HIPK4_Hsap MST---------------------------------------------------------
HIPK3_Hsap M-------ASQVLVYPPYVYQTQSSAFCSVKK--LKVEPSS-CVF-QERNYPRTYVNGRN
HIPK2_Hsap MAPVYEGMASHVQVFSPH--TLQSSAFCSVKK--LKIEPSSNWDMTGYGSHSKVYSQSKN
HIPK1_Hsap M-------ASQLQVFSPP--SVSSSAFCSAKK--LKIEPSG-WDVSGQSSNDKYYTHSKT
CG17090_Dmel MKTSYPPKASDFVDYAVA--GGGGSGFCSGLGAGLSVRATSFY---G----------DQT
HIPK4_Mmus MAT---------------------------------------------------------
HIPK3_Mmus M-------ASQVLVYPPYVYQTQSSAFCSVKK--LKVEPSG-CVF-QERTYPQIHVNGRN
HIPK2_Mmus MAPVYEGMASHVQVFSPH--TLQSSAFCSVKK--LKVEPSSNWDMTGYGSHSKVYSQSKN
HIPK1_Mmus M-------ASQLQVFSPP--SVSSSAFCSAKK--LKIEPSG-WDVSGQSSNDKYYTHSKT
hpk-1_Cele MNFH-------FTLDNDR--K-------RR--RSLSIDIDINF--------------NDK
HIPKa_Spur L-------------YPPFIFGSQSSAFCSFKK--GHVDHVA-AAT-H------------S
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque M-------ALEQQRVPLGSN-KWSSC-----------------LW-Q-------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap FGNSHPPTKGSAFQTKIP---FNRPRGH-NFSL--Q-TSAVVLKNTAGATKVIAAQAQQA
HIPK2_Hsap IPLSQPATT--TVSTSLPVPNPSLP-YEQTIVFPGS-TGHIVVT-SASST-----SVTGQ
HIPK1_Hsap LPATQGQ----ANSS-HQVANFNIPAYDQGLLLPAPAVEHIVVT-AADSS----GSAATS
CG17090_Dmel VTATTDGT---RHQEQ-QQQQL--QQQQQQHILRQP------AT-SASTSSVAA----AA
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus FGNSHPSTKGSAFQTKIP---FTKPRGH-SFSL--Q-AGAIVVKDTAGATKVLAAQAQQA
HIPK2_Mmus IPPSQPAST--TVSTSLPIPNPSLP-YEQTIIFPGS-TGHIVVT-SASST-----SVTGQ
HIPK1_Mmus LPATQGQ----ASSS-HQVANFNLPAYDQGLLLPAPAVEHIVVT-AADSS----GSAATA
hpk-1_Cele ----APGT---SSDNE-QRAPK--------------------------------------
HIPKa_Spur CGSPHPTTMTSIHRTHCP---WSQPP-------------------------------RAV
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque -----------------------AERGPAGFILP--------------------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap HVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHS----------SAMQ-IVDELSILP
HIPK2_Hsap VLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTS----------S-VQ-IIEEH---P
HIPK1_Hsap TFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNG----------S-VQ-IIEEH---P
CG17090_Dmel T-----------------------SKRKRQTDC-----------DCGCVDSYNSSH---G
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus GVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHS----------GAMQ-IVDELSILP
HIPK2_Mmus VLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTS----------S-VQ-IIEEH---P
HIPK1_Mmus TFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVESNG----------S-VQ-IIEEH---P
hpk-1_Cele -------------------------RRADEEAVNAVPKNLLTTSSTFARA-VIPAA---P
HIPKa_Spur GPHRPQNVIQASTVRLLDTYQKCGLKRKSEELDNHS----------TAAR----------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque -----Q------------------------------------------------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap AM-LQTN-MGN---------------------------------PVTVVTATTGSKQNCT
HIPK2_Hsap PMIQNNA-SGA--------------------------------TVATATTSTATSKNSGS
HIPK1_Hsap PLMLQNR-TVV---------------------------------GAAATTTTVTTKSSSS
CG17090_Dmel PPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSS
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus AM-LQTN-MGN---------------------------------PVTVVTATTGSKQNCT
HIPK2_Mmus PMIQNNA-SGA--------------------------------TVATATTSTATSKNSGS
