MSK2_Hsap MGD---------------------------------------------------------
MSK1_Hsap MEE---------------------------------------------------------
MSK2_Mmus MGD---------------------------------------------------------
MSK1_Mmus MEG---------------------------------------------------------
C54G4.1_Cele ME----------------------------------------------------------
JIL1_Dmel MSRLQKQNYEILSGTSTSRLKNHQHPRESESLAYEEPDQMVRNHLNGQLVANGNGKTRKN
MSK_Spur ------------------------------------------------------------
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap ----------------EDDDE---------------------------------------
MSK1_Hsap ----------------EGGSSGGA-AGT--------------------------------
MSK2_Mmus ----------------EDEDE---------------------------------------
MSK1_Mmus ----------------EGGGSGGA--GT--------------------------------
C54G4.1_Cele ------------------------------------------------------------
JIL1_Dmel SNSETMTNGKKSKLNTEGSGSGSGKTLNYNNNNNNNNSISATNGQYTNSSSKTTSASARD
MSK_Spur ------------------------------------------------------------
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap --------------------------------------------------SCAVELRITE
MSK1_Hsap ------------------------------SA----------DGGDGGEQLLTVKHELRT
MSK2_Mmus --------------------------------------------------GCAVELQITE
MSK1_Mmus ------------------------------SG----------DSGDGGEQLLTVKHELRT
C54G4.1_Cele --------------------------------------------D---------------
JIL1_Dmel YTYRETISPPTPPSPPTTNVADIVCISDAESEDGRDPEREYYDQDMEEDEPNGIEIDESS
MSK_Spur ------------------------------------------------------------
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap ANL---------------------------------------------------------
MSK1_Hsap ANL---------------------------------------------------------
MSK2_Mmus ANL---------------------------------------------------------
MSK1_Mmus ANL---------------------------------------------------------
C54G4.1_Cele -IL---------------------------------------------------------
JIL1_Dmel SSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEA
MSK_Spur ------------------------------------------------------------
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap ---------TGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL
MSK1_Hsap ---------TGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATI
MSK2_Mmus ---------TGHEEKVSVENFALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAAL
MSK1_Mmus ---------TGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATI
C54G4.1_Cele ---------MPEGEKVSMENFALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRV
JIL1_Dmel VTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITV
MSK_Spur ------------------------------AYGKVFLVRKVGNHNQGKLYAMKVLKKATI
AqueK023_Aque -----------HRVAIGPEDFELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSV
.**:****** : :******.* :
MSK2_Hsap VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY
MSK1_Hsap VQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER
MSK2_Mmus VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY
MSK1_Mmus VQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER
C54G4.1_Cele LTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGH
JIL1_Dmel VQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSEN
MSK_Spur VQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREH
AqueK023_Aque VRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIGP
: : *. *** :** *** :: ****.*.****:.:** ::::: ***:****
MSK2_Hsap FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE
MSK1_Hsap FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE
MSK2_Mmus FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE
MSK1_Mmus FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE
C54G4.1_Cele FDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELD
JIL1_Dmel FEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEY
MSK_Spur FRESEVRIYIAEIIIALDCLH---------------------------------------
AqueK023_Aque FSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHIVLTDFGLSKTMKPDQ--
* :. .*: :*:: **
MSK2_Hsap RTFSFCGTIEYMAPEIIRS-KTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVS
MSK1_Hsap RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEIS
