MAP2K7_Hsap_MEK7 LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GN--------KEENKRILMDLDVV
MAP2K6_Hsap_MEK3 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN--------SQEQKRLLMDLDIS
MAP2K5_Hsap_MEK5 IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL-DIT--------LELQKQIMSELEIL
MAP2K4_Hsap_MEK4 LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST-VD--------EKEQKQLLMDLDVV
MAP2K3_Hsap_MEK3 LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT-VN--------SQEQKRLLMDLDIN
MAP2K2_Hsap_MEK1 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHL-EIK--------PAIRNQIIRELQVL
MAP2K1_Hsap_MEK1 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIK--------PAIRNQIIRELQVL
MAP2K7_Mmus_MEK7 LENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRS-GN--------KEENKRILMDLDVV
MAP2K6_Mmus_MEK3 LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN--------SQEQKRLLMDLDVS
MAP2K5_Mmus_MEK5 IRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILL-DIT--------LELQKQIMSELEIL
MAP2K4_Mmus_MEK4 LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST-VD--------EKEQKQLLMDLDVV
MAP2K3_Mmus_MEK3 LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT-VN--------TQEQKRLLMDLDIN
MAP2K2_Mmus_MEK1 FERISELGAGNGGVVTKARHRPSGLIMARKLIHL-EIK--------PAVRNQIIRELQVL
MAP2K1_Mmus_MEK1 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIK--------PAIRNQIIRELQVL
mkk-4_Cele_MEK4 LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCN-NIG-------HREQIRLLREHDTI
mek-2_Cele_MEK1 lqtegelghgnggvvnkcvhrktgvimarklvhl-eik--------psvrqqivkelavl
mek-1_Cele_MEK7 LQFVEDIGHGSCGTVTKCRYK--SVIMAVKTMPRT-SN--------SYEMSRILMDLDVI
jkk-1_Cele_MEK7 IHIISLLGSGSCGVVESAT-----------TMYK-NDN--------KENLKRILRDVRIM
F35C8.2_Cele_STE7-Unclassified LHGGVRIGSGEGQS-AVYRLIYNGMVIARKDVAVR-LPQGGDEDSTNKLMAKRLREVNVI
F35C8.1_Cele_STE7-Unclassified LYGGERIGNGEGQS-AVYRLIYNGKLIARKDVAVR-LPKGVDQDSTNKLMAKKLREVNVI
E02D9.1_Cele_STE7-Unclassified LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILS-QNT-------DKT---EYEKEILAY
STE7_Scer_STE7-Unclassified LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPV-EQNN-------STIINQLVRELSIV
PBS2_Scer_STE7-Unclassified LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRL-ELD--------EAKFRQILMELEVL
MKK2_Scer_STE7-Unclassified ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTD--------PEYQKQIFRELQFN
MKK1_Scer_STE7-Unclassified IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTD--------PEYQKQIFRELQFN
Dsor1_Dmel_MEK1 LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHL-EVK--------PAIKKQILRELKVL
lic_Dmel_MEK3 LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMT-VN--------IREQHRLVMDLDIS
Mkk4_Dmel_MEK4 LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRST-VD--------EKEQKQLLMDLEVV
hep_Dmel_MEK7 LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRT-GN--------AEENKRILMDLDVV
sek-1_Cele_MEK3 LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSS-IN--------DQSQKQMLNELDAC
VZC374L.1_Cele_MEK4 LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN--N--------ICDQTRLLKEHDTH
ZC449.6_Cele_MEK4 LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLI-NNG-P-DDAFNKSMQRFRLEVEAT
Mek1_Ddis_STE7-Unclassified LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITL-DIQ--------ENIRKQIILELKTL
12278_Tthe_STE7-Unclassified FETISELGRGASGRVFKVKHKETGKFYAKKEIRI-NDD--------EMFQKQLIWEIKTL
1557_Tthe_STE7-Unclassified ------------------------------------------------------------
1909_Tthe_STE7-Unclassified LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPL-LMN--------SSFRKQLDQELKTL
26687_Tthe_STE7-Unclassified FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIM-VDD--------IELRQKILMEVKTL
MEK_Spur_MEK1 FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKL-EIK--------PAIRNQIIRELKVL
MEK3_Spur_MEK3 MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQ-VN--------STEDKRILMDMDVA
MKK4_Spur_MEK4 LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRST-VD--------EKDQKQLLMDLDVV
MKK5_Spur_MEK5 ------------------------------------------------------------
MKK7_Spur_MEK7 LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRS-GN--------KEENKRILMDLDVV
CC1G_02205_Ccin_MEK1 LKKLSDLGQGNGGSVEKVEHLPTGTIMAKKSVLI-DAK--------SSVRKQILRELDIM
CC1G_03368_Ccin_MEK1 LVDIHDLGQGNGGSVKKVEHTPTKMIMAKKTVLI-DAK--------PSVRKQILRELHIM
CC1G_01983_Ccin_STE7-Unclassified FEEISRLGEGAGGAVHKVKDKRNGMIMARKTIT-T--R--------EAPMKQLLRELTIM
CC1G_14241_Ccin_STE7-Unclassified QLDDEELGRGNYGTVKKVLHKPTNVAMAMKEIRD-SIQ---------ANSPAIIMELDVL
AqueK243_Aque_MEK1 FERLSELGHGNGGVVLKVMHKPSGIIMARKMILL-DIK--------PTVRNQIMRELKVL
AqueK244_Aque_MEK4 ---VSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVT-PD--------QAKSKSLLMEWKVP
AqueK245_Aque_MEK4 LDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRAT-PD--------QAENKRLLMDYNVA
AqueK246_Aque_MEK4 LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK-DL---------RTSGGNVLELDVI
AqueK247_Aque_MEK5 ------------------------------------------------------------
AqueK248_Aque_MEK7 MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDT--------WEEQRRVLMDLEVM
STE7-p1-1_Smoe_STE7-plant1 ------IGWGASSVVRKAIHIPTHRILALKKINV-FE---------KEKRQQLLNEIRTL
STE7-p1-2_Smoe_STE7-plant1 ------IGWGASSVVRKAIHIPTHRILALKKINV-FE---------KEKRQQLLNEIRTL
STE7-p2-2_Smoe_STE7-plant2 LEAVKVIGKGSSGVVQLVRHKWTGQVFALKAIQM-NIQ--------ETMRKQIVQEIKIN
STE7-p2-1_Smoe_STE7-plant2 LEAVKVIGKGSSGVVQLVRHKWTGQVFALKAIQM-NIQ--------ETMRKQIVQEIKIN
GK083_Glam_MEK1 LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRI-SDE--------EQTQKNIYREIKAS
MAP2K7_Hsap_MEK7 LKSHDCPYIVQCFGTFITNT----DV-FIAMELMGT-CAEKLKKR---------------
MAP2K6_Hsap_MEK3 MRTVDCPFTVTFYGALFREG----DV-WICMELMDT-SLDKFYKQVID------------
