HUNK_Hsap MPAAA-----------------------------GDGLLGEPAAPGGG--GGAEDAARPA
HUNK_Mmus MPAAA-----------------------------GDGLLGEPAAPGGD--GGAEDTTRPA
HUNKb_Spur MASAVVALP--SPHLNPTMSPAPVNRLGQETAPSSNGDVGRDVACVGD--GGEKKEDRGG
HUNKa_Spur MSALK-----------------------------PLQYVA--TRPRSS--ITKRTSSMPT
HUNKc_Spur MGDPP-----------------------------PL------------------------
AqueK060_Aque MDRDSFQVRDRFPGVTMTL-----------DASMTHGLRGRSNT---D--SCLQ---QLL
AqueK061_Aque MSSND-----------------------------QGTTREESGGPPEERTTGATAGHRPA
*
HUNK_Hsap A-----ACEGSFL---PAWVSGVPRERLRDFQHHKRVGNYLI-GSRKLGEGSFAKVREGL
HUNK_Mmus A-----ACEGSFL---PAWVSGVSRERLRDFQHHKRVGNYLI-GSRKLGEGSFAKVREGL
HUNKb_Spur N-----TGNGGRDCGQPERRRR--KSRSDGVVVRKKVGGYIL-GD-VIGEGSFAKVRLGT
HUNKa_Spur RRNYGPQLQGVMT---VVGRSALSKELMASYKHTKRLGPYLL-GP-TIGEGSFAKVKEAM
HUNKc_Spur ------------------------------------------------------KLMPPL
AqueK060_Aque D-----PIELSRL---PPAVAHVPKEDWKAYVHSKKVNNYLV-GA-TLGEGSFAKVKEAF
AqueK061_Aque -------------------SAHSSQSSGSSSKHVKCIGRYVLIGH-SLGKGNFARVEAAA
::
HUNK_Hsap HVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVM
HUNK_Mmus HVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVM
HUNKb_Spur HILTQEQVAVKVIDKKLIANRDYVRKNLRREATVLQKMRHTNIARLYEVLETASNYYLVM
HUNKa_Spur HVLVGEKVAIKIIDKKAAREDAYLHKTLRREAGLLQLLGHAHIVRLLEVMETDNNLYLVL
HUNKc_Spur -RLDPRYVALKVIEKRKIT-KPYVKKNLTREARIMSQLRHPNIVRLYETITSPQLYCLIM
AqueK060_Aque HVLVGEKIALKIIDKKKAMKDSYVAKNFKREARLLQKLRHPNIVQLYEVIETENNYYLIT
AqueK061_Aque HTLTRAKVAIKIIETDKIK-EEYVRKNLLREAQLMRRLRHPNIIRLYETMKTNNLYCLVT
* :*:*:*:. *: *.: **. : : *.:* :* : : : . *:
HUNK_Hsap ELCPGGNLMHKIY---EKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDED
HUNK_Mmus ELCPGGNLMHKIY---EKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDED
HUNKb_Spur ELAEGGTFMSFLC---KRRKLSERETRRYIRQLVTAVDHMHHLDVIHRDIKIENFLLDND
HUNKa_Spur ELCGGGPLLDKVC---EKGGLEEGVARRYIKQVASAVYHMHQMGVVHRDLKVENLLLDDN
HUNKc_Spur EYVPGRDLLTLVRG-QKGGRLKEGVARRFVRQLVSALHHMHEHGIVHSLANISRLETYLS
AqueK060_Aque ELCSGGELMKHIY---KHGKLSEDETRRYVRQIVSAVDHLHKAGLIHRDLKVENLLLDGN
AqueK061_Aque EVAEGGELLSFVRNDFKEKRLPEATTRPFIRQLTSALYYLHGNGIVHRDLKMENILLDKK
* * :: : : * * :* :::*: :*: ::* .::* ::..: .
