SgK288_Hsap ---WRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPP---DAASSDVNYLIEEAAK-MKK
RIPK3_Hsap LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSK-------------AISREVKA-MAS
RIPK2_Hsap LADLRYLSRGASGTVSSARHADWRVQVAVKHLHI-HT---PLLDSERKDVLREAEI-LHK
RIPK1_Hsap FLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNC-----IEHNEALLEEA-KMMNR
ANKRD3_Mmus FAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH-----VDDRERMELLEEAKK-MEM
ANKRD3_Hsap FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH-----VDDRERMELLEEAKK-MEM
RIPK1_Mmus LLEKTDLDSGGFGKVSLCYHRSHG-FVILKKVYTGPNR-----AEYNEVLLEEG-KMMHR
RIPK2_Mmus LADLHYLSRGASGTVSSARHADWRVRVAVKHLHI-HT---PLLDSERNDILREAEI-LHK
RIPK3_Mmus LKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSK-------------KISWEVKA-MVN
SgK288_Mmus ---WHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQK---ETTSSEVTCLFEEAVK-MEK
ANKK2_Spur ------LGGGSFGEVFKAVHKVHG-DVAVKLAKPGKGDQL------K-MHQKEARKHGLS
ANKK1_Spur ------LGGGSFGEVYKAVHKVHG-DVAVKLAKPGKEDQV------VLMYQKEAGKHVLS
ANKK3_Spur ------LGGGSFGEVYKATHAVHG-DVAVKLAKPGKERQV------E-MYQKEARKHENS
ANKK6_Spur ------LGGGSFGEVFKATHKVHG-EVAVKLAKPGXXXXXXXXXXXXXXXXXXXXXXX--
ank2_Spur ------LGGGSFGEVYKATHTVHD-DVAVKLAKPGKEGQV------V-MYQKEARKHENS
ANKK5_Spur ------LGGGSFGEVFKATHAVHG-DVAVKLAKG----QV------V-MYQKEAQKHENS
ank1_Spur ------LGGGSFGEVFKAVHAVHG-DVAVKLAKPGKERQLEMYKKQVVMYQKEAQKHENS
ANKK4_Spur ------LGGGSFGEVYKATHAVHG-DVAVKLAKPGKEDQV------K-MYKKEARKHENS
: *. . * * :*
SgK288_Hsap IKFQHIVSIYGVCKQ---------PLGIVMEFMANGSLEKVLSTH---------------
RIPK3_Hsap LDNEFVLRLEGVIEKVNW-DQD-PKPALVTKFMENGSLSGLLQSQ---------------
RIPK2_Hsap ARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRK-T-------------
RIPK1_Hsap LRHSRVVKLLGVIIEE-------GKYSLVMEYMEKGNLMHVLKAE---------------
ANKRD3_Mmus AKFRYILPVYGICQE---------PVGLVMEYMETGSLEKLLASE---------------
ANKRD3_Hsap AKFRYILPVYGICRE---------PVGLVMEYMETGSLEKLLASE---------------
RIPK1_Mmus LRHSRVVKLLGIIIEE-------GNYSLVMEYMEKGNLMHVLKTQ---------------
RIPK2_Mmus ARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRK-T-------------
RIPK3_Mmus LRNENVLLLLGVTEDLQW-DFV-SGQALVTRFMENGSLAGLLQPE---------------
SgK288_Mmus IKFQHIVSIYGVCKQ---------PLGIVMEFMASGSLEKTLPTH---------------
ANKK2_Spur LTCDYIVAIKGFVKCEEDTCPC-GLLGIVMQYMENGSLWDFRISEWQ-------------
ANKK1_Spur LTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHGSLWDFRISKWQ-------------
ANKK3_Spur LICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQ-------------
ANKK6_Spur -----XXXXXXXXXXXXXXXXX-XLFGIVMKYMENGSLWDFRKRRWQ-------------
ank2_Spur LICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWL-------------
ANKK5_Spur LICEHIVSIKGFVECKDDACTC-GLIGIVMTYMENGSLWDFRTTKWL-------------
ank1_Spur LKCEHIVPIKGFVQCEDKACDC-ELFGIVIQYMKNGSLWNFRTTKWRQHPDHLDFRTTKL
ANKK4_Spur LICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQ-------------
.:* :* *.* .