MAP2K5_Hsap_MEK5 YKC-DSSYIIGFYGAFFVE----NRI-SICTEFMDGGSLDVY------------------
MAP2K4_Hsap_MEK4 MRSSDCPYIVQFYGALFREG----DC-WICMELMST-SFDKFYKYVYS------------
MAP2K3_Hsap_MEK3 MRTVDCFYTVTFYGALFREG----DV-WICMELMDT-SLDKFYRKVLD------------
MAP2K2_Hsap_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKE---------------
MAP2K1_Hsap_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKK---------------
MAP2K7_Mmus_MEK7 LKSHDCPYIVQCFGTFITNT----DV-FIAMELMGT-CAEKLKKR---------------
MAP2K6_Mmus_MEK3 MRTVDCPFTVTFYGALFREG----DV-WICMELMDT-SLDKFYKQVID------------
MAP2K5_Mmus_MEK5 YKC-DSSYIIGFYGAFFVE----NRI-SICTEFMDGGSLDVY------------------
MAP2K4_Mmus_MEK4 MRSSDCPYIVQFYGALFREG----DC-WICMELMST-SFDKFYKYVYS------------
MAP2K3_Mmus_MEK3 MRTVDCFYTVTFYGALFREG----DV-WICMELMDT-SLDKFYRKVLE------------
MAP2K2_Mmus_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKE---------------
MAP2K1_Mmus_MEK1 HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKK---------------
mkk-4_Cele_MEK4 VKSEKGPNIVKFYGAIFSEG----DC-WICMELMDI-SMDLLYKRVYM------------
mek-2_Cele_MEK1 hkc-nspfivgfygafvdn----ndi-sicmeymdglsldivlkk---------------
mek-1_Cele_MEK7 CLSFDCPYIVRCFGYFITNF----DV-RVCMECMAT-CLDRLLIR---------------
jkk-1_Cele_MEK7 -SMCNSPFIVTSYGYFMFDS----SV-KICMQIMSA-CCEKLLRRIYH------------
F35C8.2_Cele_STE7-Unclassified NGCAPCPFIVHFFGYYVHKYKDCVKI-HIFMEEMAL-SASVLKKEVLK------------
F35C8.1_Cele_STE7-Unclassified NGCAPCPFIVHFFGYYVHKYRDCVKI-HIFMEEMAL-SASVLKTEALK------------
E02D9.1_Cele_STE7-Unclassified EECSQSDYVVGYHGCEVSS----IKK-ELVLEYMDKGDFR--------------------
STE7_Scer_STE7-Unclassified KNVKPHENIITFYGAYYNQHIN-NEI-IILMEYSDCGSLDKILSVYKRFVQRG-------
PBS2_Scer_STE7-Unclassified HKC-NSPYIVDFYGAFFIE----GAV-YMCMEYMDGGSLDKIYDESS-------------
MKK2_Scer_STE7-Unclassified KSF-KSDYIVQYYGMFTDEQ-S-SSI-YIAMEYMGGKSLEATYKNLL-------------
MKK1_Scer_STE7-Unclassified RSF-QSEYIVRYYGMFTDDE-N-SSI-YIAMEYMGGRSLDAIYKNLL-------------
Dsor1_Dmel_MEK1 HEC-NFPHIVGFYGAFYSD----GEI-SICMEYMDGGSLDLILKR---------------
lic_Dmel_MEK3 MRSSDCPYTVHFYGAMYREG----DV-WICMEVMST-SLDKFYPKVFL------------
Mkk4_Dmel_MEK4 MKSNECIYIVQFYGALFKEG----DC-WICMELMDT-SLDKFYKYIYE------------
hep_Dmel_MEK7 LKSHDCKYIVKCLGCFVRDP----DV-WICMELMSM-CFDKLLKL---------------
sek-1_Cele_MEK3 RRSDCCPQMVRFYGAMFREG----DV-WICMEVMDT-SLDKFYRHAYK------------
VZC374L.1_Cele_MEK4 MKSENVPNIVKFFGACFSEG----DC-WICMELMDI-SIDFLYKRVYS------------
ZC449.6_Cele_MEK4 KAASNCDEIVRYYGITFNEG----VA-WMCMELMDL-SLDKLYMIAHD------------
Mek1_Ddis_STE7-Unclassified HK-TSYPYIVSFYDAFYTE----GSI-FIALEFMELGSLSDIMKK---------------
12278_Tthe_STE7-Unclassified FS-CNSPHIVQYYCAFYTE----CML-HLILEYMDMGTLDTILKKT--------------
1557_Tthe_STE7-Unclassified -----HPNLITCFGAYYEE----GTI-KIILELMDFGSIRNLIDML--------------
1909_Tthe_STE7-Unclassified IQ-CESDSIVKCYGAYIQK----CMI-NITLEYMDLGTVHDLVKK---------------
26687_Tthe_STE7-Unclassified FI-CQSPYIVTYYGAFYTE----GKL-HIILEYMDVGTLDSLLKKA--------------
MEK_Spur_MEK1 HEC-NSPYIVGFFGAYYSD----GEI-CICMENMDGGSLDQVMKSA--------------
MEK3_Spur_MEK3 MRSSDCVYTVEFYGALFQEG----DV-WICMEVMDT-CLDKLYKNKLK------------
MKK4_Spur_MEK4 KRSANCVYIIKFFGALFKEG----DC-WICMELMDS-SLDKFYRFVHE------------
MKK5_Spur_MEK5 -KC-DSPFIIGFYGAFFTE----NRI-SICTEFMDGGSLEMY------------------
MKK7_Spur_MEK7 LKSHNCPFIVQCLGAIVTPS----EV-WICMEQMAT-CLDKLIKK---------------
CC1G_02205_Ccin_MEK1 HEC-QSDYIISCFGSFLAE----PNI-CICMEFMDKGSFDGIYKK---------------
CC1G_03368_Ccin_MEK1 HDC-RSDYIISFYGAFLAD----NNI-CICMEFMDKGSLDGIYKK---------------
CC1G_01983_Ccin_STE7-Unclassified SST-KHVNIITFYGAYMSPS-S-SEI-KIIMEYCEGGSLESVGKRIR-------------
CC1G_14241_Ccin_STE7-Unclassified HRA-VAPEIVEFYGAFFIE----SCV-YYCMEYMDAGSLDKLIQSNSQPPQPQIPKPPSS
AqueK243_Aque_MEK1 HDC-NASYIVGFFGSFHVN----NEI-SILMQHMDGGSLDLVL-N---------------
AqueK244_Aque_MEK4 KNSVECPYTILFYGAFFCEN----DV-WICMELMDR-SLEELYHLVYD------------
AqueK245_Aque_MEK4 MRSIDCPFTITFYGALFREG----DV-WICMELMDK-SLDKLYQLVYK------------
AqueK246_Aque_MEK4 KKVKECPFIVHFYGCLLREG----HV-WICMELLDS-SMAQVSEIVYN------------
AqueK247_Aque_MEK5 ----DSQYIIGFYGSFFQE----NRI-SICTEYMDGGSLDQY------------------
AqueK248_Aque_MEK7 -NSQHSPFIVEYYGSAIVKN----EV-WVFMELMAT-CLDRLLKR---------------
STE7-p1-1_Smoe_STE7-plant1 CEAPMAKGLVEFYGAFYSPD-S-GQI-SIALEYMDGGSLADIVRN---------------
STE7-p1-2_Smoe_STE7-plant1 CEAPMAKGLVEFYGAFYSPD-S-GQI-SIALEYMDGGSLADIVRN---------------
STE7-p2-2_Smoe_STE7-plant2 QS-SQCPYVVVCYEAFYNN----GVI-SIVFEYMDGGSLLDVIKE---------------
STE7-p2-1_Smoe_STE7-plant2 QS-SQCPYVVVCYEAFYNN----GVI-SIVFEYMDGGSLLDVIKE---------------
GK083_Glam_MEK1 ISLSCNPYMVKTYNIYSHP----GSILHILLEFCKYGSSQDMLKKL--------------
: :
MAP2K7_Hsap_MEK7 --------------------------------------------------MQGPIPERIL
MAP2K6_Hsap_MEK3 --------------------------------------------------KGQTIPEDIL
MAP2K5_Hsap_MEK5 ----------------------------------------------------RKMPEHVL
MAP2K4_Hsap_MEK4 -------------------------------------------------VLDDVIPEEIL
MAP2K3_Hsap_MEK3 --------------------------------------------------KNMTIPEDIL
MAP2K2_Hsap_MEK1 ---------------------------------------------------AKRIPEEIL
MAP2K1_Hsap_MEK1 ---------------------------------------------------AGRIPEQIL
MAP2K7_Mmus_MEK7 --------------------------------------------------MQGPIPERIL
MAP2K6_Mmus_MEK3 --------------------------------------------------KGQTIPEDIL
MAP2K5_Mmus_MEK5 ----------------------------------------------------RKIPEHVL
MAP2K4_Mmus_MEK4 -------------------------------------------------VLDDVIPEEIL
MAP2K3_Mmus_MEK3 --------------------------------------------------KNMKIPEDIL
MAP2K2_Mmus_MEK1 ---------------------------------------------------AKRIPEDIL
MAP2K1_Mmus_MEK1 ---------------------------------------------------AGRIPEQIL