HIPK1_Mmus PLMLQNR-TVV---------------------------------GAAATTTTVTTKSSSS
hpk-1_Cele AISSANNKMAP---------------------------------QSVTATAKTTTNRGKV
HIPKa_Spur GM-TDTS-VKN---------------------------------ELTGMITRTGSKKSSS
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ---------------------------------------------AQVDKGEVDQTKLGG
HIPK4_Hsap -------------IQSE-TDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRN
HIPK3_Hsap TGEGDYQLVQHEVLCSM-KNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA
HIPK2_Hsap NSEGDYQLVQHEVLCSM-TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA
HIPK1_Hsap SGEGDYQLVQHEILCSM-TNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYA
CG17090_Dmel GADGDYQLVQHEVLYSL-SAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYA
HIPK4_Mmus -------------IQSE-TDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRS
HIPK3_Mmus SGEGDYQLVQHEVLCSM-KNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA
HIPK2_Mmus NSEGDYQLVQHEVLCSM-TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA
HIPK1_Mmus SGEGDYQLVQHEILCSM-TNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYA
hpk-1_Cele SGEGEYQLIKNEVLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYA
HIPKa_Spur GGEGDYQLVQHEVLCSL-TNSYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque GPSGDYPVSIRELIPSP-TSVYDVLDRLGRGTFGQVVRAWKKNTSEIVAIKILKSTPSYA
HIPK4_Hsap RIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLP
HIPK3_Hsap RQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLP
HIPK2_Hsap RQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
HIPK1_Hsap RQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
CG17090_Dmel RQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
HIPK4_Mmus RIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLP
HIPK3_Mmus RQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLP
HIPK2_Mmus RQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
HIPK1_Mmus RQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
hpk-1_Cele RQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLP
HIPKa_Spur RQGQIEVSILARLSAENADDFNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPLP
HIPKb_Spur -----------------DDDYNSVAMYNNFPHKFHSCIIIELLERNVYDLLLRDAMSSIP
AqueK114_Aque KQGQMEVDVLSKLSRLSPDEGSFVKAYESFQHHGHICIVFELLHINLYDYLKQSRFDPLP
:: : : * . : :::*:*. *::: .. : .:*
HIPK4_Hsap ARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVR
HIPK3_Hsap LKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--
HIPK2_Hsap LKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSK--
HIPK1_Hsap LKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--
CG17090_Dmel LKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--
HIPK4_Mmus ARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVR
HIPK3_Mmus LKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--
HIPK2_Mmus LKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSK--
HIPK1_Mmus LKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--
hpk-1_Cele LNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSK--
HIPKa_Spur LKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--
HIPKb_Spur TPCVLPIYSFLCTVLVTLPRLGQIYYDFDDSRTLQCTPSCQPFQNKFYETGTSVHVK---
AqueK114_Aque LKYIRPIAQQVLCCLEKLASLGLVHADLKPENIMLVDPQRYPFKVKVIDFGSAMSRDK--
: . : * * *. :: *:. .. : *:: *. : *:: .
