ChaK2_Mmus ---------MQVKKSWIEGVFYKRECNKFIPSSKDPHRCTPGCQICHNLVRCYCGRLIEE
ChaK1_Mmus ---------M-SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQ
ChaK2_Hsap MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGD
ChaK1_Hsap ---------M-SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQ
: :****:..: **** :*****:**** * **:*::*:**:****: :
ChaK2_Mmus HHGLDRAWNLSVTE-------GHGDEQWSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIR
ChaK1_Mmus HACFTASLAMKYSDVKLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVR
ChaK2_Hsap HAGIDYSWTISAAK-------GKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIR
ChaK1_Hsap HACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVR
* : : :. :. .: *:******* :****::*.****.*.* :::**:*
ChaK2_Mmus TSWDTKSDHLLHLMLKEWNMELPKLVISVHGGLQNFKISSKLKETFSQGLVKAAETTGAW
ChaK1_Mmus LSYDTKPEIILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAW
ChaK2_Hsap TSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAW
ChaK1_Hsap LSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAW
*:*** : :*:*:****:*************:*:* : .::*: :.:**:*** *****
ChaK2_Mmus IITEGINSGVSKHVGDALKAHSSKSLRKIWTVGIPPWGVIENQRELVGKDVVCMYQTLGN
ChaK1_Mmus ILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLN
ChaK2_Hsap IITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDN
ChaK1_Hsap ILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLN
*:* *:*:**:******** *:*:* *** *:**.*******:.:*:*:***. **** *
ChaK2_Mmus PLSKLTTLNCMHSHFILCDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVM
ChaK1_Mmus PLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIF
ChaK2_Hsap PLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVV
ChaK1_Hsap PLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIF
*****..** :****** ****** ** * :***:*** :. *:** ******.*:.
ChaK2_Mmus EGGPNVILWVWETVKNKE--PVVVCEGTGRAADLLAFTYKHLEDGGILRPQVKEELFCLI
ChaK1_Mmus EGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTI
ChaK2_Hsap EGGPNVILSVWETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMI
ChaK1_Hsap EGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTI
******** * * :::. ****************: :*: : * * .: :::. *
ChaK2_Mmus QNMFNFSLRQSKHLFQILMECMVHKDSITIFDADSEEHQDLDLAILTALLKGTSLSISEQ
ChaK1_Mmus KKTFNFGQSEAVHLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQ
ChaK2_Hsap QNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQ
ChaK1_Hsap KKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQ
:: ***. :: **** :**** ::: **:*. .*:::**:*:**********. * :*
ChaK2_Mmus LNLAMAWDRMDIAKKHILTYGQHWKPGALEQAMLDALVMDRVDFVKLLIENGVNLHRFLT
ChaK1_Mmus LILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLT
ChaK2_Hsap LNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLT
ChaK1_Hsap LILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLT
* *::****:****:*:: * *:* .:***** ******** ******* **.:*:***
ChaK2_Mmus IPRLEELYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTR
ChaK1_Mmus IPRLEELYNTKQGPTNPMLFHLIRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTR
ChaK2_Hsap IPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTR
ChaK1_Hsap IPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTR
**************** :* **::**** .* ..*:*********:***:* :**..***
ChaK2_Mmus KSFRILYNNLYRKHKSVSSFAQGLSQHSL-HQRHSLRNRKESSESTLHSQFFRTAQPYKS
ChaK1_Mmus KRFRLIYNSLGGNNRRSGRNTS-SSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRP
ChaK2_Hsap KHFRALYNNLYRKYK---------------HQRHSSGNRNESAESTLHSQFIRTAQPYKF
ChaK1_Hsap KRFRLIYNSLGGNNRRSGRNTS-SSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRP
* ** :**.* : : :.:.: ** :. *. *.:*::*****:
ChaK2_Mmus KEKPEDSQKSKKKSKERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEAT
ChaK1_Mmus KMDASMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESM
ChaK2_Hsap KEKSIVLHKSRKKSKEQNV-SDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEAT
ChaK1_Hsap KIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESM
* .. . .:*::*:. ::**: * ** *:**:** ***** ** *:******:
ChaK2_Mmus VKAVIASILYRAMAREAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLL
ChaK1_Mmus AKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLL
ChaK2_Hsap VKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLL
ChaK1_Hsap AKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLL
.**::*. :**:** ***:*.:***:*****:**::*****:::**::*:*:* ***.**