mkk-4_Cele_MEK4 -------------------------------------------------VKNSRLNENVV
mek-2_Cele_MEK1 ---------------------------------------------------vgrlpekfv
mek-1_Cele_MEK7 --------------------------------------------------IKQPIPERII
jkk-1_Cele_MEK7 -------------------------------------------------SKLDFFPEFVA
F35C8.2_Cele_STE7-Unclassified --------------------------------------------------RGGIVPEFVI
F35C8.1_Cele_STE7-Unclassified --------------------------------------------------QGGAIPEFVI
E02D9.1_Cele_STE7-Unclassified --------------------------------------------------PFGILPFSVH
STE7_Scer_STE7-Unclassified ----------------------------------------------TVSSKKTWFNELTI
PBS2_Scer_STE7-Unclassified --------------------------------------------------EIGGIDEPQL
MKK2_Scer_STE7-Unclassified -------------------------------------------------KRGGRISERVI
MKK1_Scer_STE7-Unclassified -------------------------------------------------ERGGRISEKVL
Dsor1_Dmel_MEK1 ---------------------------------------------------AGRIPESIL
lic_Dmel_MEK3 --------------------------------------------------HDLRMEESVL
Mkk4_Dmel_MEK4 -------------------------------------------------KQQRHIPESIL
hep_Dmel_MEK7 --------------------------------------------------SKKPVPEQIL
sek-1_Cele_MEK3 --------------------------------------------------IGKHIPEPFI
VZC374L.1_Cele_MEK4 -------------------------------------------------VKKSRLNENII
ZC449.6_Cele_MEK4 -------------------------------------------------IQKVEIPEQIL
Mek1_Ddis_STE7-Unclassified ---------------------------------------------------TSTIPEPVL
12278_Tthe_STE7-Unclassified ----------------------------------------------------KQVSEPIL
1557_Tthe_STE7-Unclassified ----------------------------------------------------KEINYCYL
1909_Tthe_STE7-Unclassified ---------------------------------------------------VGPLPEIIV
26687_Tthe_STE7-Unclassified ---------------------------------------------------GGKVSEVVL
MEK_Spur_MEK1 --------------------------------------------------PKGRIPENIL
MEK3_Spur_MEK3 -------------------------------------------------PQKIFVPENIL
MKK4_Spur_MEK4 -------------------------------------------------VQNTYIPENIM
MKK5_Spur_MEK5 ----------------------------------------------------RCIPESIL
MKK7_Spur_MEK7 --------------------------------------------------LREPVPEQII
CC1G_02205_Ccin_MEK1 ---------------------------------------------------LGPLQVEVV
CC1G_03368_Ccin_MEK1 ---------------------------------------------------IGAIDIDIV
CC1G_01983_Ccin_STE7-Unclassified -------------------------------------------------ERGAIVGEKIA
CC1G_14241_Ccin_STE7-Unclassified DPIQTDASSPEYSFAMPFVEEDLDLTKDENFEPYNRAFNRTCPPPIPSTYSGGPIPEAIL
AqueK243_Aque_MEK1 ---------------------------------------------------TGRIPVDMI
AqueK244_Aque_MEK4 -------------------------------------------------KLKESIP----
AqueK245_Aque_MEK4 -------------------------------------------------KLNEKIPEVIV
AqueK246_Aque_MEK4 -------------------------------------------------KMNERIPEDIL
AqueK247_Aque_MEK5 ----------------------------------------------------APLSETVL
AqueK248_Aque_MEK7 --------------------------------------------------LKGPIPERII
STE7-p1-1_Smoe_STE7-plant1 ---------------------------------------------------KKFIPEPIL
STE7-p1-2_Smoe_STE7-plant1 ---------------------------------------------------KKFIPEPIL
STE7-p2-2_Smoe_STE7-plant2 ---------------------------------------------------VNALPEPYL
STE7-p2-1_Smoe_STE7-plant2 ---------------------------------------------------VNALPEPYL
GK083_Glam_MEK1 --------------------------------------------------KTGKLTENAL
.
MAP2K7_Hsap_MEK7 GK------------MTVAIVKALYYLKE-KHGVIHRDVKPSNILLD-ERGQIKLCDFGIS
MAP2K6_Hsap_MEK3 GK------------IAVSIVKALEHLHS-KLSVIHRDVKPSNVLIN-ALGQVKMCDFGIS
MAP2K5_Hsap_MEK5 GR------------IAVAVVKGLTYLWS--LKILHRDVKPSNMLVN-TRGQVKLCDFGVS
MAP2K4_Hsap_MEK4 GK------------ITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGIS
MAP2K3_Hsap_MEK3 GE------------IAVSIVRALEHLHS-KLSVIHRDVKPSNVLIN-KEGHVKMCDFGIS
MAP2K2_Hsap_MEK1 GK------------VSIAVLRGLAYLRE-KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS
MAP2K1_Hsap_MEK1 GK------------VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS
MAP2K7_Mmus_MEK7 GK------------MTVAIVKALYYLKE-KHGVIHRDVKPSNILLD-ERGQIKLCDFGIS
MAP2K6_Mmus_MEK3 GK------------IAVSIVKALEHLHS-KLSVIHRDVKPSNVLIN-TLGQVKMCDFGIS
MAP2K5_Mmus_MEK5 GR------------IAVAVVKGLTYLWS--LKILHRDVKPSNMLVN-TGGQVKLCDFGVS
MAP2K4_Mmus_MEK4 GK------------ITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGIS
MAP2K3_Mmus_MEK3 GE------------IAVSIVRALEHLHS-KLSVIHRDVKPSNVLIN-KEGHVKMCDFGIS
MAP2K2_Mmus_MEK1 GK------------VSIAVLRGLAYLRE-KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS
MAP2K1_Mmus_MEK1 GK------------VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS
mkk-4_Cele_MEK4 GH------------ITVCTVDALDYLKK-ELKIIHRDVKPSNILVD-GTGAVKLCDFGIC
mek-2_Cele_MEK1 gr------------isvavvrgltylkd-eikilhrdvkpsnmlvn-sngeiklcdfgvs
mek-1_Cele_MEK7 GK------------LSVSIIKALHYLKT-KHQIMHRDVKPSNILLD-WSGVIKLCDFGIA
jkk-1_Cele_MEK7 GH------------IVYSAISALDYLKE-KHSIIHRDIKPSNILFD-DSGNVKLCDFGIS
F35C8.2_Cele_STE7-Unclassified GR------------IACSVIHAMWFLKE-KMQIIHRDIKPGNILID-YDGRVKICDFGIS
F35C8.1_Cele_STE7-Unclassified GR------------IVCSVIHAMWFLKD-RLQIIHRDIKPGNILID-YDGRVKICDFGIC
E02D9.1_Cele_STE7-Unclassified QS------------VALSLIRAIRHVWNSGPGYIHRDIKPENILVN-SQGYVKICDFGAA
STE7_Scer_STE7-Unclassified SK------------IAYGVLNGLDHLYR-QYKIIHRDIKPSNVLIN-SKGQIKLCDFGVS
PBS2_Scer_STE7-Unclassified AF------------IANAVIHGLKELKE-QHNIIHRDVKPTNILCSANQGTVKLCDFGVS
MKK2_Scer_STE7-Unclassified GK------------IAESVLRGLSYLHE-R-KVIHRDIKPQNILLN-EKGEIKLCDFGVS
