LKB1_Hsap MEVVDPQ-----------------------------------------------------
CG9374_Dmel MTVTTMEAQVKAA--------------HHHHLHHPTGGG---------------------
LKB1_Mmus MDVADPE-----------------------------------------------------
par-4_Cele MDAPSTSSGAQSK------------------LLM--------------------------
Lkb1_Ddis MEVEQQPS----------------------------------------------------
LKB1_Spur MLERCLDEDTVS------------------------------------------------
AqueK062_Aque MASRQVARG-QSKKTTSGTGSATSQAITNGHLICPTCSEEIVDPVGKKKGHQSIECNGPC
*
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque HMWLHRQCAGLSRAAFDAAGASNDPFFCPQCVISNQNQEITTLKLKLDEVLNELSALKNE
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel --------AQHKVE----------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque VANLKTEVSQHLVQDDNNPDSIPTDSTMPRTSARPVGNSSRVNMQNRSLPRDRSCNLVIY
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque GIPECPHECLTSWLRKADRVETPKPRTIDALITALREIGENAVADGINEERQRHLTNLPA
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque CAYFTLFPANPGVCNLKHKIEKVPELEKIASKLQEKYDFLVFAVRKSLRDHCIDVEDAKA
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque LIKKSLKKKALAVSYLLPCIDILEKASDFNSFFEFLRRCDFIGYLNYKLLKALSGLIIGG
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque DEINKLFLEYEKEYAKLLNLDSFQNLIPFFEEKTDESPDAPLGLPCVSFKKPLVRKFSCS
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque YYAILKQLSGSSVPLRDSTNEKEVTSIEQDALAKWLKEGTVNLTVKRVQMLGPPGSGKTC
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele -----PGDDEADED----------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque SQLLLLNEDPPE-DVTDSTPIACRAVKATRTSIENGHMKRVDAKAFLSRLACDLIESASK
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel --------------------------------------------------------E---
LKB1_Mmus ------------------------------------------------------------
par-4_Cele -----------------------------------------------------HQNR---
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur --------------------------------------------------------H---
AqueK062_Aque LKETLVPTGGCDGTKSKGESSDNIPTGSPETEATESADTTEKVARLADSANDYHSNKVLQ
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque DIVEAIPNAEANLNCNWVYIVDSGGQTAFQELLPLFTRAASLNIITIDLSKGVDEKLDLQ
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque YRIDGASFPCDSNFSYTNIEFLRGVFSSGANLQLYHSPHSEEDAATPEYFVLGTHSDDAK
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel -------------------------------------------EEPDPVEDEMTVLLANK
LKB1_Mmus ------------------------------------------------------------
par-4_Cele -------------------------------------------GDPNLQQ--KQKIQLNV
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur -------------------------------------------IPPHWAQTD--------
AqueK062_Aque ATQQKIAIFNKEISSLTSGKKGYSIIPAEQNGDIIYPVNTMLKPGPERQE--ESKNLCDT
LKB1_Hsap ------------------------------------------------QLGMFTEGELM-
CG9374_Dmel NFHYDVASDLDDDAFVELKEDTA------------------QADDAGAGVGFYNPDELLL
LKB1_Mmus ------------------------------------------------PLGLFSEGELM-
par-4_Cele DPDY--DDDEDDDCFIDGCEASAP---ITRELVDGAIERRSKDRNVKMSIGVYDEYDDDD
Lkb1_Ddis ----------------------------------------------------YTS-----
LKB1_Spur ------------------------------------------------HFSFFGDDD---
AqueK062_Aque IFDF--DDDTLDDTFDDTIQLPVRWFAFELTLLEKAGNSSVLHMNDVLSIGRSLEMDDGD
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel DD-------------------------QPHPQ----------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele DDEE----------------E-----TEED------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque TKKALEYLHNVTIILYYPQVLPDIVFVDPHPILDILSRLLALTYKIKRKFLRRLTRETPS
