PAK6_Hsap -------------------------MFRK-------------KKKKRPEISAPQNFQHRV
PAK5_Hsap -------------------------MFGK-------------K-KKKIEISGPSNFEHRV
PAK4_Hsap -------------------------MFGK-------------R-KKRVEISAPSNFEHRV
PAK6_Mmus -------------------------MFRK-------------KKKKRPEISAPQNFQHRV
PAK5_Mmus -------------------------MFGK-------------K-KKKIEISGPSNFEHRV
PAK4_Mmus -------------------------MFGK-------------K-KKRVEISAPSNFEHRV
C45B11.1_Cele MKISINISKQSLTISYAEKKMNRTFSLRR--------------KVKKSEISTPSNFEHRI
mbt_Dmel -------------------------MFSK-------------K-KKKPLISMPSNFEHRV
PAK4_Spur MGNA-----------------LK--MTSK-------------KRNGKVKISTPSNFEHRV
AqueK236_Aque MP-----------------------LFSRSRSLRRSSKRRSVHRIKKEDISEPMGFMHCY
: : ** * .* *
PAK6_Hsap HTSFDPKEGKFVGLPPQWQNIL----------------------------------DTLR
PAK5_Hsap HTGFDPQEQKFTGLPQQWHSLLA---------------------------------DTAN
PAK4_Hsap HTGFDQHEQKFTGLPRQWQSLIE---------------------------------ESAR
PAK6_Mmus HTSFDPKEGKFVGLPPQWQNIL----------------------------------DTLR
PAK5_Mmus HTGFDPQEQKFTGLPQQWHSLLA---------------------------------DTAN
PAK4_Mmus HTGFDQHEQKFTGLPRQWQSLIE---------------------------------ESAR
C45B11.1_Cele HAGFDARSGTYTGLPKQWQALLGPP-------------------------------RSIS
mbt_Dmel HTGFDKRENKYVGLPLQWASIVGNNQI----------------------------LKSSN
PAK4_Spur HTGYDRRLGKYVGLPPQWASIIG---------------------------------AEET
AqueK236_Aque HAEIG--SEGFSGLPPQWKTLVDTTHPSTTSPTTSRATSASPSNKNETSTKRIGSKSTGN
*: . : *** ** ::
PAK6_Hsap RPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYI---SG---------------------
PAK5_Hsap RPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSI---NG---------------------
PAK4_Hsap RPKPLVDPACITSIQPGAPKTIVRGSKGAKDGAL---TL---------------------
PAK6_Mmus RPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYI---SG---------------------
PAK5_Mmus RPKPMVDPSCITPIQLAPMKTIVRGNKSCKETSI---NG---------------------
PAK4_Mmus RPKPLIDPACITSIQPGAPKTIVRGSKGAKDGAL---TL---------------------
C45B11.1_Cele RPKPMVDPSCITPVDVAELKTVIRGPSSSFRYN-SPLPF---------------------
mbt_Dmel RPLPLVDPSEITPTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHP
PAK4_Spur RPKPIVDPSCITQTEAFELKGIVRGSNAQSPE-Q---NG---------------------
AqueK236_Aque TPEPIKRPSP-----------IVRGSDSCLEDTV---KY---------------------
* *: *: ::*
PAK6_Hsap ---------------LLNDIQKLSV--------ISSNTLRGRS--PTSRRRAQS-LGL--
PAK5_Hsap ---------------LLEDFDNISV--------TRSNSLRKES--PPTPDQGASSHGPGH
PAK4_Hsap ---------------LLDEFENMSV--------TRSNSLRRDS--PPPPARARQENGM--
PAK6_Mmus ---------------LLNDIQKLSV--------ISSNTLRGRS--PTSRRRAQS-LGL--
PAK5_Mmus ---------------LLEDFDNISV--------TRSNSLRKES--PPTPDQGAASRIQGH
PAK4_Mmus ---------------LLDEFENMSV--------TRSNSLRRES--PPPPARAHQENGM--
C45B11.1_Cele ---------------GMTNSPMPSV--------ARSNSLRISA--TASPVVNVSSA----
mbt_Dmel MMSHGPGMMMPPETGGIVLPKTSHV--------ARSNSLRSSS--PPRVRRVANVPPS-V
PAK4_Spur ------------------TKPRMSV--------ARSNSLRSRG-SPPRSRRRNQEEDP-Q
AqueK236_Aque ---------------VHDHCCSLAGEEDEEVHEFIDIQLRSQTGGSSTGSQGSSSRH---
. ** ..
