TGFbR2_Hsap MGRGLLR-GLW---------P--------LH-I-VLWTR--I--ASTIPPHVQKSDVEME
MISR2_Hsap MLGSLG-----------------------------LWALLPT-----AVEAP--------
MISR2_Mmus MLGTLG-----------------------------LWTLLPA-----AAQVS--------
BMPR2_Mmus MTSSLHR-PF----------R--------VP-W-LLWAVLLVST---TAASQ--------
ACTR2B_Mmus MTAPW-A----------------------------ALALLWGSLCAGSGRGE--------
ACTR2_Mmus MGAAAKL----------------------------AFAVFLISCSSGAILGR--------
daf-4_Cele MNQKGTV-RLK---------A--------LV-L-ICLPLFLIATPVPVAVTE--------
BMPR2_Hsap MTSSLQR-PW----------R--------VP-W-LPWTILLVST---AAASQ--------
put_Dmel MSKYDLL-YLT---------A--------Q----LTLVCCLIGIHGSILPGS--------
wit_Dmel MNWAIY----------------------------LLLALISLGR---ATPVP--------
TGFBR2_Mmus MGRGLLR-GLW---------P--------LH-I-VLWTR--I--ASTIPPHVPKSDVEME
ACTR2B_Hsap MTAPW-V----------------------------ALALLWGSLCAGSGRGE--------
ACTR2_Hsap MGAAAKL----------------------------AFAVFLISCSSGAILGR--------
TGFbRII_Spur MAYDVET-DEN---------N--------VP-F-VVTVS--LGVASAFEC-LDCSEVPVE
ACTR2_Spur MAGKDPLIRLC---------E--------LFLF-LSIAVLLVE--GASVNLP--------
BMPR2_Spur MHSSEHG-DY----------T--------GK-V-I--SVITIEA---EIAEL--------
AqueK683_Aque MAELRIL----------------------------VFCLLALLLPVPSYLLV--------
AqueK684_Aque MCVYLKT---S---------D------------------VFIKCFSTACPGG------AD
AqueK685_Aque MINVTLF-IDPPDEAENAPSSFHVTDQITSS-IEPSLSMIPS-T---VPAPS--------
AqueK686_Aque MVAVLRV-VL-------------------------CFCLLST-I---VTAFQ--------
*
TGFbR2_Hsap AQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFP-----------------------
MISR2_Hsap ----------------------------------PNR-----------------------
MISR2_Mmus ----------------------------------PNR-----------------------
BMPR2_Mmus ----------------------------------NQE-----------------------
ACTR2B_Mmus ----------------------------------AET-----------------------
ACTR2_Mmus ----------------------------------SET-----------------------
daf-4_Cele ----------------------------------DDRQDRIESEAAEKEWANTLVSKVAQ
BMPR2_Hsap ----------------------------------NQE-----------------------
put_Dmel ----------------------------------HGI-----------------------
wit_Dmel ----------------------------------NRQ-----------------------
TGFBR2_Mmus AQKDASIHLSCNRTIHPLKHFNSDVMASDNGGAVKLP-----------------------
ACTR2B_Hsap ----------------------------------AET-----------------------
ACTR2_Hsap ----------------------------------SET-----------------------
TGFbRII_Spur CDAE--------------------------------------------------------
ACTR2_Spur ----------------------------------LGS-----------------------
BMPR2_Spur ------------------------------------------------------------
AqueK683_Aque ----------------------------------CYT-----------------------
AqueK684_Aque ICIELCPEGINKCHTVRRTNSYPVEMRCTNTPSCSQS-----------------------
AqueK685_Aque ----------------------------------NTL-----------------------
AqueK686_Aque ----------------------------------CRV-----------------------
TGFbR2_Hsap -----------------------------QLCK---------------------------
MISR2_Hsap -----------------------------RTCV---------------------------
MISR2_Mmus -----------------------------RTCV---------------------------
BMPR2_Mmus -----------------------------RLCA---------------------------
ACTR2B_Mmus -----------------------------RECI---------------------------
ACTR2_Mmus -----------------------------QECL---------------------------
daf-4_Cele SNGTGTIKVSAPAKPTLRRMDNEEDEVISIECV---------------------------
BMPR2_Hsap -----------------------------RLCA---------------------------
put_Dmel -----------------------------IECE---------------------------
wit_Dmel -----------------------------YSCM---------------------------
TGFBR2_Mmus -----------------------------QLCK---------------------------
ACTR2B_Hsap -----------------------------RECI---------------------------
ACTR2_Hsap -----------------------------QECL---------------------------
TGFbRII_Spur ------------------------------SCV---------------------------
ACTR2_Spur -----------------------------THCH---------------------------
BMPR2_Spur ------------------------------------------------------------
AqueK683_Aque -----------------------------DDCP---------------------------
AqueK684_Aque -----------------------------SDCVFETLQNFHSLHYCCCTGDLCNRLDNYT
AqueK685_Aque -----------------------------RSHS---------------------------
AqueK686_Aque -----------------------------NSCI---------------------------
TGFbR2_Hsap -----------------------------FCDV-RFST----C-D---NQK---------
MISR2_Hsap -----------------------------FFEA-PGVR-----GSTKTLGELL--DTGT-
MISR2_Mmus -----------------------------FFEA-PGVR-----GSTKTLGEMV--DAGP-
BMPR2_Mmus -----------------------------FKDP-YQQD----L-G---IGE---------
ACTR2B_Mmus -----------------------------YYNA-NWEL----E-RTN---Q---------
ACTR2_Mmus -----------------------------FFNA-NWER----D-RTN---Q---------
daf-4_Cele -----------------------------YYDEMECEK----S-GD-C--E---------
BMPR2_Hsap -----------------------------FKDP-YQQD----L-G---IGE---------
put_Dmel -----------------------------HFDEKMCNT----T-QQ-C--E---------
wit_Dmel -----------------------------SYQE-DDNSFHDDDGDQDSSGELQ--EQQV-
TGFBR2_Mmus -----------------------------FCDV-RLST----C-D---NQK---------
ACTR2B_Hsap -----------------------------YYNA-NWEL----E-RTN---Q---------
ACTR2_Hsap -----------------------------FFNA-NWEK----D-RTN---Q---------
