10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    VHPLDELGFSQGRKSSQTHNDQKHKGAARHKSMEARSERSGPESTDEPQVSNIRSTRKEA


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    AEDGKPEESCLASRPTSSANSSNQKGGQDKARGSGDGSERSSGFPRLPPVRLKSVEKIPD


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    EWVAHCRVGSDADVEMDPLDASSFALGSFLDVPVGQDILSSGTKRCAAINRPSVSHGIVE


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    DPSASFANAGDGSAAEYPDEYWDSDAYEDDDDPGYTRRPIDDEKEFLASEINYPSEEERA


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    RIEHNPAQQGTTYGKYDDDDRSYVESYFSGEEYYRGRDARDNNGDADVDALCGAADELSF


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    RPHANDYDGQLLDSEELKQIRSEPAWQGFVVQGNAIRKDQAATTANDQDDFSREIRETYL


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    AESSDGEVGSLQDCDFQGRNGFLDVEKRRQQCFKQGGPSSAEEEHDIVLQYYNRPWGHKA


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    QANGCEEVDRNGSVETQLAEEQLGAFQFGGFSFPSPSSAGDVDGSRAESGRSLWSTREIS


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    SRGEEVDQFANGFVGPDDTLASWKRKSNESSPIISGGEDHELRLALSTHSTVSPGSTEDS


10580_Tthe      ------------------------------------------------------------
22423_Tthe      ------------------------------------------------------------
DYRKP-2_Smoe    ------------------------------------------------------------
DYRKP-1_Smoe    LSVEEERVDDEDVDAQRDETEAAAAYDEEAIAVHEHFHRLQAEEEEFETFDLKIIHRKNR


10580_Tthe      --------------------YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFD
22423_Tthe      --------------------YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFD
DYRKP-2_Smoe    ------------------------------------------------MKIIKNNKDFFD
DYRKP-1_Smoe    TGFEEDKDFQVLINSVIAGRYHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFD
                                                                ****:****:**

10580_Tthe      QSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRENETQ
22423_Tthe      QSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFNRENEQQ
DYRKP-2_Smoe    QSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
DYRKP-1_Smoe    QSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
                **:******:*** :. .*: ::*: :*****:*****: ***. *****:*:**:.  :

10580_Tthe      PYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHD
22423_Tthe      RYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHD
DYRKP-2_Smoe    VYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSD
DYRKP-1_Smoe    VYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSD
                 ***: ***.**:* * .*:::*.* ************:** .: :**:**:*****  *

10580_Tthe      HLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAELWTGNVLFQNDTVQGLLARVIGI
22423_Tthe      HLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAELWTGNVLFQNDNIQGLLARVIGI
DYRKP-2_Smoe    HLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAELCSGNVLFQNDSLATLLARVVGI
DYRKP-1_Smoe    HLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAELCSGNVLFQNDSLATLLARVVGI
                **.**************:*  ** :**:********** :********.:  *****:**

10580_Tthe      IGPIPEWMFQEGRLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKIQILVP
22423_Tthe      IGPFPEWMMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVP
DYRKP-2_Smoe    IGPLDPEMVARGRESYKFLTKNSKLYE--------------------RNQETSRMEYLIP
DYRKP-1_Smoe    IGPLDPEMVARGRESYKFLTKNGKLYE--------------------RNQETSRMEYLIP
                ***:   *. .**   :*:*.:  **                     :. ::.::: *:*

10580_Tthe      KKSNLRARLKTDDLMFLDFVKSLLQIDRTRRPSAKEALQHPWL
22423_Tthe      KHSNLKARLRTEDHLFIDFVRQCLQIDFTRRPTAKEALSHPWF
DYRKP-2_Smoe    KKTTLAHRLPMGDQGFLEFVAFLLQINPKNRPSAAEALKHPWL
DYRKP-1_Smoe    KKTTLAHRLPMGDQGFLEFVAFLLQINPKNRPSAAEALKHPWL
                *::.*  **   *  *::**   ***: ..**:* ***.***: