rl_Dmel MEEFNSS-----------------------------------------------------
ERK2_Mmus MAAAAAA-----------------------------------------------------
ERK1_Mmus MAAAAAA-----------------------------------------------------
mpk-1_Cele MPTWIPN-----------------------------------------------------
SMK1_Scer MNCTLTD-----------------------------------------------------
SLT2_Scer MADKIER-----------------------------------------------------
KSS1_Scer MART--------------------------------------------------------
FUS3_Scer MPKR--------------------------------------------------------
Erk2_Hsap MAAAAAA-----------------------------------------------------
Erk1_Hsap MAAAAAQ-----------------------------------------------------
YKL161C_Scer MATDTER-----------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin MQRRS-------------------------------------------------------
AqueK118_Aque MATVKPP-----------------------------------------------------
AqueK119_Aque MATNSFA-----------------------------------------------------
AqueK120_Aque MATNSFA-----------------------------------------------------
ERK-p2-2_Smoe MSKGGLKWPIRSVVLGWGQRRNSGESDCGVERRKWGGGVFRVPGATRTPRPRKQGMQQSE
ERK-Un_Smoe MSLAAAR-----------------------------------------------------
ERK5_b_Smoe QSGVA-------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe MAETE-------------------------------------------------------
ERK-p1_b-1_Smoe MAQKVDP-----------------------------------------------------
ERK7_Smoe MSEDVD------------------------------------------------------
ERK5_a-1_Smoe MAETE-------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe MQQSEAM-----------------------------------------------------
ERK-p1_a-1_Smoe MATKMDP-----------------------------------------------------
ERK-p1_b-2_Smoe MAQKVDP-----------------------------------------------------
GK037_Glam MPLAVF------------------------------------------------------
rl_Dmel --G---SVV-----------NG--------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus --P---GGG-----------GGE---------------------PRGT------------
mpk-1_Cele --N---LCAQPTTRNAKPPSNGHPQATQQQSAPGSLAYRNSSNIPNGATNHVRQQKWQYT
SMK1_Scer --N---TRAI----------NV--------------------------------------
SLT2_Scer ------------------------------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap --G---A-----------------------------------------------------
Erk1_Hsap --G---GGG------------GE---------------------PRRT------------
YKL161C_Scer ------------------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque --S---CSE-----------E---------------------------------------
AqueK120_Aque --S---CSE-----------E---------------------------------------
ERK-p2-2_Smoe AMEAAAAAA-----------EGN------------------------F------------
ERK-Un_Smoe --L---MIS---------------------------------------------------
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe --------------------P---------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe --EAAAAAA-----------EGN------------------------F------------
ERK-p1_a-1_Smoe --------------------P---------------------------------------
ERK-p1_b-2_Smoe --------------------P---------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ----------TGSTEV--PQSN--------------------------------------
ERK2_Mmus ---------------------G--------------------------------------
ERK1_Mmus ----------AGVVPV--VPGE--------------------------------------
mpk-1_Cele RSGHRKMADGEAVI-S--TVNN--------------------------------------
SMK1_Scer ----------ASNLG---APQQ--------------------------------------
SLT2_Scer ---------------------H--------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ---------------------G--------------------------------------
Erk1_Hsap ----------EGVGPG--VPGE--------------------------------------
YKL161C_Scer ---------------------C--------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque --------------------DG--------------------------------------
AqueK120_Aque --------------------DG--------------------------------------
ERK-p2-2_Smoe ----------TGVLVH--SGRY--------------------------------------
ERK-Un_Smoe -----------GAVRRGGIEFRVILVQGFGWKLQLQACTRSAASSGMVRSRFETRCLLHW
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe -----------GGIAH--PGKH--------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe ----------TGVLVH--SGRY--------------------------------------
ERK-p1_a-1_Smoe -----------NGYCP--PDKH--------------------------------------
ERK-p1_b-2_Smoe -----------GGIAH--PGKH--------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ------------------AEVIRGQIFEVGPRYI-KLAYIGEGAYGMVVSADD--TL--T
ERK2_Mmus ------------------PEMVRGQVFDVGPRYT-NLSYIGEGAYGMVCSAYD--NL--N
ERK1_Mmus ------------------VEVVKGQPFDVGPRYT-QLQYIGEGAYGMVSSAYD--HV--R
mpk-1_Cele ------------------VEEVHGQLFEVAPRYV-NLSYIGEGAYGMVASALD--TI--T
SMK1_Scer ------------------RTIFAKERISIPGYYE-IIQFLGKGAYGTVCSVKFKGRS--P
SLT2_Scer ------------------TFKVFNQDFSVDKRFQ-LIKEIGHGAYGIVCSARF--AEAAE
KSS1_Scer ------------------------ITFDIPSQYK-LVDLIGEGAYGTVCSAIH--KP--S
FUS3_Scer ------------------------IVYNISSDFQ-LKSLLGEGAYGVVCSATH--KP--T
Erk2_Hsap ------------------PEMVRGQVFDVGPRYT-NLSYIGEGAYGMVCSAYD--NV--N
Erk1_Hsap ------------------VEMVKGQPFDVGPRYT-QLQYIGEGAYGMVSSAYD--HV--R
YKL161C_Scer ------------------IFRAFGQDFILNKHFH-LTGKIGRGSHSLICSSTY--TESNE
ERK1_Spur --------------------------FDVGLLYT-ELEAIAQGALALCSSAVD--TR--H
CC1G_02007_Ccin -------------------FTALNSVFCVDAQYE-FVKELGQGAYGCVVAARH--RQ--T
AqueK118_Aque ------------------PEIVRGQAFDVGPRYS-NLSYIGEGAYGMVCSAVD--NQ--S
AqueK119_Aque ------------------VLVLPGHYWRVGKRYK-DLEYLALGGNGLVCKAID--TY--T
AqueK120_Aque ------------------VLVLPGHYWRVGKRYK-DLEYLALGGNGLVCKALD--TY--T
ERK-p2-2_Smoe -----------------VQYNIFGNLFEVTAKYVPPIRPIGRGAYGIVCSAVN--SE--T
ERK-Un_Smoe PWRSIRRSKFPKIWHRFRCFHAWISCRAVGPRYL-LHEHIGSGSYGDVCRATD--CQ--A
ERK5_b_Smoe ---------------------NFITEYGEAQRYK-VLEVIGKGSYGVVCSAID--TR--T
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ----------------------FFTEYGEASRYK-ILEVIGKGSYGVVCSATD--MH--T
ERK-p1_b-1_Smoe ------------------YYMLWRSLFEIDQRYA-PIKPIGKGAYGVVCSATN--SE--S
ERK7_Smoe --------------------------KHVLRKYH-VCQKLGKGAYGIVWKAFD--RK--T
ERK5_a-1_Smoe ----------------------FFTEYGEASRYK-ILEVIGKGSYGVVCSATD--MH--T
ERK5_c_Smoe ---------------------NFITEYGEAQRYK-VLEVIGKGSYGVVCSAID--TR--T
ERK-p2-1_Smoe -----------------VQYNIFGNLFEVTAKYVPPIRPIGRGAYGIVCSAVN--SE--T
ERK-p1_a-1_Smoe ------------------YYMLWHSLFEIDTKYV-PIRPLGKGAYGVVCSADN--LE--T
ERK-p1_b-2_Smoe ------------------YYMLWRSLFEIDQRYA-PIKPIGKGAYGVVCSATN--SE--S
GK037_Glam --------------------NIKGTRFCVPDYYK-VTKALGAGAYGVVAEAVD--TR--T
rl_Dmel NQRVAIKKISP-FEHQTYCQRTLREITILTRFK-HE-----NIIDIRDI--LRVDSI---
