MNK2_Hsap MVQKKPAELQ---------------------------------------------GFHRS
MNK1_Hsap MVSSQKLE----------------------------------------------------
Lk6_Dmel MVEPKSGTAA---------------------------------------------SAAA-
MNK2_Mmus MVQKRTAELQ---------------------------------------------GFHRS
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele MTILHAGYPQ---------------------------------------------SPVVH
Mnk_Spur MGNDRGKQAI---------------------------------------------VYKK-
AqueK075_Aque MEGTASRAASTKMEDREEIRDLLQFKHDFTLGLVSENGSSKTNGSIDGKMGAAEKRNDES
MNK2_Hsap FKGQNP--------------------------------FELAFSLDQ-PDHGDSDF-GLQ
MNK1_Hsap ----KP------------------------------------------------------
Lk6_Dmel AKASNN---------------------------------------------------NNN
MNK2_Mmus FKGQNP--------------------------------FELAFSLDL-AQHRDSDF-SPQ
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele FGRHHNVNINQLNLNHLGQVDNIPNNSAVGGGGAAFHHLHTSAATPRHVATSEFYDDEEA
Mnk_Spur -QVLQP--------------------------------VMRSFVFPT-VCPQDSYP-SQE
AqueK075_Aque IKSLKE--------------------------------FQKSFKLGK-SEQSNSVL-SPH
MNK2_Hsap ------------------CSARP-------------------------------------
MNK1_Hsap ----------------------I-------------------------------------
Lk6_Dmel NHPRGSGDSGIRSGSGISCSNT-DNSCSQSQSDGQNELTRYSSEDV--SGN---ESSEAP
MNK2_Mmus ------------------CEARP-------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele TSPRGGIEIG--AGGGKMMANL-R-------RHRQRERETYEDEDVLSSSD---ESSGRP
Mnk_Spur TTPITKMP----TGDKMTVSQRPPATAAVQMPDCKATAENYANNNI--ADETCLLSEQMD
AqueK075_Aque ---------------------------------------------V--NGS---DCSQRE
MNK2_Hsap -------------------------------------------DMPASQP-ID---IPD-
MNK1_Hsap -------------------------------------------EMGSSEP-LP---IAD-
Lk6_Dmel -------------------------------------------NMTEVERQAE---LNRH
MNK2_Mmus -------------------------------------------DMPSSQP-ID---IPD-
MNK1_Mmus --------------------------------------------MGSSEP-LP---IVD-
R166.5_Cele IPRYVGRDTDHVFGEFEMDDEDVVMRREDGYGEDETDEDYFDEEEPVAEL-LP---LGG-
Mnk_Spur -------------------LM--------------------M-SISSVED-FHS--GLD-
AqueK075_Aque VP-----------------RS--------------------L-D-ITAQP-VSRGQANTS
:
MNK2_Hsap AKKRGKKKKRGRATDSF-SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEK
MNK1_Hsap GDRRRKKKRRGRATDSL-PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK
Lk6_Dmel KEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDK
MNK2_Mmus AKKRGRKKKRCRATDSF-SGRFEDVYQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEK
MNK1_Mmus SDKRRKKKRKTRATDSL-PGKFEDVYQLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEK
R166.5_Cele GTR-RVPRTPGRKNSS-K-CGFFDYYKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDK
Mnk_Spur DSRRKRKKKKKRTSGIV-PNRFEDVYDLTGELLGSGSYASVRTCRQISSGKEYAVKMMEK
AqueK075_Aque KKKKQKKKRLKPIPDDI-DYSFNDLYELTSEILGSGARATVITCIKRTTRQQYAAKIINN
. : . * : *.* : **.*: . * . . . :**.*::::
MNK2_Hsap QP-GHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH
MNK1_Hsap QA-GHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKH
Lk6_Dmel IP-GHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHIC
MNK2_Mmus QL-GHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRH
MNK1_Mmus QA-GHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKH
R166.5_Cele QGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKY
Mnk_Spur RP-GNSRTKIFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHIEQRGT
AqueK075_Aque SG-PEVRDRVLKEVEILYSCSSCDNFLKIEDFFETSEKFYLVFEKMEG-PLLELIQKRER
. * ::::**: : *.. ..::: ::** . .***::**: * .:* * .:
MNK2_Hsap FNELEASVVVQDVASALDFLHNK-------------------------------------
MNK1_Hsap FNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQV
Lk6_Dmel FSEHEASQIIKEIASGLDFLHKK-------------------------------------
