SYK_Hsap MASSGMADS--------------AN-HLPFFFG-----------------NITREEAEDY
shark_Dmel MS-----RD--------------SD-PMKWYHG-----------------NLSREAADEL
SYK_Mmus MAGSA-VDS--------------AN-HLTYFFG-----------------NITREEAEDY
ZAP70_Mmus MP-----DP--------------AA-HLPFFYG-----------------SISRAEAEEH
ZAP70_Hsap MP-----DP--------------AA-HLPFFYG-----------------SISRAEAEEH
Shark_Spur MSLLGMYPVIVGFRQERGCAFTCCDRRCQFEVG-----------------RATFEKWAEG
Syk_Spur MP-----VD--------------PL-SRRFYHG-----------------RITREEAEAR
AqueK439_Aque MA-----DL--------------S--NEPWYHG-----------------RISRSDAEQI
AqueK440_Aque MAMSNSRDV-----------------ADAWFHG-----------------KITRENAAHL
AqueK441_Aque MSPPIVP-----------------V-VRPFFALCEPGTGYALCQSMKLTAPQSRKTYQLR
*. : :
SYK_Hsap -----------LV-QGGMSDGLYL-----------LRQSRNYLGGFALSVAHGRKAHHYT
shark_Dmel -----------LK--QGYEDGTFL-----------VRESSTAAGDFVLSLLCQGEVCHYQ
SYK_Mmus -----------LV-QGGMTDGLYL-----------LRQSRNYLGGFALSVAHNRKAHHYT
ZAP70_Mmus -----------LK-LAGMADGLFL-----------LRQCLRSLGGYVLSLVHDVRFHHFP
ZAP70_Hsap -----------LK-LAGMADGLFL-----------LRQCLRSLGGYVLSLVHDVRFHHFP
Shark_Spur -----------VAM--IIEDNLCS-----------PLDARNAEGRTAL------------
Syk_Spur -----------LR-NAGCHQGMFL-----------LRESLGREGNYALSLCYEDDVYHYA
AqueK439_Aque -----------LT-QCGGVDGSFL-----------VRDSLTTSGEYVLSLCHQTKRYHYL
AqueK440_Aque -----------VTSLPGKLDGYFL-----------VRESLRIPGSFVLTMWADNTVHHFQ
AqueK441_Aque IFINAGQNSVCLKKYSGAARNYYFTQLKTDFITGRLQHRMASSGNIALQMAA--------
: . . * .*
SYK_Hsap IEREL--NGTYAIAGG---RTHASPADLCHYHSQESDGLVCLLKKPF-NR--PQGVQPKT
shark_Dmel VRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPL-IRDLPPHNTRSH
SYK_Mmus IEREL--NGTYAISGG---RAHASPADLCHYHSQEPDGLICLLKKPF-NR--PPGVQPKT
ZAP70_Mmus IERQL--NGTYAIAGG---KAHCGPAELCQFYSQDPDGLPCNLRKPC-NR--PPGLEPQP
ZAP70_Hsap IERQL--NGTYAIAGG---KAHCGPAELCEFYSRDPDGLPCNLRKPC-NR--PSGLEPQP
Shark_Spur ------------------------------------------------------------
Syk_Spur IERQY--DGTVAIKDG---KNFAGPIELVSNHMNREDGLLCRLLRPC-NL--QQGIAARA
AqueK439_Aque ISRKP--DGTLAIQDG---TKFDSPVDLVRYHGQKIDGLLTTLVYPC-RR--PPGQPPQG
AqueK440_Aque IIGHG--DGWFSVDNG---PLFQGLDELIHHYQVKPDGLPKRLLDFVPGQ--PPPLSARK
AqueK441_Aque --------------------------------------IDMVLEAV-SHK--PKPLTSYE
SYK_Hsap GPFEDLKEN-LIREYVK--QTWN-----------------------LQG-----------
shark_Dmel GVTNLLHRA-TSKNESK--VVFEL----LK-CG-----YRNFDAKNQDGQTAL-------
SYK_Mmus GPFEDLKEN-LIREYVK--QTWN-----------------------LQG-----------
ZAP70_Mmus GVFDCLRDA-MVRDYVR--QTWK-----------------------LEG-----------
ZAP70_Hsap GVFDCLRDA-MVRDYVR--QTWK-----------------------LEG-----------
Shark_Spur ------------------------------------------------------------
Syk_Spur --FSDMDHQ-QMEGALI--DLAK-----------------------SQGMA---------
AqueK439_Aque YRF--ITHD-EMQQAMR--EGAL-----------------------LLGYQ---------
AqueK440_Aque RVLTNLHKA-VAVNDIK--IVRKY----LS--GPPSLTVGTVDSPNAEGQTPV-------
AqueK441_Aque DVLDHFKVSKFLPSYVKSQQAWKKTLSHLFEEY-----YQALSTREPDVIKVQYIYAYEK
SYK_Hsap ------------------------------------------------------------
shark_Dmel --------------------------HLAALHSDE--------DILK-------------