HIPK4_Hsap YVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICE
HIPK3_Hsap TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQ
HIPK2_Hsap AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ
HIPK1_Hsap AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ
CG17090_Dmel TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQ
HIPK4_Mmus YVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICE
HIPK3_Mmus TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQ
HIPK2_Mmus AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ
HIPK1_Mmus AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQ
hpk-1_Cele AVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQ
HIPKa_Spur AVCSTYLQSRYYRCVKFLLSITLIEIVCMKSLSCVQTTFYVGWYMYVSFCIHVNVRYIIQ
HIPKb_Spur SQYSLCLQ-RSCRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQ
AqueK114_Aque TSPSCYLQSRYYRAPEVILGVNFNEGIDMWSLGCVLAELYLGWPLFPGASEFDQITYICQ
. :* * *. :.:*.: : * : : **.** : :.:** :: . . :: :* :
HIPK4_Hsap TQGLPKPHLLHAACKAHHFFKR-------NPHPDAANPWQLKSSADYLAETK-VRPLERR
HIPK3_Hsap TQGLPGEQLLNVGTKSTRFFCK-------ETDM-SHSGWRLKTLEEHEAETG-MKSKEAR
HIPK2_Hsap TQGLPAEYLLSAGTKTTRFFNR-------DTDS-PYPLWRLKTPDDHEAETG-IKSKEAR
HIPK1_Hsap TQGLPAEYLLSAGTKTTRFFNR-------DPNL-GYPLWRLKTPEEHELETG-IKSKEAR
CG17090_Dmel TQGLPTEHMLNSASKTSKFFYR-------DVDS-TYPFWRLKTTEEHEAETN-TKSKEAR
HIPK4_Mmus TQGLPKPHLLHAARKAHHFFKR-------NPHPDATNPWQLKSSADYLAETK-VRPLERR
HIPK3_Mmus TQGLPGEQLLNVGTKSTRFFCR-------ETDM-SHSGWRLKTLEEHEAETG-MKSKEAR
HIPK2_Mmus TQGLPAEYLLSAGTKTTRFFNR-------DTDS-PYPLWRLKTPDDHEAETG-IKSKEAR
HIPK1_Mmus TQGLPAEYLLSAGTKTTRFFNR-------DPNL-GYPLWRLKTPEEHELETG-IKSKEAR
hpk-1_Cele TQGLPPTSMLESASKLHRFFKEVKSESPNHTNV-GGSYYRLKTVEEYEASSSTAKSKETR
HIPKa_Spur VVALPGLSHLNLKNKSADFSIR-------GTTM-SSSTWLLKACSKRPSETG-VSD-SRS
HIPKb_Spur TQGLPAEHLLSAATKTTRFFKR-------DIES-NFPLWRLKNPEEHETETS-VKSKEAR
AqueK114_Aque TLGPLPHHLMRNITKATRFFNC-------DP---VTSTWSLKSISQYTQETG-IQSKESR
. . : * * : ** . .: .
HIPK4_Hsap KYMLKSLDQIETVN-GGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSA
HIPK3_Hsap KYIFNSLDDVAHVN-TVM-----DLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAE
HIPK2_Hsap KYIFNCLDDMAQVN-MTT-----DLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIE
HIPK1_Hsap KYIFNCLDDMAQVN-MST-----DLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLK
CG17090_Dmel KYIFNCLDDIGQVN-VPT-----DLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAE
HIPK4_Mmus KYMLKSLDQIETVN-GGGAVSRLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSA
HIPK3_Mmus KYIFNSLDDIVHVN-TVM-----DLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIE
HIPK2_Mmus KYIFNCLDDMAQVN-MTT-----DLEGSDMLVEKADRREFIDLLKKMLTIDADKRVTPIE
HIPK1_Mmus KYIFNCLDDMAQVN-MST-----DLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLK
hpk-1_Cele KYIFNVIDDISRVC-YGF-----ESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAE
HIPKa_Spur NYLFNTINDMLHLF----------------------------------------------
HIPKb_Spur KYIFNCLDDIAGVN-LPT-----DLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLE
AqueK114_Aque KYIFRSLLDMNHLPPLAA-----GIDNREAILTSVDRMEFISLLSRMLSLDPTQRIRPLS
:*::. : :: :
HIPK4_Hsap ALRHPFVSMQQLRSAHETTHYY----QLSLRSYRL------S------------------
HIPK3_Hsap TLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCD---TNNHNKT---SLLRPVAS
HIPK2_Hsap TLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYD---TVNQSKT---PFITHVAP