MNK2_Mmus FNELEASVVVQDVASALDFLHNK-------------------------------------
MNK1_Mmus FNEREASRVVRDVATALDFLHTK-------------------------------------
R166.5_Cele FTEEEARRVTKDISLALKFMHDR-------------------------------------
Mnk_Spur FTEQEASQVIRDIASALSFLHNK-------------------------------------
AqueK075_Aque FTEREASEVTREVAAALSFLHRQ-------------------------------------
*.* ** : :::: .*.*:* :
MNK2_Hsap ----GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGD-CSP----ISTPELLTP
MNK1_Hsap AGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNS-CTP----ITTPELTTP
Lk6_Dmel ----GIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSP----AATPQLLTP
MNK2_Mmus ----GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGD-CSP----ISTPELLTP
MNK1_Mmus ----GIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNS-CTP----ITTPELTTP
R166.5_Cele ----GIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHE-RHPLSQVASEPDLASP
Mnk_Spur ----GIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLSSQYNTP----VTTPELLTP
AqueK075_Aque ----GIAHRDLKPENILCQTKDEVVPIKVCDFDLSSMM---SQ-HTP----ATTPNLFTP
******:****:** : *:*:**:.*.* . * : *:* :*
MNK2_Hsap CGSAEYMAPEVVEAFSE--EASIYDKRCDLWSLGVILYILLSGYPPFVGRCG-SDCGWDR
MNK1_Hsap CGSAEYMAPEVVEVFTD--QATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDR
Lk6_Dmel VGSAEFMAPEVVDLFVG--EAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCG-EDCGWNR
MNK2_Mmus CGSAEYMAPEVVEAFSE--EASIYDKRCDLWSLGVILYILLSGYPPFVGHCG-SDCGWDR
MNK1_Mmus CGSAEYMAPEVVEVFRD--EATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDR
R166.5_Cele VGSAEFMAPEVVDAYVG--DSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSE
Mnk_Spur VGSAEFMAPEIVEAFIYDLQATVYDKRCDLWSLGVILYILLCGHPPFVGSCG-EDCGWDR
AqueK075_Aque VGSAEYMAPEVLDTFTG--EIFSYDKKCDLWSLGVLVYMMLSGSPPFTGGCR-TDCGWEK
****:****::: : : ***:** *****: *::*.* .** * * ****..
MNK2_Hsap GEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQR-----------
MNK1_Hsap GEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQR-----------
Lk6_Dmel GENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNR-----------
MNK2_Mmus GEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQR-----------
MNK1_Mmus GEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQR-----------
R166.5_Cele GKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVNPFA
Mnk_Spur GEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQR-----------
AqueK075_Aque GEECEKCQAILLEKIGKGQYSFPQEIWASISSEAKDLISSLLQRDVRKR-----------
*: * *: *:. * .* :.* * :* ****:* ** :. .*
MNK2_Hsap ---------------------------------------------LSAAQVLQHPWVQGC
MNK1_Hsap ---------------------------------------------LSAAQVLQHPWVQGQ
Lk6_Dmel ---------------------------------------------LSAEAVLNHPWIRMC
MNK2_Mmus ---------------------------------------------LSAAQVLQHPWVQGC
MNK1_Mmus ---------------------------------------------LSAAQVLQHPWVQGQ
R166.5_Cele NRIRLTLVAQSVACAIPTQPIVGSIPSYPALSLFIDCGAWKWRRKFNADQILSHRWLQQS
Mnk_Spur ---------------------------------------------YTAGMVLNHPWVKQ-
AqueK075_Aque ---------------------------------------------LSADEVLAHPWIKTE
.* :* * *::
MNK2_Hsap APE----------NTLPTPMV-LQRN-SCAKDLTSFAAEAIAMNRQLAQHDEDL------
MNK1_Hsap APE----------KGLPTPQV-LQRN-SSTMDLTLFAAEAIALNRQLSQHEENE------
Lk6_Dmel EQEPPASKHGRRHKALQTPSN-IRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKE
MNK2_Mmus APE----------NTLPTPLV-LQRN-SCAKDLTSFAAEAIAMNRQLAQCEEDA------
MNK1_Mmus APE----------RGLPTPQV-LQRN-SSTMDLTLFAAEAIALNRQLSQHEENE------
R166.5_Cele AAS----------TILQTPSNLINRK-DSARDVQQMSEHFNLMNRLADTRLSAR------
Mnk_Spur PPS----------TPLLTPAI-IKRN-NSAKDLSQFAADAVACNRLVAQKEEDE------
AqueK075_Aque VPD----------TPLKTPGV-LRLNPSITDELSQVAASCLKCNRRLSTHFEK-------
. * ** :. : . : :: .: :* .
