PKN3_Hsap MEE-GAPR----------------------------------------------------
PKN2_Hsap MASN-PERG--------------------------EILL---------------------
PKN1_Hsap MAEA-NNPS-----------------------------E---------------------
CG2049_Dmel MSKL-VKRI--------------------------RSMI---------------------
PKN3_Mmus MEPEGAVR----------------------------------------------------
PKN2_Mmus MASN-PDRG--------------------------EILL---------------------
PKN1_Mmus MAAD-P-PL-----------------------------D---------------------
F46F6.2_Cele MDYH-SNGNG--------------------------I-----------------------
PKN_Spur MLQD-SKTK---------------------------------------------------
AqueK022_Aque MLIA-VTFSAFLKIEIVCIYGITAKKKRIEKRDRGEKLKSFACYLRPLLCLPLSSIKVNQ
*
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap ---TE-------------------------------------------------------
PKN1_Hsap ---QE-------------------------------------------------------
CG2049_Dmel ---NPSSQRDREDTTSVSASEGFIARRKCHS-----------------------LPRRSN
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus ---TE-------------------------------------------------------
PKN1_Mmus ---SE-------------------------------------------------------
F46F6.2_Cele ---NGMNGSSR----------------------------------HSADGPST--PTHSG
PKN_Spur ------------------------------------------------------------
AqueK022_Aque ALLYSMSSDLTSSLSSWRASV--------HLLLRHIWSLWYYKKAEEASEPSSCLPDSLF
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap -------------------------------------------------------LQG--
PKN1_Hsap -------------------------------------------------------LES--
CG2049_Dmel RHSTARRSNSGLWNRLVTNVFGPEDSYDFDNEGDSGGAVFYTDSVNGSN--YEISAEGE-
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus -------------------------------------------------------LQG--
PKN1_Mmus -------------------------------------------------------LES--
F46F6.2_Cele ---------------------------------------------NG-----HSNGEGNS
PKN_Spur ------------------------------------------------------------
AqueK022_Aque ---------------------------------------------AGSTVCFLSGCHGE-
PKN3_Hsap --------------------------Q-PGPSQWPPEDEKEVIRRAIQKELKIKEGVENL
PKN2_Hsap -----DSRSLPFSENVSAVQKLDF---SDTMVQQKLDDIKDRIKREIRKELKIKEGAENL
PKN1_Hsap -----EPRSWSLLEQLGL-AGADL---AAPGVQQQLELERERLRREIRKELKLKEGAENL
CG2049_Dmel --YIKHPVLYELSHKYGF-T-ENL---PESCMSIRLEEIKEAIRREIRKELKIKEGAEKL
PKN3_Mmus --------------------------Q-PGTGQRAPKDEKEMVRRAIQKELKIKEGMENM
PKN2_Mmus -----DSRTLPFSENVSAVQKLDF---SDTMVQQKLDDIKDRIKREIRKELKIKEGAENL
PKN1_Mmus -----EPRSWSLLEQLGL-AGADL---AAPGVQQQLELERERLKREIRKELKLKEGAENL
F46F6.2_Cele TYWETAP--AEMVELAD---KYNFTINEGSSIQQEALELRSVIRKDLTKKLKIKSGYSRI
PKN_Spur ---------------------------------------IEFIRMQI---LKT-QQAQQS
AqueK022_Aque --KE-RP--AXLLKYSGF-NWKQI-LDMDGGNALDLDTLKESLRLEIRKEFKIKEGAENL
. :: : :* . ..