HUNK_Hsap ------------N-NIKLIDFGLSNCAGI-------------------------------
HUNK_Mmus ------------N-NIKLIDFGLSNCAGI-------------------------------
HUNKb_Spur ------------Q-NLKVIDFGLSNIL---------------------------------
HUNKa_Spur ------------D-KIRIIDFGLSNFIGNLERETDLRDAKKRERDFSSRKQADVRASRRV
HUNKc_Spur LSLSLSDVHTVKNYVAFRLDFGLSNQC---------------------------------
AqueK060_Aque ------------M-DLKLIDFGLSNEEFIV------------------------------
AqueK061_Aque ------------KRYVKIVDFGLSNAQ---------------------------------
:******
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur ------------------------------------------------------------
HUNKa_Spur SRTVGGRNGATGDDGGGPGRPGEPKGVARARLPSDDGTKRRTRGSSLREDNGQETWRERA
HUNKc_Spur ------------------------------------------------------------
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque ------------------------------------------------------------
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur ------------------------------------------------------------
HUNKa_Spur GLQRKSSKEHPSMTRSNPKQNGVRFNGGNVRFPGQDVHRRMGAEEQDSPEKRRNMLRNRT
HUNKc_Spur ------------------------------------------------------------
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque ------------------------------------------------------------
HUNK_Hsap ---LGYSDPFSTQCGSPAYAAPELL-ARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPF-
HUNK_Mmus ---LGYSDPFSTQCGSPAYAAPELL-ARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPF-
HUNKb_Spur ----GYDGFLRTQCGSPAYAAPEIF-CNSSYGPSVDVWSIGVNMYAMLTGELPFVVDPPN
HUNKa_Spur LDVFGTRDFAGTLCGSPAYAAPEII-ARKRYGPKVDVWSIGVNAYAMLTGTLPFIVEPF-
HUNKc_Spur ----GPEELFKTHCGSPEYAAPELYVAGRDYGPEVDIWSLGVIMFAMVTGKLPFTT-PHS
AqueK060_Aque -DETGREIHCRTQCGSPAYAAPELL-GQKQYDRAVDIWSIGVNMYAMLTGCLPFTVEPF-
AqueK061_Aque ----KAGALLQTHCGSPEYAAPELFIPGRHYGPEVDVWSLGVNMYAMLVGKLPFRS-PRQ
* **** *****: *. :*:**:** :**:.* *** *
HUNK_Hsap SLRALYQKMVDKEMNPL-------PTQLSTGAISFLRSLLEPDPVKRPNIQ---------
HUNK_Mmus SLRALYQKMVDKAMNPL-------PTQLSTGAVNFLRSLLEPDPVKRPNIQ---------
HUNKb_Spur NMSKLHARIMQGA--TI-------PDTLTKDCRDLLRRLLEPKELDRIKLP---------
HUNKa_Spur NLRQLLSKIQKGEAGPL-------PSGLSSGTE---------------------------
HUNKc_Spur ENR-RQ-HLLLQIKKGLKGVHDKEMAHLTDED-MALRLKVKPDKIQDVVLENKLDDVSAI
AqueK060_Aque NITALHAKMLQNKMNPI-------PDHISANATDLLRRMLTASPDKRITMD---------
AqueK061_Aque GTK-KRQKLLEQISAGITEHHEKEMEHLSTSAVNLICHLLQPNSSRRASLD---------
:: : ::
HUNK_Hsap ------QALA--NRWLNENYTGKV-PCNVTYPNRIS----LEDLSPSVVLHMTEKLGY-K
HUNK_Mmus ------QALA--NRWLNENYTGKV-PCNVTYPNRIS----LEDLSPSVVLHMTEKLGY-K
HUNKb_Spur ------DIMR--HPWMNRGYSRRL------YPSRFEDSTPKPLVDQRIIKAL-VQCGH-Q
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur FNILMEEHLIKRGVWTGEH-TRPPTPQT-PTPADSA----R----SR------------T
AqueK060_Aque ------ELIA--HPWLSEGHALPF-Q-PAPYPNVMT----QSQINNDIVDHITDVLKLGT
AqueK061_Aque ------DVMH--HPWTTKDGAHQLIPYEYTPPDPIT----Q----NLVIELMQKVLGE-T