MSK2_Mmus RTFSFCGTIEYMAPEIIRS-KAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVS
MSK1_Mmus RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEIS
C54G4.1_Cele RANSYCGTIEYMSPEVINRPEGGYSDVVDWWSLGVISFELLTGCSPFTVDGAQNSSKDIA
JIL1_Dmel RAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEIS
MSK_Spur ------------------------------------------------------------
AqueK023_Aque VAHSYCGTVEYMAPEIIRGGDDGHNLLVDWWSLGVLLHELLTCESPFAPTGEDNSQKEIS
MSK2_Hsap RRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAA
MSK1_Hsap RRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAA
MSK2_Mmus RRILKCSPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFFQGLDWVALAA
MSK1_Mmus RRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKIKWDDLAA
C54G4.1_Cele KRIMTKKVPFPKTMDVDARDFIGQLLEKKLEKRLGYN--GVDEIKNHKFMSSIDWDAAVK
JIL1_Dmel RRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRT
MSK_Spur -RILTSHPPMPNTFSKEVKDFINKLLVKDPTKRLGCN--GVKDIKSHSFFKGLNWDDVAA
AqueK023_Aque RRILYEAPPIPHKLSPSCRELLFGLMRKNKDERLGAN--GAHEVKSHRWFSSLNWDDVLA
** * :. :::: :: *. .*** . .. :::.* ::. :.*
MSK2_Hsap RKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQ-GYSFVAPSILFDH
MSK1_Hsap KKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQ-GYSFVAPSILFKR
MSK2_Mmus RKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPAGSPPPGDPRIFQ-GYSFVAPSILFDH
MSK1_Mmus KKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQ-SSERLFQ-GYSFVAPSILFKR
C54G4.1_Cele RTLKPVIVPRIGHDLDTQFFSAEFTSQPPLYSPAESPL-NANTLFR-GYSYVSPSVIFAN
JIL1_Dmel KRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPP-SRIRLFR-GYTYVAPEHLEQM
MSK_Spur KRVSPPFRPHINGELDTSNFAEEFTSLVPADSPADIPKTADARVFRVGYSFIAPSILYSD
AqueK023_Aque KKVRPPFKPYVSNEMDVGNFADEFTNQDPVDSPALPIS-KHNQVFR-GYSFIGPPVLFTS
: . * : : *. *: *** * . :*: **:::.* :
MSK2_Hsap NNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPA-LGQGSFSVCRRCR
MSK1_Hsap NAAV-IDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKP-LGEGSFSICRKCV
MSK2_Mmus NNAVMADVLQAPGAGYRPGRAAVARSAMMQDSPFFQQYELDLREPA-LGQGSFSVCRRCR
MSK1_Mmus NAAV-IDPLQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKP-LGEGSFSICRKCV
C54G4.1_Cele DNVI-GEELMAE-----------DVNALLASSSFFAKYKLDKSDAGLLGKGAFSVVRRCE
JIL1_Dmel RRDN-HCEIQYF-------------NTGLQNIPC-RPDDLELGT-R-TSNGAYGTCHFVV
MSK_Spur NAI-TQDMLTQPSEHNRPSLASILSIHELKDSPFNKYYELDMKSAP-IGDGSFSICRRCT
AqueK023_Aque NTVL-SS----------------LPPLLLHDSPFLQKYELS--NTN-LGTGSFSTCRVCI
: . . .*. . *::. :
MSK2_Hsap QRQSGQEFAVKILSRRLEANTQREVAALRLC----QSHPNVVNLHEVHHDQ---------
MSK1_Hsap HKKSNQAFAVKIISKRMEANTQKEITALKLC----EGHPNIVKLHEVFHDQ---------
MSK2_Mmus QRQSGQEFAVKILSRRLEENTQREVAALRLC----QSHPNVVNLHEVLHDQ---------
MSK1_Mmus HKKTNQAFAVKIISKRMEANTQKEITALKLC----EGHPNIVKLHEVFHDQVAASAQPPG
C54G4.1_Cele RVVDGAQFAVKIVSQKFASQAQREARILEMV----QGHPNIVQLHDVHSDP---------
JIL1_Dmel DSSTDLVFLAKIIPLSK--FRPSEVDALISCALDTTNHKNIVSYHGTFREK---------
MSK_Spur HRKTEKEYAVKIVSRRVA--CTQEITTLQLC----QKHPNIVHLKEEFKDK---------
AqueK023_Aque EKETKQEFAVKIVSKRH--NPMREISILQLC----QGHPNIVRLHEVLQDQ---------
: .**:. * * * *:* : :
MSK2_Hsap --------------------------------------------------------LHTY
MSK1_Hsap --------------------------------------------------------LHTF
MSK2_Mmus --------------------------------------------------------LHTY
MSK1_Mmus QVVLCSLLLLALLFNRSLTRKPVTWTWLVHSTSQLPPLPPPMPEIVLFILLSDNGQLHTF
C54G4.1_Cele --------------------------------------------------------LHFY
JIL1_Dmel --------------------------------------------------------CETW
MSK_Spur --------------------------------------------------------LHTY
AqueK023_Aque --------------------------------------------------------LHVY
. :
MSK2_Hsap LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD
MSK1_Hsap LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD-VGVVHRDLKPENLLFTD
MSK2_Mmus LVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD
MSK1_Mmus LVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHD-VGVVHRDLKPENLLFTD
C54G4.1_Cele LVMEILTGNELLERIRKLERFTESEAADIMRQLVSAVKYLHD-KRIVHRDLKPENILFES
JIL1_Dmel IVMEYLSGPELTASIRM----DEDSCREIFLQLVMAVRHIHS-KHFIHGDLKPENIMFEN
MSK_Spur IIMELCKGGELLGRIRKKKHFDELEASMIMRKLVSAVDYMHS-RGIVHRDLKPENILFTD
AqueK023_Aque IIMERLRGGELLDRIRSNNSFTEAQASHLFRQLVSAVHFIHS-KRVVHRDLKPENLIFSN
:::* * ** *: * .. :: .** ** .:*. .:* ******::: .