PAK6_Hsap LGD--------------------EHWATDPD-----------------------MYLQSP
PAK5_Hsap AEENG--------------FITFSQYSSESDTTADYTT--EKYREKSLYGDDLDPYYRGS
PAK4_Hsap PEEPA--------------------------TT-----------------ARGGPGKAGS
PAK6_Mmus LGD--------------------DQWAADPD-----------------------MYLQSP
PAK5_Mmus SEENG--------------FITFSQYSSESDTTADYTT--EKYRDRSLYGDDLDLYYKSS
PAK4_Mmus LEERA--------------------------AP-----------------ARMAPDKAGS
C45B11.1_Cele ------------------------------------------------------------
mbt_Dmel PEEEGPPAAGTPG---------------------------------------VGGASSGG
PAK4_Spur -GQQGPQGGG-EKKPEDNTKIPAHPYDQNPNSSAQQMMMNREMRD------RLNSKGSGG
AqueK236_Aque SSQQQ------------LASPPFSTVAVTTPTIP-----PLSTRSSTL-----------S
PAK6_Hsap QSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQ-SLG---P-------
PAK5_Hsap HAAKQNGHVMKMK--------HGEAYYSEVKPLKSDFARFSA----DYHSHLDSLSKPSE
PAK4_Hsap R-GRFAGHS---------------------------------------------------
PAK6_Mmus QSEHTDPHGLYLSCNGGTPAGHRQVPWPEPQSPQALPNGMAAKAQ-SLG---P-------
PAK5_Mmus HAAKQNGHAMKMK--------HGDAYYPEMKSLKTDLAGFPV----DYHTHLDSLRKSSE
PAK4_Mmus R-ARATGHS---------------------------------------------------
C45B11.1_Cele ------------------------------------------------------------
mbt_Dmel F-KPPGAHP------------------------SLLYNSQHAHANGATG---PLAVRTDQ
PAK4_Spur S-GPPPNHP------------------------DQR--GGQSWSRGGSHEKRSATTRNDP
AqueK236_Aque HIS--SDH-----------------SHHHPSSPFSFTAPLDAIQS-DLG---L-------
PAK6_Hsap -----AEFQGASQRCL-Q---LGACLQSSPPGASPPTGTNRHGMKA------AKHGSEEA
PAK5_Hsap YSDLKWEYQRASSSS--P---LDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDR
PAK4_Hsap -------------------------------EAGGGSGD--------RR-----RAGPEK
PAK6_Mmus -----AEFQGASQRCLQQ---LGACLQSSPPGTSPPMATGRRGVKV------AKHSSEEA
PAK5_Mmus YGDLRWDYQRASSSS--P---LDYSFQLTPSRTAGTSRCSKESLAYSESDWGPSLDDYDR
PAK4_Mmus -------------------------------EAGSGSGD--------RR-----RVGPEK
C45B11.1_Cele -----------------------------------------------RH-----SFRPTL
mbt_Dmel TN-L----QQ--------------------------------------------YRSNLA
PAK4_Spur RNDPRNDPRQNPRQD--PRQDPRYDPRNDPRRTDPRNQDPRNRDPRNQDPRNQDPRYQDR
AqueK236_Aque -----YDSEGSSSV-LT----TSSHIIYSPSDSSGYFGSTHSSLYS------SRLSTSQH