HIPK1_Hsap TLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYD---TVSQIKS---PFTTHVAP
CG17090_Dmel ALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGD--FH---TVQ-PAS---TLVTNFVP
HIPK4_Mmus ALRHPFVSMQQLRSAHEATRYY----QLSLRGCRL------S------------------
HIPK3_Mmus TLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPS-SCE---TNNHSKM---SLLRPVAS
HIPK2_Mmus TLNHPFVTMTHLLDFPHSAHVKSCFQNMEICKRRVNMYD---TVNQSKT---PFITHVAP
HIPK1_Mmus TLNHQFVTMSHLLDFPHSSHVKSCFQNMEICKRRVHMYD---TVSQIKS---PFTTHVAP
hpk-1_Cele GLESKFVTMTHINGYNFANYVHEAHKRMEICRKPGPAMA---TPY-RAANVATPITPVEK
HIPKa_Spur -----------------------------ICKSDR-TCS---LNYHTHE---SLLKVKAS
HIPKb_Spur ALNHPFVSLSHLAEYAHCRNTKASVRAMEVCKRGTQLFE---NTNQSKY---AFLTHLAS
AqueK114_Aque ALQSPFITMQHLATHTNTQTVWSWIQAMAVCHQPRLSTTPLSINTHPSL---QLLGHTGL
:
HIPK4_Hsap -----------------------------------------------------LQVEGKP
HIPK3_Hsap SSTATLTANFT----KIGTLRSQAL------TTSA-------------------------
HIPK2_Hsap STSTNLTMTFNN---QLTTVHNQAP------SSTSATISLANPEVSILNYPSTLYQPSAA
HIPK1_Hsap NTSTNLTMSFSN---QLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA
CG17090_Dmel SSTENMTFTINN---QLTSQ--------------V-------------------------
HIPK4_Mmus -----------------------------------------------------LQVDGKP
HIPK3_Mmus NGTAALAANFT----KVGTLRSQAL------TTSA-------------------------
HIPK2_Mmus STSTNLTMTFNN---QLTTVHNQAP------TTSSATLSLANPEVSILNYQSALYQPSAA
HIPK1_Mmus NTSTNLTMSFSN---QLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA
hpk-1_Cele PPAPKLQQPMIAVLPQLNQI----A------ATNIPPVP-TQPDL---------------
HIPKa_Spur IGNAPISKN---------------------------------------------------
HIPKb_Spur STCTILAIK------ELPT-------------ISTEILKLENHELHLFSYYSAVYQPPQI
AqueK114_Aque TGGGVLPTS--------------------------------CCR----------------
HIPK4_Hsap PTPVVAA-----E--DG-------------------------------------------
HIPK3_Hsap --HSVVHHGIPLQ--AGTAQF-----------G-CGDAFQQTL---------------II
HIPK2_Hsap SMAAVAQRSMPLQ--TGTAQI-----------CARPDPFQQAL---------------IV
HIPK1_Hsap PVPGVAQQGVSLQ--PGTTQI-----------CTQTDPFQQTF---------------IV
CG17090_Dmel --QRLVRDGRPLA-YEGLYQIYNGRSVARQYPQTRTDSFQHQLV------------SNIL
HIPK4_Mmus PPPVIASA----E--DG-------------------------------------------
HIPK3_Mmus --HSVVHHGIPLQ--AGTAQF-----------G-CGDAFHQTL---------------II
HIPK2_Mmus SMAAVAPRSMPLQ--TGTAQI-----------CARPDPFQQAL---------------IV
HIPK1_Mmus PVPGVAQQGVSLQ--PGTTQI-----------CTQTDPFQQTF---------------IV
hpk-1_Cele --TNLMHHYSQMAAATGSAAT-----------A--AQFFYQPLPPAPLFQYAQLHHPFAA
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur A-QRVSQNTNQPQ--PATTQY------------PRPDPFQQVM---------------IM
AqueK114_Aque ---------QSLQ--TGLYQ------------------------------T---------
HIPK4_Hsap -TPYYCLAEEKEA--AGMGSVAGSSPFFREEKAPGMQRAIDQLDDLS-------------
HIPK3_Hsap CPPAIQGIPATHGKPTSY-SIRVDNTVPLVTQAPAVQPLQIRPGVLS-------------
HIPK2_Hsap CPPGFQGLQASPSKHAGY-SVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------
HIPK1_Hsap CPPAFQTGLQATTKHSGF-PVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLH
CG17090_Dmel CPPSYQTMPS-PTKHV------------VVGSATMQPPLQVPPQQYVNV-----------
HIPK4_Mmus -PPYYRLAEEEET--AGLGGVTGSGSFFREDKAPGMQRAIDQLDDLS-------------
HIPK3_Mmus CPPAIQGIPAAHGKPTSY-SIRVDNTVPLVTQAPAVQPLQIRPGVLSQ------------