TGFbRII_Spur -----------------------------P------IS----C-T---TSV---------
ACTR2_Spur -----------------------------LYSSQECEK----D-GTKC--G---------
BMPR2_Spur -----------------------------YTET-FI------------------------
AqueK683_Aque -----------------------------YDNNL-L-C----Y-KTC---T---------
AqueK684_Aque DSVDPILNVTSAIPTVPVPVRPSDVLICERYNC-SFND----D-GI-C--Y---------
AqueK685_Aque ------------------------------------------------------------
AqueK686_Aque -----------------------------RCSS-SSPV-----DCTVTPVDQYSYNYYCE
TGFbR2_Hsap ----SCMSNCSI-TSICEKPQEVCVAVW-RKN---DENIT------------LE---TVC
MISR2_Hsap --------ELPR-AIRCL-YSRCCFGIW-NLT---QDRAQ------------VE--MQGC
MISR2_Mmus --------GPPK-GIRCL-YSHCCFGIW-NLT---HGRAQ------------VE--MQGC
BMPR2_Mmus ----SRISHENG-TILCS-KGSTCYGLW-EKS---KGDIN------------LV--KQGC
ACTR2B_Mmus ----SGLERCEG---EQD-KRLHCYASW-RNS---SGTIE------------LV--KKGC
ACTR2_Mmus ----TGVEPCYG---DKD-KRRHCFATW-KNI---SGSIE------------IV--KQGC
daf-4_Cele ----ITKKTCYS---EAHLKAVGCLAVF-GLPT---QEINSTEPYLKVDKPQYK--SLGC
BMPR2_Hsap ----SRISHENG-TILCS-KGSTCYGLW-EKS---KGDIN------------LV--KQGC
put_Dmel ----TRIEHCKM---EAD-KFPSCYVLW-SVN-ETTGILR------------IK--MKGC
wit_Dmel --ESTPIPSEPH-RRTCPDGYTFCFTIW-NQT---ANGAR------------VV--KQGC
TGFBR2_Mmus ----SCMSNCSI-TAICEKPHEVCVAVW-RKN---DKNIT------------LE---TVC
ACTR2B_Hsap ----SGLERCEG---EQD-KRLHCYASW-RNS---SGTIE------------LV--KKGC
ACTR2_Hsap ----TGVEPCYG---DKD-KRRHCFATW-KNI---SGSIE------------IV--KQGC
TGFbRII_Spur ----PCVGYCLI-ATFPDMTSSSMTNGS-DPS---SQNIN------------GM---FAC
ACTR2_Spur ----NTTEECDN---KEA-EIPSCYVLW-KNETSSGGGVD------------VM--MRGC
BMPR2_Spur -----------------------------NIS---RLHQS------------LY--IQGC
AqueK683_Aque ----PSSNSCVR---IAA-ID--------RSN---FPPAR------------IIFQEFGC
AqueK684_Aque ----HGYEVCPETFSSNP-DDHSCIATY-HKN-PTTNLIE------------LM--YKGC
AqueK685_Aque ---------------------------F-DES---TGTIR------------SV---TGF
AqueK686_Aque APSHCTPQNVPG---SNR-DGYYCYASLFIRN---LNSTD------------F----DGH
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ------------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus ------------------------------------------------------------
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele MPYQ--------------------------------------------------------
BMPR2_Hsap ------------------------------------------------------------
put_Dmel ------------------------------------------------------------
wit_Dmel ------------------------------------------------------------
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur ------------------------------------------------------------
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque RHNRLPNPLTLQACSNSTSMCHIDNPLVSDQDSAVYYCCCGESLCNQNITFTHPTQVSTY
AqueK685_Aque ------------------------------------------------------------
AqueK686_Aque ------------------------------------------------------------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ------------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus ------------------------------------------------------------
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele ------------------------------------------------------------
BMPR2_Hsap ------------------------------------------------------------
put_Dmel ------------------------------------------------------------
wit_Dmel ------------------------------------------------------------
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur ------------------------------------------------------------
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque DIDECAINNGGCSETCINTPGNYSCECNAGRYLSPHSGRCEDNDGIICLYRNCTLDGSCH
AqueK685_Aque ------------------------------------------------------------
AqueK686_Aque ------------------------------------------------------------
TGFbR2_Hsap --------------------------------------------HDPKLPYHDFILEDAA
MISR2_Hsap --------------------------------------------RDSDE-------PGCE
MISR2_Mmus --------------------------------------------RDSDE-------PGCE
BMPR2_Mmus --------------------------------------------WSHIGDP-----QECH
ACTR2B_Mmus --------------------------------------------WLDDF-------NCYD
ACTR2_Mmus --------------------------------------------WLDDI-------NCYD
daf-4_Cele --------------------------------------------HADSM-------NCEN
BMPR2_Hsap --------------------------------------------WSHIGDP-----QECH
put_Dmel --------------------------------------------FTDMH-------EC-N
wit_Dmel --------------------------------------------WKDNTDRT----SICS
TGFBR2_Mmus --------------------------------------------HDPKLTYHGFTLEDAA
ACTR2B_Hsap --------------------------------------------WLDDF-------NCYD
ACTR2_Hsap --------------------------------------------WLDDI-------NCYD
TGFbRII_Spur --------------------------------------------INETNP------EIGG
ACTR2_Spur --------------------------------------------WQNQG-------DCLD
BMPR2_Spur --------------------------------------------WGNEAKS-----LNCN
AqueK683_Aque ----------------------------------------------SSL-------RCNT
AqueK684_Aque TNTTEHCASSHLISDDLRTETHLHYCVALFHFINGTFYPNTQSCFAGSH-------SSCQ
AqueK685_Aque --------------------------------------------TT---SLT-----SI-
AqueK686_Aque --------------------------------------------WFSFFQVE-----SCE
TGFbR2_Hsap -------SPKCIMKE--K----KKPGETFFMCSCSSDECN--------------------
MISR2_Hsap -------SLHCDPSPRAH----PSPGSTLFTCSCGTDFCN--------------------