MKK1_Scer_STE7-Unclassified GK------------IAEAVLRGLSYLHE-K-KVIHRDIKPQNILLN-ENGQVKLCDFGVS
Dsor1_Dmel_MEK1 GR------------ITLAVLKGLSYLRD-NHAIIHRDVKPSNILVN-SSGEIKICDFGVS
lic_Dmel_MEK3 GK------------IAMSVVSALHYLHA-QLKVIHRDVKPSNILIN-RAGQVKICDFGIS
Mkk4_Dmel_MEK4 AK------------ITVATVNALNYLKE-ELKIIHRDVKPSNILLH-RRGDIKLCDFGIS
hep_Dmel_MEK7 GK------------VTVATVNALSYLKD-KHGVIHRDVKPSNILID-ERGNIKLCDFGIS
sek-1_Cele_MEK3 GK------------MALSVIEGLNFMKE-QLNLIHRDVKPSNILLN-RHGQVKICDFGIS
VZC374L.1_Cele_MEK4 GH------------ITVCIVDALDYLKR-KLNRIHRDVKPSNILIN-AAGDVKLCDFGIC
ZC449.6_Cele_MEK4 GA------------VAVATIRALEHLKT-THHIIHRDIKPSNILLD-RHGCVKLCDFGIC
Mek1_Ddis_STE7-Unclassified GK------------IAFQVLQGLVYLHR-KLHLIHRDIKPSNILVN-NKGEAKIADFGVS
12278_Tthe_STE7-Unclassified IY------------TTYQIIKGIHYLHK-DLKIIHRDLKPGNILVN-SEGEIKISDLGIC
1557_Tthe_STE7-Unclassified SKILCNQKYQYHFFILKQLLKGLEFLHK-ERHQVHRDIKPENILIN-KRGNVKLTDFGIS
1909_Tthe_STE7-Unclassified AI------------MAIQVLKGLDYIHN-KAKVIHRDIKPSNLLVN-SKGQVKIADFGVS
26687_Tthe_STE7-Unclassified KY------------LTYQILKGLKYLHK-DLHIIHRDIKPGNILVN-SKGEIKISDLGIC
MEK_Spur_MEK1 GK------------VTVAVLRGLIYLRD-VHDIMHRDVKPSNILVN-SRGEIKLCDFGVS
MEK3_Spur_MEK3 SR------------ISFSIVSALKYLQT-RLKVIHRDVKPSNVLAN-HNGKIKLCDFGIS
MKK4_Spur_MEK4 GK------------VAYATVKALNYLKE-TLKIIHRDVKPSNILLD-RGGNIKLCDFGIS
MKK5_Spur_MEK5 GR------------MTVSIVKGLNYLWN--LKIMHRDVKPSNILVN-TQGEIKLCDFGVS
MKK7_Spur_MEK7 GK------------MVVAIVNALNYLKE-KHGVMHRDVKPSNMLLD-EKGVVKLCDFGIS
CC1G_02205_Ccin_MEK1 GM------------VALSVLEGLTYLYD-VHRIMHRDIKPSNILFN-SQGQIKLCDFGVS
CC1G_03368_Ccin_MEK1 GK------------IALAVLEGLTYLYD-VHRIIHRDIKPSNILCN-SRGQIKICDFGVS
CC1G_01983_Ccin_STE7-Unclassified GR------------LAEGVLQGLSYLHS-K-KTIHRDIKPSNILLS-KEGVVKLCDFGVS
CC1G_14241_Ccin_STE7-Unclassified GR------------IAASMVRGLKFLKD-ELNIIHRDVKPTNVLVN-CKGQVKLCDFGVS
AqueK243_Aque_MEK1 GQ------------ITVAVLNGLKYLRD-THHIIHRDVKPSNILVN-SEGEIKLCDFGVS
AqueK244_Aque_MEK4 ----------------ELTLKALTYLHD-KLNVMHRDVKPSNILIN-QNGEIKLCDFGIA
AqueK245_Aque_MEK4 GK------------MADSTLKALTYLHD-ELQVMHRDVKPSNILIN-KKGEIKLCDFGIA
AqueK246_Aque_MEK4 GK------------MTVAVINALHFLQK-ELKIIHRDVKPSNILVS-KVGEFKLCDFGIS
AqueK247_Aque_MEK5 SK------------ITAAILKGLNYLWS--IKVLHRDIKPSNMLVN-THGQIKLCDFGVS
AqueK248_Aque_MEK7 GK------------MCVSIVKALDYLKR-AHKVIHRDVKPSNILID-VNGNVKLCDFGIS
STE7-p1-1_Smoe_STE7-plant1 SV------------ITRKVLQGLQFLHG-VRHLVHRDIKPANLLIN-LIGEPKITDFGIS
STE7-p1-2_Smoe_STE7-plant1 SV------------ITRKVLQGLQFLHG-VRHLVHRDIKPANLLIN-LIGEPKITDFGIS
STE7-p2-2_Smoe_STE7-plant2 AA------------ICKQVLKGLVYLHL-DRRIIHRDIKPSNLLVN-HKGEVKITDFGVS
STE7-p2-1_Smoe_STE7-plant2 AA------------ICKQVLKGLVYLHL-DRRIIHRDIKPSNLLVN-HKGEVKITDFGVS
GK083_Glam_MEK1 AV------------FIIDTLRGLAYLHD-NCKIIHRDIKSANILID-EHGYCKLADFGVA
: .: : :***:*. *:* * *: *:* .
MAP2K7_Hsap_MEK7 GRLVD---SKAKT-RSAGCAAYMAPERIDPPDP---------------------------
MAP2K6_Hsap_MEK3 GYLVD---SVAKT-IDAGCKPYMAPERINPEL----------------------------
MAP2K5_Hsap_MEK5 TQLVN---SIAKT--YVGTNAYMAPERIS-------------------------------
MAP2K4_Hsap_MEK4 GQLVD---SIAKT-RDAGCRPYMAPERIDPSA----------------------------
MAP2K3_Hsap_MEK3 GYLVD---SVAKT-MDAGCKPYMAPERINPEL----------------------------
MAP2K2_Hsap_MEK1 GQLID---SMANS--FVGTRSYMAPERLQ-------------------------------
MAP2K1_Hsap_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
MAP2K7_Mmus_MEK7 GRLVD---SKAKT-RSAGCAAYMAPERIDPPDP---------------------------
MAP2K6_Mmus_MEK3 GYLVD---SVAKT-IDAGCKPYMAPERINPEL----------------------------
MAP2K5_Mmus_MEK5 TQLVN---SIAKT--YVGTNAYMAPERIS-------------------------------
MAP2K4_Mmus_MEK4 GQLVD---SIAKT-RDAGCRPYMAPERIDPSA----------------------------
MAP2K3_Mmus_MEK3 GYLVD---SVAKT-MDAGCKPYMAPERINPEL----------------------------
MAP2K2_Mmus_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
MAP2K1_Mmus_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
mkk-4_Cele_MEK4 GQLEE---SFAKT-HDAGCQPYLAPERITS------------------------------
mek-2_Cele_MEK1 gmlid---smans--fvgtrsymaperlt-------------------------------
mek-1_Cele_MEK7 GRLIE---SRAHS-KQAGCPLYMGPERLDPN-----------------------------
jkk-1_Cele_MEK7 GFMTD---SMAHS-KSAGCPPYMAPERLTIE-----------------------------
F35C8.2_Cele_STE7-Unclassified GILQD---SIAVS--ATGCQQYTAPEINELAMV---------------------------
F35C8.1_Cele_STE7-Unclassified GILEN---SIAVS--DTGCQQYTAPEILVKGVS---------------------------
E02D9.1_Cele_STE7-Unclassified KRIDN---TYRIASSAAGTQMYQAPEQQM-------------------------------
STE7_Scer_STE7-Unclassified KKLIN---SIADT--FVGTSTYMSPERIQ-------------------------------
PBS2_Scer_STE7-Unclassified GNLVA---SLAKT--NIGCQSYMAPERIKSLNP---------------------------
MKK2_Scer_STE7-Unclassified GEAVN---SLAMT--FTGTSFYMAPERIQ-------------------------------
MKK1_Scer_STE7-Unclassified GEAVN---SLATT--FTGTSFYMAPERIQ-------------------------------
Dsor1_Dmel_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
lic_Dmel_MEK3 GYLVD---SIAKT-IDAGCKPYMAPERIDPQG----------------------------
Mkk4_Dmel_MEK4 GQLVD---SIAKT-KDAGCRPYMAPERIDPE-----------------------------
hep_Dmel_MEK7 GRLVD---SKANT-RSAGCAAYMAPERIDPK-----------------------------
sek-1_Cele_MEK3 GHLTN---SMAKT-VQAGCKPYMPPERIDGE-----------------------------
VZC374L.1_Cele_MEK4 GDLVG---SYAIT-VEAGCVQYLAPERIEN------------------------------
ZC449.6_Cele_MEK4 GYLQN---SVAQS-VDVGCRPYMAPERLAP------------------------------
Mek1_Ddis_STE7-Unclassified GQLQH---TLSKAVTWVGTVTYMSPERIS-------------------------------
12278_Tthe_STE7-Unclassified GKVNG---TMDQKNTFVGTTIYMSPERLN-------------------------------
1557_Tthe_STE7-Unclassified KQLEK---TQQLCMTYVGTTLYMSPERLI-------------------------------
1909_Tthe_STE7-Unclassified ANLES---AVEV-KNWVGTVTYMSPERFR-------------------------------