ERK2_Mmus KVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HE-----NIIGINDI--IRAPTI---
ERK1_Mmus KTRVAIKKISP-FEHQTYCQRTLREIQILLRFR-HE-----NVIGIRDI--LRAPTL---
mpk-1_Cele RDRVAIKKISP-FEHQTFCQRTLREIKILNRFK-HE-----NIINIQEI--IRSETV---
SMK1_Scer AARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHK-----NIVNLIDL--EIV-TS---
SLT2_Scer DTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHK-----NITCLYDMDIVFYP-D---
KSS1_Scer GIKVAIKKIQ-PFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDK--VRPVSI---
FUS3_Scer GEIVAIKKIE-PFDKPLFALRTLREIKILKHFK-HE-----NIITIFNI--QRPDSF---
Erk2_Hsap KVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HE-----NIIGINDI--IRAPTI---
Erk1_Hsap KTRVAIKKISP-FEHQTYCQRTLREIQILLRFR-HE-----NVIGIRDI--LRASTL---
YKL161C_Scer ETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHP-----NIVWLFDTDIVFYP-N---
ERK1_Spur GGKVAIKKISP-FEHQTYCQRTLREIKILTRFN-HE-----NIINIQDI--IKADTI---
CC1G_02007_Ccin GEGCAIKKITNINTKRILTKRCLREIRLLHHFRGHK-----NITCLYDMDIVFQP-N---
AqueK118_Aque LTKVAIKRITP-FEHQTYCQRTLREIKILTRFR-HE-----NIIGILDI--LKPPSM---
AqueK119_Aque DKRVVISKRDSLF-SKTYCQRDLRELQVISRLQ-KALGDDLPIPELIDI--VCEPANQPI
AqueK120_Aque DKRVVLSKRDSLF-SKTYCQRDLRELQVLSRLQ-KALGDDLPLPELLDL--VCEPANQPL
ERK-p2-2_Smoe NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HE-----NIVAIRDI--IRPPSK---
ERK-Un_Smoe SLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HR-----YVITLTDV--FISMSME-V
ERK5_b_Smoe NEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DVVEIKHI--LLPPSR---
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe GDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DIVEIKHI--MLPPSR---
ERK-p1_b-1_Smoe GEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HE-----NIIGIKDI--MKPVGR---
ERK7_Smoe NDVVALKKIFDAFQNSTDAQRTFREVMFLQEINDHE-----NVIKLTNV--LKA---E--
ERK5_a-1_Smoe GDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DIVEIKHI--MLPPSR---
ERK5_c_Smoe NEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DVVEIKHI--LLPPSR---
ERK-p2-1_Smoe NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HE-----NIVAIRDI--IRPPSK---
ERK-p1_a-1_Smoe GDKVAIKKIGNAFENSIDALRTLREMRLLRYLQ-HE-----NVVGLLDI--MKPVGR---
ERK-p1_b-2_Smoe GEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HE-----NIIGIKDI--MKPVGR---
GK037_Glam NTTVAIKKISNLFVHLVDSKRTLREITILRMLD-HE-----NIVKLLDV--LVPEDP---
rl_Dmel DQMRDVYIVQCLMET-DLYKLLKT-Q----RLSNDHICYFLYQILRGLKYIHSANVLHRD
ERK2_Mmus EQMKDVYIVQDLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD
ERK1_Mmus EAMRDVYIVQDLMET-DLYKLLKS-Q----QLSNDHICYFLYQILRGLKYIHSANVLHRD
mpk-1_Cele DSLKDIYIVQCLMET-DLYKLLKT-Q----KLSNDHVCYFLYQILRGLKYIHSANVLHRD
SMK1_Scer SPYDGLYCYQELIDY-DLAKVIHSSV----QLSEFHIKYFLYQILCGLKYIHSADVIHRD
SLT2_Scer GSINGLYLYEELMEC-DMHQIIKSGQ----PLTDAHYQSFTYQILCGLKYIHSADVLHRD
KSS1_Scer DKLNAVYLVEELMET-DLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRD
FUS3_Scer ENFNEVYIIQELMQT-DLHRVISTQ-----MLSDDHIQYFIYQTLRAVKVLHGSNVIHRD
Erk2_Hsap EQMKDVYIVQDLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD
Erk1_Hsap EAMRDVYIVQDLMET-DLYKLLKS-Q----QLSNDHICYFLYQILRGLKYIHSANVLHRD
YKL161C_Scer GALNGVYLYEELMEC-DLSQIIRSEQ----RLEDAHFQSFIYQILCALKYIHSANVLHCD
ERK1_Spur EAMRDVYIVQSLMET-DLYKLLKT-Q----PLSNDHICYFLYQILRGLKYIHSANVLHRD
CC1G_02007_Ccin GNFDEVYLYEELMEA-DLHAIIRSGQ----PLTDAHFQSFIYQTLCGLKYIHSANVLHRD
AqueK118_Aque AEMKDVYIVQTLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD
AqueK119_Aque GEGTKFYVVQEAKEG-TIEIILQADQ----LPSPEQVKILMYQLLRALKLFHSAGIIHRC
AqueK120_Aque GEGTKFYVVQEAKEG-TLELLLQADQ----LPSPEQVKLLMYQLLRALKLFHSAGLLHRC
ERK-p2-2_Smoe DEFNDVYIVYELMDT-DLHQIIRSNQ----QLTDDHCQYFLYQLLRGLKYVHSANVLHRD
ERK-Un_Smoe SGGIDLYIATEFADGGDMYHL---RE----PLTPEHVKFLMWQLLTGMSYIHSCRVWHRD
ERK5_b_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLMPEHYQFFLYQLLRGLKFIHTANVFHRD
ERK-p1_a-2_Smoe ---------------------------------------------RGLKYIHSANVLHRD
ERK5_a-2_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLTPEHYQFFLYQLLRALKYIHTANVFHRD
ERK-p1_b-1_Smoe SSFNDVYLVYELMDT-DLHQIIRSSQ----ALTDDHCQYFIYQLLRGLKYVHSANVLHRD
ERK7_Smoe -NDRDLYLVFEYMET-DLHAVIRAN-----ILEDVHKQYIMYQLFKSLKYLHSAGLLHRD
ERK5_a-1_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLTPEHYQFFLYQLLRALKYIHTANVFHRD
ERK5_c_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLMPEHYQFFLYQLLRGLKFIHTANVFHRD
ERK-p2-1_Smoe DEFNDVYIVYELMDT-DLHQIIRSNQ----QLTDDHCQYFLYQLLRGLKYVHSANVLHRD
ERK-p1_a-1_Smoe YTFNDVYLVYELMDT-DLHQIIRSSQ----PLTDEHYQFFIYQLLRGLKYIHSANVLHRD
ERK-p1_b-2_Smoe SSFNDVYLVYELMDT-DLHQIIRSSQ----ALTDDHCQYFIYQLLRGLKYVHSANVLHRD
GK037_Glam SNFDDLYVVFDFMQT-DMHKIISSKQ----DLSPDHMQYFVYQLLRGLKYLHSANCVHRD
.:. .* . *
rl_Dmel LKPSNLLLNKTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT
ERK2_Mmus LKPSNLLLNTTCDLKICDFGLARVADPD------------------HDHTGFLTEY-VAT
ERK1_Mmus LKPSNLLINTTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT
mpk-1_Cele LKPSNLLLNTTCDLKICDFGLARVTDPQ------------------TDHTGFLTEY-VAT
SMK1_Scer LKPGNILCTLNGCLKICDFGLARGIHAGFFKC-------------HSTVQPHITNY-VAT
SLT2_Scer LKPGNLLVNADCQLKICDFGLARGYSEN-----------------PVENSQFLTEY-VAT
KSS1_Scer IKPSNLLLNSNCDLKVCDFGLARCLASSS-DSR-------------ETLVGFMTEY-VAT
FUS3_Scer LKPSNLLINSNCDLKVCDFGLARIIDESAADNS----------E-PTGQQSGMTEY-VAT
Erk2_Hsap LKPSNLLLNTTCDLKICDFGLARVADPD------------------HDHTGFLTEY-VAT
Erk1_Hsap LKPSNLLINTTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT
YKL161C_Scer LKPKNLLVNSDCQLKICNFGLSCSYSENH-----------------KVNDGFIKGY-ITS
ERK1_Spur LKPSNLLLNTTCDLKICDFGLARIADPG------------------HDHTGFLTEY-VAT
CC1G_02007_Ccin LKPGNLLVNADCELKICDFGLARGYTPGS-GTS----------R-AAGNQGFMTEY-VAT
AqueK118_Aque LKPSNLLLNTTCDLKICDFGLARIADPE------------------QDHTGILTEY-VAT
AqueK119_Aque IRSNDILIDADCDLRVCDFRLAAVNGIES-DP-------------NFELLRFTDSYRVEH
AqueK120_Aque LRSNDLLLDADCDLRVCDFRLAAVNGLES-DP-------------NFELLRFTDSYRVEH
ERK-p2-2_Smoe LKPSNLLLNANCDLKICDFGLARTTSE-----T-----------------DYMTEY-VVT
ERK-Un_Smoe LKSENILLMADMSVKICDFGLSRSA-----------------------------EE-VVT
ERK5_b_Smoe LKPKNVLANANCKLKICDFGLARVAFNDA-PTA-----------------IFWTDY-VAT
ERK-p1_a-2_Smoe LKPGNLLLNANCDLKIADFGLARTGRE----KG-----------------QFMTEY-VVT
ERK5_a-2_Smoe LKPKNILANADCKLKICDFGLARVAFNDA-PTAIFWTVSASNKGWTYLTLLFFKDY-VAT
ERK-p1_b-1_Smoe LKPSNLLLNASCDLKICDFGLARTGSD----KG-----------------QFMTEY-VVT
ERK7_Smoe IKPSNLLLDSDCRCKLADFGLARSVAQLK-DD--------------MGQAQVLTDY-VAT
ERK5_a-1_Smoe LKPKNILANADCKLKICDFGLARVAFNDA-PTAIFWTVSVSNKGWTYLTLLFFKDY-VAT
ERK5_c_Smoe LKPKNVLANANCKLKICDFGLARVAFNDA-PTA-----------------IFWTDY-VAT
ERK-p2-1_Smoe LKPSNLLLNANCDLKICDFGLARTTSE-----T-----------------DYMTEY-VVT
ERK-p1_a-1_Smoe LKPGNLLLNANCDLKIADFGLARTGRE----KG-----------------QFMTEY-VVT
ERK-p1_b-2_Smoe LKPSNLLLNASCDLKICDFGLARTGSD----KG-----------------QFMTEY-VVT
GK037_Glam LKPSNLLLNSDCALEICDLGLARLVDDHA-AKTKEL------KD-AEKHDTQMTEY-VAT