MISR2_Mmus -------SLHCDPVPRAH----PNPSSTLFTCSCGTDFCN--------------------
BMPR2_Mmus -------YEECVVTTTPP----SIQNGTYRFCCCSTDLCN--------------------
ACTR2B_Mmus -------RQECVATEE---------NPQVYFCCCEGNFCN--------------------
ACTR2_Mmus -------RTDCIEKKD---------SPEVYFCCCEGNMCN--------------------
daf-4_Cele -------ESSCRQGR--------SFRGGIGMCCCSTNNCN--------------------
BMPR2_Hsap -------YEECVVTTTPP----SIQNGTYRFCCCSTDLCN--------------------
put_Dmel -------QTECVTSAE------P-RQGNIHFCCCKGSRCN--------------------
wit_Dmel -------QSECTS--SAP----TSKTSSLYYCCCSGGVCN--------------------
TGFBR2_Mmus -------SPKCVMKE--K----KRAGETFFMCACNMEECN--------------------
ACTR2B_Hsap -------RQECVATEE---------NPQVYFCCCEGNFCN--------------------
ACTR2_Hsap -------RTDCVEKKD---------SPEVYFCCCEGNMCN--------------------
TGFbRII_Spur -------KKHCQAHPDDY----SYAAEGSYSCSCASDGCN--------------------
ACTR2_Spur -------MDYCMSSSP--------ADQNLFFCCCVGNLCN--------------------
BMPR2_Spur -------QENCTAHSKPSEYLVRTKNQTSRICCCAGDYCN--------------------
AqueK683_Aque -------RDLLCS---------PNITDLTQHCCCTGDRCNNPGGRADALAELMKPKFSYH
AqueK684_Aque -------NTNCTLTNITR----LSHNNDVYSCCCYGDLCN--------------------
AqueK685_Aque -----EHSSSRI-I--SS----IP-QSTNSLT----------------------------
AqueK686_Aque EAAGSELTDDCLSITKRV----SSLEGTNIFCRCTEDNCQ--------------------
TGFbR2_Hsap ---------------------------------------------------DNII-FSE-
MISR2_Hsap ---------------------------------------------------ANYS-HL--
MISR2_Mmus ---------------------------------------------------ANYS-HL--
BMPR2_Mmus ---------------------------------------------------VNFT-EN--
ACTR2B_Mmus ---------------------------------------------------ERFT-HL--
ACTR2_Mmus ---------------------------------------------------EKFS-YF--
daf-4_Cele ---------------------------------------------------MPDLIEM--
BMPR2_Hsap ---------------------------------------------------VNFT-EN--
put_Dmel ---------------------------------------------------SNQK-YI--
wit_Dmel ---------------------------------------------------AQYS-VV--
TGFBR2_Mmus ---------------------------------------------------DYII-FSE-
ACTR2B_Hsap ---------------------------------------------------ERFT-HL--
ACTR2_Hsap ---------------------------------------------------EKFS-YF--
TGFbRII_Spur ---------------------------------------------------KVLY-TAEA
ACTR2_Spur ---------------------------------------------------MNFS-FL--
BMPR2_Spur ---------------------------------------------------RNVS-DAY-
AqueK683_Aque LSPPNEPVPSTEPGCSVANTSDITPDCIIDVPFIGALKNEYTCYCNESLCNINES-IT--
AqueK684_Aque ---------------------------------------------------ERGL-IF--
AqueK685_Aque --------------------------------------------------------SVST
AqueK686_Aque ---------------------------------------------------DIFN-VTII
TGFbR2_Hsap ---EYNT-S---------------------------------------------------
MISR2_Hsap PPP-GSP-G---------------------------------------------------
MISR2_Mmus PPS-GNQ-G---------------------------------------------------
BMPR2_Mmus FPP-PDT-----------------------------------------------------
ACTR2B_Mmus PEP-GGP-----------------------------------------------------
ACTR2_Mmus PEM-EVT-----------------------------------------------------
daf-4_Cele VNP-SLK-----------------------------------------------------
BMPR2_Hsap FPP-PDT-----------------------------------------------------
put_Dmel KST---T-----------------------------------------------------
wit_Dmel EPA-PLELG---------------------------------------------------
TGFBR2_Mmus ---EYTT-S---------------------------------------------------
ACTR2B_Hsap PEA-GGP-----------------------------------------------------
ACTR2_Hsap PEM-EVT-----------------------------------------------------
TGFbRII_Spur TIPEEPT-V---------------------------------------------------
ACTR2_Spur PTP-EP------------------------------------------------------
BMPR2_Spur VPL-PST-----------------------------------------------------
AqueK683_Aque HPT-RLS-SYGFKECLSYNCEYNCNIVNNTNINCSCPAGFIAIGFTRCRDVNECLVSNGG
AqueK684_Aque PDF-NAT-----------------------------------------------------
AqueK685_Aque RS--STE-----------------------------------------------------
AqueK686_Aque IDP-PNDVS-------------------------------------------SSTLINGV
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap -------------------------------------------------TP-G-------
MISR2_Mmus -------------------------------------------------AP-G-------
BMPR2_Mmus -------------------------------------------------TP-L-------
ACTR2B_Mmus -------------------------------------------------EV-T-------
ACTR2_Mmus -------------------------------------------------QP-T-------
daf-4_Cele -------------------------------------------------KD-S-------
BMPR2_Hsap -------------------------------------------------TP-L-------
put_Dmel -------------------------------------------------EA-T-------
wit_Dmel -------------------------------------------------SNEG-R-----
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap -------------------------------------------------EV-T-------
ACTR2_Hsap -------------------------------------------------QP-T-------
TGFbRII_Spur -------------------------------------------------PP-S-------
ACTR2_Spur -------------------------------------------------TP-T-------
BMPR2_Spur -------------------------------------------------KP-T-------
AqueK683_Aque CQQTCVNTIGSYYCECFDGYFFDSRTLSCLSKFANFYCSHYSDDDIRLTEI-T-------