PKN3_Hsap RRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGP----AE------
PKN2_Hsap RKVTTDK-KSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCP-RT------
PKN1_Hsap RRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGP-QS------
CG2049_Dmel REVAKDR-RSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACI
PKN3_Mmus RRVATDR-RHLGHVQQLLRASNRRLEQLHGELRELHAQVLLPASA--------E------
PKN2_Mmus RKVTTDK-KNLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDSTDCP-RT------
PKN1_Mmus RRATTDLGRSLAPVELLLRGSARRLDLLHQQLQELHAHVVLPDPAAGSDAT-QS------
F46F6.2_Cele KLITSDR-RQSEFLRYELSDLNEQIADLQEDLQALEMYNSGAFDEDVMYLD---------
PKN_Spur RQIPTGE-KEAGEVSDMGF---RRTSAVELQLTP--------------------------
AqueK022_Aque LKVTRDK-KARAHVGSILKTCTERIDQLRSDLTALLAQVPDE--EDATEVP--V------
. . : : : :. .*
PKN3_Hsap -------------------PVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHT
PKN2_Hsap -------------------PDTPNNDPRCS-TSNNRLKALQKQLDIELKVKQGAENMIQM
PKN1_Hsap -------------------PGA--GGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQT
CG2049_Dmel DPNGGFLVSGAVGGLGGGNTALEGGAP--ATANDKVLASLEKQLQIEMKVKTGAENMIQS
PKN3_Mmus -------------------PVTSEPQPRAEQSRARLSEALHRQLQVELKVKQGAENMIHT
PKN2_Mmus -------------------PDTPNSDSRSS-TSNNRLMALQKQLDIELKVKQGAENMIQM
PKN1_Mmus -------------------LAE--GSPICSSTNLSRVAGLEKQLAIELKVKQGAENMIQT
F46F6.2_Cele --------------------NLED--CDVENGPPSKLVILQLELEKELKVKRGLEQFLR-
PKN_Spur --------------------------------IEFRVEEVRHHYKVELALVEGFKNVIKM
AqueK022_Aque -------------------PGSPP--AQRRSNQSQAITDLDRQLEIEQKVKAGAENMIKM
: . * : * ::. :
PKN3_Hsap CASG-TPKERKLLAAA-QQMLRDSQLKVALLRMKISSLEA--------------------
PKN2_Hsap YSNG-SSKDRKLHGTA-QQLLQDSKTKIEVIRMQILQAVQT---NELA------------
PKN1_Hsap YSNG-STKDRKLLLTA-QQMLQDSKTKIDIIRMQLRRALQA---GQLENQ----------
CG2049_Dmel LG---IGCDKKLLAEA-HQMLADSKAKIEFLRLRIIKVKQN---REQADRLKASRQMIDE
PKN3_Mmus CASG-TPKERKLLAAA-QQMLKDSQLKVALLRMKISSLES--------------------
PKN2_Mmus YSNG-SSKDRKLHGTA-QQLLQDSKTKIEVIRMQILQAVQT---NELA------------
PKN1_Mmus YSNG-SSKDRKLLLTA-QQMLQDSKTKIDIIRMQLRRALQALQAGELESQ----------
F46F6.2_Cele ---G-APDKSKVHGDS-QSLLDDSRAKIAMLRMQIERLSQE---APAV-E----------
PKN_Spur YNNA-KTSDKKGLAERGFKLCHYGFRRTSAVELQ--------------------------
AqueK022_Aque YSNAKSSKDRKLLVEA-QQMYSDSRTKIEVLRMRIMKTKSA---LSSSPE----------
. * .: . : :.::
PKN3_Hsap -----------SGSPEP-GPELLAEELQHRLHVEAAVAEGAKNVVKLLS-SRRTQDRKAL
PKN2_Hsap -------FD--NAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLG-SGKVTDRKAL
PKN1_Hsap -----AAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLS-AAKAPDRKAV
CG2049_Dmel HGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKAL
PKN3_Mmus -----------SGSPEP-GPDLLAEELQHRLRVEAAVAAGAKNVVKLLG-GQRMQDRKAL
PKN2_Mmus -------FD--NAKPVISPLELRMEELRHHFKIEFAVAEGAKNVMKLLG-SGKVTDRKAL
PKN1_Mmus -----AAPDEAQGDPELGAVELRIEELRHHFRVEHAVAEGAKNVLRLLS-GAKAPDRKAV
F46F6.2_Cele ------------GEPK-TKVELAIDDLIIRFHKEKLIMDGSRNMIRILR-SKRKPDSKAV
PKN_Spur ----------------LTPIEFRVEEVRHHYKVELALVEGFKNVIKMYN-NAKTSDKKGL
AqueK022_Aque -----KGEDTHFGRNLLSKPEGRVSYIRYRIDVESRLIEGARKIMRA------NPNSKAY
: . : : * : * ::::: : *.