SYK_Mmus ------------------------------------------------------------
ZAP70_Mmus ------------------------------------------------------------
ZAP70_Hsap ------------------------------------------------------------
Shark_Spur --------------------------HEAAALGEE--------NIIF-------------
Syk_Spur ------------------------------------------------------------
AqueK439_Aque ------------------------------------------------------------
AqueK440_Aque --------------------------HEAAKRGYI--------EMVA-------------
AqueK441_Aque DIGCGQHLFQAKVYLFPDRPLYEGRIQASWKNGIVMMAATRKEVILMQDIEQIDVSLERL
SYK_Hsap ------------------------------------------------------------
shark_Dmel ----HLLNAKVQVNSSDSFGCQPLHYAARSKP-ASFIRTLISA--QANVQGRNIDNGYVP
SYK_Mmus ------------------------------------------------------------
ZAP70_Mmus ------------------------------------------------------------
ZAP70_Hsap ------------------------------------------------------------
Shark_Spur ----RLLEKSANINSKDSNGVTPLYTACSSNQ-PRACQFLMQK--GADPTLRHPRTGWVP
Syk_Spur ------------------------------------------------------------
AqueK439_Aque ------------------------------------------------------------
AqueK440_Aque ----LLVEHKPDLSLRDSKGSTALHLAAQNGY-ADIIKLLVEN-GKADVQERNTTTGWVA
AqueK441_Aque SLSIQLKETAASLNSTSSNSSTGGATDTDSKSQNPITKTLQFKSVEEMI-------SFCS
SYK_Hsap --------------------------------------------QALEQAII-SQ--KPQ
shark_Dmel LHEAAKHGNLEAVQELLLAEAPPLPRT--SSGEFPFDLAKEAGQTAVEEFLL---NY---
SYK_Mmus --------------------------------------------QALEQAII-SQ--KPQ
ZAP70_Mmus --------------------------------------------DALEQAII-SQ--APQ
ZAP70_Hsap --------------------------------------------EALEQAII-SQ--APQ
Shark_Spur LHEAAMKGHAGCVKELIMHGAPCHPRS--ADNDTPLDLARRYEHSHVVMYLK-SC--KPK
Syk_Spur -------------------------------------------PEVITKALHSTQ--RPQ
AqueK439_Aque -------------------------------------------EHQINDALL-KR--RSA
AqueK440_Aque LHEAAFRGHVDCCKMLLTHNAPLRPRTPSPDEDTPRELANRYKQDKVISLLD-WVAANYP
AqueK441_Aque IIDGYYRLKVDINTSILSGDAS-----PADNEHT---------------------KE---
SYK_Hsap LEKLIATTAHEKMPWFHGKISREESEQIVLIGS----------KTNGKFLIRARD-N-NG
shark_Dmel ---KLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAAS
SYK_Mmus LEKLIATTAHEKMPWFHGNISRDESEQTVLIGS----------KTNGKFLIRARD-N-SG
ZAP70_Mmus VEKLIATTAHERMPWYHSSLTREEAERKLYSGQ----------QTDGKFLLRPRK-E-QG
ZAP70_Hsap VEKLIATTAHERMPWYHSSLTREEAERKLYSGA----------QTDGKFLLRPRK-E-QG
Shark_Spur VP------RLQGKPWFHGSMDRKKALESIQKHG----------AKDGQFLLRSSANK-PD
Syk_Spur LERALKKIMHQDKPWFHHKLSREEAEQRIVSAG----------LQEGKFLVRERT-E-EG
AqueK439_Aque FEQLVGGILHRRQQWFHGPISRDESELRLRQFG----------LKDGLFLVRERT-Q-VN
AqueK440_Aque KP------RTNTSEWLHKVLDRNHAVEYLRQNG----------QVDGSFLVRPNSRK-PG
AqueK441_Aque ---TLGK-DIAARDLCHGPISKESANEVFAKQH----------NEEGLYLVRESRTK-DC
* : :. : . .* :*:*
SYK_Hsap SYALCLLHEGKVLHYRIDKDKT------------GKLSIPEGK----------KFDTLWQ
shark_Dmel GLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGP----------YWPSVEH
SYK_Mmus SYALCLLHEGKVLHYRIDRDKT------------GKLSIPEGK----------KFDTLWQ
ZAP70_Mmus TYALSLVYGKTVYHYLISQDKA------------GKYCIPEGT----------KFDTLWQ