::. ::* .:.:: *: :
rl_Dmel RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSR
ERK2_Mmus RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
ERK1_Mmus RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
mpk-1_Cele RWYRAPEIMLN-SKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSN
SMK1_Scer RWYRAPELLLS-NQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDK
SLT2_Scer RWYRAPEIMLS-YQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPD
KSS1_Scer RWYRAPEIMLT-FQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSF
FUS3_Scer RWYRAPEVMLT-SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS
Erk2_Hsap RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
Erk1_Hsap RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
YKL161C_Scer IWYKAPEILLN-YQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPE
ERK1_Spur RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQ
CC1G_02007_Ccin RWYRAPEIMLS-FANYSTAIDVWSVGCILAELLGGRPIFKGRDYVDQLNQILHYLGTPSE
AqueK118_Aque RWYRAPEIMLN-SKGYSKAIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILNVIGSPTE
AqueK119_Aque LHYWAPEVLIN--EEITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSP
AqueK120_Aque LHYWAPEVLLN--EELTPVVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSP
ERK-p2-2_Smoe RWYRAPELLLN-CSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPED
ERK-Un_Smoe PSYRAPEVIMS-RGQYSSSIDIWSLGCIFWVSVSSNDI-----TILNLDVIFNVIGTPGW
ERK5_b_Smoe RWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQ
ERK-p1_a-2_Smoe RWYRAPELLLS-CEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKE
ERK5_a-2_Smoe RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSA
ERK-p1_b-1_Smoe RWYRAPELLLS-CEEYTSAIDMWSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEE
ERK7_Smoe RWYRAPEILLG-STNYTFGVDMWSSGCILGELLNGKPVFPGASTMNQIEKVLDLIGKPAS
ERK5_a-1_Smoe RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSA
ERK5_c_Smoe RWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQ
ERK-p2-1_Smoe RWYRAPELLLN-CSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPED
ERK-p1_a-1_Smoe RWYRAPELLLS-CEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKE
ERK-p1_b-2_Smoe RWYRAPELLLS-CEEYTSAIDMWSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEE
GK037_Glam RWYRAPEIILG-WPQYGKPVDIFSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEK
* ***: :*::: **:: . : :: : :* *
rl_Dmel -DDLECIINEKARNYLE--SLPFK-PNVPWAKLFPNA--DALALDLLGKMLTFNPHKRIP
ERK2_Mmus -EDLNCIINLKARNYLL--SLPHK-NKVPWNRLFPNA--DSKALDLLDKMLTFNPHKRIE
ERK1_Mmus -EDLNCIINMKARNYLQ--SLPSK-TKVAWAKLFPKS--DSKALDLLDRMLTFNPNKRIT
mpk-1_Cele -ADLQCIINDKARSYLI--SLPHK-PKQPWARLYPGA--DPRALDLLDKMLTFNPHNRID
SMK1_Scer -DILIKFGTIKAWNLGKNSNNPVY-KKIPWSNIFPFA--SHEAINLIESLLHWDSTHRLN
SLT2_Scer -ETLRRIGSKNVQDYIH--QLGFI-PKVPFVNLYPNA--NSQALDLLEQMLAFDPQKRIT
KSS1_Scer -EDFNQIKSKRAKEYIA--NLPMR-PPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRIS
FUS3_Scer DNDLRCIESPRAREYIK--SLPMY-PAAPLEKMFPRV--NPKGIDLLQRMLVFDPAKRIT
Erk2_Hsap -EDLNCIINLKARNYLL--SLPHK-NKVPWNRLFPNA--DSKALDLLDKMLTFNPHKRIE
Erk1_Hsap -EDLNCIINMKARNYLQ--SLPSK-TKVAWAKLFPKS--DSKALDLLDRMLTFNPNKRIT
YKL161C_Scer -ETLQEIASQKVYNYIF--QFGNI-PGRSFESILPGA--NPEALELLKKMLEFDPKKRIT
ERK1_Spur -DDLKCIINEKARAYLQ--GLPFK-SKIPLKSLFPKA--DNKALDFLERMLSFNPDKRIT
CC1G_02007_Ccin -DTLRRVGSPRAQDYIR--SLPIR-PRISFSTLFPQA--NPLAIDLLSRMLCFDPARRIS