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ---------VTWLDDDEIE-TLDR------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele --------QRRRFVEGIR------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque EPELDKLSKEGIFTESLLDKLKDDQRFSKSDFINLLLHLHIIVETQDGYFIPFALPPFAL
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque PPFGSTGSLPKSDIINPLLIVWLNPVTKEVLPVPRGIFPLAVVNLMKLNQPLFQFFPGSQ
LKB1_Hsap -----------------------------------------------S------------
CG9374_Dmel ----------------------------------------------VT------------
LKB1_Mmus -----------------------------------------------S------------
par-4_Cele -NIRHKQQES-------------------------FDLEEH-PIPVES------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque EYLRYRDAMSFRVRVHDEFIGTIHFIKKHRHIEIHFDTNELKYCPLICEAVTEAIRSSNV
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque VINLKPLHKLAFACCDMKDCYCIVTNEAEEKVECTLCPRPALISGRKEYWNWFHVTHKSL
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque TEAPKLARETTPKTLDITDLKDVLTLLRECHFNGDWEGLGIELGLYKHPTLSDIQQSYTR
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque SSTLTECLASWLLRVDGVDQNGGATYVSLANAFETLGQNAIADHIRINDAHHILDITCLR
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque DVHLSLCDLYESKWLDLGDQLGLYAKTLQAIEDDYSDDRRCLRETLVKWLAGADDVLPSW
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque GSLVQALEAIGENNVAENIIKNGSSSKKLPVCTSLMATAMMNTPPHPPSGGGRGGSGRGH
LKB1_Hsap ------------------------------------------------------------
CG9374_Dmel ------------------------------------------------------------
LKB1_Mmus ------------------------------------------------------------
par-4_Cele ------------------------------------------------------------
Lkb1_Ddis ------------------------------------------------------------
LKB1_Spur ------------------------------------------------------------
AqueK062_Aque GITIDVSPPSPHDYIHSSPQPHSSRDRDYTSGMSPGSGDLPSPFFNHPQLIESPIPEEPG
LKB1_Hsap ---VG-MDTFIHRID------------STEVIYQP--RRKRAKLIGKYLMGDLLGEGSYG
CG9374_Dmel ---LDMGNMFFNRVD------------SQDIIYQQ--KKKSIKMVGKYIMGDVLGEGSYG
LKB1_Mmus ---VG-MDTFIHRID------------STEVIYQP--RRKRAKLIGKYLMGDLLGEGSYG
par-4_Cele ---EA-MRQFINQQVNNAMMFNQDNSEFQHIEFEPIVKQKGPKIIEGYMWGGQIGTGSYG
Lkb1_Ddis ----N-FIIHLNENE------------DNGISYRS--RKSTPKLVKHYILGEVLGEGAYG
LKB1_Spur ----D-DHIFIHRVD------------SADIVYQP--RKKRAKMVGKYLMGDTLGEGSYG
AqueK062_Aque EDHFGDDFTDFPRYD------------SRDIVYEE--PQRQAK------IGDLLGVGAYS
: . : :. : * * :* *:*.
LKB1_Hsap KVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEE
CG9374_Dmel KVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEE
LKB1_Mmus KVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEE
par-4_Cele KVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRMNHRNVIKLIEIFNIPA
Lkb1_Ddis KVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNKHIIKLIDHFIIEE
LKB1_Spur KVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDE
AqueK062_Aque KVREMLDCVTLCRRAVKIMKQRRLSRILNGEENVRREIKILKKLNHRNVIKLLDVFSDDN
**:: :: . * ****:. :* :* * .: *: : :::.: ::::*:: :
LKB1_Hsap KQKMYMVMEYCVCGM-QEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG
CG9374_Dmel KQKMYLVMEYCVGGL-QEMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPG
LKB1_Mmus KQKMYMVMEYCVCGM-QEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPG
par-4_Cele KGKVYMVFEYCIGSV-QQLLDMEPARRLTIGESHAIFIELCQGLNYLHSKRVSHKDIKPG
Lkb1_Ddis KGKLYIVYEYVGGGTSQNILENAPNGRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPD
LKB1_Spur KQKMYLFMEYCVSGL-QDMLDAAECKKFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPS
AqueK062_Aque KQKLYIVLEYCVGGL-QEMLDKAPRNKFPIWQAHKYFVQLIEGLEYLHSCGIVHKDIKPG
* *:*:. ** . *:::: ::. ::: * :* :. :*:** : *:****.