ZAP70_Hsap TYALSLIYGKTVYHYLISQDKA------------GKYCIPEGT----------KFDTLWQ
Shark_Spur TMVLSMAANGTVFNFEINTK-M------------ESFYIDDGP----------YFDTLEQ
Syk_Spur SFALSLCYNNFVYHYKIDKDCT------------GQLSIKEGP----------KFDSLIQ
AqueK439_Aque SFALCISFKMKIYHYLLDMNTL------------GQLSIENGR----------KFENLLQ
AqueK440_Aque YYALTLVYKQMPFHYEIICESD------------RWYYIDDGP----------LFDSISL
AqueK441_Aque TFILSLCQKEGVFNYRISKDYD------------HRFALVDTTGISPVPRSVNSCHTLND
* : :: : : : .:
SYK_Hsap LVEHYSYKADGLLRVLTVPCQKIGTQGNVN--FGGRPQLP-------GSHPATWS-----
shark_Dmel LIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFA--TIPRS--------NMKP---------
SYK_Mmus LVEHYSYKPDGLLRVLTVPCQKIGAQM-------GHPGSP-------NAHPVTWS-----
ZAP70_Mmus LVEYLKLKADGLIYRLKEVCPNSSASAA-----VAAPTLP--------AHPSTFT-----
ZAP70_Hsap LVEYLKLKADGLIYCLKEACPNSSASNA-S--GAAAPTLP--------AHPSTLT-----
Shark_Spur LIDHYSRYDDGLPTMLLHPIPPPPGRIDNGPPTREKPS-P-------APRPVDLT-----
Syk_Spur MVDHYQLKKDGLLCCLLVPCHDNNRDTP-T--RRRHSGSQSIHVDDVHEYDAYADRNQRR
AqueK439_Aque VVDHYSRTPDGLLCSLGDYCPVRGFEESK---GKSAPRVR--------------------
AqueK440_Aque CVDHYMMFADGLPTILRHPIAPIDNRICRTLSK--APP-P-------GQ----LL-----
AqueK441_Aque LILHHHHFADGLPILLKQNCPPSKTGPM-----PLFPETP--------------------
: : ** * .
SYK_Hsap ------------AGGIISRIKSYSFP----KPGHR-KSSPAQG----------NRQ----
shark_Dmel -----------------KAA-SPATPPTPVSP-HSHHQHPHVPAL--TITKKKQKEN---
SYK_Mmus ------------PGGIISRIKSYSFP----KPGHK-KPAPPQG----------SRP----
ZAP70_Mmus -----------------------------------------QP----------QRR----
ZAP70_Hsap -----------------------------------------HP----------QRR----
Shark_Spur ------------AHR-VTPV-RRDSPEPPLSPIEREGSIPMSPPPELPSG---RAPKSNA
Syk_Spur IASEDGGGVPPTPLRTALSV-SVSSPPGIRAPLEY-NPSPPTP----------NRT----
AqueK439_Aque ------------------------------------------------------------
AqueK440_Aque ------------FSQ-SQPL-HHTRPPLPTPP-SRQSSRPPAPLP--PMG---NAPALNG
AqueK441_Aque --------------------------NTPT----AVT-----------------------
SYK_Hsap ------------------------------------------------------------
shark_Dmel SSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSL
SYK_Mmus ------------------------------------------------------------
ZAP70_Mmus ------------------------------------------------------------
ZAP70_Hsap ------------------------------------------------------------
Shark_Spur FSKI--------------------------------------------------------
Syk_Spur ------------------------------------------------------------
AqueK439_Aque ------------------------------------------------------------
AqueK440_Aque IP-S--------------------------------------------------------
AqueK441_Aque ------------------------------------------------------------
SYK_Hsap -----ESTVSFNPYEPEL-APWAAD-KG-PQ---RE------------------------
shark_Dmel SFSTEFSTFNADGVTGSG-AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVA
SYK_Mmus -----ESTVSFNPYEPTG-GPWGPD-RG-LQ---RE------------------------
ZAP70_Mmus -----VDTLNSDGYTPEP-ARLASS-TD--K---PR------------------------
ZAP70_Hsap -----IDTLNSDGYTPEP-ARIT-S-PD--K---PR------------------------