AqueK118_Aque -KDLSCIRNEKAKSYLK--NLPFK-PTVPWSRLYPKA--DPKALDILGKMLTFNPDERIS
AqueK119_Aque -EDLAFVKGDASRTALT--SVQN-SSP-TFEERFKNI--DPVARDLLKKMLVFNPSQRIT
AqueK120_Aque -EDLAFVKGDASRTALT--SVQN-SSP-TFEERFKNL--DPVARDLLKKMLVFNPSQRLT
ERK-p2-2_Smoe -ADLGFLRNDNARRYVR--QLQRY-PRQSFAHRFPNV--PPLAVDLVERMLVFNPQNRIS
ERK-Un_Smoe -SDIESVPSESWRSYLK--HLPGR-VRNLTEQLLGYV--DQEALDLLFRMLAFNPGRRCT
ERK5_b_Smoe -DVISRVRNEKARRYLS--TMSKK-SPVPFSEKFKNI--DPLARNLLQKMLAFDPKDRPS
ERK-p1_a-2_Smoe -SQLGFISNHKARSYIR--SLPPT-PRVPLSRLYPHA--NPQALQLIERMLAFDPKERIT
ERK5_a-2_Smoe -ESVARVRNEKARRYLS--GMRKK-TAIPFTQKFPNA--DPLALRLLERLLAFDPKDRPT
ERK-p1_b-1_Smoe -DDLQFILSNKARSYIR--SLPFA-PKIPLERLYPRA--NPLALNLIDQMLVFDPKKRLT
ERK7_Smoe -EDIAAFESPFAAAMIE--NMAITGPSRSFRKAFPSA--TPEAADLLRKLLHFNPQKRLT
ERK5_a-1_Smoe -ESVARVRNEKARRYLS--GMRKK-TAIPFTQKFPNA--DPLALRLLERLLAFDPKDRPT
ERK5_c_Smoe -DVISRVRNEKARRYLS--TMSKK-SPVPFSEKFKNI--DPLARNLLQKMLAFDPKDRPS
ERK-p2-1_Smoe -ADLGFLRNDNARRYVR--QLQRY-PRQSFAHRFPNV--PPLAVDLVERMLVFNPQNRIS
ERK-p1_a-1_Smoe -SQLGFISNHKARSYIR--SLPPT-PRVPLSRLYPHA--NPQALQLIERMLAFDPKERIT
ERK-p1_b-2_Smoe -DDLQFILSNKARSYIR--SLPFA-PKIPLERLYPRA--NPLALNLIDQMLVFDPKKRLT
GK037_Glam -ELLDRIASDSAKSYVL--ALKPS-APQDLSQKFPML--DEAGIDLLTRMLTLDPLKRIT
. . :: :* :. *
rl_Dmel VEE-------------------ALAHPYLEQYYDPGDEPVA------EVP----------
ERK2_Mmus VEQ-------------------ALAHPYLEQYYDPSDEPIA------EAP----------
ERK1_Mmus VEE-------------------ALAHPYLEQYYDPTDEPVA------EEP----------
mpk-1_Cele IEQ-------------------ALAHPYLEQYYDPGDEPVC------EEP----------
SMK1_Scer VEQ-------------------AISHPFLNEVRKPDDEPVCL-----QGP----------
SLT2_Scer VDE-------------------ALEHPYLSIWHDPADEPVCS--E----K----------
KSS1_Scer AAE-------------------ALRHPYLAMYHDPSDEPEYP--PL---N----------
FUS3_Scer AKE-------------------ALEHPYLQTYHDPNDEPEGE--PIPPSF----------
Erk2_Hsap VEQ-------------------ALAHPYLEQYYDPSDEPIA------EAP----------
Erk1_Hsap VEE-------------------ALAHPYLEQYYDPTDEPVA------EEP----------
YKL161C_Scer VED-------------------ALEHPYLSMWHDIDEEFSCQ--K----T----------
ERK1_Spur VEE-------------------ALAHPYLEQYYDPDDEVTV------IEQ----------
CC1G_02007_Ccin CEE-------------------ALNHPYLAVWHDPADEPNCD--S----I----------
AqueK118_Aque VDA-------------------ALAHPYLEQYYDPDDEPVA------EVP----------
AqueK119_Aque AEK-------------------ALEHEYLAEYHDPSEEPVYN--A--EKPLWKELLVSDQ
AqueK120_Aque AEK-------------------ALEHEYLAEYHDPSEEPVYN--A--EKPLWKELLVSDQ
ERK-p2-2_Smoe VTE-------------------ALAHPYLTNLHDVNDEPSCH------GP----------
ERK-Un_Smoe AEE-------------------ALSHIYVSNRL----------------Y----------
ERK5_b_Smoe ATEVKYSLTSEQVMLTRELDFQALADPYFQSMSHLQREPAAN--P--ISR----------
ERK-p1_a-2_Smoe VSE-------------------ALDHPYFNLVHDNHAGDVYQFRPDNIIP----------
ERK5_a-2_Smoe AEE-------------------ALADPYFRGLAKVEREPSAQ--P--ITK----------
ERK-p1_b-1_Smoe VTD-------------------ALEHPYLSMLHDAALEPSAS------AA----------
ERK7_Smoe AEQ-------------------ALQHPYVAQFHNPREEPSCN--R--L------------
ERK5_a-1_Smoe AEE-------------------ALADPYFRGLAKVEREPSAQ--P--ITK----------
ERK5_c_Smoe ATE-------------------ALADPYFQSMSHLQREPAAN--P--ISR----------
ERK-p2-1_Smoe VTE-------------------ALAHPYLTNLHDVNDEPSCH------GP----------
ERK-p1_a-1_Smoe VSE-------------------ALDHPYFNLVHDNHAGDVYQFRPDNIIP----------
ERK-p1_b-2_Smoe VTD-------------------ALEHPYLSMLHDAALEPSAS------AA----------
GK037_Glam VNE-------------------CLSHPYFEGIHDESDEPVYT--G---QP----------
.: . :.