HIPK2_Mmus CPPGFQGLQASPSKHAGY-SVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------
HIPK1_Mmus CPPAFQTGLQATTKHSGF-PVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLH
hpk-1_Cele RPPHFLSLAT-PS-----------------HMVPQFVPVPIMDPS---------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur YSPGFEGVLGLPSSHLGV-SLEK-------------------------------------
AqueK114_Aque ------------------------------------------------------------
HIPK4_Hsap -------------------------------------------------LQEAGH-----
HIPK3_Hsap -------------------------------------QTWSGRTQQ-MLVP-AWQQVTPL
HIPK2_Hsap -------------------------------------QAWPSGTQQ-ILLPPAWQQLTGV
HIPK1_Hsap PQVATITPQYAVPFTLS----CAAGRPALVEQTAAVLQAWPGGTQQ-ILLPSTWQQLPGV
CG17090_Dmel ------------PVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVP-SWPQQAPA
HIPK4_Mmus -------------------------------------------------LQEARR-----
HIPK3_Mmus -------------------------------------QTWSGRTQQ-MLIP-AWQQVTPM
HIPK2_Mmus -------------------------------------QAWPGGAQQ-ILLPPAWQQLTGV
HIPK1_Mmus PQVATITPQYAVPFTLS----CAAGRPALVEQTAAVLQAWPGGTQQ-ILLPSAWQQLPGV
hpk-1_Cele ----------------------------------MLQGQWPPGAAQQFAVL-AND-----
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ------------------------------------------------------------
HIPK4_Hsap ----------------------GLWGETCTNA--VSDMMVPLKAA-ITGHHVP---DSGP
HIPK3_Hsap APAT----TTLTSESVAGSHRLGDWGKMISCSNHYNSVM--PQP--LLTNQIT---LSAP
HIPK2_Hsap ATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIM--QQPA-LLTGHVT---LPAA
HIPK1_Hsap ALHNSVQPTAMIPEAMGSGQQLADWRQAHSHGNQYSTIM--QQPS-LLTNHVT---LATA
CG17090_Dmel HSLIVDSTP----------------------------LF--NVEEI-YPKHHLNLPRNDL
HIPK4_Mmus ----------------------GLWSDTRADM--VSDMLVPLKVA-STSHRVP---DSGP
HIPK3_Mmus APAA----ATLTSEGMAGSQRLGDWGKMIPHSNHYNSVM--PPP--LLTNQIT---LSAP
HIPK2_Mmus ATHTSVQHAAVIPETMAGTQQLADWRNTHAHGSHYNPIM--QQPA-LLTGHVT---LPAA
HIPK1_Mmus ALHNSVQPAAVIPEAMGSSQQLADWRNAHSHGNQYSTIM--QQPS-LLTNHVT---LATA
hpk-1_Cele -------------------------------------IM--RVPAPQGINQMF---ASTP
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ---------AVIP----------------------------HNGA-HLVCHVA---PSTF
HIPK4_Hsap EPILAFYSSRLAGRHKARKPP------AGSKSDSNF----S-NLIRLSQV----------
HIPK3_Hsap QPVSVGI------AHVVWPQP------ATTKKNKQC-QNRG-ILVKLMEWEPGR-EEI--
HIPK2_Hsap QPLNVGV------AHVMRQQP------TSTTSSRKSKQHQS-SVRNVSTCEVSSSQAI--
HIPK1_Hsap QPLNVGV------AHVVRQQQ------SSSLPSKKNKQSA--PVSSKSSLDVLPSQVY--
CG17090_Dmel KKES--P------AHHIAKGNSYRVPR---HEKKEH-QQLSPVKKRVKESSPPH-QQRYQ
HIPK4_Mmus EPILAFYGSRLTGRHKARKAP------AGSKSDSNF----S-NLIRLSQA----------
HIPK3_Mmus QPISVGI------AHVVWPQP------ATTKKNKLC-QNRG-ILVRLMEWEPGR-EEI--
HIPK2_Mmus QPLNVGV------AHVMRQQP------TSTTSSRKSKQHQS-SVRNVSTCEVTSSQAI--
HIPK1_Mmus QPLNVGV------AHVVRQQQ------SSSLPSKKNKQSA--PVSSKSSLEVLPSQVY--
hpk-1_Cele QTFS--L------PQFL----SSSIPSATTAFNGNA-PNIP-FPEENSSWAL--------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ---------------------------------------------------ITSGVVI--
AqueK114_Aque GYLPVSH------SHLIQTHQ------RET---------H--PVLT--------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap -----------------NAF-SWSNSLQNTNIPHSAFISPKIINGKDVE----EVSCIET
HIPK2_Hsap -----------------SSP-QRSKRVKENTPPRCAMV----------------------
HIPK1_Hsap -----------------S------------------LV----------------------