26687_Tthe_STE7-Unclassified GAINA---TLDERQTFVGTSIYMSPERLS-------------------------------
MEK_Spur_MEK1 GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
MEK3_Spur_MEK3 GQLVN---SMAKT-QDAGSRQYMAPERIDPDM----------------------------
MKK4_Spur_MEK4 GQLVD---SIART-MDAGCKPYMAPERIDPFQ----------------------------
MKK5_Spur_MEK5 AQLVS---SITRT--YIGTNAYMAPERVL-------------------------------
MKK7_Spur_MEK7 GRLVD---SKART-RSAGCAAYMAPERIDPPDP---------------------------
CC1G_02205_Ccin_MEK1 GEVIN---SIANT--FVGTSVYMSPERIQSH-----------------------------
CC1G_03368_Ccin_MEK1 GELIN---SIADT--FVGTSTYMSPERIQ-------------------------------
CC1G_01983_Ccin_STE7-Unclassified GELIL---SQAGT--FTGTSFYMAPERIQ-------------------------------
CC1G_14241_Ccin_STE7-Unclassified GQLDK---SMAKT--NIGCQSYMAPERIRGESRVVGAVPASEGGTGTAAAAQGGVPGTAA
AqueK243_Aque_MEK1 GQLIN---SMANS--FVGTRSYMAPERLQ-------------------------------
AqueK244_Aque_MEK4 GELVD---SLAKT--DIGCRPYLAPERIDEP-----------------------------
AqueK245_Aque_MEK4 GELVN---SLAKT--DIGCRPYLAPERIYGG-----------------------------
AqueK246_Aque_MEK4 GKLVD---SIART-MDVGCRPYMAPERIDPAR----------------------------
AqueK247_Aque_MEK5 VQLMT---SLTKT--YIGTNAYMAPERIL-------------------------------
AqueK248_Aque_MEK7 GRLVD---SKAFT-RGAGAAAYMAPERINMSH----------------------------
STE7-p1-1_Smoe_STE7-plant1 AGLDN---SIAMCATFVGTVTYMSPERIN-------------------------------
STE7-p1-2_Smoe_STE7-plant1 AGLDN---SIAMCATFVGTVTYMSPERIN-------------------------------
STE7-p2-2_Smoe_STE7-plant2 AVLAN---SMGQRDTFVGTYTYMSPERIS-------------------------------
STE7-p2-1_Smoe_STE7-plant2 AVLAN---SMGQRDTFVGTYTYMSPERIS-------------------------------
GK083_Glam_MEK1 SSVLPNDDEAAM-KTFVGSLSYMSPERIQ-------------------------------
* * **
MAP2K7_Hsap_MEK7 ----TKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKN-------------------
MAP2K6_Hsap_MEK3 ----NQKGYSVKSDIWSLGITM-------IELAILRFPYDS-------------------
MAP2K5_Hsap_MEK5 -----GEQYGIHSDVWSLGISF-------MELALGRFPYPQIQKN---------------
MAP2K4_Hsap_MEK4 ----SRQGYDVRSDVWSLGITL-------YELATGRFPYPK-------------------
MAP2K3_Hsap_MEK3 ----NQKGYNVKSDVWSLGITM-------IEMAILRFPYES-------------------
MAP2K2_Hsap_MEK1 -----GTHYSVQSDIWSMGLSL-------VELAVGRYPIPPPDAKELEAIFGRPVVDGEE
MAP2K1_Hsap_MEK1 -----GTHYSVQSDIWSMGLSL-------VEMAVGRYPIPPPDAKELELMFGCQV----E
MAP2K7_Mmus_MEK7 ----TKPDYDIRADVWSLGISLQCLSPSQVELATGQFPYKN-------------------
MAP2K6_Mmus_MEK3 ----NQKGYSVKSDIWSLGITM-------IELAILRFPYDS-------------------
MAP2K5_Mmus_MEK5 -----GEQYGIHSDVWSLGISF-------MELALGRFPYPQIQKN---------------
MAP2K4_Mmus_MEK4 ----SRQGYDVRSDVWSLGITL-------YELATGRFPYPK-------------------
MAP2K3_Mmus_MEK3 ----NQKGYNVKSDVWSLGITM-------IEMAILRFPYES-------------------
MAP2K2_Mmus_MEK1 -----GTHYSVQSDIWSMGLSL-------VELAIGRYPIPPPDAKELEASFGRPVVDGAD
MAP2K1_Mmus_MEK1 -----GTHYSVQSDIWSMGLSL-------VEMAVGRYPIPPPDAKELELLFGCHV----E
mkk-4_Cele_MEK4 -----SDKYDVRSDVWSLGITL-------YEIATGKFPYQEWN-----------------
mek-2_Cele_MEK1 -----gshytissdiwsfglsl-------velligrypvpapsqaeyatmfnvae---ne
mek-1_Cele_MEK7 ----NFDSYDIRSDVWSFGVTL-------VELATGQYPYAG-------------------
jkk-1_Cele_MEK7 ----TNSKYDVRSDVWSLGITV-------YQLVTGLYPFPL-------------------
F35C8.2_Cele_STE7-Unclassified ----HSPGYSIKSDIWSLGITI-------FELATL-------------------------
F35C8.1_Cele_STE7-Unclassified ----NSPGYSIKSDIWSLGITI-------FELATLRYPYPV-------------------
E02D9.1_Cele_STE7-Unclassified -----GQDYSEKVDIWCFGLTL-------WEFAIGPNLEEYLN-----------------
STE7_Scer_STE7-Unclassified -----GNVYSIKGDVWSLGLMI-------IELVTGEFPLGGHNDT---------------
PBS2_Scer_STE7-Unclassified ----DRATYTVQSDIWSLGLSI-------LEMALGRYPYPPET-----------------
MKK2_Scer_STE7-Unclassified -----GQPYSVTCDVWSLGLTL-------LEVAGGRFPFESDKIT---------------
MKK1_Scer_STE7-Unclassified -----GQPYSVTSDVWSLGLTI-------LEVANGKFPCSSEKMA---------------
Dsor1_Dmel_MEK1 -----GTHYSVQSDIWSLGLSL-------VEMAIGMYPIPPPNTATLESIFADNAE--ES
lic_Dmel_MEK3 ----NPAQYDIRSDVWSLGIGM-------IEMATGRYPYDN-------------------
Mkk4_Dmel_MEK4 ----RAKGYDVRSDVWSLGITL-------MEVATGNFPYRK-------------------
hep_Dmel_MEK7 -----KPKYDIRADVWSLGITL-------VELATARSPYEG-------------------
sek-1_Cele_MEK3 ----TKSAYDVRADVWSLGITI-------IEIAVGTHPYAN-------------------
VZC374L.1_Cele_MEK4 -----MDKYDIRSDVWSLGITL-------YEIATGVYPYRGWS-----------------
ZC449.6_Cele_MEK4 ----NGDGYDIKSEVWSLGITM-------VEVANGKYPYDGFM-----------------
Mek1_Ddis_STE7-Unclassified -----GRSYSFDSEIWSLGLTI-------LECAIGKFPYGSNLPHQQQQPLQQQQQ--QQ
12278_Tthe_STE7-Unclassified -----GDSYTMKTDIWSVGLLL-------IEFSEGKHPIQA-------------------
1557_Tthe_STE7-Unclassified -----GNQYGLRSDIWSVGLVI-------IELATGLYPYDVKN-----------------
1909_Tthe_STE7-Unclassified -----GQAYTANTDIWSLGLTI-------CECALGTYPYFDSNQYEKK------------
26687_Tthe_STE7-Unclassified -----GESYSVKTDIWSFGLLL-------LEFSESKNPLQLNE-----------------
MEK_Spur_MEK1 -----GTHYTVQSDIWSLGLSL-------VEMAIGRYPIPAPDETALANLFGYEL---QA
MEK3_Spur_MEK3 ----SAKGYDVKSDVWSFGITM-------IEIATNAYPYER-------------------
MKK4_Spur_MEK4 ----SRPGYDIRSDVWSLGITM-------YEVATGEFPYPK-------------------
MKK5_Spur_MEK5 -----GDEYGVHSEVWSLGVFL-------LEMATGRFPYPATPRD---------------
MKK7_Spur_MEK7 ----NNPDYDVRADVWSLG-----------------------------------------
CC1G_02205_Ccin_MEK1 -----GDGYSVKSDVWSLGMSL-------VELALGAFPFTDPPDDD-DDDLSDLEG--DS
CC1G_03368_Ccin_MEK1 -----GAQYTVKSDVWSLGISL-------IELALGRFPFSQSDSDESDDEFSDASD--YE
CC1G_01983_Ccin_STE7-Unclassified -----GKEYTIRSDVWSTGISL-------LELVQNRFPFPPDL-----------------
CC1G_14241_Ccin_STE7-Unclassified LADELYGAYTVSSDVWSLGLSI-------IELGLGRYPYPPET-----------------
AqueK243_Aque_MEK1 -----GEVYSVLSDIWSLGVSL-------IEMAIGSYPIPAPPKEQLDEEMRNPP----A
AqueK244_Aque_MEK4 -----QHEYDHRSDVWSLGITM-------YEIAMGEFPYPVDT-----------------