PAK6_Hsap RPQSCLVGSATGRPGGEGSPSPKTRESSLKRR--LFRSMFLSTAATAPPSSSKPGPPPQS
PAK5_Hsap RPKSSYLN--------QTSPQPTMRQ-----R--SRSGSGLQEPMM-PFGASAFKTHPQG
PAK4_Hsap RPKSSREG--------SGGPQESSRD----KR--PLSGPDVGTPQ--PAGLASGAKLAAG
PAK6_Mmus RPQSCLVGSAIGRPGGEGSPSPKNQESSLKHR--LFRSMFLSTPATGAASSSKPVPLPQN
PAK5_Mmus RPKSSYLH--------QTSPQPAMRQ-----R--SKSGSGLQEPMM-PFGASAFKTHPQG
PAK4_Mmus RPKSSRDG--------PGGPQEASRD----KR--PLSGPDVSTPQ--PGSLTSGTKLAAG
C45B11.1_Cele PPVSQ---------------------R--------------------------------G
mbt_Dmel PPS----G--------GSMPQQQ---------QTSPVG--SVASGT-RS-----------
PAK4_Spur RPD----G--------HSLPRGASGD----PRAHPPQG--QGPPGY-PGGPGGPRGDPRG
AqueK236_Aque IPSSAL-----PPP-PPVAPLPSTSQYSTH----------QSPP--------------HH
*
PAK6_Hsap KPNSSFR---------------------------------------------PPQKDNP-
PAK5_Hsap HSYNSYTYPRLSEPTMCIPKVDYDRAQM--VLSPPLSGSDTYPRGPA----KLPQSQS--
PAK4_Hsap RPFNTYPRADTDHPSRG-------------AQGEPH---DVAPNGPSAGGLAIPQSSS--
PAK6_Mmus KPNSAFR---------------------------------------------PPQKDSS-
PAK5_Mmus HSYNSYTYPRLSEPTMCIPKVDYDRAQM--VFSPPLSGSDTYPRGPT----KLPQSQS--
PAK4_Mmus RPFNTYPRADTDHPPRG-------------AQGEPH---TMAPNGPSATGLAAPQSS---
C45B11.1_Cele YPF----------------------------------------------------NDPSY
mbt_Dmel ------------NH-----------------------SH---TNNGNSGGSYPPMYPTSH
PAK4_Spur DP-RGY---QRDSTSSG-------------GSGPRTTGS---PGQPQPPGGFPPRHPDAQ
AqueK236_Aque RPLGP--------IHSCLP---FDTTSTDASNALPS--SSTH----DVAGVQYMHHYHNH
PAK6_Hsap PSLVAK-----------AQ---------SLPSDQ----PVGTFSPLTTSDTSSPQKSLRT
PAK5_Hsap ----------KSGYSSSSH---------QYPSGYHKATLYHH-PSLQSSSQYISTASYLS
PAK4_Hsap ----------------SSS---------RPPTRARGAPSPGVLGPHASEPQLAPPACTPA
PAK6_Mmus SNLVAK-----------AQ---------SLPSEQ----PMGTFSPLTTSDTSSPQKSLRT
PAK5_Mmus ----------KAGYSSGSH---------QYPSGYHKASLYHH-PSLQTSSQYISTASYLS
PAK4_Mmus ----------------SSS---------RPPTRARGAPSPGVLGPHASEPQLAPPARALA
C45B11.1_Cele APLPLR-----------NQ---------KPPMST----TFGVEKPHQYQ-QIITIV-APS
mbt_Dmel QQQQQQQQ--QAKQGGDQN---------QNPLHPHAHPHPHHHQHLAKSASRASSSSGGA
PAK4_Spur GRHPLQ-----------NR---------QPPPQGYGGPPPPGQQQQ-----QRPPGQMPH
AqueK236_Aque PHFSSLQRPAKSGTSPSRNTQRIRRSDLMNPSHATATPVS-H-VMTTSSSRNITSST-GA
* .
