BIKE_Hsap VTLEESLAEGGFSTVFLVRTH---------------GGIRCALKRMYVN-NMPDLNVCKR
AAK1_Hsap VTVDEVLAEGGFAIVFLVRTS---------------NGMKCALKRMFVN-NEHDLQVCKR
BIKE_Mmus VTLEESLAEGGFSTVFLVRTH---------------SGIRCALKRMYVN-NTPDLNICKR
AAK1_Mmus VTVDEVLAEGGFALVFLVRTS---------------NGVKCALKRMFVN-NEHDLQVCKR
sel-5_Cele VTIEKQIAEGGFAIVYVASDRK--------------N-NKFALKRQFTKDNEKQLEACCR
DDB0229347_Ddis VTEVKLVAEGGFGFVYLVRDDY--------------N-NMYALKRMFIQ-ERERLEAMKN
DDB0229350_Ddis ------IAEGGFSYVFLVKDSN--------------TSKHYALKRILIR-DEDELKGVKH
Nak_Dmel VTVEDVLAEGGFAMVFLARGNGG---------G-SSSATKYALKRMYVN-NEHDLNVAKR
AKL1_Scer VEVVNYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQ-DENGLNEMRN
ARK1_Scer VEIIKYLTSGGFAQVYSALINPP---------DPHSNSSVACLKRVIVP-DKPSLNTLRA
PRK1_Scer AKIIKYLTSGGFAQVYTAEISPP---------DPYSNANIACLKRVIVP-HKQGLNTLRA
AAK1_Spur ------------------------------------------------------------
AqueK170_Aque YIVEDVIAEGGYAIVLEVKCTA-------------GTNERLALKRVAVN-SEQDLYLCRQ
BIKE_Hsap EITIMKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TG
AAK1_Hsap EIQIMRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TG
BIKE_Mmus EITIMKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TG
AAK1_Mmus EIQIMRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TG
sel-5_Cele EHSFLKQCIGHKNIVEFVDSYTNCL-GN--GIWECMLLTEYHQ-KNVLQLMNERISQNQY
DDB0229347_Ddis EIDVMQKLRNNPNIVKLEGFKINEN-RNT-RETEVLMLMEYCSGGSVLDIMNARGEF-TR
DDB0229350_Ddis EISIMKRLTKHKNIVKILDYHKVSD--K--NNTEMFILMEYCSGGHLVEIMQKRLSSGSK
Nak_Dmel EIQIASNLSGHKNIIGYVDSSITPT-GN--GVCEVLLLMPYCKH-HMLAMMNARLH--VG
AKL1_Scer EVEVMKKLKGAPNIVQYFDSNASRR-RDGVQGFEVLLLMELCPNKSLLDYMNQRLS--TK
ARK1_Scer EVDAMRLLKNNRYVVSYIDSHAAKAMLHN-GSYEVFVLMEYCERGGLIDFMNTRLQ--NR
PRK1_Scer EVDAMKLLRNNKHVVSYIDSHAARS-VNG-IAYEVFVLMEFCERGGLIDFMNTRLQ--NR
AAK1_Spur ------------------------------------------------------------
AqueK170_Aque EIAILKALSDSPNSVTYLASQINKL-SR--EVYEVLILMQLYGGQTGLQLIRQYHGQGKR
BIKE_Hsap FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--GGNYVLCDFGSATNKFL
AAK1_Hsap FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQ
BIKE_Mmus FTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--AGNYVLCDFGSATNKFL
AAK1_Mmus FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQ
sel-5_Cele LTNDEILSIFTDLCEAVSFIHNRPQPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQIL
DDB0229347_Ddis LEEREILAIFSDVCNGVLAMHQQQPPIAHRDLKIENVLYCE-HSNRYKLCDFGSSTIKTF
DDB0229350_Ddis FTDQEILKIFQDICESVAYMHSQQPLIIHRDLKVENVLLDE-ESGIYKLCDFGSATEEIT
Nak_Dmel FTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTD--AGNFVLCDFGSATAKTL
AKL1_Scer LTEAEIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDA--KNNFKLADFGSTSTCFP
ARK1_Scer LHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISA--NNEYKLCDFGSVCGIIR
PRK1_Scer LQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISH--DGLYKVCDFGSVSGVIR
AAK1_Spur FTEQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHR--SGNYMLCDFGSATGRVL
AqueK170_Aque LPEALILKIFTDVCLAVSRLHHRTKPIIHRDLKVTLLQM---------------------
: : :: *: : .: :* : ***:*: :
BIKE_Hsap NPQ-KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF
AAK1_Hsap NPQ-TEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF
BIKE_Mmus NPQ-KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF
AAK1_Mmus NPQ-AEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF
sel-5_Cele SVE-KYGVEYVKSEVERNTTMCYRSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPF
DDB0229347_Ddis NT--ATERGKAEDDINMFTTLFYRAPEMVDLYRGQIIDEKVDVWALGCLLFKMAFYVDPF