PKN3_Hsap AEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAV-PGY----------
PKN2_Hsap SEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSP---RQS-
PKN1_Hsap SEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAA-SSAAFST---RLA-
CG2049_Dmel QEAHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQLSTSPAP-VTYTSL
PKN3_Mmus AEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTQELWMAM-LGN----------
PKN2_Mmus SEAQARFNESSQKLDLLKYSLEQRLNELPRNHPKSSVVIEELSLV-ASPTLSP---RQS-
PKN1_Mmus SEAQEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREELTAA-SSSAFSA---ILP-
F46F6.2_Cele DEAMNSYVIASEKADLIKLALLKYASSLPLEHDHRKYLIGEINSGL-IPKPPSLSQDRNS
PKN_Spur AEAQKGLVEASHKLDILREGLEKRIQELPPDQTRFNQIKEELKSGK-I------------
AqueK022_Aque STAGENEKLSAQKLKLLKLSLENRLTEFPHLAEDSK------------EDPA--------
* : .* ::: .* .*
PKN3_Hsap ------------PQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAAL--------
PKN2_Hsap --------MISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSV--------
PKN1_Hsap --------GPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSM---------
CG2049_Dmel QSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRSRRDKD--------
PKN3_Mmus ------------PQPLGTLVKPIALTGTLQVRLLGCKDLLVAVPGRSPMAVL--------
PKN2_Mmus --------MLSTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSV--------
PKN1_Mmus --------GPFPATHYSTLSKPAPLTGTLEVRVVGCKNLPETIPWSPPPSV---------
F46F6.2_Cele PSSEDGGNGTSTSRRCSFMPYSLQISGCLEVTINGCAGILSEVFERKIRK----------
PKN_Spur -------------KSDNPLPKPAALTGVLEVRIMGCQDLQEMIPYRARNSIT--------
AqueK022_Aque ---------------SILIPRPAQLTGTLTIKLLGCEGLVDIVTLRMNYGLDTLSSHTRP
::* * : : ** : :
PKN3_Hsap ----------------------------------AS-SPS-----EGW-----L------
PKN2_Hsap --------------------------------ALPGWSPS-----ETR--SSFMSRT---
PKN1_Hsap --------------------------------GGPG-TP------DSR--PPFLSRPARG
CG2049_Dmel ---------------------------------NNS-SPG-----DLR--SFV-----KG
PKN3_Mmus ----------------------------------AG-SPS-----ESW-----L------
PKN2_Mmus --------------------------------ALPGWSPS-----DNR--SSFMSRT---
PKN1_Mmus --------------------------------GASG-TP------ESR--TPFLSRPARG
F46F6.2_Cele --------------------------------DVPG-VPGFIS-------VYG-------
PKN_Spur ---------------------------------SLN-SPS-----ESK--GGILR----G
AqueK022_Aque TTGSLLSHIMTLPRSHRSNSTPQADLERDLESSAPT-TSGYSSSTMAWNRPRGGSRHNKL
.