HUNK_Hsap NSDVINTVLSNRACHILAIYFLLNKKLER------YLS----------------------
HUNK_Mmus NSDVINTVLSNRACHILAIYFLLNKKLER------YLS----------------------
HUNKb_Spur EDILTECVQENRPTSENAAYCLLAKRIAM------GWGY-P-------------------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur GSRAGSRSSSARPGSAYAVIFAIPSTIA-Y-K-DFF-V-TPLPPPE-SSSSPPLSPPESS
AqueK060_Aque AMEIKQDLITNRATSLYAIYNLLASRLAR------Y------------------------
AqueK061_Aque PSQIKETVKRDRCDWLAAIYNLLMDQPEGRNVLQRMITADPIDKLVSSSDHQTIAEHLSL
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur ------------------------------------------------------------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur SSPYYHLQNHLRHPTITSRIIFVTLLSPPESSSSPHNHLQNHLRHPTITSIIIFVTPQSP
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque SQGYGHSQHSQEHNDATG------------------------------------------
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur ------------------------------------------------------------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur PESSSSPHNHLQNHLRHPTITSRIIFVTPQSPPESSSSPYYHLQNHLRHPTITSRIIFVT
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque ------------------------------------------------------------
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur ------------------------------------------------------------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur LLSPPESSSKNKKIIDFELDVVEEEQTSWAQRTGLPPPCAKKSRPLGNATTANRVKAQTS
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque ------------------------------------------------------------
HUNK_Hsap -------------------GKSDIQDS---------------------------------
HUNK_Mmus -------------------GKSDIQDS---------------------------------
HUNKb_Spur -------------------ESNNVLDSD--------------------R-----------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur YRMSTPGTGLSTPNQEYVYAHTDLLDASTDHILVPVPSFESLPTSNADLDDSKSPSVPWA
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque --------------------------------ILNKPSFSMKHLRSKD-DDQQA------
HUNK_Hsap -------------------------------------LCYKTRLYQIEKYRAPKESYEAS
HUNK_Mmus -------------------------------------ICYKTQLYQIEKCRATKEPYEAS
HUNKb_Spur ------------------------------SEM----VSVLTGAGVDDTMEAEHEEKPSP
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur NLHSKGRLRSGPKPRGGCMKQKTFKPITNVRVSFCGSTLEKNNGLQKEQKRALKEKQIPC
AqueK060_Aque ----------------------------------------EKQF------PSKAPVR---
AqueK061_Aque ------------------HSR-----------------------------------AEYD
HUNK_Hsap LDTWTRDLEF-----------------------------------------HAVQDKKPK
HUNK_Mmus LDTWTRDFEF-----------------------------------------HAVQDKKPK
HUNKb_Spur VLALRRPISG-----------------------------------------RGTRSMAAK
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur TDDGTNDRAQDVNVGDMSKNFAGKHHNYHGYHLVGTPITTEGAASKTVDCVKTAESGKDK
AqueK060_Aque --PRRRSFKK-----------------------------------------KI-------