ChaK2_Mmus TYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPP
ChaK1_Mmus TYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP
ChaK2_Hsap TYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPP
ChaK1_Hsap TYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP
****:*************. *****:*:******:*******:****** *:*:**::**
ChaK2_Mmus MILTLEFKSKAEMSHVPQSQDF-QFTWNYSDQGLSNTKESACVKDYDLERGPDEKPDEPL
ChaK1_Mmus AILMLEYKTKAEMSHIPQSQDAHQMTMEDSENNFHNITEEIPMEVFKEVKILDSSDGK-N
ChaK2_Hsap TILTLEFKSKAEMSHVPQSQDF-QFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQ
ChaK1_Hsap AILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGK-N
** **:*:******:***** *: *::. . .*. :: :. : *.. .:
ChaK2_Mmus HLDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVHEWL
ChaK1_Mmus EMEIHIKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVKMEQLPSVQEWI
ChaK2_Hsap HFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWL
ChaK1_Hsap EMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWI
.: :. : ** **:.* ** **:***** *:***.****:*:.***:*: ***:**:
ChaK2_Mmus VIIYIFTNAIEKVREICISEPSKFKQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGH---
ChaK1_Mmus VIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFVGFGLRFGAKWN
ChaK2_Hsap VSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGD---
ChaK1_Hsap VIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWN
* **** *** ***: :**..*..**:*:*:*:*:*: :*:** * ** **:*
ChaK2_Mmus ------PPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPYVTMIAKMAANMFYIVIIMA
ChaK1_Mmus YINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMA
ChaK2_Hsap ------PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMA
ChaK1_Hsap FANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMA
. .*******::****: **:**:****:***** **.**.*******:***
ChaK2_Mmus IVLLSFGVARKAILSPKEPPSWRLARDIVFEPYWMMYGEVYASDIDVCSNETS----CPP
ChaK1_Mmus LVLLSFGVPRKAILYPHEEPSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTICGP
ChaK2_Hsap IVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPS----CPP
ChaK1_Hsap LVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGP
:*******.***** *:* *** **:****.****::***** :****:.:. * *
ChaK2_Mmus GSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWL
ChaK1_Mmus GTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVL
ChaK2_Hsap GSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWL
ChaK1_Hsap GTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVL
*::*********************** ***:**::::*** :***:**::**:**:** *
ChaK2_Mmus PPPFILLNHLCLLLRGLCCRPAPQDQEEGDGGLKLYLTKDDLKKLHDFEEQCVEKYFHEK
ChaK1_Mmus PPPLIILSHIVSLF---CCVCKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFDEK
ChaK2_Hsap PPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEK
ChaK1_Hsap PPPLIILSHIVSLF---CCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEK
***:*:*.*: *: ** :.::: . * **:*:::* ************ **.**
ChaK2_Mmus TEGLNCSFEEQIRMTSERVSEMFFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSAITVDT
ChaK1_Mmus DDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDT
ChaK2_Hsap MEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDT
ChaK1_Hsap DDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDT
: .:.. **:**:* *** :* :*:**:.::*.:** ** *****:********:****
ChaK2_Mmus LKVLSAVDTLQEDEILLA-NRKHSTCRK-----------RPHSWTNVICAKVLSDMESCG
ChaK1_Mmus LKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDVPVRP-LWKKPSAVNTLSSSLPQG
ChaK2_Hsap LKVLSAVDTLQEDEALLA-KRKHSTCKK-----------LPHSWSNVICAEVLGSMEIAG
ChaK1_Hsap LKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQG
**.*:* .: : .: .*: * .:: * *.: .:.*.. *
ChaK2_Mmus KKKLQYYSMPPSLLRSLARSQLPPS-VQRGALVEVTHSKREASHVREEQEEREMEQRTTA
ChaK1_Mmus DRESN----NPFLCNIFMKDEKDPQYNLFGQDLPVIPQRKEF----NIPEAGSSCGALFP
ChaK2_Hsap EKKYQYYSMPSSLLRSLAGGRHPPR-VQRGALLEITNSKREATNVRNDQERQETQSSIVV
ChaK1_Hsap DLESN----NPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEF----NFPEAGSSSGALFP
. : : . . : . * * : .::* : * .
ChaK2_Mmus SGISHVRQAHSKYGQFLLVPSSG-KQVPLSLETPPHLFRSSEEAGIDGLVLEHIHQSDLT
ChaK1_Mmus SAVSPPELRQRRHGVEMLKIFNKNQKLGSSPNSSPHMSSPPT---------------KFS
ChaK2_Hsap SGVSPNRQAHSKYGQFLLVPSNL-KRVPFSAETVLPLSRPSV---PDVLATEQDIQTEVL
ChaK1_Hsap SAVSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPT---------------KFF
*.:* . : :* :* . ::: * : : .. ..