AqueK245_Aque_MEK4 -----QHKYDHRSDVWSLGITL-------CELATGEFPYPP-------------------
AqueK246_Aque_MEK4 ----ACLGYTIQSDVWSYGITL-------VELAQGSFPYKKWN-----------------
AqueK247_Aque_MEK5 -----GGEYGVHSEIWSLGLSL-------MELSLGYFP----------------------
AqueK248_Aque_MEK7 ----DSKGYDVRADVWSLGISL-------VEMATGSAPYKFNE-----------------
STE7-p1-1_Smoe_STE7-plant1 -----NECYSYPADIWSLGLAL-------LECGTGEFPYNAS------------------
STE7-p1-2_Smoe_STE7-plant1 -----NECYSYPADIWSLGLAL-------LECGTGEFPYNAS------------------
STE7-p2-2_Smoe_STE7-plant2 -----GGAYGFESDIWSLGLTL-------LECATGRFPYLPPGQENG-------------
STE7-p2-1_Smoe_STE7-plant2 -----GGAYGFESDIWSLGLTL-------LECATGRFPYLPPGQENG-------------
GK083_Glam_MEK1 -----NQPYSYVSDVWSMGLTY-------VELLTGSYPYDNV------------------
* ::*. *
MAP2K7_Hsap_MEK7 ------------------------------------------------------------
MAP2K6_Hsap_MEK3 ------------------------------------------------------------
MAP2K5_Hsap_MEK5 ------------------------------------------------------------
MAP2K4_Hsap_MEK4 ------------------------------------------------------------
MAP2K3_Hsap_MEK3 ------------------------------------------------------------
MAP2K2_Hsap_MEK1 GEPHSISPR------PR---------PP------------------GR------------
MAP2K1_Hsap_MEK1 GDAAETPPR------PR---------TP------------------GR------------
MAP2K7_Mmus_MEK7 ------------------------------------------------------------
MAP2K6_Mmus_MEK3 ------------------------------------------------------------
MAP2K5_Mmus_MEK5 ------------------------------------------------------------
MAP2K4_Mmus_MEK4 ------------------------------------------------------------
MAP2K3_Mmus_MEK3 ------------------------------------------------------------
MAP2K2_Mmus_MEK1 GEPHSVSPR------PR---------PP------------------GR------------
MAP2K1_Mmus_MEK1 GDAAETPPR------PR---------TP------------------GR------------
mkk-4_Cele_MEK4 ------------------------------------------------------------
mek-2_Cele_MEK1 iela--dsl------e-------------------------------e------------
mek-1_Cele_MEK7 ------------------------------------------------------------
jkk-1_Cele_MEK7 ------------------------------------------------------------
F35C8.2_Cele_STE7-Unclassified ------------------------------------------------------------
F35C8.1_Cele_STE7-Unclassified ------------------------------------------------------------
E02D9.1_Cele_STE7-Unclassified ------------------------------------------------------------
STE7_Scer_STE7-Unclassified ------------------------------------------------------------
PBS2_Scer_STE7-Unclassified ------------------------------------------------------------
MKK2_Scer_STE7-Unclassified ------------------------------------------------------------
MKK1_Scer_STE7-Unclassified ------------------------------------------------------------
Dsor1_Dmel_MEK1 G-----------------------------------------------------------
lic_Dmel_MEK3 ------------------------------------------------------------
Mkk4_Dmel_MEK4 ------------------------------------------------------------
hep_Dmel_MEK7 ------------------------------------------------------------
sek-1_Cele_MEK3 ------------------------------------------------------------
VZC374L.1_Cele_MEK4 ------------------------------------------------------------
ZC449.6_Cele_MEK4 ------------------------------------------------------------
Mek1_Ddis_STE7-Unclassified -Q-QQQQPL------QQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNN
12278_Tthe_STE7-Unclassified ------------------------------------------------------------
1557_Tthe_STE7-Unclassified ------------------------------------------------------------
1909_Tthe_STE7-Unclassified ------------------------------------------------------------
26687_Tthe_STE7-Unclassified ------------------------------------------------------------
MEK_Spur_MEK1 GETKN-IRK------TR-------------------------------------------
MEK3_Spur_MEK3 ------------------------------------------------------------
MKK4_Spur_MEK4 ------------------------------------------------------------
MKK5_Spur_MEK5 ------------------------------------------------------------
MKK7_Spur_MEK7 ------------------------------------------------------------
CC1G_02205_Ccin_MEK1 S---SPSPSD--AQHQR---------TPTHRDSFLLSKKTAKRASKRR------------
CC1G_03368_Ccin_MEK1 GTL-SPQPAGSVSLADL---------PPP---------------KPRR------------
CC1G_01983_Ccin_STE7-Unclassified ------------------------------------------------------------
CC1G_14241_Ccin_STE7-Unclassified ------------------------------------------------------------
AqueK243_Aque_MEK1 GSL---PPR------R-------------------------------N------------
AqueK244_Aque_MEK4 ------------------------------------------------------------
AqueK245_Aque_MEK4 ------------------------------------------------------------
AqueK246_Aque_MEK4 ------------------------------------------------------------
AqueK247_Aque_MEK5 ------------------------------------------------------------
AqueK248_Aque_MEK7 ------------------------------------------------------------
STE7-p1-1_Smoe_STE7-plant1 ------------------------------------------------------------
STE7-p1-2_Smoe_STE7-plant1 ------------------------------------------------------------
STE7-p2-2_Smoe_STE7-plant2 ------------------------------------------------------------
STE7-p2-1_Smoe_STE7-plant2 ------------------------------------------------------------
GK083_Glam_MEK1 ------------------------------------------------------------
MAP2K7_Hsap_MEK7 ----------------------------CKTDFEVLTKVL--QEEPPLLPGH--------
MAP2K6_Hsap_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K5_Hsap_MEK5 --------------------------QGSLMPLQLLQCIV--DEDSPVLPV---------