AqueK061_Aque ILSKAPDRRK-----------------------------------------HLTVDHKPL
HUNK_Hsap EQEKR----------GDFLHRP-FSKKLDKNLPSHKQPSGSLMTQ---IQ--NTKA----
HUNK_Mmus EQEKR----------GDFLHRP-FSKKLDKNLPSHKQPSPSLITQ---LQ--STKA----
HUNKb_Spur EQNFD----------MENKLKSDRMKLENTNSPIEKTPKYSVSPTKREIQDDMRKA----
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur MKEVR----------LCVAHRE-FLQDGQRS--SGGRPAATPYS-TPRTR--DTDNELVL
AqueK060_Aque ----------------------------SKDQGFYDEDDSDVSST---CT--APVK----
AqueK061_Aque GQLRNVHSAFYQSLFSNHTHHA-SGRRLNNDLSPHHHVDMGGVT---KRH--TSHHHD--
HUNK_Hsap ---------LLKDRK-----ASKSSFPDKDSF----GCRNIFRKTSDSNCVASSSMEFIP
HUNK_Mmus ---------LLKDRK-----ASKSGFPDKDSF----VCRNLFRKTSDSNCVASSSMEFIP
HUNKb_Spur ---------WSKLQT-----NSKNSDESTKDHSKNNSVRSTNSEGSDMNSTGSK-MDTGE
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur TTKLYPP-TLESDEHTTQSDDASTPMPSKAIAGRFN-STSKKKKKEPCRVYSASTTSSIT
AqueK060_Aque ---------LRKDVK-----KTTSA-GSGTG----HSRRPISEDFSDYHVPMSQ------
AqueK061_Aque EFYMGMGGLEPPPRP-----HSRMSAPEPLPIPFQK-SM---LNKSLYNYAP-SSNEQLP
HUNK_Hsap VPP-------------------PRT---PRIVKKPEPHQPGPGSTGIPHKEDP-------
HUNK_Mmus VPP-------------------PRT---PRIVKKLEPHQPGPGSASILPKEEP-------
HUNKb_Spur APKQSKTKHVQKVPDNKTTSHLPRR----VHSSLPAKTRTLPSPNSAPSLQNNTCIFI--
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur VPS-------------------PRSLLHPSIASIHCK-------------KENTSIV-SN
AqueK060_Aque -----RDEKSQAVPQD-TKSRFPRS---PVRYSHPQPSQPLPPAYTNKHYHNPSPLPSEQ
AqueK061_Aque S---------------------ESPP--PTILTPDNM-----------------------
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur --VNG---KVTAPD------QMVGR--SAG----------RNAA----------QMPGK-
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur ---FA---ILR---CSDNKGGTFAKLLKNGVPVKRNGQNKKKGEKERKNAVCKSPESPVC
AqueK060_Aque YEIDTRTKRPTTHSGS---KEMVPP--PTG----------AWQS----------NPPSR-
AqueK061_Aque -------------------HQENSP--RTG----------KGLA----------PTITT-
HUNK_Hsap ------------------------LMLDMVRSFESVDRDD--H----V------------
HUNK_Mmus ------------------------LLLDMVRSFESVDRED--H----I------------
HUNKb_Spur -RHSF----------HGGEK-----MIYTKRGLERAKTVPAVH----I------------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur RRTTVELTDREVRGQKFKMYDEMPQRALQKRPIRQVTRRE--QSYNYIKIIFIPTRVCLL
AqueK060_Aque ---------------SGSRASMYSKLPSLNQSMQSVDLDSYDN----I------------
AqueK061_Aque ---------------SSSRRRSAGNLKPLMRKTLSASVDT--H----L------------
HUNK_Hsap --------------------EVL--------------SPSHHYRILNSPVSLA-------
HUNK_Mmus --------------------ELL--------------SPSHHYRILSSPVSLA-------
HUNKb_Spur --------------------ESL-----------------------------D-------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur VSSLFFHSFLSAYQFIYRMKM--------------TRHPPSHSRIQSADTA-SRKTSPLR
AqueK060_Aque --------------------EFH-----------------------------D-------
AqueK061_Aque --------------------EQGGGGGATSWKGKNQIGPVRRMSYEAPPVGWSSQS----
HUNK_Hsap -------------------------------------RR---------------------