Shark_Spur -----FGGIRASEKT------KRKD-KE-MD---RQ------------------------
Syk_Spur -----NSSNNVNDLHLTQMGGHGWD-E--PE---HE-GE---------------------
AqueK439_Aque ------------------------------------------------------------
AqueK440_Aque -----FKTVSANSSS-------------------PS------------------------
AqueK441_Aque ------------------------------------------------------------
SYK_Hsap ---------------------------------------------ALPMDTE-------V
shark_Dmel IERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGT
SYK_Mmus ---------------------------------------------ALPMDTE-------V
ZAP70_Mmus ---------------------------------------------PMPMDTS-------V
ZAP70_Hsap ---------------------------------------------PMPMDTS-------V
Shark_Spur ---------------------------------------------RKELQKA-------I
Syk_Spur -------------------------T-------------------SIEEFVL-------V
AqueK439_Aque ------------------------------------------------------------
AqueK440_Aque ---------------------------------------------SLSGPAS-------R
AqueK441_Aque ---------------------------------------------VMPPPEE-------E
SYK_Hsap YESPYAD-PEEIRPK-----------------------EVYLDRKLLTLEDKELGSGNFG
shark_Dmel PSTPSAT-EVEAAKL-----------------------RFFIEPEKL-VLDREIGHGEFG
SYK_Mmus YESPYAD-PEEIRPK-----------------------EVYLDRSLLTLEDNELGSGNFG
ZAP70_Mmus YESPYSD-PEELKDK-----------------------KLFLKRENLLVADIELGCGNFG
ZAP70_Hsap YESPYSD-PEELKDK-----------------------KLFLKRDNLLIADIELGCGNFG
Shark_Spur HEAPGGG-SDEV---------------------------QCIDASLI-ERGNEIGQGEFG
Syk_Spur EELPSQR-PREYHDDDDKIYGVANEQEKLYDYLAKTKTTKKLDATCL-NQGDQIGKGNFG
AqueK439_Aque -----HG-PR------------------------------RIEDSEL-ETQGELGAGTFG
AqueK440_Aque SHQPHQD-PYSM---------------------------VYIQEKSL-SLGPELGQGEFG
AqueK441_Aque LDSPIIQELVQAGVR-----------------------RIHYRRELT-V-LKELG-----
::*
SYK_Hsap TVKKGYYQMKK-----VVKTVAVKI--LKNEA-NDPALKDELLAEANVMQQLDNPYIVRM
shark_Dmel SVHSGWLLRKSGAGEESRLEVAIKM--LSDE----HSNKQEFLREASVMMRLEHKCIVRL
SYK_Mmus TVKKGYYQMKK-----VVKTVAVKI--LKNEA-NDPALKDELLAEANVMQQLDNPYIVRM
ZAP70_Mmus SVRQGVYRMRK-----KQIDVAIKV--LKQGT--EKADKDEMMREAQIMHQLDNPYIVRL
ZAP70_Hsap SVRQGVYRMRK-----KQIDVAIKV--LKQGT--EKADTEEMMREAQIMHQLDNPYIVRL
Shark_Spur SVLEGKYKEKD-----RWVKVALKT--LHADH--LQTGQKEFLREAKVMCGLDHPCIVKL
Syk_Spur SVLKGTCMANG-----QLIPVAVKT--LKADF-GIPNSEPEIVREAELMAGLDHPHIVRM
AqueK439_Aque TVRQGVYRPLSG---EPPVKCALKF--LKPTE-ELPNQKAEILREADAMAMLDHPNIVRL
AqueK440_Aque SVLRGTYRMPD----GKSVDVAVKT--LRVDA--MGHGEKEFLREAKIMMGLHHPGIVQL
AqueK441_Aque -------------------SVAIKIPTFPQQTSKAQVVLDEMKREILTMYQLDHQYITTL
*:* : *: * * *.: *. :
SYK_Hsap IGICEAE--------SWMLVMEMAELGPLNKYLQQNR-HVK-------------DKNIIE
shark_Dmel IGIAKGE--------MLMMVQELAPLGSMLQYILDHGHEI-TA-----------NAELKV
SYK_Mmus IGICEAE--------SWMLVMEMAELGPLNKYLQQNR-HIK-------------DKNIIE
ZAP70_Mmus IGVCQAE--------ALMLVMEMAGGGPLHKFLLGKKEEIP-------------VSNVAE
ZAP70_Hsap IGVCQAE--------ALMLVMEMAGGGPLHKFLVGKREEIP-------------VSNVAE
Shark_Spur MGVCLGP--------PMMLVQELVSQGALLDFLQND--SIT-------------ASDLKL
Syk_Spur IGICHAA--------EMMLVLELAELGPLHKYLKKHQ-EMS-------------TRNVLE