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele ------------------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer ------------------------------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer ------------------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque NLEVLRSQLLKEVHELKAWLMGPEVEAPLVNGHPWHVGSRYRNLEFLTKGSNGSMCFATD
AqueK120_Aque NLEVLRSQLIKEVHEIKAWLMGPEVEAPIVNGHPWHVGSRYRNLEFLTKGSNGSMCFATD
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele ------------------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer ------------------------------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer ------------------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque TRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSG
AqueK120_Aque TRTSSRVVISKRDGLYSQEYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSG
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele ------------------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer ------------------------------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer ------------------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque PKQAELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHL
AqueK120_Aque PKQAELYVVQTAFDVNLADILNQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHL
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele ------------------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer ------------------------------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer ------------------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque LLTSEFDLALCDLRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCYDEQTTACDLWSA
AqueK120_Aque LLTSEFDLAICDLRRSIMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCYDEQTTACDIWSA
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele ------------------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer ------------------------------------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer ------------------------------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ------------------------------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque GCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESP
AqueK120_Aque GCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESP
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe ------------------------------------------------------------
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe ------------------------------------------------------------
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe ------------------------------------------------------------
ERK5_c_Smoe ------------------------------------------------------------
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ---------------------------------------------------------FRI
ERK2_Mmus ---------------------------------------------------------FKF
ERK1_Mmus ---------------------------------------------------------FTF
mpk-1_Cele ---------------------------------------------------------FTL
SMK1_Scer ---------------------------------------------------------FDF
SLT2_Scer ---------------------------------------------------------FEF
KSS1_Scer ---------------------------------------------------------LDD
FUS3_Scer ---------------------------------------------------------FEF
Erk2_Hsap ---------------------------------------------------------FKF
Erk1_Hsap ---------------------------------------------------------FTF
YKL161C_Scer ---------------------------------------------------------FRF
ERK1_Spur ---------------------------------------------------------FNF
CC1G_02007_Ccin ---------------------------------------------------------FDF
AqueK118_Aque ---------------------------------------------------------FKF
AqueK119_Aque SLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYFAKLHDPAEEPVYTGKMSS
AqueK120_Aque SLDSNLRKRNVDGQVIDLLKKMLAFSPAKRITAEEALKHPYFAKLHDPAEEPVYTGKMSS
ERK-p2-2_Smoe ---------------------------------------------------------FDF
ERK-Un_Smoe ---------------------------------------------------------FAF
ERK5_b_Smoe ---------------------------------------------------------MEF
ERK-p1_a-2_Smoe ---------------------------------------------------------PDV
ERK5_a-2_Smoe ---------------------------------------------------------MEF
ERK-p1_b-1_Smoe ---------------------------------------------------------FEF
ERK7_Smoe ---------------------------------------------------------IRI
ERK5_a-1_Smoe ---------------------------------------------------------MEF
ERK5_c_Smoe ---------------------------------------------------------MEF
ERK-p2-1_Smoe ---------------------------------------------------------FDF
ERK-p1_a-1_Smoe ---------------------------------------------------------PDV
ERK-p1_b-2_Smoe ---------------------------------------------------------FEF
GK037_Glam ---------------------------------------------------------LEL
rl_Dmel NM-----------EN-DDISRDALKSLIFEETL---------------KFKERQ------
ERK2_Mmus DM-----------EL-DDLPKEKLKELIFEETA---------------RFQPG-------
ERK1_Mmus DM-----------EL-DDLPKERLKELIFQETA---------------RFQPGA------
mpk-1_Cele EM-----------EF-DDLPKEKLKELIWEEAE---------------AHHRRMEAE---
SMK1_Scer TY-----------ES-ELNSMSKLRDYLVEEVK---------------NFKTDL------
SLT2_Scer SF-----------ES-VN-DMEDLKQMVIQEVQ---------------DFRLFVRQPLL-
KSS1_Scer EFWKLDNKIMRPEEE-EEVPIEMLKDMLYDELM---------------------------
FUS3_Scer DH-----------YK-EALTTKDLKKLIWNEIF---------------------------
Erk2_Hsap DM-----------EL-DDLPKEKLKELIFEETA---------------RFQPG-------
Erk1_Hsap AM-----------EL-DDLPKERLKELIFQETA---------------RFQPGV------
YKL161C_Scer EF-----------EH-IE-SMAELGNEVIKEVF---------------DFRKVVRKHPI-
ERK1_Spur SM-----------TH-VDIPKSYLKELLFQKFT---------------I-----------
CC1G_02007_Ccin SF-----------EE-ED-SIEGMKRLIVEEVN---------------NFRAEVRAQAR-
AqueK118_Aque EM-----------EL-DDLPKDRLKQLIYEETM---------------NFHP--------
AqueK119_Aque EV-----------VT-DDLPTSQLRAKLLEEVH---------------L-----------
AqueK120_Aque EV-----------VT-DDLPTSQLRAKILEEVH---------------L-----------