LKB1_Hsap NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANG-LDTFSGFKVDIW
CG9374_Dmel NLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANG-HETFAGFKVDIW
LKB1_Mmus NLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANG-LDTFSGFKVDIW
par-4_Cele NLLVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKFQPPECIYGNHDFFDGYKADMW
Lkb1_Ddis NILFTHANVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQF-QTTFSPFKIDIW
LKB1_Spur NLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANG-QDVFSGFKVDIW
AqueK062_Aque NLLLTTDDVVKISDFGVAEELDRFSQSDRCCNFQGSPAFQSPEIASG-QDNWSGFKADIW
*:*.: :*:.*:**** : *:* **.** : :* *:*
LKB1_Hsap SAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG---DCGPPLSDLLKGMLEYEPAK
CG9374_Dmel SSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSK
LKB1_Mmus SAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC---DCGPPLSDLLRGMLEYEPAK
par-4_Cele SAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNV-QLTKDLQDLLTKLLEKDFNE
Lkb1_Ddis AMGVTLYLMTIGKFPFSGANMFVLFENISKCKIEFPN---DLDKDLVNLIKGILQVDHIQ
LKB1_Spur SSGITLYNIVTGKFPFEGDNIYRLFENIGKGDYTIPA---DVPPQLTNLLEGMLSIDPDT
AqueK062_Aque ASGVTLYHFTTGKFPFEGESVYKLFAVISQCTYTLPPE---LPPVLQDLIRGMLLKDPDK
: *:*** :. * :**. : * *. * : :*: :* :
LKB1_Hsap RFSIRQIRQHSWFRKKH--PPAEAPVPIPPS-----------------------------
CG9374_Dmel RLSLQEIRHDTWFRSAP--VKTGPPIPIPP------------------------------
LKB1_Mmus RFSIRQIRQHSWFRKKH--PLAEALVPIPPS-----------------------------
par-4_Cele RPTCLETMIHPWFLSTF--PEDQGLGRIMER-----------------------------
Lkb1_Ddis RFSLGQIKNHPWCIKYI--PEVEPFVPLLEESKFLPLEMAYGDDEGDDGGGGRGGGGDDE
LKB1_Spur RLNVHQIKEHVWVRKKH--DLVGEPVHLPLL-----------------------------
AqueK062_Aque RLDIEQIRRHTWFISKHSKPLKEELVRFPPY-----------------------------
* : . * . :
LKB1_Hsap ----------------------PDTKDRWRSMTVVP------------------------
CG9374_Dmel -----------------------LKGDKYRNSTVIP------------------------
LKB1_Mmus ----------------------PDTKDRWRSMTVVP------------------------
par-4_Cele ----------------------MRTGDR--PLTMLS------------------------
Lkb1_Ddis LIFGYENDGNTIDLQDPEYIPSISVGDQPPSTPILHSSDHHHHHHHNNQHQHQQQQQQLQ
LKB1_Spur ----------------------PDSCDEVRSMTVVP------------------------
AqueK062_Aque ----------------------QDSKDRYRGSTVIP------------------------
*. .::
LKB1_Hsap YLEDLHGAD--------------EDEDLFDIEDDIIYTQDFTV-----------------
CG9374_Dmel YLEAYHYGT--------------QEEDVYFTEHDVN--QELA------------------
LKB1_Mmus YLEDLHGRA-----------EEEEEEDLFDIEDGIIYTQDFTV-----------------
par-4_Cele SMTALYDGI-------------TP-EDELIIEDNLGIIQQI-L-----------------
Lkb1_Ddis QSQQFHGNG--------------DNNLLFDSNNNLIFDSNNNLLFNTNNNEHLINGLPVH
LKB1_Spur YIEDMFNPC-----------PSE--DGSYSDE----YYEDR-------------------
AqueK062_Aque YLESFYNYEGVAGLEATGRWDSQDEEALFDTQESS-TG----------------------
. : :
LKB1_Hsap -----PGQV------------------------------------------------PEE
CG9374_Dmel ------RQA------------------------------------------------AAA
LKB1_Mmus -----PGQV------------------------------------------------LEE
par-4_Cele -----PINLTSEAV--------LERGSFPGFKFLE----AKPGDGPDG---VEG---SED
Lkb1_Ddis PIELDPVNIKKSSIGTNISDVALIRENYI-----CSDNDASS--GQDDEDYSDDNEISGE
LKB1_Spur ----------------------------------------------------------EQ
AqueK062_Aque ---------------------------------------------------IPS---ATQ
LKB1_Hsap EAS--------------HNG--QRRGLPKAV-----CMN----GTEAA-------QLSTK
CG9374_Dmel ASE--------------IRA--KQSAAALAA-----CHTYEPPSTSAAAASNSLGNGSRE
LKB1_Mmus EVG--------------QNG--QSHSLPKAV-----CVN----GTE-P-------QLSSK
par-4_Cele SAA----------PLGPQRR-PSSRSMPTCAPPGPAAGNAQNSTAENGAETDGVASA-SD
Lkb1_Ddis DLNPTNHHHHRADRVGSRDK-SSRSSKRKNS----SSNNNNNNSTSPKVEFN--PNRSSP
LKB1_Spur YSA---------------QA---SQDAPQIV-------------VE-P-------DESSD
AqueK062_Aque SLA----------SVSHERSLDTIASRK------SRVHSQENVLFPTSKSVDELGVTAIG
LKB1_Hsap SRAEGR--APNPARKAC-SASSKIRRL-SACKQQ
CG9374_Dmel EAPVKKKGSALKRRAKKLTSCISVRKL-SHCRTS
LKB1_Mmus VKPEGRPGTANPARKV--CSSNKIRRL-SACKQQ
par-4_Cele PPPTAAPGAP-PRRRK--RNFFSCIF-RSRTDSA
Lkb1_Ddis QPPLRNS--S-NRRPK--ITFESPHNK-SKCIIN
LKB1_Spur PSPEA----EEPQKEK--K-ISRVRKLSSTCKQQ
AqueK062_Aque PIPS--PKPP-K--KR--RG-SKRRI-SEQCTHQ
. .