DDB0229350_Ddis RMKNKTEMQNAEDDISRHTTLQYRAPEIVDFYRSPVINEKIDIWALGCLLYKLLFYVTPF
Nak_Dmel NPQ-QHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPF
AKL1_Scer IVTTHQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPF
ARK1_Scer PPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPF
PRK1_Scer PPRNTQEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPF
AAK1_Spur DPK-VHSINDIKDEIEKYTTVSYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPF
AqueK170_Aque DPK-EVGVGECQDQLQKFTTLAYRAPEMVDLYSGYTISTKSDIWALGCLLYKFCFFDTPF
:: ** **:**::: : * * *:**** :*::: :: **
BIKE_Hsap GES-QVAICDGNFTIPD-NSRYSRNIHCLIRFMLEPDPEHRPDIFQVS------------
AAK1_Hsap GES-QVAICDGNFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVS------------
BIKE_Mmus GES-QVAICDGSFTIPD-NSRYSHNVHCLIRFMLEPDPECRPDIFQVS------------
AAK1_Mmus GES-QVAICDGSFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVS------------
sel-5_Cele EES-PLAIQSVNYQFPS-VPNIPDEIKVLIYMLLDIDVNRRPSIYQTSV-----------
DDB0229347_Ddis DGG-SLQIINNNYKIPD-NSKYSNNFHKLIQFILVADPTQRPS-----------------
DDB0229350_Ddis EDSGSLGILNSNYTIPP-NHTHSNDLISLIKIMLNPDPINRPNIFEITNQL---------
Nak_Dmel GES-TLAIQNGQFSIPD-SSKYSKGMHQLIKYMLEPDMEKRPNIWQVCE-----------
AKL1_Scer EMTGQFAILHSKYEFPV-N-KYSSKLINLIIIMLAENPNLRPNIYQVLYH----------
ARK1_Scer EKGGDLAILSGKFEFPL-YPNYSEQLKGLIRDILVQDPRHRPNVYQLLKR----------
PRK1_Scer EKSGEAGILHARYQYPS-FPQYSDRLKNLIRLMLMEAPSQRPNICQVLEE----------
AAK1_Spur GES-SLAIQSGNFTIPD-NTKYSREMHALIRYMLEVDAEKRPDIFQVSHVAFKAASSETP
AqueK170_Aque GEQ-TLAIMRGTFSFPADASNYSNGLLGLIKYTLNTDPNKRPDIFQVS------------
* : * . . ** * **.
BIKE_Hsap ------------------------------------------------------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus ------------------------------------------------------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel ------------------------------------------------------------
AKL1_Scer ------------------------------------------------------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur IQNLHKSPVPDGNKLPLPLTESEQRQQHSRSKTNNQNRTPAGPMEVSTSVTPRQRPKASQ
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ------------------------------------------------------------
AAK1_Hsap ------------------------------------------------------------
BIKE_Mmus ------------------------------------------------------------
AAK1_Mmus ------------------------------------------------------------
sel-5_Cele ------------------------------------------------------------
DDB0229347_Ddis ------------------------------------------------------------
DDB0229350_Ddis ------------------------------------------------------------
Nak_Dmel ------------------------------------------------------------
AKL1_Scer ------------------------------------------------------------
ARK1_Scer ------------------------------------------------------------
PRK1_Scer ------------------------------------------------------------
AAK1_Spur QGVAPAAGGISLPTPSSITRQRSSKQGQPPTTGPTVAAAAQRLSPPQVQAQQAIQQQQQQ
AqueK170_Aque ------------------------------------------------------------
BIKE_Hsap ---------------YF
AAK1_Hsap ---------------YF
BIKE_Mmus ---------------YF
AAK1_Mmus ---------------YF
sel-5_Cele ----------------L
DDB0229347_Ddis ----------------I
DDB0229350_Ddis ---------NLLRNQQP
Nak_Dmel --------------VAF
AKL1_Scer --------------LCE
ARK1_Scer --------------ISI
PRK1_Scer -------------VSRL
AAK1_Spur QQQQQQQQQQLLQEQQL
AqueK170_Aque ---------------WV