MAP2K4_Hsap_MEK4 ----------------------------WNSVFDQLTQVV--KGDPPQLSNS-E------
MAP2K3_Hsap_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K2_Hsap_MEK1 ----------------PVS-GHGMDSRPAMAIFELLDYIV--NEPPPKLPN---------
MAP2K1_Hsap_MEK1 ----------------PLS-SYGMDSRPPMAIFELLDYIV--NEPPPKLPS---------
MAP2K7_Mmus_MEK7 ----------------------------CKTDFEVLTKVL--QEEPPLLPGH--------
MAP2K6_Mmus_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K5_Mmus_MEK5 --------------------------QGSLMPLQLLQCIV--DEDSPVLPL---------
MAP2K4_Mmus_MEK4 ----------------------------WNSVFDQLTQVV--KGDPPQLSNS-E------
MAP2K3_Mmus_MEK3 ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K2_Mmus_MEK1 ----------------PISVGHGMDSRPAMAIFELLDYIV--NEPPPKLPS---------
MAP2K1_Mmus_MEK1 ----------------PLS-SYGMDSRPPMAIFELLDYIV--NEPPPKLPS---------
mkk-4_Cele_MEK4 ------------------------------SLFDQIATVV--SGDPPILHPDSD------
mek-2_Cele_MEK1 ----------------p--nyhppsnpasmaifemldyiv--ngppptlpk---------
mek-1_Cele_MEK7 ------------------------------TEFDMMSKIL--NDEPPRLDPA--------
jkk-1_Cele_MEK7 ----------------------------NDMEFTTLTIIANLNLPSPSLREE-T------
F35C8.2_Cele_STE7-Unclassified ------------------------------------------------------------
F35C8.1_Cele_STE7-Unclassified ----------------------------GFSEFTLLSAIV--TTPAPYLERV--------
E02D9.1_Cele_STE7-Unclassified ----------------------------GLSSYEE---IT-------VEPI---------
STE7_Scer_STE7-Unclassified ----------------------------PDGILDLLQRIV--NEPSPRLPKD--------
PBS2_Scer_STE7-Unclassified ----------------------------YDNIFSQLSAIV--DGPPPRLPSD--------
MKK2_Scer_STE7-Unclassified ---------------------------QNVAPIELLTMIL--TFSP-QLKDEPEL-----
MKK1_Scer_STE7-Unclassified ---------------------------ANIAPFELLMWIL--TFTP-ELKDEPES-----
Dsor1_Dmel_MEK1 ---------------------QPTDEPRAMAIFELLDYIV--NEPPPKLEH---------
lic_Dmel_MEK3 ----------------------------WRTPFEQLRQVV--EDSPPRLPEG--------
Mkk4_Dmel_MEK4 ----------------------------WDSVFEQLCQVV--QGEPPRLLTSYN------
hep_Dmel_MEK7 ----------------------------CNTDFEVLTKVL--DSEPPCLPYG-E------
sek-1_Cele_MEK3 ----------------------------WKTPFEQLKQVV--KEPPPKLPME--------
VZC374L.1_Cele_MEK4 ------------------------------NQMEHIEIVV--NGDSPILLQNMH------
ZC449.6_Cele_MEK4 ----------------------------DAPILDQVRMVV--YGDPPILDSDH-------
Mek1_Ddis_STE7-Unclassified NNNNNNNNNVLDISNGG-LVDSGSSVPEGMGFWVLLDCIV--KEEVPILPS---------
12278_Tthe_STE7-Unclassified ----------------------------SNNFFEVLNNII--DFKIPPLK-N--------
1557_Tthe_STE7-Unclassified -----------------------------KSIVQFVSNIL--QSKEPTLPDN--------
1909_Tthe_STE7-Unclassified ---------------------------ENLSFWELLEYFN--MKPAPRLPE---------
26687_Tthe_STE7-Unclassified ----------------------------NASFFEILAKVM--NFSIPELN-S--------
MEK_Spur_MEK1 -----------------V-GGVFSDSPRPMAIFELLNYIV--EEHPPRLPS---------
MEK3_Spur_MEK3 ----------------------------WHDMFQQLTQVV--KGTSPALPKE--------
MKK4_Spur_MEK4 ----------------------------WNSVFEQLSQVV--KGDPPRLKHN-D------
MKK5_Spur_MEK5 ---------------------------QELSPIALLQCIV--EEHPPRLPS---------
MKK7_Spur_MEK7 ------------------------------------------------------------
CC1G_02205_Ccin_MEK1 ----------------SKLTYNPDGQLSTMSIFELIHQIV--QEPSPRLP-S--------
CC1G_03368_Ccin_MEK1 ----------------QKNA-NGNGSTTKKDKRKSKGHIV--NEPAPRLTPE--------
CC1G_01983_Ccin_STE7-Unclassified ------------------------------PPIELMMYIT--NSEPPRLEDEP-------
CC1G_14241_Ccin_STE7-Unclassified ----------------------------YSNVFAQLTAIV--HGPPPCLPSG--PPPPLS
AqueK243_Aque_MEK1 ----------------P---YASHANAIRMPVFELLQMIF--TDDPPRLPD---------
AqueK244_Aque_MEK4 ----------------------------LRSIFGLIEMIV--KGSPPRLTSD--------
AqueK245_Aque_MEK4 ----------------------------YRNLFEQIKLVV--EGAPPQLPDD--------
AqueK246_Aque_MEK4 ------------------------------TIFDQLNAVV--SGDPPSLPPE--------
AqueK247_Aque_MEK5 ------------------------------------------------------------
AqueK248_Aque_MEK7 ----------------------------FSSEFDLLTHIV--QAPPPLLDED--------
STE7-p1-1_Smoe_STE7-plant1 -----------------------------KGPVNLMLQVM--YDPSPAPPAD--------
STE7-p1-2_Smoe_STE7-plant1 -----------------------------KGPVNLMLQVM--YDPSPAPPAD--------
STE7-p2-2_Smoe_STE7-plant2 ----------------------------YLNFYELLETIV--EQPAPVASPE--------
STE7-p2-1_Smoe_STE7-plant2 ----------------------------YLNFYELLETIV--EQPAPVASPE--------
GK083_Glam_MEK1 -----------------------------NSFWDAMNVIV--NGAPPLLKED--------
MAP2K7_Hsap_MEK7 -------------------------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLL
MAP2K6_Hsap_MEK3 --------------------------------KFSAEFVDFTSQCLKKNSKERPTYPELM
MAP2K5_Hsap_MEK5 -------------------------------GEFSEPFVHFITQCMRKQPKERPAPEELM
MAP2K4_Hsap_MEK4 ------------------------------EREFSPSFINFVNLCLTKDESKRPKYKELL
MAP2K3_Hsap_MEK3 --------------------------------RFSPEFVDFTAQCLRKNPAERMSYLELM
MAP2K2_Hsap_MEK1 -------------------------------GVFTPDFQEFVNKCLIKNPAERADLKMLT
MAP2K1_Hsap_MEK1 -------------------------------GVFSLEFQDFVNKCLIKNPAERADLKQLM
MAP2K7_Mmus_MEK7 -------------------------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLL
MAP2K6_Mmus_MEK3 --------------------------------KFSADFVDFTSQCLKKNSKERPTYPELM
MAP2K5_Mmus_MEK5 -------------------------------GEFSEPFVHFITQCMRKQPKERPAPEELM
MAP2K4_Mmus_MEK4 ------------------------------EREFSPSFINFVNLCLTKDESKRPKYKELL
MAP2K3_Mmus_MEK3 --------------------------------QFSPEFVDFTSQCLRKNPAERMSYLELM
MAP2K2_Mmus_MEK1 -------------------------------GVFSSDFQEFVNKCLIKNPAERADLKLLM
MAP2K1_Mmus_MEK1 -------------------------------GVFSLEFQDFVNKCLIKNPAERADLKQLM
mkk-4_Cele_MEK4 ------------------------------DFHYSLPLVKFINTCLTKDRRHRPKYDTLK