CG17090_Dmel RAAHVSPQYHAHHNCNYGNGSGYSAS-AGSVVASSAASSSNIVNGSSSSSHHHHVPVAHA
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus -----------------NAF-RWSNSLQNTNIPHSAFISPKIISGKEVE----EVSCVDT
HIPK2_Mmus -----------------SSP-QRSKRVKENTPPRCAMV----------------------
HIPK1_Mmus -----------------S------------------LV----------------------
hpk-1_Cele -----------------GTAA---------------------------------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur -----------------YSV-SLVKRLIEIPL----------------------------
AqueK114_Aque ---------------------------------------------------TG-------
HIPK4_Hsap -----SPED--DRPC------------R-----------GSSWE-----EGEHLG-ASAE
HIPK3_Hsap QDNQNSEGE--ARNC------------C-----------ETSIR----QDSDSSV-SDKQ
HIPK2_Hsap --------H--SSPA------------C-----------STSVTCGWGDVASSTT-RERQ
HIPK1_Hsap --------G--SSPL------------R-----------TTSS------YNSLVP-VQDQ
CG17090_Dmel QPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPH-----PQSSQHP-QHVK
HIPK4_Mmus -----SPED--AGPC------------R-----------GSGWE-----EGEGRT-TSTE
HIPK3_Mmus QDNHTSEGE--AGTC------------R-----------EASV------RQDSSV-SDKQ
HIPK2_Mmus --------H--SSPA------------C-----------STSVTCGWGDVASSTT-RERQ
HIPK1_Mmus --------G--SSPL------------R-----------TTSS------YNSLVP-VQDQ
hpk-1_Cele ------------------------QQQQ-----------QQAQ-----RAQSMINGNVKV
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ---------------------------------------------QW-------------
HIPK4_Hsap PLAILQRDEDGPNIDNMTMEAERPDPELFDP-SS--CPGE----------------WLSE
HIPK3_Hsap RQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSS
HIPK2_Hsap RQTIVIPDTPSPTVSVITISSDTDEEEEQKHA----------------------------
HIPK1_Hsap HQPIIIPDTPSPPVSVITIRSDTDEEEDNKYK----------------------------
CG17090_Dmel QPTITIHDTPSPT-AVITISDSEDEGGEAGG-----------------------------
HIPK4_Mmus PSVIPQREGDGPGIKDRPMDAERPGPELFDP-SS--CPGE----------------WLSE
HIPK3_Mmus RQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSS
HIPK2_Mmus RQTIVIPDTPSPTVSVITISSDTDEEEEQKHA----------------------------
HIPK1_Mmus HQPIIIPDTPSPPVSVITIRSDTDEEEDNKYK----------------------------
hpk-1_Cele KPLAAQPKKNSPAPSVITLSSDEDSNGAG-------------------------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ---------------------------------------------------------IL-
HIPK4_Hsap PDCTLESVR---------------------------------------------------
HIPK3_Hsap PDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDT---VDGSPTSDSSGHDSP----F--
HIPK2_Hsap PTSTVSKQ------------------RKNVISCVT---VHDSPYSDSSSNTSP----Y--
HIPK1_Hsap PSSSGLKP------------------RSNVISYVT---VNDSPDSDSS-LSSP----Y--
CG17090_Dmel AQVPVLKQ------------------RAHAQSQTSGSLLQHAPSSSCS-RSSAHQQPHPH
HIPK4_Mmus PEWTLEGIR---------------------------------------------------
HIPK3_Mmus PDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCET---VDGSPTSDSSGHDSP----F--
HIPK2_Mmus PTSTVSKQ------------------RKNVISCVT---VHDSPYSDSSSNTSP----Y--
HIPK1_Mmus PNSSSLKA------------------RSNVISYVT---VNDSPDSDSS-LSSP----H--
hpk-1_Cele SSNSGSTT------------------RTGAVNPVR---NDTLPMGN--------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ------------------------------------------------------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap AESTFVEDTHENTELVSS-ADT-------------------E--T---------------
