Cdk5_Dmel -------MQ---KY----------DKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDED
CDK5_Mmus -------MQ---KY----------EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD
cdk-5_Cele -------ML---NY----------DKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDD
CDK5_Hsap -------MQ---KY----------EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD
Cdk5_Ddis -------ME---KY----------SKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSE
PHO85_Scer -------MSSSSQF----------KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-
9119_Tthe MVMKNSKLE---RY----------EKLNKLGEGTYGVVYKAREKTTKELYALKKIRLESE
CDK5_Spur -------MA---SHYCMRQRSTEAKEYYTTAERTYGTVFKAKNRETQEIVALKRVRLDDD
CC1G_03767_Ccin -------MM---NY----------IQLEKLGEGTYATVYKGRSRTTNEIVALKEIHLDA-
AqueK097_Aque -------ME---KY----------ERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDED
GK023_Glam MTD---PLN---RY----------ERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENA
: . . .: **. *:*. .: : *** ::*:
Cdk5_Dmel DEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLN-----
CDK5_Mmus DEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-----
cdk-5_Cele DEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLN-----
CDK5_Hsap DEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-----
Cdk5_Ddis DEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECG-----
PHO85_Scer EEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTP
9119_Tthe DEGIPSTAIREISLLKELQHPNVVRLHDVIHSNKKLVLVFEFVDQDLKKFMNNFKD----
CDK5_Spur DE----------------------------------------------------------
CC1G_03767_Ccin EEGTPSTAIREISLMKELKHVNIVRLHDVIHTETKLVLIFEYCEQDLKKYMDQHGER---
AqueK097_Aque DEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSG-----
GK023_Glam DEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQ-----
:*
Cdk5_Dmel GEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPV
CDK5_Mmus GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV
cdk-5_Cele GYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPV
CDK5_Hsap GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV
Cdk5_Ddis GEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPV
PHO85_Scer RGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV
9119_Tthe KGLDPHIIKSLLYQLLKGIEVCHKNKILHRDLKPQNLLISKECILKLADFGLARASGIPV
CDK5_Spur ---------SFMYQLLRGLAFCHSHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPV
CC1G_03767_Ccin GALEPEVVRSFMYQLLKGTAFCHENQVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPV
AqueK097_Aque GIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPV
GK023_Glam GKLTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPV
: **: * * ..:*********:*:. ***.******. *:**
Cdk5_Dmel KCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKI
CDK5_Mmus RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI
cdk-5_Cele RCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRI
CDK5_Hsap RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI
Cdk5_Ddis RTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMA-SGRPLFPGSGTSDQLFRI
PHO85_Scer NTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLI
9119_Tthe KNYTHEVVTLWYRPPDVLLGSKHYSTSIDIWSIGCIFAEMV-NLKPLFPGNSETDELKRI
CDK5_Spur RCYSAEVVTLWYRPPDVLFGAKVYTTSIDMWSAGCIFAEMANAGRPLFPGNDVEDQLKRI
CC1G_03767_Ccin NTFSNEVVTLWYRAPDVLLGSRTYSTSIDVWSCGCIFAEMI-SGVPLFRGRDNQDQLLHI
AqueK097_Aque RLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANAGRPLFPGSDVDEQLKRI
GK023_Glam RSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYECV-TGKPLFPAKTEKDELIKI
. :: ******** *.**:*.: * .:*:** * *: * *** . ::* *
Cdk5_Dmel FRVLGTPNEDSWPGVSH-LSDYVA--LPSFPAITSWSQLVP-----RLNSKGRDLLQKLL
CDK5_Mmus FRLLGTPTEEQWPAMTK-LPDYKP--YPMYPATTSLVNVVP-----KLNATGRDLLQNLL
cdk-5_Cele FKQLGSPSEDNWPSITQ-LPDYKP--YPIYHPTLTWSQIVP-----NLNSRGRDLLQKLL
CDK5_Hsap FRLLGTPTEEQWPSMTK-LPDYKP--YPMYPATTSLVNVVP-----KLNATGRDLLQNLL
Cdk5_Ddis FKILGTPNEESWPSITE-LPEYKTD-FPVHPA-HQLSSIVH-----GLDEKGLNLLSKML