AqueK684_Aque -------------------------------------------------SP-I-------
AqueK685_Aque -------------------------------------------------SV-LV------
AqueK686_Aque ITS----------------------------------------------SP-SPPSVYSS
TGFbR2_Hsap --------------------------------------------------NP------DL
MISR2_Hsap ---------------------------------------------------S------QG
MISR2_Mmus ---------------------------------------------------P------QE
BMPR2_Mmus -------------------------------------------------SPP------H-
ACTR2B_Mmus -------------------------------------------------YEP------PP
ACTR2_Mmus -------------------------------------------------SNP------VT
daf-4_Cele ---------D-------N-------------------------SALLWASTP------SN
BMPR2_Hsap -------------------------------------------------SPP------H-
put_Dmel -------------------------------------------------TQV------PK
wit_Dmel -------------------------------------------------TSI------TN
TGFBR2_Mmus --------------------------------------------------SP------DL
ACTR2B_Hsap -------------------------------------------------YEP------PP
ACTR2_Hsap -------------------------------------------------SNP------VT
TGFbRII_Spur -------------------------------------------------SEP------DA
ACTR2_Spur -------------------------------------------------VTQ------TT
BMPR2_Spur -------------------------------------------------VTQ------YK
AqueK683_Aque -------------------------------------------------ENTKIGSLDCT
AqueK684_Aque -------------------------------------------------PMS------ST
AqueK685_Aque --------------------------------------------------PS------ST
AqueK686_Aque VPLSLSLSSSTIDLTTSSVSFSINTSPTLITVTNTHTTGILTTSSV---VPS------ST
TGFbR2_Hsap L-----------------------L-----------------------------------
MISR2_Hsap P-----------------------Q-A---------------AP----------------
MISR2_Mmus P-----------------------Q-A---------------TP----------------
BMPR2_Mmus ------------------------------------------------------------
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele M-----DL----------------E-----------------SL----------------
BMPR2_Hsap ------------------------------------------------------------
put_Dmel E-------------------------K---------------TQ----------------
wit_Dmel R-----------------------A-T---------------EK----------------
TGFBR2_Mmus L-----------------------L-----------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur T-----------------------PTK---------------TKGPPIENTDPNKTEEGR
ACTR2_Spur V--TGSNID---------------E-K---------------KK----------------
BMPR2_Spur V-----------------------I-S---------------DQ----------------
AqueK683_Aque P-VQSCFAQLMYSHHHWYLNAMTCG-Q---------------SP----------------
AqueK684_Aque SLMASSDS------------------ITIFLSSSPYVSATQTAS----------------
AqueK685_Aque -------------------------------------------V----------------
AqueK686_Aque G-----------------------V-----------------IP----------------
TGFbR2_Hsap -------VIFQV-TG---ISLLPPLGVAI---SV-I-IIFYCY-RVNRQQKLS-------
MISR2_Hsap ----GESIWMAL-VL---LGLFLLLLLLL---GS--IILALLQ---RKNYRVRGE--P--
MISR2_Mmus ----GGPVWMAL-LL---LGMFLVL--LL---SS--IILALLQ---RKACRVQGG--S--
BMPR2_Mmus -----SFNRDET-II---IALASVSVLAV---LI--VALCFGY-RMLTGDRKQG---L--
ACTR2B_Mmus ----TAPTLLTV-LA---YSLLPIGGLSL---IV-LL-AFWMY-RHRKPPYGHVD--IHE
ACTR2_Mmus ----PKPPYYNI-LL---YSLVPLMLIAG---IV-IC-AFWVY-RHHKMAYPPV------
daf-4_Cele ----DKFPFYWI-II---IALSVILCIAL---LI-LAYVGWKF-QQNKKEEIKKQQKIK-
BMPR2_Hsap -----SFNRDET-II---IALASVSVLAV---LI--VALCFGY-RMLTGDRKQG---L--
put_Dmel ----DGSNLIYIYIG---TSVFSVLM--V---IV-GM-GLLLY-RRRKQAHFN-------
wit_Dmel ----QHQSFLAS-TM---LGLAGGLTALT---IG--IFLAVQY---CRTAKEKPE--P--
TGFBR2_Mmus -------VIIQV-TG---VSLLPPLGIAI---AV-I-IIFYCY-RVHRQQKLS-------
ACTR2B_Hsap ----TAPTLLTV-LA---YSLLPIGGLSL---IV-LL-AFWMY-RHRKPPYGHVD--I--
ACTR2_Hsap ----PKPPYYNI-LL---YSLVPLMLIAG---IV-IC-AFWVY-RHHKMAYPPV------
TGFbRII_Spur KGQMLDREILVI-VV---CSVVPAVLLTI---VI-A-VAGYIHFTRYRQPMNDEL--N--
ACTR2_Spur ----KNEMLTKT-IL---YSIVPIVAIAL---VI-IM-LYWMC-RRHRYH-SLI------
BMPR2_Spur ----MNHEMERT-IL---IAVIPIFCVSV---AI--AIMYFIF-RMRLRSTKAQ---M--
AqueK683_Aque ----G-HT-VTV-GFWSA--IGSLSMIIIGIVCALWITIAFKW-KTTRSKYRKA------
AqueK684_Aque ----SNRVVYPSV-F---AALLLIMVLIL---CS--I-SIILC-RVRVAFRKRLD--M--
AqueK685_Aque ----TSTAAVTI-GLASGISILALMIALIAVVMM--LILAYSW-RKHS-PKFHRC--S--
AqueK686_Aque ----STDTMVTI-ILSSVIAFLAITLAIIGLLIA-CTLVCYC--RKYS-SNSRRH--S--
.
TGFbR2_Hsap -------------------------------STWETGKTR-KLMEFSEHCAIILEDDRSD
MISR2_Hsap ----------------------------VPEPRPDSGR----------------------
MISR2_Mmus ----------------------------DPEP--GSGG----------------------
BMPR2_Mmus ----------------------------HSMNMME--A----------------------
ACTR2B_Mmus VRQCQRWAGRRDGCADSF----------KPLPFQDPGP----------------------
ACTR2_Mmus -----------------------------LVPTQDPGP----------------------
daf-4_Cele -----------------FDMEKTDALEAGNVPLVEPEE----------------------
BMPR2_Hsap ----------------------------HSMNMME--A----------------------
put_Dmel -----------------------------EIPTHEAEI----------------------
wit_Dmel ----------------------------EESPLAPSGP----------------------
TGFBR2_Mmus -------------------------------PSWESSKPR-KLMDFSDNCAIILEDDRSD
ACTR2B_Hsap --------------------------------HEDPGP----------------------
ACTR2_Hsap -----------------------------LVPTQDPGP----------------------
TGFbRII_Spur -------------------------------TQTQTSNTESTSIDMTTD-----ESETKR