SgK288_Hsap ---SL-CWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKW
RIPK3_Hsap --CPR-PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF
RIPK2_Hsap -EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKW
RIPK1_Hsap --MST-PLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVDNDFHIKIADLGLASF
ANKRD3_Mmus ---PL-PWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKC
ANKRD3_Hsap ---PL-PWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKC
RIPK1_Mmus --IDV-PLSLKGRIIVEAIEGMCYLHDK--GVIHKDLKPENILVDRDFHIKIADLGVASF
RIPK2_Mmus -EYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKW
RIPK3_Mmus --CPR-PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTF
SgK288_Mmus ---SL-CWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKW
ANKK2_Spur -PFPD-LWPLTNRMVYQISCGMHFLHSK--NIIHRDLKLENVLVDGDLHVKIADLGLATN
ANKK1_Spur -DRPD-LWPLTNRMVHQISSGMHFLHSK--DIIHRDLKLENVLVDGNLNVKVADLGLATN
ANKK3_Spur -QHPD-LLPLTNRMVYEMSSGMQFLHSK--DIIHRDLKLENVLVDGDLHVKIADLGLATN
ANKK6_Spur -DHPD-LWPLTNR-VYEISCGMHFLHSN--DIIHRDLKLENVLVDGNLHAKIADLGLAAD
ank2_Spur -QHPD-LLPLINRMVYEMSSGMQFLHSK--DIIHRDLKLENVLVDGDLHVKIADLGLATN
ANKK5_Spur -HHPD-LWPLTNRMIYQISCGMHFLHSN--DIIHRDLKLENVLVDGDLNVKISDLGLATN
ank1_Spur LHHPD-LWPLTNRMVYQISRGMHFLHSK--YIIHRDLKLENVLVDRNLNVKIADLGLATN
ANKK4_Spur -QHPD-LLPLTNRMVYEMSSGMQFLHSK--DIIHRDLKLENVLVDGDLHVKIADLGLATN
: * : : .: :** ::* *** *:*:* . : *::*:*::
SgK288_Hsap MEQSTRMQ----------YIER-SALRGMLSYIPPEMFLES----NKAPGPKYDVYS-FA
RIPK3_Hsap QGGSQSGT-------------GSGEPGGTLGYLAPELFVNV----NRKASTASDVYS-FG
RIPK2_Hsap RMMSLSQS---------RSSK-SAPEGGTIIYMPPENYEPG---QKSRASIKHDIYS-YA
RIPK1_Hsap KMWSKLNNEEHNELRE-VDGTA-KKNGGTLYYMAPEHLND----VNAKPTEKSDVYS-FA
ANKRD3_Mmus NGMSHSHD-----------LSM-DGLFGTIAYLPPERIREK----SRLFDTKHDVYS-FA
ANKRD3_Hsap NGLSHSHD-----------LSM-DGLFGTIAYLPPERIREK----SRLFDTKHDVYS-FA
RIPK1_Mmus KTWSKLTKEKDNKQKEVSSTTK-KNNGGTLYYMAPEHLND----INAKPTEKSDVYS-FG
RIPK2_Mmus RMMSLSQS---------RSYK-SAPEGGTIIYMPPENYEPG---QKSRASVKHDIYS-YA
RIPK3_Mmus QGGSQSGS---------GSGSGSRDSGGTLAYLDPELLFDV----NLKASKASDVYS-FG
SgK288_Mmus MEQSTQKQ----------YIER-SALRGTLSYIPPEMFLEN----NKAPGPEYDVYS-FA
ANKK2_Spur LQTS----------------SG-DRCWGTDSHKPPEAFRTDLPNSTKVVTPKYDVYS-FA
ANKK1_Spur LQTS----------------FG-DERCGTNSHKPPEAFRTDLPNSTKVVTPEYDVYS-FA
ANKK3_Spur LQTS----------------FG-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDV-----
ANKK6_Spur LRTS----------------FG-DRCWGTDSHKPPEAFRTDLSKSIKVVNPKYDVYS-FA
ank2_Spur LQTS----------------FG-DRCWGTDSHKPPEAFRTDLPNSTK-------------
ANKK5_Spur LQTS----------------FG-DRCWGTDSHKPPEAFRTDLPDSTKVVTPKYDVYREFE