PAK6_Hsap APATGQLPGRSSPAGSPRTWHAQISTSNLYLPQ---DPTVAKGA---LAGEDTGVVTHEQ
PAK5_Hsap SLSL----------------------S---SST---YPPPSWGS---SSDQQPSRVSHEQ
PAK4_Hsap APAV---------------------------------PGPPGPR---SPQREPQRVSHEQ
PAK6_Mmus APAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQ---DPTVAKGA---LGGEDTGIVTHEQ
PAK5_Mmus SLSI----------------------S---SST---YPPPSWGS---SSDQQPSRVSHEQ
PAK4_Mmus APAV---------------------------PP---APGPPGPR---SPQREPQRVSHEQ
C45B11.1_Cele R-T----------------------TTPQ-LQP----KSPSTPQAMRQQPKCTEGVSDEE
mbt_Dmel SSA---------------------------AQQ---ASGASGGA--AGQPKQDQRLTHEQ
PAK4_Spur ------------------------------SNS---SPSPSNP---T-PNPGEQHVSHEQ
AqueK236_Aque AVN---------P----H----F--VSDV-YSTGRGHTVPAKP---H-RNRPSSKMSAEQ
. :: *:
PAK6_Hsap FKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELL
PAK5_Hsap FRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELL
PAK4_Hsap FRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELL
PAK6_Mmus FKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELL
PAK5_Mmus FRAALQLVVSPGDPREYLDNFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELL
PAK4_Mmus FRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELL
C45B11.1_Cele FRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELL
mbt_Dmel FRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELL
PAK4_Spur FRSALQMVVSPGDPRYKLENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELL
AqueK236_Aque FRATISLLVNSSDPRRDLDWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELL
*: :: ::*. *** * : :******* * * : : **** *.* :***:***
PAK6_Hsap FNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCE
PAK5_Hsap FNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCL
PAK4_Hsap FNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCL
PAK6_Mmus FNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQV-RLNEEQIATVCE
PAK5_Mmus FNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCL
PAK4_Mmus FNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCL
C45B11.1_Cele FNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTAT-RMTEPQIATISR
mbt_Dmel FNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHS-RMDEEQIATVCK
PAK4_Spur FNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGGALTDIVTHTGRMQEEQVAYVCQ
AqueK236_Aque FNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGGSLTDIIRRV-HLQESQIAAICK
**** *:::* * *:* :.*.**.:****:**:::**:****: :: * *:* :.
PAK6_Hsap AVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWM
PAK5_Hsap SVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWM
PAK4_Hsap AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWM
PAK6_Mmus AVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWM
PAK5_Mmus SVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWM
PAK4_Mmus AVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWM
C45B11.1_Cele QVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWT
mbt_Dmel QCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWM
PAK4_Spur AILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWM
AqueK236_Aque SCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWM
* ** ** . *********.*** ** :**:***:*.::... :*:********
PAK6_Hsap APEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVS
PAK5_Hsap APEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVS
PAK4_Hsap APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS
PAK6_Mmus APEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVS
PAK5_Mmus APEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVS
PAK4_Mmus APELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKAS
C45B11.1_Cele AAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVS
mbt_Dmel SPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVS
PAK4_Spur APEVISRLPYGTEVDIWSLGIMVMEMVDGEPPFFNEPPLQAMRRIRDMPPPKLKNTHKAS
AqueK236_Aque APEVISKQPYGTEVDIWSLGIMVIEMIDGQPPYFNLPASEAMNCIRTLPPPTSKSPEKIS
:.*:*:: * ...****:*:*::**::*:**:*. . :**. :* . . * *
PAK6_Hsap PVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQ-----------
PAK5_Hsap SVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRH------------
PAK4_Hsap PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT------------
PAK6_Mmus PVLRDFLDRMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQ-----------
PAK5_Mmus SMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRH------------
PAK4_Mmus PSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLMRQHRT------------
C45B11.1_Cele VELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIAPLLLQLQGNTINGNNPPTHH
mbt_Dmel PRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNARH------------
PAK4_Spur PRLLGFIERLLVRDPSQRASAFELLEHPFLRQCGPTSSLLPTMSQLRH------------
AqueK236_Aque PRLRDFLSKALVYNSEERATASELLRHPFLQFASPPSSLSKLIQFRNT------------
* ::. :* : :* .* :** ***: . : : .
PAK6_Hsap ------TSTC
PAK5_Hsap ---------H
PAK4_Hsap ---------R
PAK6_Mmus ------TSTC
PAK5_Mmus ---------H
PAK4_Mmus ---------R
C45B11.1_Cele HSSQITTVIQ
mbt_Dmel --------HP
PAK4_Spur ---------K
AqueK236_Aque ---------V