PKN3_Hsap ---RT---KAKHQR-GRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERAR
PKN2_Hsap --SKSKSGSSRNLLK-TDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSR
PKN1_Hsap LYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERAR
CG2049_Dmel VTSRSS---SKSYS-VKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSR
PKN3_Mmus ---RT---RSRQQR-GGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQSFIISLDRAR
PKN2_Mmus --SKSKSGSSRNLLK-TDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSR
PKN1_Mmus LYSRSGSLSGRSSLRGEAENATEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERAR
F46F6.2_Cele ---MDASGKKKKSAR-GPNSSEEVFCVLRIDNRFIGATELRKIVDRNWDQKFDVDLDRSR
PKN_Spur KASFHGRSSSRSSS-TKEEISNEISAIMKLDSVLVGQTPFKPISNQCWDQKFLFNLDKAR
AqueK022_Aque KGSLSKQPSAQDLLD-DALPGGTICAVLSMDNKEVGRTKWSPPSNTAWEQQYRLELDRNR
: : :: :*. :* * *:* : . *:: *
PKN3_Hsap ELEIGVHWRDW--RQLCGVAFLRLEDFLDNA-CHQLSLSLVPQGLLFAQVTFCDPVIE-R
PKN2_Hsap ELEISVYWRDW--RSLCAVKFLRLEDFLDNQ-RHGMCLYLEPQGTLFAEVTFFNPVIE-R
PKN1_Hsap ELELAVFWRDQ--RGLCALKFLKLEDFLDNE-RHEVQLDMEPQGCLVAEVTFRNPVIE-R
CG2049_Dmel ELEIGVYWRDW--RSLCAVKVLRLEEFIDDV-RHGMALQLEPQGLLFAEVKFLNPMIS-Q
PKN3_Mmus ELEIGVHWRDW--RQLCGVAFLKLEDFLDNA-CHQLSLSLVPQGRLFAQVTFCEPVIE-R
PKN2_Mmus ELEISVYWRDW--RSLCAVKFLRLEDFLDNQ-RHGMCLYLEPQGTLFAEVTFFNPVIE-R
PKN1_Mmus ELELAVFWRDQ--RGLCALKFLKLEDFLDNE-RHEVQLDMEPQGCLVAEVTFRNPIIE-R
F46F6.2_Cele ELQIELFYHDD--RSMCGFAAVKLSNLIETSSKVGIIVPVEPQGNIFVQFKYMNPVVS-R
PKN_Spur ELEINVRWKDQ--RSLCAVKFLRLEDFLDNQ-RHGMCLNLEPEGLLFTEITFTTPVIE-R
AqueK022_Aque ELEICVRYRDDEGESLCGVLYLRLEDFLSTP-SSILCIPMEPQGILLAEISYEDPKTELR
**:: : ::* . :*.. ::*.:::. : : : *:* :..:..: * . :
PKN3_Hsap RPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLL-PPCSSPSTISPPKGCPRTP
PKN2_Hsap RPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAI-PTVNHSGTFSPQAPVPTTV
PKN1_Hsap IPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLI-PNATGTGTFSPGASPGSEA
CG2049_Dmel KPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNA-PNHVHMGSAGSGSSLTGSS
PKN3_Mmus RPRLQRQRCIFSKRRGRDFMRASQMNLSMAAWGRLVMSLL-PPCSSPNTASPPKGRPSTA
PKN2_Mmus RPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAI-PTVNHSGTFSPQTPVPATV
PKN1_Mmus IPRLQRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLI-PSAVATGTFSPNASPGAEI
F46F6.2_Cele KPKLERQRRLFRVKE---SNDGARQKLGVFAFSRLIKNRGNEPSEKFAAFTG-FTPMPSS
PKN_Spur RTKLRRQRKIFPKHKGKNFLRAGQMNINVATWGRLMKRSI-PSSLTPSGTSPPTAIRPRP
AqueK022_Aque QPKLKRNRKIFKGGK---ILRPSEINTNIATWSRLLSRAA-PAITAGADLASPMGGASGA
.:*.*:. :* . . : .: :: **:
PKN3_Hsap -----------------TTL-REA-----------SDPATP-------------------
PKN2_Hsap -----------------PVVDVRI-----------PQLAPP-A-----------------
PKN1_Hsap R----------------TTGDISV-----------EKLNLGTD-----------------
CG2049_Dmel PMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPA
PKN3_Mmus -----------------V---CGT-----------PSAASP-------------------
PKN2_Mmus -----------------PVVDARI-----------PDLAPP-A-----------------
PKN1_Mmus R----------------HTGDISM-----------EKLNLGAD-----------------
F46F6.2_Cele S------------------SQHQP-----------GT-----------------------
PKN_Spur -----------------PI----------------QRLSFGEA-----------------
AqueK022_Aque K----------------SSGNLKP-----------VTLNFDS------------------
PKN3_Hsap ------------------------------------------------SNFLPKKTPLGE
PKN2_Hsap ------------------------------------------------SDSTVTKLDFDL
PKN1_Hsap ------------------------------------------------SDSSPQK-----
CG2049_Dmel ASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAA-P
PKN3_Mmus ------------------------------------------------SNFLPMKTLSKE
PKN2_Mmus ------------------------------------------------SDSTVTKLDFDL
PKN1_Mmus ------------------------------------------------SDSSSQK-----
F46F6.2_Cele -------------------------------------------------SSSGPSTSSSI
PKN_Spur ------------------------------------------------DSSESAGS--NS