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel RPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRR
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel SSRNASRNASAIYPNSGGFKTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETL
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel GEDRFRRQSGSEGDEVEDDEDGENEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEE
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel EFEDEPKEETQADNLKLSKAYVEQVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQ
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap -------------------AE--------EEAAGQ-------------------------
MNK1_Hsap -------------------LA--------E------------------------------
Lk6_Dmel SEFAKLTIMRNDAQTEENKIMQQQDEEKKEEKQQDDVDGAKKQGPSSDISATTITDNNKL
MNK2_Mmus -------------------GQ--------D------------------------------
MNK1_Mmus -------------------LA--------E------------------------------
R166.5_Cele -------------------FD--------NKMTMSE--C---------------------
Mnk_Spur -------------------IQ--------EEVIEEDVDT---------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel QTPVMTTTHINNWQTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPA
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ----------------------------------------GQP-----------------
MNK1_Hsap -----------------------------------------EP-----------------
Lk6_Dmel ASATRPPTDNPEEDDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTV
MNK2_Mmus -----------------------------------------QP-----------------
MNK1_Mmus -----------------------------------------EQ-----------------
R166.5_Cele -------------------------------------GSDLGTATIHGD-----------
Mnk_Spur -------------------------------------EDDGGICIIRPS-----------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel NFAPDAYQNDEDADIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLAD
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel QVPQRQHTENWRYRTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNQQRNYLGSFSHSGGA
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele ------------------------------------------------------------
Mnk_Spur ------------------------------------------------------------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------------------------------------
MNK1_Hsap ------------------------------------------------------------
Lk6_Dmel AGYKIAPMPPPMQPPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQG
MNK2_Mmus ------------------------------------------------------------
MNK1_Mmus ------------------------------------------------------------
R166.5_Cele -----------------------------------------------------G------
Mnk_Spur -----------------------------------------------------G------
AqueK075_Aque ------------------------------------------------------------
MNK2_Hsap ------------------------------VLVRAT-------------------SRCL-
MNK1_Hsap ------------------------------EALADG-------------------LCSM-
Lk6_Dmel PEQQRHNRSSGQRVQQQPRIGSGRFAHLQAAQLMDEL-----------------PDMRI-
MNK2_Mmus ------------------------------VVIRAT-------------------SRCL-
MNK1_Mmus ------------------------------EALAEG-------------------LCSM-
R166.5_Cele ------------------------------SFLSMGGEPFGTFPRKKSVGIAIEKSRSGE
Mnk_Spur ------------------------------QLNNGG-------------------LNNF-
AqueK075_Aque ---------------------------------------------------------SF-
MNK2_Hsap ----------QLSPPSQSKL--------AQRRQRASLSS-----------------APVV
MNK1_Hsap ----------KLSPPCKSRL--------ARRRALAQAGR-----------------GEDR
Lk6_Dmel ----------GLSPPSESVL--------LQRRLRQQ-QR-----------------ANDL
MNK2_Mmus ----------QLSPPSQSKL--------AQRRQRASLSA-----------------TPVV
MNK1_Mmus ----------KLSPPSKSRL--------ARRRALAQAGR-----------------SRDA
R166.5_Cele FTPPISRASPTTPPPSMLNLSEDLTDSPVKRRSADDSGTFSLFSPASSNGDDSICSPPMV
Mnk_Spur ----------GLSPPGQSAL--------AKRRAAMH-SQ-----------------GRDQ
AqueK075_Aque ----------KLSPPGSSEL--------ALRRGGDHK-----------------------
.** * **
MNK2_Hsap -------------------------------------------------LVGDHA
MNK1_Hsap -------------------------------------------S------PPTAL
Lk6_Dmel -------------------------------------------SEY-CEPATASG
MNK2_Mmus -------------------------------------------------LVGDRA
MNK1_Mmus -------------------------------------------NP--C-LTPAGL
R166.5_Cele FVDMPSIQLFGTGALLTSVQMTPRHTTEDDASLKSFEDEQENANPIHRIETQVNV
Mnk_Spur -------------------------------------------------CITIQA
AqueK075_Aque -----------------------------------------------------FP