AqueK439_Aque YGICVGD--------PIRLVMELAACGPLNKFLRKHV-GFP-------------VLKIVN
AqueK440_Aque IGVTKNK--------PLMLVQELVPCGALVDYLYDGK-YPKPE-----------IMTLKL
AqueK441_Aque LGVADERHILDTIGRFPMIVMEFIDGGSLRGILNDFR-PSRLQPRPIKPPPSDWEVRYLR
*: :* *: *.: :
SYK_Hsap LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK
shark_Dmel WASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGR
SYK_Mmus LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK
ZAP70_Mmus LLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK
ZAP70_Hsap LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK
Shark_Spur WATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGR
Syk_Spur LMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGK
AqueK439_Aque MIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGR
AqueK440_Aque WAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGR
AqueK441_Aque YSQQIAEGMDYLGSRNVVHRDLATRNVLVVSDQHVKIADFGLARQFMENRDYYRSTKRTD
::: ** ** ..******:**:*: .**:***::: . *
SYK_Hsap WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMG
shark_Dmel WPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDS-GERLP
SYK_Mmus WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMG
ZAP70_Mmus WPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQ-GKRME
ZAP70_Hsap WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ-GKRME
Shark_Spur WPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIEN-GHRLN
Syk_Spur WPLKWYAPECIYKFKFSSKSDVWSYGVTLWEALSYGKRPYASMRGQELMQFIEN-GDRLS
AqueK439_Aque WPLKWYAPECIYYAKFDSKSDVWSYGVTAWEAFSYGAKPYQGMRGTDIMQMLEG-NERLD
AqueK440_Aque WPVKWYAPESINYGTFSHASDVWSYGVTLWEMFSYGEPPYGEMTGAEVLDFIENRNGRLD
AqueK441_Aque LPVYWYAPECLIELNFKPASDVWSFGVTLWEIFTLGRRPQEFLEHVVMQA--Q-ADPRHG
*: *****.: *. ****.:** ** : * * . . *
SYK_Hsap CP----------------------AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY-
shark_Dmel QP----------------------NLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDP
SYK_Mmus CP----------------------AGCPREMYDLMNLCWTYDVENRPGFTAVELRLRNY-
ZAP70_Mmus CP----------------------PECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNY-
ZAP70_Hsap CP----------------------PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC-
Shark_Spur RP----------------------EGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMFRDDP
Syk_Spur QP----------------------DRCPDDVYSLMRRCWLSEAKDRPGFGDIESVLSDI-
AqueK439_Aque RP----------------------DKCPQAIYEIMLRCWSWRPEDRPSFGELVSTISEIA
AqueK440_Aque RP----------------------PTCPLPIYHLMLNCWSLETNQRPTFAELYDFFNKSD
AqueK441_Aque HPLQAVRKKRRETHTKLYNNRLPNIGIPDQIYRMLKETWHIDPSRRPTFSHLSDKLSRQL
* * :* :: * ** * : :
SYK_Hsap -YYDV---------------------------VN
shark_Dmel DYQNLP--------------------ELVQTVHI
SYK_Mmus -YYDV---------------------------VN
ZAP70_Mmus -YYSLASRAEGP----------PQCEQVAEAACG
ZAP70_Hsap -YYSLASKVEGP----------PGSTQKAEAACA
Shark_Spur EYGAFYH-----------------RGVHNPPSRR
Syk_Spur -LKRLQA-----------------GTLRMRTDRQ
AqueK439_Aque QFHMTQSPLSRPPMRPPRPGHNPGLPPGTPPRRM
AqueK440_Aque D---IPH-----------------KELYQNPGKL
AqueK441_Aque LLF------------------------QATSATS