HIPK2_Hsap SVQQRAGH--NNANAFDTKGSL-------------------ENHC---------------
HIPK1_Hsap STDTLSALRGNSGSVLEGPGRV-------------------VADG---------------
CG17090_Dmel PQQQQQQQI--NYGDHDPEDARRRHHAAAAAAQQQQQYQPQPPPQQVLPQPQPSIKYEPG
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus AENSFVEDAHQNTELGTC-AGP-------------------E--A---------------
HIPK2_Mmus SVQQRTGH--NGTNTLDTKGGL-------------------ENHC---------------
HIPK1_Mmus PTDTLSALRGNSGTLLEGPGRP-------------------AADG---------------
hpk-1_Cele ------------------------------------------------------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ------------------------------------------------------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap ------------------------------------------------------------
HIPK2_Hsap ------------------------------------------------------------
HIPK1_Hsap ------------------------------------------------------------
CG17090_Dmel QSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRS
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus ------------------------------------------------------------
HIPK2_Mmus ------------------------------------------------------------
HIPK1_Mmus ------------------------------------------------------------
hpk-1_Cele ------------------------------------------------------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ------------------------------------------------------------
HIPK4_Hsap -----------GPRAQGLPP----------------------------------------
HIPK3_Hsap ---------KPAVCSVVVPPVELENG------------LNADEHMANTDSICQPLIKGRS
HIPK2_Hsap ---------TGNPRTIIVPPLKTQASEVLVECDSLVP-VNTSHHSSSYKSKSSSNVTSTS
HIPK1_Hsap ---------T-GTRTIIVPPLKTQLGDCTV-----------ATQASGLLSNKTKPVASVS
CG17090_Dmel SWAPTSSGSGVSALPLAHPKREAP------------------------------------
HIPK4_Mmus -----------GSRAQGLPA----------------------------------------
HIPK3_Mmus ---------KPAVGTAVEPPVGRESG------------LSVDEHMANTDSTCQPLRKGQP
HIPK2_Mmus ---------TGNPRTIIVPPLKTQASEVLVECDSLGPAISASHHSSSFKSKSSSTVTSTS
HIPK1_Mmus ---------I-GTRTIIVPPLKTQLGDCTV-----------ATQASGLLSSKTKPVASVS
hpk-1_Cele ---------TIKTEDILVPPTTFD------------------------------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ------------------------------------------------------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap APGRLNQPSAVGTRQQKLTSAFQQ------------------------------QHLNFS
HIPK2_Hsap GHSSGSSSGAITYRQQRPGPHFQQQ-----------------------------QPLNLS
HIPK1_Hsap GQSSGCCITPTGYRAQRGGTSA--A-----------------------------QPLNLS
CG17090_Dmel ------SVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWG
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus APGKLHQPPALGARQQKPAAAFPQ------------------------------QHLNLS
HIPK2_Mmus GHSSGSSSGAIAYRQQRPGPHFQQQ-----------------------------QPLNLS
HIPK1_Mmus GQSSGCCITPTGYRAQRGGASA--V-----------------------------QPLNLS
hpk-1_Cele ------G--QLPNLQYF-------------------------------------------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque ----------------EPTTRLQQQ-----------------------------QQQQQQ
HIPK4_Hsap --------------------R--------------RSHQHGPPRG---------------
HIPK3_Hsap QVQHFGSG--HQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHA-HLAG-----
HIPK2_Hsap QAQQHITTD------RTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHP-HLAAA----