mek-2_Cele_MEK1 -------------------------------rfftdevigfvskclrklpseratlkslt
mek-1_Cele_MEK7 --------------------------------KFSPDFCQLVESCLQRDPTMRPNYDMLL
jkk-1_Cele_MEK7 ------------------------------KRSFSPLFIEFLDLCLRKDVRERPEYRQLM
F35C8.2_Cele_STE7-Unclassified ------------------------------------------------------------
F35C8.1_Cele_STE7-Unclassified --------------------------------TFSNN-----------------------
E02D9.1_Cele_STE7-Unclassified -------------------------------DGFPESLAVLISNCLYSH-------TNFV
STE7_Scer_STE7-Unclassified -------------------------------RIYSKEMTDFVNRCCIKNERERSSIHELL
PBS2_Scer_STE7-Unclassified --------------------------------KFSSDAQDFVSLCLQKIPERRPTYAALT
MKK2_Scer_STE7-Unclassified ------------------------------DISWSKTFRSFIDYCLKKDARERPSPRQML
MKK1_Scer_STE7-Unclassified ------------------------------NIIWSPSFKSFIDYCLKKDSRERPSPRQMI
Dsor1_Dmel_MEK1 -------------------------------KIFSTEFKDFVDICLKKQPDERADLKTLL
lic_Dmel_MEK3 --------------------------------TFSPEFEDFIAVCLQKEYMARPNYEQLL
Mkk4_Dmel_MEK4 ------------------------------GMEFSKEFVDFVNTCLIKKESDRPKYSRLL
hep_Dmel_MEK7 ------------------------------GYNFSQQFRDFVIKCLTKNHQDRPKYPELL
sek-1_Cele_MEK3 -------------------------------SGFSVDCQYFVKRCLEKDYNERPKYPELL
VZC374L.1_Cele_MEK4 ------------------------------NLHYTDPLCRFINTCLRKNKDDRPKYVNLK
ZC449.6_Cele_MEK4 --------------------------------EVSMSMKRFIALCTIKDRNLRASFDDLK
Mek1_Ddis_STE7-Unclassified --------------------------------TFSKEFRSFISECLQKEPTERPTASNLL
12278_Tthe_STE7-Unclassified --------------------------------INSPEFTNFIEICLKSDQNERADITQLL
1557_Tthe_STE7-Unclassified -------------------------------GKYSAALMDFVKKCVAKEQKDRLDISDLL
1909_Tthe_STE7-Unclassified --------------------------------NYSEEMKDFVAKCFKKSPLDRPHSHDLL
26687_Tthe_STE7-Unclassified --------------------------------IKSKEFIQFVEQCTKINPKERADVVQLL
MEK_Spur_MEK1 -------------------------------RAFSEEFVDFVDVCLIKNPNERADLKKLK
MEK3_Spur_MEK3 --------------------------------KFSEDIQDFINKCLKKNCTERPSYTRLL
MKK4_Spur_MEK4 ------------------------------FYSYSEDFISFVNKCLTKDEKYRPKYKNLL
MKK5_Spur_MEK5 -------------------------------DKFSAPFVDFVNRCLQKRPGDRPKPQDLM
MKK7_Spur_MEK7 ------------------------------------------------------------
CC1G_02205_Ccin_MEK1 -------------------------------DKFPADAVDLVDICLLKNPEERQTPKALL
CC1G_03368_Ccin_MEK1 -------------------------------GRYPKAAESFIDACLLKDPDARQTPKDLL
CC1G_01983_Ccin_STE7-Unclassified ------------------------------GVNWSEEMKDFIKQALTVDPVDRPTPKDML
CC1G_14241_Ccin_STE7-Unclassified PDDDSSFEEPVLPPTLDDQDPLISPTTGRQRPGYSPFARDWVNKCMRKDAKERATYKELL
AqueK243_Aque_MEK1 -------------------------------EYFDDKFKSFVALCLQKDVKKRGTLSALL
AqueK244_Aque_MEK4 --------------------------------RFSGEHKDFVAQCLTKSRDSRPRYKDLN
AqueK245_Aque_MEK4 -------------------------------GTFSEDFRDFVSKCLTKERDERPRYEVLN
AqueK246_Aque_MEK4 --------------------------------NFTRELREFTAACLVKDSDQRPNYVQLQ
AqueK247_Aque_MEK5 ------------------------------------------------------------
AqueK248_Aque_MEK7 --------------------------------KFSPNFYDFVAQCLCKDVDERPQYDKLL
STE7-p1-1_Smoe_STE7-plant1 --------------------------------RFSCEFRSFVEACLRKDADTRPTAEQLL
STE7-p1-2_Smoe_STE7-plant1 --------------------------------RFSCEFRSFVEACLRKDADTRPTAEQLL
STE7-p2-2_Smoe_STE7-plant2 --------------------------------MFSAEFCSLISACIQKEPKDRMTAAELL
STE7-p2-1_Smoe_STE7-plant2 --------------------------------MFSAEFCSLISACIQKEPKDRMTAAELL
GK083_Glam_MEK1 -------------------------------AGYSPGLCDLVNAMLEKDPSKRMTAAQLL
MAP2K7_Hsap_MEK7 ----------EHSFI
MAP2K6_Hsap_MEK3 ----------QHPFF
MAP2K5_Hsap_MEK5 ----------GHPFI
MAP2K4_Hsap_MEK4 ----------KHPFI
MAP2K3_Hsap_MEK3 ----------EHPFF
MAP2K2_Hsap_MEK1 ----------NHTFI
MAP2K1_Hsap_MEK1 ----------VHAFI
MAP2K7_Mmus_MEK7 ----------EHSFI
MAP2K6_Mmus_MEK3 ----------QHPFF
MAP2K5_Mmus_MEK5 ----------GHPFI
MAP2K4_Mmus_MEK4 ----------KHPFI
MAP2K3_Mmus_MEK3 ----------EHPFF
MAP2K2_Mmus_MEK1 ----------NHAFI
MAP2K1_Mmus_MEK1 ----------VHAFI
mkk-4_Cele_MEK4 ----------SFDFY
mek-2_Cele_MEK1 ----------advff
mek-1_Cele_MEK7 ----------QHPFV
jkk-1_Cele_MEK7 ----------KHDFY
F35C8.2_Cele_STE7-Unclassified --------------T
F35C8.1_Cele_STE7-Unclassified --------------Y
E02D9.1_Cele_STE7-Unclassified ----------KMFFL
STE7_Scer_STE7-Unclassified ----------HHDLI
PBS2_Scer_STE7-Unclassified ----------EHPWL
MKK2_Scer_STE7-Unclassified ----------KHPWI
MKK1_Scer_STE7-Unclassified ----------NHPWI
Dsor1_Dmel_MEK1 ----------SHPWI
lic_Dmel_MEK3 ----------KHSFI
Mkk4_Dmel_MEK4 ----------EMPFI
hep_Dmel_MEK7 ----------AQPFI
sek-1_Cele_MEK3 ----------AMPFM
VZC374L.1_Cele_MEK4 ----------TFSFY
ZC449.6_Cele_MEK4 ----------K---T
Mek1_Ddis_STE7-Unclassified ----------NHEFV
12278_Tthe_STE7-Unclassified VNTTSFSSFNEHPFL
1557_Tthe_STE7-Unclassified ----------KHEWI
1909_Tthe_STE7-Unclassified ----------NHEMV
26687_Tthe_STE7-Unclassified ----------ELPFV
MEK_Spur_MEK1 ----------VHTFA
MEK3_Spur_MEK3 ----------EHEFI
MKK4_Spur_MEK4 ----------EYKFI
MKK5_Spur_MEK5 ----------QHPFI
MKK7_Spur_MEK7 --------------I
CC1G_02205_Ccin_MEK1 --------VRNHPWI
CC1G_03368_Ccin_MEK1 ----------KHEWI
CC1G_01983_Ccin_STE7-Unclassified ----------EHPWI
CC1G_14241_Ccin_STE7-Unclassified ----------EHPWL
AqueK243_Aque_MEK1 ----------EHKFV
AqueK244_Aque_MEK4 ----------AHSFI
AqueK245_Aque_MEK4 ----------GHKFI
AqueK246_Aque_MEK4 ----------EKEFF
AqueK247_Aque_MEK5 --------------Y
AqueK248_Aque_MEK7 ----------LHPLI
STE7-p1-1_Smoe_STE7-plant1 ----------QHPFI
STE7-p1-2_Smoe_STE7-plant1 ----------QHPFI
STE7-p2-2_Smoe_STE7-plant2 ----------KHPFI
STE7-p2-1_Smoe_STE7-plant2 ----------KHPFI
GK083_Glam_MEK1 ----------KLPFC