLTNANTPSMSDLLQFSPNLNGSTIELNFKCLKSIIVSSPK--GPHE
Shk2_Ddis PWNSFIVNFSLYCGFESNLS----------------ADDIKIKFLKLLLV-------PVD
Shk3_Ddis PWEAFIDALCNWSKAPARNQCD---------KT--SIDYLNIKCLKAVLAESPKSEGTGV
Shk4_Ddis EWSDFEKTLKATHKQLN----------------------LDYAPLKELLVQQSHQTVQKT
Shk5_Ddis PWNEFVYKLSSVVNLPTQV----------------------LSPLAQLFVSQSYE--EEI
*. * : * ::.
Shk1_Ddis EEVVLMEQFGKVLAWFGNLKE--DGSQILDKIRQLMECAWFHGDISTSESENRLRQKPEG
Shk2_Ddis SDMVTIDNFGKILTWVGPLT---NGREFFDKVYSICSIKGFMAATSSKNASQYLAGKKTG
Shk3_Ddis ETVVNIEKFGKILEFFGPVPEPAPGHSIMDTVREILSQKWFHGDLDTTEAASRLNGQPIG
Shk4_Ddis KQVVTMERFDKVSKWFGSFFEPNTGIETIDNINKLSAKIWFHGDIVREQATSRLSKAAEG
Shk5_Ddis GGVVTMERFDLMNKWFGNFFNSKYGPAILYEMIELLKKRWFHFDISRDISEKRLRGRPEN
:* ::.*. : :.* . * : : .: * : . * .
Shk1_Ddis TFLVRFSTSEYG--AYTISKVSKNGGISHQRIHR---P------------QGK----FQV
Shk2_Ddis TYILRFSS-DPG--SYAISYLNKNKEIIHARVIY---KQGS---------GYI----HHG
Shk3_Ddis SFLIRFSSTNAG--CFTISQVVDGGSIKHQRVSR---Q------------GVK----FNY
Shk4_Ddis AFLIRLSSTEPK--TCPFTLSMKNN--QHRRIQLIDENNF---------TGFK----IQG
Shk5_Ddis TFLLRLSANDPIKTPFTISK-TKGSKPTHKRVSR---EDVQINEIKQFPMGYKFTVPLDG
::::*:*: : .:: .. * *: .
Shk1_Ddis NNSKYLSVKELITGEAQA--------LGINTPCLGSRFLSLIYK--------------AQ
Shk2_Ddis GQTHYATLDDLIKNTFKS--------LGIKEPFEGGPFHALTVAASSSKPFNIAGAYIPV
Shk3_Ddis QNVIYNSLIEIVSKNGGGANGDVKLDSQLGVPNY--KFMSLFCV------------L-NK
Shk4_Ddis KTAVYNSLIELVEKCND---------YPLLVPCP--KFTQET--------------F-NP
Shk5_Ddis NELVFGSITQMVEELHRI--------GNLSIPCP-------ITE--------------IK
: :: ::: : *
Shk1_Ddis LSGYIN
Shk2_Ddis APSKKI
Shk3_Ddis ESEVYQ
Shk4_Ddis YDPYTN
Shk5_Ddis VPYLTD