MSK2_Hsap DTP-GAPVKIIDFGFARLRPQSPGVP---------------------MQTPCFTLQYAAP
MSK1_Hsap END-NLEIKIIDFGFARLKPPD-NQP---------------------LKTPCFTLHYAAP
MSK2_Mmus DTP-GAPVKIIDFGFARLRPQSPAEP---------------------MQTPCFTLQYAAP
MSK1_Mmus END-NLEIKVIDFGFARLKPPD-NQP---------------------LKTPCFTLHYAAP
C54G4.1_Cele IDS-SARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYAAP
JIL1_Dmel RE-D-RTVKLIDFGSACYNNRFK-SW---------------------KDKPRYTLDYAPP
MSK_Spur DSD-DAELKIIDFGFARITN-SN-QP---------------------LKTPCFSLHFAAP
AqueK023_Aque EDDDTAVLKIIDFGFARLLPEAP-QV---------------------LTTPCYTLPYGAP
::::*** * .* ::* :..*
MSK2_Hsap ELLAQ-----QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQA--AEIMCKIREG
MSK1_Hsap ELLNQ-----NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSA--VEIMKKIKKG
MSK2_Mmus ELLAQ-----QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQA--AEIMCKIREG
MSK1_Mmus ELLTH-----NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSA--VEIMKKIKKG
C54G4.1_Cele EVLDVG-DSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQ---ESA--TEIMQRICRA
JIL1_Dmel EMLADA-N-LVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRG
MSK_Spur EVLKRAYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSISKS-NSA--SDIMKRIKHG
AqueK023_Aque EVISH----SNGYTESCDIWSLGVILYTLLSGQAPFHAPTW-----PT--EKIVDCIQHG
*:: * *::.**. *: :* *: *:: : .: : ..
MSK2_Hsap RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVL
MSK1_Hsap DFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL
MSK2_Mmus RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQDGSARSSPPLRTPDVL
MSK1_Mmus DFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL
C54G4.1_Cele EFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSAS-MDTPLQTPSIL
JIL1_Dmel TFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIILPQQM
MSK_Spur NFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQNEWIQGQQLSTSTPLMTPDIL
AqueK023_Aque SVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLTIDSLSVHPWLMPDSA-PDTPLCTTVSL
.. . * ..* : *: * :. * . . : *: . : . :
MSK2_Hsap ESS-----------GPAVRSGLNATFMAFNR-GKREGFFLKS------------------
MSK1_Hsap GSS-----------GAAVHTCVKATFHAFNK-YKREGFCLQN------------------
MSK2_Mmus ESS-----------GPAVRSGLNATFMAFNR-GKREGFFLKS------------------
MSK1_Mmus GSS-----------GAAVHTCVKATFHAFNK-YKREGFCLQN------------------
C54G4.1_Cele PSS-----------A-D--ETFNETLRAFLH-ANRDGFHLLD------------------
JIL1_Dmel VVDLSEDTMEQPTGG-MFDDQQQLEFMHDK-SAEDEGITLVSEPMDTTVATHESRRNAAA
MSK_Spur NSC-----------A-SIQKRVKATMRAFHT-AQREGFLLTD------------------
AqueK023_Aque KSL-----------G-ATRTAINHTLHAYYQVTSKDGLVLGD------------------
. : : . :*: * .