ACTR2_Spur -----------------------------AIPTTE-------------------------
BMPR2_Spur ----------------------------SQLPMIE--A----------------------
AqueK683_Aque ------------------------------IDY---------------------------
AqueK684_Aque --------------------------------S-NYQL----------------------
AqueK685_Aque ----------------------------HQIQFSSETS----------------------
AqueK686_Aque ----------------------------HQIQFPA--A----------------------
TGFbR2_Hsap ISSTCA--NNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YE
MISR2_Hsap -----DWS---VELQELPELCFSQVIREGGHAVVWAGQLQ------GKLVAIKAFP--PR
MISR2_Mmus -----DCS---EELPELAELRFSQVIQEGGHAVVWAGRLQ------GEMVAIKAFP--PR
BMPR2_Mmus -----AAA---EPSLDLDNLKLLELIGRGRYGAVYKGSLD------ERPVAVKVFS--FA
ACTR2B_Mmus -----PP---PSPLVGLKPLQLLEIKARGRFGCVWKAQLM------NDFVAVKIFP--LQ
ACTR2_Mmus -----PP---PSPLLGLKPLQLLEVKARGRFGCVWKAQLL------NEYVAVKIFP--IQ
daf-4_Cele -----EMI-EMVETPKELPITDFQLISKGRFGKVFKAQYTPDS-GEKRLVAVKKLN--EF
BMPR2_Hsap -----AAS---EPSLDLDNLKLLELIGRGRYGAVYKGSLD------ERPVAVKVFS--FA
put_Dmel -----TN---SSPLLSNRPIQLLEQKASGRFGDVWQAKLN------NQDVAVKIFR--MQ
wit_Dmel -----GYS---SNLRNVDNMNLIGMLGSGKYGTVMKGLLH------DQEVAVKIYP--EE
TGFBR2_Mmus ISSTCA--NNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YE
ACTR2B_Hsap -----PP---PSPLVGLKPLQLLEIKARGRFGCVWKAQLM------NDFVAVKIFP--LQ
ACTR2_Hsap -----PP---PSPLLGLKPLQLLEVKARGRFGCVWKAQLL------NEYVAVKIFP--IQ
TGFbRII_Spur LGEYSPPDSPLHLNGNYLPITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFL--EY
ACTR2_Spur -----PT---PSPMNSLPPIQLLEIKARGRFGAVWKASCL------NDIVAVKVFP--IQ
BMPR2_Spur -----PPP---EPTFDLDQLKMMELVGQGRYCNVYRAALS------ENEVAVKVFT--GS
AqueK683_Aque -------------SLSLDNSN-STLIYSHQIVTVRKA-EN------NRIIAVYKST--VS
AqueK684_Aque -----SS---PSPTLY-DSPEFMKIIGHGRFARVYHARMG------TRDVAIKIFNGTLQ
AqueK685_Aque -----TII-ELDEEPGLPPFQLIQSIGNGRFGSVWKALYE------KETVAVRVFS--QR
AqueK686_Aque -----PNI-ELDERSAPLPFQLLQPIGNGRFGSVWKALYN------NETVAVKALS--LH
* . :*:
TGFbR2_Hsap EYASWKTEKDIFSD--IN---LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQ
MISR2_Hsap SVAQFQAERALYEL--PG---LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLC
MISR2_Mmus AVAQFRAERAVYQL--LG---LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLC
BMPR2_Mmus NRQNFINEKNIYRV--PL---MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLC
ACTR2B_Mmus DKQSWQSEREIFST--PG---MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLT
ACTR2_Mmus DKQSWQNEYEVYSL--PG---MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLS
daf-4_Cele QKASFLAEKRIFDE--LNEYPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLY
BMPR2_Hsap NRQNFINEKNIYRV--PL---MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLC
put_Dmel EKESWTTEHDIYKL--PR---MRHPNILEFLGVEKHMD-----KPEYWLISTYQHNGSLC
wit_Dmel HHQYYVNERNIYAL--PL---MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQ
TGFBR2_Mmus EYSSWKTEKDIFSD--IN---LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQ
ACTR2B_Hsap DKQSWQSEREIFST--PG---MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLT
ACTR2_Hsap DKQSWQNEYEVYSL--PG---MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLS
TGFbRII_Spur DSASWNVEKELFTDHSVM---MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLH
ACTR2_Spur DRNSWANEREIYSL--PH---MHHENLLHFIATEKHGEG---LEVEYWLISEFHHHGSLC
BMPR2_Spur SKQCYMNELDIMGL--PH---MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLM
AqueK683_Aque ALSQWKIERDIYLT--PE---LRHESILTLLRAKR-VK--D---IGYQLVLKGSITGSLY
AqueK684_Aque AKGSWTQEKDIYAT--ER---LEHENILKFLYHDHRFHE---GQDTLWLIFDYHSNGSLY
AqueK685_Aque HRTSWQNERDIHLL--NS---TPHENILKFISSESRGRG---PSSEYFIITEYLPLGSLH
AqueK686_Aque HKLSWQNERDIHLL--DS---TPHENILKFISSESRGRG---SSSEYFIITEYLPLGSLH
: * : : . :: *
TGFbR2_Hsap EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-G---RPKMPIVHRDLKSSNILVKND
MISR2_Hsap HYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQN-G---QYKPGIAHRDLSSQNVLIRED
MISR2_Mmus HYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQD-G---QYKPGIAHRDLSSQNVLIRED
BMPR2_Mmus KYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG-D---HYKPAISHRDLNSRNVLVKND
ACTR2B_Mmus DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR-G-EGHKPSIAHRDFKSKNVLLKSD
ACTR2_Mmus DFLKANVVSWNELCHIAETMARGLAYLHEDIPGL--K-DGHKPAISHRDIKSKNVLLKNN
daf-4_Cele ELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFF---GHPKKPIIHRDIKSKNILVKSD
BMPR2_Hsap KYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG-D---HYKPAISHRDLNSRNVLVKND
put_Dmel DYLKSHTISWPELCRIAESMANGLAHLHEEIPASK-T-DGLKPSIAHRDFKSKNVLLKSD
wit_Dmel DWLIANTLTFSECCGMLRSITRGISHLHTELRLG-D---QHKPCVAHRDINTRNVLVQAD
TGFBR2_Mmus EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-G---RPKMPIVHRDLKSSNILVKND
ACTR2B_Hsap DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR-G-EGHKPSIAHRDFKSKNVLLKSD
ACTR2_Hsap DFLKANVVSWNELCHIAETMARGLAYLHEDIPGL--K-DGHKPAISHRDIKSKNVLLKNN
TGFbRII_Spur DYLRQRSVNWIDLCKLCGSAARGLAHLHAETYGSHG---LHKVPVAHRDLKSTNILVKDD
ACTR2_Spur DYLKANVISWKELCGIAFSMAKGLAYLHEDIPPTT-AIPFVKHSVAHRDFKSKNVLIKNN
BMPR2_Spur SYLRENTYDWHTMCRLAQTTAAGLAHLHQVIDTQ-V---GLKPAVVHRDINSRNVLVNAE
AqueK683_Aque QYLQSHSPDELEAAKITHSMSSGLAHLHYMESSQS-HSKYRVITIAHCNINSHNILMKED
AqueK684_Aque DYLQLHRLTFDELFSLCLSGAAGLEHLHSVDNC---P-ETYKPAIAHRDLKSKNILVKKD
AqueK685_Aque QFLRHNTLSWEQAWNIMYSITSGITHLHSSSYYS-NGLLADKFSIAHRDIKPSNILVKSP
AqueK686_Aque QFLRHNTLSWEQAWNIMYSIASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKSV
* : : *: .** : * ::.. *:*:.
