Cdk4_Dmel       MSYVRQL--------------------------KRQKMSQAKK-----------------
CDK6_Mmus       MEKD--------------------------------SLSR--------------------
CDK4_Mmus       MA----------------------------------------------------------
cdk-4_Cele      MTIRHILAIRKKSLELPSDLKTFLRVLANCQHLKKNKKCRRTIFSVDFQNNQRQKPSNFH
CDK4_Hsap       MA----------------------------------------------------------
CDK6_Hsap       MEKD--------------------------------GLCR--------------------
CDK4_Spur       MASS--------------------------------APSR--------------------
                *

Cdk4_Dmel       ---------------------------------FGDGDPFNYQELNIIGEGAYGTVYRAR
CDK6_Mmus       ------------------------------------A-DQQYECVAEIGEGAYGKVFKAR
CDK4_Mmus       --------------------------------------ATRYEPVAEIGVGAYGTVYKAR
cdk-4_Cele      FWTVIKKFSKKILKSFIIKFGNNGTIAVVFSIFPTGATPSLTFLFQALGKGAYGNVYRVR
CDK4_Hsap       --------------------------------------TSRYEPVAEIGVGAYGTVYKAR
CDK6_Hsap       ------------------------------------A-DQQYECVAEIGEGAYGKVFKAR
CDK4_Spur       ------------------------------------STPERYVQAAEIGSGAYGIVYKAR
                                                               :* **** *::.*

Cdk4_Dmel       DVIT-GNIVALKKVRISLN---ENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLER
CDK6_Mmus       DLKNGGRFVALKRVRVQTS---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRT
CDK4_Mmus       DPHS-GHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRT
cdk-4_Cele      SLHD-GKDYALKQIMISSK---NEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDP
CDK4_Hsap       DPHS-GHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRT
CDK6_Hsap       DLKNGGRFVALKRVRVQTG---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRT
CDK4_Spur       DTET-GHFVALKSVRIPIG---EEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDV
                .    *.  *** : :        *:* *.:**::::::*    *.*:: * .*

Cdk4_Dmel       DG-QLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLK
CDK6_Mmus       DR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK
CDK4_Mmus       DR-DIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLK
cdk-4_Cele      VRAILKINMIMERCDWDLHTFLRNIP-RGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLK
CDK4_Hsap       DR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK
CDK6_Hsap       DR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK
CDK4_Spur       GRSEMMLTLVFELVDQDLAQYLEKCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLK
                      : :::*  : **   : . *  *:.    : :  ::: .:::**:: : *****

Cdk4_Dmel       PQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSAAC
CDK6_Mmus       PQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGC
CDK4_Mmus       PENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGC
cdk-4_Cele      PQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQSYYNSTVDMWALGC
CDK4_Hsap       PENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGC
CDK6_Hsap       PQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGC
CDK4_Spur       PQNILVASDKKLKLTDFGLSRVYSFQMALTPVVVTMWYRAPEVLLQASYATPVDMWSVGC
                *:*:*:     :*::****:: *.    :*.:***:***:*****   * :.**:*: .*

Cdk4_Dmel       IIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCP
CDK6_Mmus       IFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVT
CDK4_Mmus       IFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVP
cdk-4_Cele      IVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSP
CDK4_Hsap       IFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVP
CDK6_Hsap       IFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVT
CDK4_Spur       IFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWP-DVALPWSSFRQTGQRSFLDLVQ
                *. *:: *:.** * .: :**  *:.  * *  .:**    :.   *         ..

Cdk4_Dmel       HLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQE------------------------
CDK6_Mmus       DIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNL-----------------
CDK4_Mmus       EMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEE-----------------------
cdk-4_Cele      QMSKQAIEFVQQCLRYDHSKRLSARGALSHPFLKPAVATKSRV-----------------
CDK4_Hsap       EMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE-----------------------
CDK6_Hsap       DIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL-----------------
CDK4_Spur       EICNQGLDLLERMLCFNPDHRMTAEQGLLHGFFGDEEEDDEEDDDTEVEDDDDEEDEDDE
                .: : . ::: . * ::   * :*   * * ::

Cdk4_Dmel       --------------------------------------------PL
CDK6_Mmus       ------------------------------NSHLPSNQSTSELNTA
CDK4_Mmus       ------------------------------------------SDAE
cdk-4_Cele      ------------------------------L--------KQINFNK
CDK4_Hsap       ------------------------------------------GNPE
CDK6_Hsap       ------------------------------DSHLPPSQNTSELNTA
CDK4_Spur       GVDVSQEHSQSASTSSMSQATDDSGSHSQFFSDSSQSQDVTPTNKR