MSK2_Hsap --------------------------------VENAPL--AK------------------
MSK1_Hsap --------------------------------VDKAPL--AK------------------
MSK2_Mmus --------------------------------VENAPL--AK------------------
MSK1_Mmus --------------------------------VDKAPL--AK------------------
C54G4.1_Cele --------------------------------VAAAPL--MK------------------
JIL1_Dmel FSSVVAPTTDDEIVHERFDPAFEVQADFYGFDENAPPLPLPEEYYSELPLPEEDRQYIPP
MSK_Spur --------------------------------VSNAPL--AK------------------
AqueK023_Aque --------------------------------PAQNPL--AR------------------
** .
MSK2_Hsap -------------RR---KQKLRSATASRRGSP----APANPG-----------------
MSK1_Hsap -------------RR---KMKKTSTSTETRSSS----SESSHS-----------------
MSK2_Mmus -------------RR---KQKLRSAAASRRGSP----VPASSG-----------------
MSK1_Mmus -------------RR---KMKRTSTSTETRSSS----SESSRS-----------------
C54G4.1_Cele -------------RR---GIKRQSGDKDASGNS----KNSRVT-----------------
JIL1_Dmel PPALIPVEPETTFRRPRTRQQRRTESQLVQPVSVATYEDSKASLRVLMQQLPPPGDNVVA
MSK_Spur -------------RR---KKKKDSST-ETRSSS----SESTHS-----------------
AqueK023_Aque -------------KR---KLKSERSPQ---------------------------------
:* :
MSK2_Hsap ------------------------------------------------------------
MSK1_Hsap ------------------------------------------------------------
MSK2_Mmus ------------------------------------------------------------
MSK1_Mmus ------------------------------------------------------------
C54G4.1_Cele ------------------------------------------------------------
JIL1_Dmel RIPKRTHRVVRTLPPTFGTTKREENFYGFSKTAISWRKTRASWRHFCLLINGVQQVLKVR
MSK_Spur ------------------------------------------------------------
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap ----------------------------RAPV-ASKGAPRRANGPL--------------
MSK1_Hsap ----------------------------SSSHSHGKTTPTKTLQPS--------------
MSK2_Mmus ----------------------------RLPASAAKGTTRRANGPL--------------
MSK1_Mmus ----------------------------SSSQSHGKTTPTKTLQPS--------------
C54G4.1_Cele -----QFECLPEEQEAEMTSSTSRPSNLGMMN------------YR--------------
JIL1_Dmel FKKARRVYCLPHIKEEKLDHAYEKPLTFPRPKAQLKRTKREPKVPR--------------
MSK_Spur ----------------------------QSSSSQESTTPTPTANPVLTIPVTTVSCAPRT
AqueK023_Aque --------------------PGTRPTT---------------------------------
MSK2_Hsap ------------------------------------------------------------
MSK1_Hsap --------NPA-------------------------------------------------
MSK2_Mmus ------------------------------------------------------------
MSK1_Mmus --------NPT-------------------------------------------------
C54G4.1_Cele --------EPN-------------------------------------------------
JIL1_Dmel --------PPT-------------------------------------------------
MSK_Spur TTATGAPSIPSVQPLPSLSKQTGARLDQYESLESLGFSPILPFSAGGSQELPPLLARQDS
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap ------------------------------------------------------------
MSK1_Hsap ------------------------------------------------------------
MSK2_Mmus ------------------------------------------------------------
MSK1_Mmus ------------------------------------------------------------
C54G4.1_Cele ------------------------------------------------------------
JIL1_Dmel ------------------------------------------------------------
MSK_Spur GYVGQMPSYAQVTPVPRTNVGSHGVTYAPILDPSMYPCGLQQPILDFSSSIPEYLSVQYA
AqueK023_Aque ------------------------------------------------------------
MSK2_Hsap ----------------------------------------PPS
MSK1_Hsap -------DSNNPETL------------------F--QFSDSVA
MSK2_Mmus ----------------------------------------SPS
MSK1_Mmus -------EGSNPDTL------------------F--Q---FSD
C54G4.1_Cele -------SGTI----------------------R-ETRGSDSS
JIL1_Dmel -------RVQP-ERA------------------RAMRQLYQFQ
MSK_Spur STEQPSIPMTVPRTLHQPHPHPLPLPHQHLSHLPTISEDPSTT
AqueK023_Aque --------LEI------------------------TDLKSATN