ank1_Spur LQTS----------------SV-L------------------------------------
ANKK4_Spur LQTS----------------FG-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDVYS-FA
*
SgK288_Hsap IVIWELLTQKKPYSGF-NMMMIIIRVAAGMRPSLQP--VSDQWPSE--AQQMVDLMKRCW
RIPK3_Hsap ILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLKELMQLCW
RIPK2_Hsap VITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHR---ARMISLIESGW
RIPK1_Hsap VVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDD--ITEYCPR-----EIISLMKLCW
ANKRD3_Mmus IVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPP--ICRPRPRA--CASLIGLMQRCW
ANKRD3_Hsap IVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPP--VCRARPRA--CSHLIRLMQRCW
RIPK1_Mmus IVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEE--ILEYCPR-----EIISLMERCW
RIPK2_Mmus VIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHR---GLMISLIQSGW
RIPK3_Mmus ILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTE--LPPGSPETPGLEKLKELMIHCW
SgK288_Mmus IVIWEILTQKKPYAGL-NMMTIIIRVAAGMRPSLQD--VSDEWPEE--VHQMVNLMKRCW
ANKK2_Spur MTLYELLTGIHPYSDRGFDMMKLLKVEAKQPPCLQP--VPVNAPK-----DLIEVMQECW
ANKK1_Spur MTLYELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQP--IPASTPE-----DLIRVMEESW
ANKK3_Spur ------------------------------------------------------------
ANKK6_Spur MTLYELLTGIHPYAERGLEMVKVFKL-SDQAPCLKP--VPVNTPT-----PLIKVMTDSW
ank2_Spur ------------------------------------------------------------
ANKK5_Spur FVKQQKVDNTTPC--------------------EDP--VPENTPE-----ALIEVMRDSW
ank1_Spur -------------------------------------------------------LDLLW
ANKK4_Spur MTLYELLTGIHPY-----------------------------------------------
SgK288_Hsap DQDPKKRPCF----------------------------L
RIPK3_Hsap SSEPKDRPSFQECLPKTD------------------EVF
RIPK2_Hsap AQNPDERPSF----------------------------L
RIPK1_Hsap EANPEARPTFPGIEE----------------------KF
ANKRD3_Mmus HADPQVRPTFQEITSE--------------------TED
ANKRD3_Hsap QGDPRVRPTFQEITSE--------------------TED
RIPK1_Mmus QAIPEDRPTFLGIEE----------------------EF
RIPK2_Mmus AQNPDERPSF----------------------------L
RIPK3_Mmus GSQSENRPSFQDCEPKTN------------------EVY
SgK288_Mmus DQDPKKRPCF----------------------------L
ANKK2_Spur SYEANERPNFREIRDRVKN-LGTEPTYASLGFYLGEQVV
ANKK1_Spur SYEPNDRPNFREITE----------------------WV
ANKK3_Spur --------------------------------------Y
ANKK6_Spur RYAANSRPAFIEITDWVKNQLNIKPTHRSLG---ICLGE
ank2_Spur --------------------------------------I
ANKK5_Spur SYEANDRPN-----------------------------F
ank1_Spur --------------------------------------G
ANKK4_Spur --------------------------------------S