ChaK2_Mmus THLPQQTPAASHQALVAEHKDQHEAVTQMSDKPAKAEQDLLAFSGTPAPMTVTSLPSRAI
ChaK1_Mmus VSTPSQPSCKSH--LESTTKDQEPI-----------------------------------
ChaK2_Hsap VHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPLSQAK
ChaK1_Hsap VSTPSQPSCKSH--LETGTKDQETV-----------------------------------
. . *.. *. *::.
ChaK2_Mmus SMQDEGGYVNWAFSENDETGVFSFKKKWKTCLASTCNSDSNPGGDYFLHTGGRSGLDNSR
ChaK1_Mmus -------FYKAAEGDNIEFGAFV---------------------------GHRDSMDLQ-
ChaK2_Hsap IMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNST
ChaK1_Hsap -------CSKATEGDNTEFGAFV---------------------------GHRDSMDLQ-
: : .:. * *.* . * .
ChaK2_Mmus RLAQSCEC-PAGPWTQARRSFWINPLCRDKALIKSHSFRFHKE-EKLRKTWKNNSHSKSL
ChaK1_Mmus --------------------------------------RFKETSNKIRELLSN-------
ChaK2_Hsap RSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKE-EKLMKICKIKNLSGSS
ChaK1_Hsap --------------------------------------RFKETSNKIKILSNN-------
**:: :*: .
ChaK2_Mmus ET-RSTWLKAKLLTKTRSLSKKKRKTQGLQVPVITVNACYQSDQLNAEPGETNTT-EEFS
ChaK1_Mmus ----------------------------------------------------DTP-ENTL
ChaK2_Hsap EIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYS
ChaK1_Hsap ----------------------------------------------------NTS-ENTL
. . *:
ChaK2_Mmus KKWLSVSNFSQIGLEPYIYQKM------------KMKEIKRHTTQASDHLRQPQENRDKT
ChaK1_Mmus KHVG-AAGYSECCKTSTSLHSVQE-SCSRRASTEDSPEVDSKAALLPDWLRDRPSNRE--
ChaK2_Hsap KNWFTVSKFSHTGVEPYIHQKM------------KTKEIGQCAIQISDYLKQSQEDLSKN
ChaK1_Hsap KRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNRE--
*. : ::. . :. . *: : .* *:: .: .
ChaK2_Mmus PTWNSGSTSLSRSFLTRSPNEVHKISTSLKSPQEPHHHYSAIERNNLMRLSQTIPFTPIQ
ChaK1_Mmus --------------MPSEGGTLNGLASPFKPVLDTNYYYSAVERNNLMRLSQSIPFVPVP
ChaK2_Hsap SLWNSRSTNLNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQ
ChaK1_Hsap --------------MPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVP
: . :. :::.:*. :.:::***:**********:***.*:
ChaK2_Mmus LFTGEEVTIYKLEESSPLTLDKSMSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSE
ChaK1_Mmus P-RGEPVTVYRLEESSPSILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVLCTWSE
ChaK2_Hsap LFAGEEITVYRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSE
ChaK1_Hsap P-RGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSE
** :*:*:****** *::******* * .* *:.**:***.****:*::* .****
ChaK2_Mmus DDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQT
ChaK1_Mmus HDILKSGHLYIIKSFLPEVINTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKS
ChaK2_Hsap DDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQT
ChaK1_Hsap HDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKS
.*:**.*:::*:*******:.** .*::*.******************* ::***:**::
ChaK2_Mmus IPYTPRFLEVSLVYCHSANQWLTIEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWT
ChaK1_Mmus IPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWT
ChaK2_Hsap IPYTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWT
ChaK1_Hsap IPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWT
***:****** *:*****.**:::*: **************** *******:********
ChaK2_Mmus YEYTRGELLVLDLQGVGENLTDPSVIKPEDKQSRGMVFGPANLGEDAIRSFIAKHRCNSC
ChaK1_Mmus YEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSC
ChaK2_Hsap YEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSC
ChaK1_Hsap YEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSC
***************************.* *:* .*************:.* ***:****
ChaK2_Mmus CGKLRLPDLKRNDYSLSRTHCNLGF--GQTIEPTEELPERDKNRSSLEDHTRL
ChaK1_Mmus CRKLKLPDLKRNDYTPDKIIFPQDESSDLNLQSGNSTKE---SEATNSVRLML
ChaK2_Hsap CRKLKLPDLKRNDYSPERINSTFGL--EIKIESAEEPPARETGRNSPEDDMQL
ChaK1_Hsap CRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKE---SESTNSVRLML
* **:*********: .: . .::. :. .. : . *