TGFbR2_Hsap -LTCCLCDFGLSLRLDPTLS-------VD-DLANSGQVGTARYMAPEVLESRMNLENV-E
MISR2_Hsap -GSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGM
MISR2_Mmus -RSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGT
BMPR2_Mmus -GACVISDFGLSMRLTGNRLV---RPGEE-DNAAISEVGTIRYMAPEVLEGAVNLRDCES
ACTR2B_Mmus -LTAVLADFGLAVRFEPGK---------P-PGDTHGQVGTRRYMAPEVLEGAINFQR--D
ACTR2_Mmus -LTACIADFGLALKFEAGK---------S-AGDTHGQVGTRRYMAPEVLEGAINFQR--D
daf-4_Cele -MTTCIADFGLARIYSYDI---------E-QSDLLGQVGTKRYMSPEMLEGATEFTP--T
BMPR2_Hsap -GTCVISDFGLSMRLTGNRLV---RPGEE-DNAAISEVGTIRYMAPEVLEGAVNLRDCES
put_Dmel -LTACIADFGLAMIFQPGK---------P-CGDTHGQVGTRRYMAPEVLEGAINFNR--D
wit_Dmel -LSCCIADFGFALKVFGSKYEYKGEVAMA-ETKSINEVGTLRYMAPELLEGAVNLRDCET
TGFBR2_Mmus -LTCCLCDFGLSLRLDPTLS-------VD-DLANSGQVGTARYMAPEVLESRMNLENV-E
ACTR2B_Hsap -LTAVLADFGLAVRFEPGK---------P-PGDTHGQVGTRRYMAPEVLEGAINFQR--D
ACTR2_Hsap -LTACIADFGLALKFEAGK---------S-AGDTHGQVGTRRYMAPEVLEGAINFQR--D
TGFbRII_Spur -GSCAIADFGLAIRLDPQSS-------TD-HLANSGQVGTPRYMSPEALECKVNLQDI-E
ACTR2_Spur -TTACIADFGLACVFEAGK---------N-PGDTHGQVGTRRYMAPEVLEGAIQFKR--D
BMPR2_Spur -GNCVIGDFGFAMQVCGSSVV---GEGDG-DNSTITDVGTVRYMSPEVLDGAVNLRDCEC
AqueK683_Aque -GTVFLSDFSRSVKFNGGI---------I-AVGRDSEVIILGICLPEVLQGFQSFTI--T
AqueK684_Aque -MTCCISDFGLAIKFDGVDM--------I-LSEAKGQVGTSRYMAPEILEGAVRFNQ--E
AqueK685_Aque SGQCVVADFGQAFVLDPAAD-------DR-KLAVSGQVGTYRYMSPEALDARVNLRDS-E
AqueK686_Aque SGHCVVADLGLAFILDPAAD-------DR-KLAVSGQVGTYRYMSPEALDARVNLRDI-E
: *:. : :. ** *: :
TGFbR2_Hsap SFKQTDVYSMALVLWEMTSRCNAV----GEVKDYEPPFGSKVRE-HPCVESMKDNVLRDR
MISR2_Hsap ALRRADIYSLALLLWEILSRCPDL-RPDSSPPPFQLAYEAELGN-TPTSDELWALAVQER
MISR2_Mmus ALQRADVYSLALLLWEILSRCSDL-RPDHRPPPFQLAYEAELGS-NPSACELWALAVEER
BMPR2_Mmus ALKQVDMYALGLIYWEVFMRCTDL-FPGESVPDYQMAFQTEVGN-HPTFEDMQVLVSREK
ACTR2B_Mmus AFLRIDMYAMGLVLWELVSRCKAA---DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKK
ACTR2_Mmus AFLRIDMYAMGLVLWELASRCTAA---DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKK
daf-4_Cele AFKAMDVYSMGLVMWEVISRTKLH--QTDEPPNYQMPFQ-VIGF-DPTIGLMRNYVVSKK
BMPR2_Hsap ALKQVDMYALGLIYWEIFMRCTDL-FPGESVPEYQMAFQTEVGN-HPTFEDMQVLVSREK
put_Dmel AFLRIDVYACGLVLWEMVSRCDFA----GPVGEFQLPFEAELGL-RPSLDEVQESVVMKK
wit_Dmel SLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGS-HPSFDQMQALVVRHK
TGFBR2_Mmus SFKQTDVYSMALVLWEMTSRCNAV----GEVKDYEPPFGSKVRE-HPCVESMKDSVLRDR
ACTR2B_Hsap AFLRIDMYAMGLVLWELVSRCKAA---DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKK
ACTR2_Hsap AFLRIDMYAMGLVLWELASRCTAA---DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKK
TGFbRII_Spur SFKQMDTYALALILWEITSRCTLL----KDINEYELPFSRSLGDRRASLEMMKTLVVLRR
ACTR2_Spur AFLRIDMYAFGLVLWELVTRCTVQ---DGPVPEYRLPFEEELGQ-GTSLEDMQEWVVVKR
BMPR2_Spur ALKQVDVYALGLVVWEIAMRCKDL-YPRDEMGNYQMPFEEQVGL-HPTFEDMQILVSRER
AqueK683_Aque SLTNSDIYSLGLCIWEVLNCCQIT---G---NSYTPPFHEVSDS-DISMDIMRSMIVEQG
AqueK684_Aque AFLKIDIYAFGLILWEMLSCCDLN--NITSNPSYYPPFDGWVSA-NPSIDEMKRIVVEEK
AqueK685_Aque SFKQIDVYAMSLVLWEVCMRYQSN---DVPVPPYQSPFFDMVGE-KPTLDQMKEIVVINK
AqueK686_Aque SFKQIDMYALSLVLWEVCMRYQSD---DVPVPPYQSPFFDMVGE-KPTLEQMKEIVVNAN
:: * *: .* **: : .: :
TGFbR2_Hsap GRPEIPSFWLNHQ-GIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRL-SG--RS
MISR2_Hsap RRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQES-HP--FP
MISR2_Mmus KRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPHGA-SS--FP
BMPR2_Mmus QRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSV-SP
ACTR2B_Mmus MRPTIKDHWLKHP-GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVN-GT-----
ACTR2_Mmus KRPVLRDYWQKHA-GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTN-II-----
daf-4_Cele ERPQWRDEIIKHE-YMSLLKKVTEEMWDPEACARITAGCAFARVWNHIMSSPD-SS----
BMPR2_Hsap QRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSV-SP
put_Dmel LRPRLLNSWRAHP-GLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPST-Q-----
wit_Dmel ARPLFPTGWGGGA-AAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQA--QP
TGFBR2_Mmus GRPEIPSFWLNHQ-GIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPERL-SG--RS
ACTR2B_Hsap MRPTIKDHWLKHP-GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVN-GT-----
ACTR2_Hsap KRPVLRDYWQKHA-GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTN-II-----
TGFbRII_Spur ERPPITDEWLRNP-GLTIIKNTVVDCWDEDPEARLTASCVEARFQELILWHEG-EP--HA
ACTR2_Spur KRPVISDHWLKHR-GLELLCETIEECWDQDAEARLSAGCVEERIAQFSHSHMNGHM----
BMPR2_Spur KRPQFPDAWKQNSQALRSLKETIEDCWDHDAEARLTALCVEERIIELMVLWDKHRMI-SP
AqueK683_Aque IVPALPAVFDEIK-EFSSVRNTVSECFDLEPEARPNSHILKNLFSKLLHDLLEKKSS-SP
AqueK684_Aque KRPPIPQKFQTNL-KYSFIADIIVECWDDDADGRPAASLISRRLSEFQTAGYTASP----
AqueK685_Aque QRPLLPEKWNNDK-NLKRIIKLIVEGWDEDPEARLTAANIKIQLESLVGMRPKPPPSSTS
AqueK686_Aque KRPGFTGVWYSDK-NLKRIIKLIKEGWDEDPEARLTAANIKIQLESLIGMRPKLDSLSSP
* . : :* :. .* : .