HIPK1_Hsap QNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGHP-HLAP-----
CG17090_Dmel PPQVYRQP--SQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGH-------H-HHQAG----
HIPK4_Mmus --------------------H--------------HPHPHGPPR----------------
HIPK3_Mmus QVQHFGTG--HQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHA-HLAG-----
HIPK2_Mmus QAQQHMAAD------RTGSHRRQQAYITPTMAQAPYTFPHNSPSHGTVHP-HLAA-----
HIPK1_Mmus QNQQSSSASTSQERSSNPAPRRQQAFVAP-LSQAPYAFQHGSPLHSTGHP-HLAP-----
hpk-1_Cele ------------------------------------------------------------
HIPKa_Spur ---------------------EIEALISNHVKERPFCLTHGAVYQTVFHH-HIKN-----
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque QQQ-----------------------------------QHGGGGGGGVYAHHLCTCHQHS
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap ----------------NTHLGGQPTLLPYPSS---ATLSSAAPVAHLLASPC-TSRPMLQ
HIPK2_Hsap --------------AAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQG-SARHTVQ
HIPK1_Hsap ---------------APAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQG-SSRHAAA
CG17090_Dmel -----------------TPLGGSP--------------SST-AAAALLQPDIYAQGDIYR
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus ----------------STHLGGQPTLLPYPSS---ASLSSAAPVAHLLASPC-TSRPMLQ
HIPK2_Mmus ----------------AAHLPTQPHLYTYTAP---TALGSTGTVAHLVASQG-SARHTVQ
HIPK1_Mmus ---------------APAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQG-SSRHAAA
hpk-1_Cele ------------------------------------------PGSHLFDPK---------
HIPKa_Spur ------------------------------------------------------------
HIPKb_Spur ------------------------------------------------------------
AqueK114_Aque QSQQQVILPSDQVVTAATHLPTD-------------------------------------
HIPK4_Hsap ------------------------------------------------------------
HIPK3_Hsap HPTYNISHPSGIVHQVPVG---LNPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGF
HIPK2_Hsap H----TAYPASIVHQVPVS---MGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGY
HIPK1_Hsap Y----TTHPSTLVHQVPVS---VGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGY
CG17090_Dmel RPTVFVS-------QAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQF
HIPK4_Mmus ------------------------------------------------------------
HIPK3_Mmus HPTYNISHPSGIVHQVPVG---INPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGF
HIPK2_Mmus H----TAYPASIVHQVPVS---MGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGY
HIPK1_Mmus Y----TTHPSTLVHQVPVS---VGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGY
hpk-1_Cele --------------------------TVA----------GLL-----------P------
HIPKa_Spur -----ISSSSSSSSSSPLS---VIPYTLTSPTIHWPEFQNIFKKHSRCASAL--------
HIPKb_Spur ------------------------------------------PPCALII-----------
AqueK114_Aque ------------------S---ITNK--------------------------------LL
HIPK4_Hsap ----ATSFL-----------QHVTGHH
HIPK3_Hsap -PLSPTKLS-------------QYPYM
HIPK2_Hsap -PLSPAKVN-------------QYPYI
HIPK1_Hsap -PLSPTKIS-------------QYSYL
CG17090_Dmel GPLSPAQVAASKHAAHFAPTNIWYGAE
HIPK4_Mmus ----TTSFL-----------QHVGGHH
HIPK3_Mmus -PLSPTKLS-------------QYPYM
HIPK2_Mmus -PLSPAKVN-------------QYPYI
HIPK1_Mmus -PLSPTKIS-------------QYSYL
hpk-1_Cele NPFLD-------------TSHIPRAFN
HIPKa_Spur ----------------------CYTVF
HIPKb_Spur ------ASS-------------PFESS
AqueK114_Aque -PLQLPAYH-------------PFSRL