PHO85_Scer FDIMGTPNESLWPSVTK-LPKYNP-NIQQRPP-RDLRQVLQPHTKEPLDGNLMDFLHGLL
9119_Tthe FKLTGTPCVEKWPGLAD-LPNWKADAFEKYPG-EPLQNICP-----KLDELGLDLLGKML
CDK5_Spur FKLLGTPTEDTWPGISK-LPDFKP--YPIYPVTTPLASVVP-----SLSATGRDLLQRLM
CC1G_03767_Ccin MRIIGTPSPAQFAKICKETPEIQPKQFPNYPR-LPFHQVLP-----KASPQALDLLDKLL
AqueK097_Aque FKLVGTPTERSWPGLTK-LPEFKE--FPPYPP-ACIESVVP-----ALNDAGVDLLQRHL
GK023_Glam FKTLGTPDKQSWPDVDT-LPQWQK-DFPVYPG-INVAELLP-----TLDEAGRDLFSKMM
: *:* :. : .. .: . ::: :
Cdk5_Dmel ICRPNQRISAEAAMQHPYFTDSSS------------------------------------
CDK5_Mmus KCNPVQRISAEEALQHPYFSDFC-------------------------------------
cdk-5_Cele VCNPAGRIDADAALRHAYFADTS-------------------------------------
CDK5_Hsap KCNPVQRISAEEALQHPYFSDFC-------------------------------------
Cdk5_Ddis QYDPNQRITAAAALKHPYFDGLEP------------------------------------
PHO85_Scer QLNPDMRLSAKQALHHPWFAEYYH------------------------------------
9119_Tthe RCNPQERITAKAGLEHPYFNDIPDTLKKMNMRMLSYQLVIFNKRLINKIKSPKTIKCNYF
CDK5_Spur MCNPALRMSAEEGLMHQYFADLNS------------------------------------
CC1G_03767_Ccin KFDPAERISAADALAHPYFTTATNTPFGLN-------------------SSPSSMPPPSF
AqueK097_Aque ICHPTERISAEEAMRHEYFADIDPS-----------------------------------
GK023_Glam ALDPSKRPSARDCLKHPYFA----------------------------------------
* * * : * :*
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe DRKKSYIQKEKERDQLSKQEDIDRRKNIVSKLGNLASNVHILNKQIASFSVWKNPTNYLP
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin NFPHSHVHQAQQQHQQRQQQQQQQQ-----------------------------------
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe EKAKFPSPKELFPKDNENSWKTLNDLTPSLFKDVQGFKEKQVQRAAYMQIAKPNGQMYHI
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin ----------------------------------QQQQQQQQQQQVHHQQIQPHYS----
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe FDASKMPLGRMCQKIAFFLQGKHRPTFKNCDQVTYDNIIVVNAANIMLTGKKALLKTVKY
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin -----------------------R------------------------------------
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe HTGFVGGLKEKSYKFFLTEKPEQLVNIYIQLVSKVFYCISKMLPKNLKRRDLLKKVEIYR
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin --------------------------------------------------------PIYG
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe DFQHEKQGLPNVIQVKINYASFILNSLIELIQFVPYTEKETFDQYFNPFVHNFEDLVIKF
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin QIPQHPQNPAQVKNVQVPYGN---------VQYPPY------------------------
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe QSSKETPKELEGIKKEIDPEITLPFNQRSKIFKLNAHNRRVMKQWKMYYRRLRRYKVHKI
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin ------------------------------------------------------------
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ------------------------------------------------------------
CDK5_Mmus ------------------------------------------------------------
cdk-5_Cele ------------------------------------------------------------
CDK5_Hsap ------------------------------------------------------------
Cdk5_Ddis ------------------------------------------------------------
PHO85_Scer ------------------------------------------------------------
9119_Tthe KAPKNRDPNLSNKSFMITSDRQIKDFNLHNRIVPEEVPEDDDEIMRTIPRQGGGSATAGP
CDK5_Spur ------------------------------------------------------------
CC1G_03767_Ccin ------------------------------------------------------------
AqueK097_Aque ------------------------------------------------------------
GK023_Glam ------------------------------------------------------------
Cdk5_Dmel ---------------------SGH
CDK5_Mmus ----------------------PP
cdk-5_Cele ----------------------DV
CDK5_Hsap ----------------------PP
Cdk5_Ddis ----------------------IN
PHO85_Scer ---------------------HAS
9119_Tthe AKPAGGNANAGAAAAKGGKQGGKK
CDK5_Spur ---------------------VVN
CC1G_03767_Ccin -------------------GAPPR
AqueK097_Aque ---------------------LRA
GK023_Glam -----------------------K