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ESCPRG------------------------------------------------------
MISR2_Mmus ES-PQG------------------------------------------------------
BMPR2_Mmus TVNPMSTAMQNER--NLSHNRRVPKIG--PYPDY-------------------SSSSYIE
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele ------------------------------------------------------------
BMPR2_Hsap TVNPMSTAMQNER--NLSHNRRVPKIG--PYPDY-------------------SSSSYIE
put_Dmel ------------------------------------------------------------
wit_Dmel SS-PLLNTN------NL------------------------------------VASPTAE
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur TINPTTQGNAIPTHTMNEYTTRPTDIISREYPGIARLADGTMIAVRSNGQPVLGAA----
AqueK683_Aque IV----------------------------------------------------------
AqueK684_Aque HLPPLSNKS---------------------------------------------------
AqueK685_Aque ----QPDGR------NN------------------------------------FLSPILE
AqueK686_Aque LS-PPPEGE------GV------------------------------------FLSPVSE
TGFbR2_Hsap ------CS----------------------------------------------------
MISR2_Hsap ------------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus DSIHHTDS-IVKNISSEHSMSS-------------TPLTIGE-KNRNSINYERQQA---Q
ACTR2B_Mmus ------TS----------------------------------------------------
ACTR2_Mmus ------TT----------------------------------------------------
daf-4_Cele ------E--------GYHSGSS-------------M--K-NRGVD---------------
BMPR2_Hsap DSIHHTDS-IVKNISSEHSMSS-------------TPLTIGE-KNRNSINYERQQA---Q
put_Dmel ------------------------------------------------------------
wit_Dmel QGINIIAT-TTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALE-REKNHLSYPQQQLQPYQ
TGFBR2_Mmus ------CS----------------------------------------------------
ACTR2B_Hsap ------TS----------------------------------------------------
ACTR2_Hsap ------TT----------------------------------------------------
TGFbRII_Spur ------QS----------------------------------------------------
ACTR2_Spur ------NG--------HHPVSP-------------TPLI---------------------
BMPR2_Spur SETSGTAS-DTKNHHGLHSSVS-------------SGLE----KN----------E---R
AqueK683_Aque ------EEEE--------------------------------------------------
AqueK684_Aque ------SK-----ESGFHSLSG-------------QPLLSSSGVNNDALATDYNINT---
AqueK685_Aque ----SSES-SCK-------------------------------KYRLSS-----------
AqueK686_Aque ----TSHS-SCK-------------------------------KVHISA-----------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ----CP------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus ARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMP--YPD-ETHLHATNV---AQSI
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele -----------------------DVEQ-----------SEKPE-----------------
BMPR2_Hsap ARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMP--YPD-ETNLHTTNV---AQSI
put_Dmel ------------------------------------------------------------
wit_Dmel GRNPCQERNLAPLT----------------------------------------------
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur LRLMSPGTISTSLSSQS-DLNLIDLTASAPPVDPKNLH--HSDDSIERYTTDLKYGPQQS
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque -----------------------PLPP-----------TPTPS-----------------
AqueK685_Aque -----------SFSESS-G-----------NAVIFSNPSS----K--LSGR---------
AqueK686_Aque -----------SFSGST-N------------AML--SPAAAPH-S--FHGR---------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap --------------------PL----------C---------------------------
MISR2_Mmus --------------------------------C---------------------------
BMPR2_Mmus GPTPVCLQLTEEDLETNKLDPK----------EVDKNLKES--SDENLMEH---------
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele ------------G--------------------IE----EMQH---------YH---A--
BMPR2_Hsap GPTPVCLQLTEEDLETNKLDPK----------EVDKNLKES--SDENLMEH---------
put_Dmel ------------------------------------------------------------
wit_Dmel ----------------MRTPPV----------LVERSKKHS--FQTQPQEN---------
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ---------------------------------M-------QT---------MH---N--
BMPR2_Spur GP-KYCDQYGFSEPSTSPSRPL----------VVNEMRAGL--SKDQMTDNLSHGMGKLK
AqueK683_Aque ----------------------------------------------------LE---A--
AqueK684_Aque ------------SPS------------------I-------TLSPTEIKSHTVH---D--
AqueK685_Aque ---------------------FSVDH-TNNASSH--------------------------
AqueK686_Aque ---------------------FSLDHGGHNPVTV--------------------------
TGFbR2_Hsap --------E---------------------------------------------------
MISR2_Hsap ------------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus -------SLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQ--DFTQ-------------A
ACTR2B_Mmus --------D-C------L----VS------------------------------------
ACTR2_Mmus --------E-D------I----VT------------------------------------
daf-4_Cele ----SSPSKRQHPSPNPFFDSCPP--PPPIPVILENGGILQPD-----------------
BMPR2_Hsap -------SLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQ--DFTQ-------------T
put_Dmel ---------------------L--------------------------------------
wit_Dmel -------SLSCLEHDVSVE-----EL-----IASHQHQQQ------------KNTIVSTG
TGFBR2_Mmus --------Q---------------------------------------------------
ACTR2B_Hsap --------D-C------L----VS------------------------------------
ACTR2_Hsap --------E-D------I----VT------------------------------------
TGFbRII_Spur --------F---------------------------------------------------
ACTR2_Spur ----STSFE-N------TGNTEST------------------------------------
BMPR2_Spur NKSSSMPSWNHINGVDPRSRGANQP-VNMAKLDTNLHRQQ--ARSASPKQSNQNGYEASG
AqueK683_Aque ----FTGTE-Q------T------------------------------------------
AqueK684_Aque ----FSSSS-T------SSSSCPT--RS--------------------------------
AqueK685_Aque -----------------------RTIL--N------------------------------
AqueK686_Aque -----------------------SMILSLS------------------------------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap --PEDC------------------------------------------------------
MISR2_Mmus --PENC------------------------------------------------------
BMPR2_Mmus ANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKN-STKEPRLKFGNKHKSNL-KQV
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele --------------N--AEPEPEELPDLPIVEKI----YDIATNML--------------
BMPR2_Hsap ANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKN-STKEPRLKFGSKHKSNL-KQV
put_Dmel ------------------------------------------------------------
wit_Dmel GNGNSCLGQ--------GFPKQQNTDQKLRGW--HGVR-ALIHKK-LFRKEHAEELCRQL
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur SSGASSEG--------AGPSSIPNMNIRPNSLPLQSTHRGSKKKLMAVYNPNTGPT-TKV
AqueK683_Aque ----------------------EELPSSE-------------------------------