ERK-p2-2_Smoe DF-----------EQ-PTFSEDNIKELIYEESL---------------TFTTADM-----
ERK-Un_Smoe S-----------------------------------------------------------
ERK5_b_Smoe EF-----------ER-RRLTREDVRELIYREVTHDCRFESLSTASQILEYHPQMKME---
ERK-p1_a-2_Smoe ME-----------DQ-MVDTSSNLREYVWREMC---------------YYHPQAI-----
ERK5_a-2_Smoe EF-----------ER-RRISKDDVRELIYREIL---------------EYHPQMLEE---
ERK-p1_b-1_Smoe DF-----------ED-EELREDALREKVWNEMC---------------YYHPEATN----
ERK7_Smoe PI-----------DDNHKFTIHEYRERLYAEII---------------SRKKEIRKKARE
ERK5_a-1_Smoe EF-----------ER-RRISKDDVRELIYREIL---------------EYHPQMLEE---
ERK5_c_Smoe EF-----------ER-RRLTREDVRELIYREIL---------------EYHPQMKME---
ERK-p2-1_Smoe DF-----------EQ-PTFSEDNIKELIYEESL---------------TFTTADM-----
ERK-p1_a-1_Smoe ME-----------DQ-MVDTSSNLREYVWREMC---------------YYHPQAI-----
ERK-p1_b-2_Smoe DF-----------ED-EELREDALREKVWNEMC---------------YYHPEATN----
GK037_Glam FF-----------EK-YELTKPLLEMCFLNEAR---------------KFHPDELKD---
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele -------AAA--------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer ---------EEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGN--AAASEENYPKQMATSNS
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer --------SGDSPSSSLSLEDA----------IP-------QEVVQV--H-PSR--KV--
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ---------GSA-QNH------RSTKDSDNLGIPSRDEIISSPVKEFGPH-PGH--TSN-
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque ------------------------------------------------------------
AqueK120_Aque ------------------------------------------------------------
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe -------YV--------------NGNDQANFMYPSAVDQFRRQFAHLEEHYAKG----NA
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe -------YL--------------NGTDHANFMYPSAVDQFKRQFAQLEEHYGKGG---HN
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe RERSLHREM--------------SRMQ---------------------------------
ERK5_a-1_Smoe -------YL--------------NGTDHANFMYPSAVDQFKRQFAQLEEHYGKGG---NN
ERK5_c_Smoe -------YV--------------NGNDQANFMYPSAVDQFRRQFAHLEEHYAKG----NA
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam -------EV--------------AKRA---------------------------------
rl_Dmel ------------------------------------------------------------
ERK2_Mmus ------------------------------------------------------------
ERK1_Mmus ------------------------------------------------------------
mpk-1_Cele ------------------------------------------------------------
SMK1_Scer ------------------------------------------------------------
SLT2_Scer VAPQQESFGIHSQNLPRHDADFPPRPQES-------------------------------
KSS1_Scer ------------------------------------------------------------
FUS3_Scer ------------------------------------------------------------
Erk2_Hsap ------------------------------------------------------------
Erk1_Hsap ------------------------------------------------------------
YKL161C_Scer --------------LPSY----SP------------------------------------
ERK1_Spur ------------------------------------------------------------
CC1G_02007_Ccin ----------YTTNA--------P------------------------------------
AqueK118_Aque ------------------------------------------------------------
AqueK119_Aque ------------------------------------------------------------
AqueK120_Aque ------------------------------------------------------------
ERK-p2-2_Smoe ------------------------------------------------------------
ERK-Un_Smoe ------------------------------------------------------------
ERK5_b_Smoe MVPLE----RQHASLPRLVV--------SFS--------CCIDNRGKCSSAGTTILAVPC
ERK-p1_a-2_Smoe ------------------------------------------------------------
ERK5_a-2_Smoe NAAVE----RHHASLPRFEA--------FLFIVNVILKRINITGRRRCT---------PA
ERK-p1_b-1_Smoe ------------------------------------------------------------
ERK7_Smoe ------------------------------------------------------------
ERK5_a-1_Smoe NAAVE----RHHASLPRFEA--------FLFIVNVILKRINITGRRRCT---------PA
ERK5_c_Smoe MVPLE----RQHASLPR-------------------------------------------
ERK-p2-1_Smoe ------------------------------------------------------------
ERK-p1_a-1_Smoe ------------------------------------------------------------
ERK-p1_b-2_Smoe ------------------------------------------------------------
GK037_Glam ------------------------------------------------------------
rl_Dmel ------------------------------------------PDNAP
ERK2_Mmus --------------------------------------------YRS
ERK1_Mmus -------------------------------------------PEGP
mpk-1_Cele -------------------------------------R-NNGGQNPV
SMK1_Scer ------------------------------------------SSSSL
SLT2_Scer --MME----MR-PATGNTADIPPQN-DNGTLLDLEKELEFGLDRKYF
KSS1_Scer -------------------------------------------KTME
FUS3_Scer ----------------------------------------------S
Erk2_Hsap --------------------------------------------YRS
Erk1_Hsap -------------------------------------------LEAP
YKL161C_Scer -------------EFSYVSQLPSLT-TTQPYQNLMGIS-SNSFQGVN
ERK1_Spur ----------------------------------------------F
CC1G_02007_Ccin -------------------RAPSPI-MDDPSAELEREL-ASTHISKK
AqueK118_Aque --------------------------------------------HAV
AqueK119_Aque -----------------------------------------F-SSPQ
AqueK120_Aque -----------------------------------------F-SSPQ
ERK-p2-2_Smoe --------------------------------------------VTE
ERK-Un_Smoe ------------------------------------------YKYSM
ERK5_b_Smoe WLFLSMCY-LREQA--CRSSEESPVPIVSLFYLF--LH-ITHLFYSC
ERK-p1_a-2_Smoe --------------------------------------------NEM
ERK5_a-2_Smoe LLLLQVTVLARNEN--TTTRGSSRR-SLSRRSRLE-RH-RKVVTKAS
ERK-p1_b-1_Smoe --------------------------------------------EYS
ERK7_Smoe --------------------------------S---RR-SSYHPRAS
ERK5_a-1_Smoe LLLLQVTVPARNEN--TTTRGSSRR-SLSRRSRLE-RH-RKVVTKAS
ERK5_c_Smoe ----------------------------------------LVVSFSC
ERK-p2-1_Smoe --------------------------------------------VTE
ERK-p1_a-1_Smoe --------------------------------------------NEM
ERK-p1_b-2_Smoe --------------------------------------------EYS
GK037_Glam --------------------------------K---AL-GIPESVWM