HUNK_Mmus -------------------------------------RR---------------------
HUNKb_Spur ------------------------------------------------------------
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur RVVDISEQAMNSLVNEAIREKKTNQHVSGGDIVKSLQRHFSDLRKSQKRSPGYEMYTRFI
AqueK060_Aque ------------------------------------------------------------
AqueK061_Aque -------------------------------------QF---------------------
HUNK_Hsap --NSSERTLS-PGLPSGSMSPLHTP-LHPTLV--SFA--HED---------KNSPPKEEG
HUNK_Mmus --NSSERTLS-QGLLSGSTSPLQTP-LHSTLV--SFA--HEE---------KNSPPKEEG
HUNKb_Spur -------------TKNGSDDPLTSVPDKETS----MDTQI--S-------ELHAP-----
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur PVQTSEKTGNEIGMLRPSSSPVPRL-NVPKEPV--FN--IK---------ETLPVPPHPY
AqueK060_Aque -------------VGSGTISPIGRA-K--------FF--MEDS-------DNGSPAA---
AqueK061_Aque --SGSQRSIS-RNGPADIQSLMADP-NQKFLLEPPSA--HGMKSESMELKSELFAMKKEV
HUNK_Hsap LCCPPPVPSNGPMQPLGS------------------------------PNCVKSRGRFPM
HUNK_Mmus VCSPPPVPSNGLLQPLGS------------------------------PNCVKSRGRFPM
HUNKb_Spur ---YQPH-NAFPIHRLGSEYT--------LPSQA-HRHSSRYLPGSVSTSAVTSATHPPP
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur LTP-PPPSSASAPPPVDK------------------------------AESPRGAGRAVM
AqueK060_Aque ---TTPVNSGNPAMRQRRTASMRSRKNGIVPPSGDYSFKT-ELP--------TSAIMSEL
AqueK061_Aque VGA-PGSKTDMSAEGLDN------------------------------DGTEQERGRSVY
HUNK_Hsap MGIGQM-------------LRKRHQSLQPS--------ADRPLEASLPPLQPL-APVNLA
HUNK_Mmus MGIGQM-------------LRKRHQSLQPS--------SERSLDASMSPLQPT-APSSLS
HUNKb_Spur YQYAQHLQ----------YHSNRHQSLRRS-----RPHHQRSMTAPH--PQGR-SHSPLP
HUNKa_Spur -------------------------------------------------------Y----
HUNKc_Spur A-TGIT-------------KRNAVSATDASGA-------------TLGQVEEWDATY-R-
AqueK060_Aque IQVTQDMRMKKAEPLSRTEMRCRHHSIDMSISIRKKSVHDCTVHFEW--LSGG-SYQTFS
AqueK061_Aque RSSSAK-------------NQPRLLSQIP-----------------------------EF
HUNK_Hsap ------------------------------------------------------------
HUNK_Mmus ------------------------------------------------------------
HUNKb_Spur FPPASQISRAEERGSGKPAKAVAWQDPPATVVL--------SNNGPSRSIRNRQRE----
HUNKa_Spur ------------------------------------------------------------
HUNKc_Spur --------------------------------LERKVSATVKGAAYVRNMRNDQRTRAWV
AqueK060_Aque ETCSDI------------------------------------------------------
AqueK061_Aque SASAKHIGIGG---------------------GEGGSEHVNGL----RIDVPTHRELPSI
HUNK_Hsap ------------------------------------------FDMADGVKTQC
HUNK_Mmus ------------------------------------------FDMADGVKGQC
HUNKb_Spur ------------------------------------------LPNIKGFVGYM
HUNKa_Spur -----------------------------------------------QQIKTF
HUNKc_Spur A--------------------------------------DLASDFAPNNVSEQ
AqueK060_Aque -----------------------------------------------ISRSKM
AqueK061_Aque KTVKGEKISPGSRKKTFNLFGALRIKTAGSGGRSEDRASLTTQGSTPSSSDVV