AqueK684_Aque -----------------------SLPIHFSPAKK----SDTSDPRS--------------
AqueK685_Aque ----D--------------------LRRYR------------------------------
AqueK686_Aque ----DV-----------------QVQYRPP------------------------------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ---------TSI-------------------------PAPTILPC-RPQ---R-------
MISR2_Mmus ---------LSA-------------------------PASAVFPC-RPQ---Q-------
BMPR2_Mmus ETGVAKMN-TIN--------AAEPHVVTVT------------------------------
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele --------------------------------------------F-SR------------
BMPR2_Hsap ETGVAKMN-TIN--------AAEPHVVTVT------------------------------
put_Dmel ------------------------------------------------------------
wit_Dmel QLGEEKSN-LVT--------AL---------------RRPNNLDL-NPR---LD------
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur QTGIAKMD-SVAPSCHQVKMAANTHKQQPTHNAVEKLRNGNVGNL-EPE---ADRPHSWA
AqueK683_Aque ----------------------------------------VVLP----------------
AqueK684_Aque --------------------------------------------R-K-------------
AqueK685_Aque -DGIGLSNNIST-------------------------TTTDS---T----QPN-------
AqueK686_Aque -DTVATANSESI-------------------------TVPALIPQSEPTTAPQ-------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ------------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus --MNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSS
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele ---------------------------------------E---------------ELDLM
BMPR2_Hsap --MNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSS
put_Dmel ------------------------------------------------------------
wit_Dmel ------------------------------------------------------------
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur CDSSSGSDRSH-------EIDRKNGNACSGSASCIAKGDNGKRKVTPFRLLTEKLSIHKG
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque ------------------------------------------------------------
AqueK685_Aque ------------------------GAYTGG------------------------------
AqueK686_Aque ------------------------L-----------------------------------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ------------------------------------------------------------
MISR2_Mmus ------------------------------------------------------------
BMPR2_Mmus PDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEG-GRTNSNNNNSNPCSEQDILTQGV
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele NA----------QRQ-------VEYE-------------------------------AGA
BMPR2_Hsap PDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEG-GRTNSNNNNSNPCSEQDVLAQGV
put_Dmel ------------------------------------------------------------
wit_Dmel --KPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHIN-GTTNNNSIQS-HGSELQTLTRPA
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur KDKKEP--KDQTDCNGVNNRNPVELNVNNNARAIAPQTLANGSDNDSVACSDLSNGHAGV
AqueK683_Aque ------------------------------------------------------------
AqueK684_Aque ------------------------------------------------------------
AqueK685_Aque ----------------------------------------GSRDEVSSSESQDEV-----
AqueK686_Aque ----------------------------------------ASNNEVSNGGSQDEV-----
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap ----------SACHFSVQQGPCS-------------------------------------
MISR2_Mmus ----------SSCLLSVQQGPGS-------------------------------------
BMPR2_Mmus T------------STAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSG
ACTR2B_Mmus -----------LVT--S----V--------------------------------------
ACTR2_Mmus -----------VVT--M----V--------------------------------------
daf-4_Cele -----------DTR--A----S--------------------------------------
BMPR2_Hsap P------------STAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSG
put_Dmel -----------LIK--N----H--------------------------------------
wit_Dmel SKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFR-------------EVFSG-RGSS
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap -----------LVT--S----V--------------------------------------
ACTR2_Hsap -----------VVT--M----V--------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur -----------DIA--L----Y--------------------------------------
BMPR2_Spur -------------SLNGDAYPLN-------------------------------------
AqueK683_Aque -----------LT---Q--HSQT-------------------------------------
AqueK684_Aque -----------AVT--P----L---RSNPGKPTDLGSGNISGGDLFS--QYDLSSSSGAG
AqueK685_Aque ----------NVVD--V-------------------------------------------
AqueK686_Aque ----------NVID--ATTGQPK-------------------------------------
TGFbR2_Hsap ------------------------------------------------------------
MISR2_Hsap -RNPQ-----------P-------------------------------------------
MISR2_Mmus -RSPD-----------P-------------------------------------------
BMPR2_Mmus EKIK---RRVKTP----YSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAE
ACTR2B_Mmus ------------------------------------------------------------
ACTR2_Mmus ------------------------------------------------------------
daf-4_Cele ------------------------------------------------------------
BMPR2_Hsap EKIK---KRVKTP----YSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAE
put_Dmel ------------------------------------------------------------
wit_Dmel ERLRDPSERVKTPGDVPPSVRKARASK-------------------------TLSLY--D
TGFBR2_Mmus ------------------------------------------------------------
ACTR2B_Hsap ------------------------------------------------------------
ACTR2_Hsap ------------------------------------------------------------
TGFbRII_Spur ------------------------------------------------------------
ACTR2_Spur ------------------------------------------------------------
BMPR2_Spur ------------------------------------SKL---------------------
AqueK683_Aque -GTMS-----------P-------------------------------------------
AqueK684_Aque D--------VVSP----LCDDVRKFSLQLDYTE---------------------DF----
AqueK685_Aque ------------------------------------------------------------
AqueK686_Aque -RLSD-------------------------------------------------------
TGFbR2_Hsap ----EKIPED-GSLNTTK
MISR2_Hsap -----------ACTLSPV
MISR2_Mmus ------VGD-TVQVYVNE
BMPR2_Mmus GGTATTTVS-KDIGMNCL
ACTR2B_Mmus -----TNVDL-LPKESSI
ACTR2_Mmus -----TNVDF-PPKESSL
daf-4_Cele ----TPTPS-GTFGTFTT
BMPR2_Hsap GGTATTMVS-KDIGMNCL
put_Dmel -----TNIDDAKESTNCL
wit_Dmel -----DRMM-DSSLLNIL
TGFBR2_Mmus ----EKIPED-GSLNTTK
ACTR2B_Hsap -----TNVDL-PPKESSI
ACTR2_Hsap -----TNVDF-PPKESSL
TGFbRII_Spur ----YTSKGK-RGRTTLV
ACTR2_Spur ----RNSPSP-PPKESNL
BMPR2_Spur -VNGSAKLQ-ANFELECV
AqueK683_Aque -------GHV-IIAETHL
AqueK684_Aque ----KPDNE-ENPTETTL
AqueK685_Aque ----------TTGQPKSH
AqueK686_Aque ------AEH-DDTTTSLS