AqueK022_Aque -------------------------------------------------DTSPPQSDSQS
PKN3_Hsap EMTPPPKPPRLYLPQEPTS-----------------------------------------
PKN2_Hsap EPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSI--------------
PKN1_Hsap --SSRDPPSSPSSLSS--------------------------------------------
CG2049_Dmel TTAPPP-PPVLKA------TSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMA
PKN3_Mmus DTKPPPKPPRLYL-QEPA------------------------------------------
PKN2_Mmus EPEPPPAPPRASSLGETDESSELRVLDIPGQGSETVFNIENDRNNL--------------
PKN1_Mmus --SPPGLPSTSCSLSS--------------------------------------------
F46F6.2_Cele --ASTPTPSTSNSL----------------------FDKV--------------------
PKN_Spur QEGGAGSPSK------------DKMGGVEVQDALSSFDFLNNSSSS--------------
AqueK022_Aque GENSPKTPDTPSSYR--------------HQSHTSVFDKD-DDGGV--------------
*
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap ------------------------------------------------------------
PKN1_Hsap ------------------------------------------------------------
CG2049_Dmel LDAGALENLLLQQQQTEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPT
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus ------------------------------------------------------------
PKN1_Mmus ------------------------------------------------------------
F46F6.2_Cele ------------------------------------------------------------
PKN_Spur ------------------------------------------------------------
AqueK022_Aque ------------------------------------------------------------
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap ----------------------------LPKS----------------------------
PKN1_Hsap -----------------------------PIQ----------------------------
CG2049_Dmel LANQTPTFPPLASNQIMPSLNARPCQSQSPNH-------------------NEFQLQPQP
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus ----------------------------RPKS----------------------------
PKN1_Mmus -----------------------------PTH----------------------------
F46F6.2_Cele --------------------------------SNHLPSFNPRKSAKKREAREAAAVAPMT
PKN_Spur ----------------------------SPKV----------------------------
AqueK022_Aque ----------------------------APETNGPLPPPSPVSDAELMHTPDQI-IIPPP
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap ------------------------------------------------------------
PKN1_Hsap ------------------------------------------------------------
CG2049_Dmel PHPA--------------------------------------------------------
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus ------------------------------------------------------------
PKN1_Mmus ------------------------------------------------------------
F46F6.2_Cele AAVA------------------------------------------------------AV
PKN_Spur ------------------------------------------------------------
AqueK022_Aque PQFVEDKTTPTKGGASGERRLSNGVVEPLRPPSPLPELCKHIPYLDNLGKHEDGLNIAYS
PKN3_Hsap --------------EETPRT--------------------KRPHME-PRTRRG-------
PKN2_Hsap -----------------QSE--------------------YKPDTP-QSGLEY-------
PKN1_Hsap -----------------ES---------------------TAPELP-SETQET-------
CG2049_Dmel -----------------QKP--------------------TNPEPP-SAVEQQLHRPVLI
PKN3_Mmus --------------PGTPCT--------------------KRPHMD-PRPAVV-------
PKN2_Mmus -----------------KSE--------------------YELSIP-DSGRSC-------
PKN1_Mmus -----------------EST--------------------TSPELP-SETQET-------
F46F6.2_Cele N----------LNAPSTSNSMQPSTQERNLVVDEFPTDRS----G-PSQAPPV-------
PKN_Spur -----------------SSPLTPP------------AARSSPPPSPLSQTQGQ-------
AqueK022_Aque HPPAPPVPPRNYQLPNNTHQKVGRMSTE-----GTSV---------SASGTPE-------
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap ------------------------------------------------------------
PKN1_Hsap ------------------------------------------------------------
CG2049_Dmel LPPVVLLGGREEDRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEV
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus ------------------------------------------------------------
PKN1_Mmus ------------------------------------------------------------
F46F6.2_Cele ------------------------------------------------------------
PKN_Spur ------------------------------------------------------------
AqueK022_Aque ------------------------------------------------------------
PKN3_Hsap --------------------------------------------P-S-------------
PKN2_Hsap --------------------------------------------S-GI-Q-E--------
PKN1_Hsap --------------------------------------------P-GP-A-L--------
CG2049_Dmel IPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFP-QP-A-QRQEKQPPQ
PKN3_Mmus --------------------------------------------P-A-------------
PKN2_Mmus --------------------------------------------W-GV-G-E--------
PKN1_Mmus --------------------------------------------P-GP-G-L--------
F46F6.2_Cele --------------------------------------------P-AV-R-H--------
PKN_Spur --------------------------------------------H-GA-Q-E--------
AqueK022_Aque --------------------------------------------RKGTSSSY--------
PKN3_Hsap ------------------------------------------------------------
PKN2_Hsap -------------------------------------------------------LE---
PKN1_Hsap ------------------------------------------------------------
CG2049_Dmel QQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGR
PKN3_Mmus ------------------------------------------------------------
PKN2_Mmus -------------------------------------------------------LD---
PKN1_Mmus ------------------------------------------------------------
F46F6.2_Cele -------------------------------------------------------ID---
PKN_Spur ------------------------------------------------------------
AqueK022_Aque -------------------------------------------------------RD---
PKN3_Hsap -PPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIES
PKN2_Hsap -DRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDS
PKN1_Hsap --CSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVES
CG2049_Dmel AGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVES
PKN3_Mmus -LAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDS
PKN2_Mmus -DKRAQQRFQFSLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDS
PKN1_Mmus --CSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRSSGELFAIKALKKGDIVARDEVES
F46F6.2_Cele -FFASSDGAPLTVEQFRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVES
PKN_Spur -ISAMDDGTLMTLENFRLISVLGRGHFGKVLLTEYKTTGEFFAIKALKKRDVVAREEVES
AqueK022_Aque -TGGSVLPHMKGINEYKFIAVLGRGHFGKVLLAEDKNTKELVAVKVLKKGDIISRDEVES
::::: :**********:* : . . : *:*.*** :::.*:*::*
PKN3_Hsap LYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARF
PKN2_Hsap LMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF
PKN1_Hsap LMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIF
CG2049_Dmel LLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVF
PKN3_Mmus LYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVFPEPQACF
PKN2_Mmus LMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF
PKN1_Mmus LMCEKRILAAVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVF
F46F6.2_Cele LMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDDVFDEVRGCF
PKN_Spur LMCEKRIFEAANSIRHPFLVNLFACFQTEHHVCFVMEYAMGGDLMMHIHNDVFTEPRTVF
AqueK022_Aque LMSEKRIFEKINAVRHPFLVNLHCCFQSENNVCFVMEYACGGDLMMHIHQDIFKEPRACF
* ****: ****:.* *:*: :. * *: ***** :** *:* * : *
PKN3_Hsap YVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTP
PKN2_Hsap YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP
PKN1_Hsap YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP
CG2049_Dmel YAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTP
PKN3_Mmus YLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTP
PKN2_Mmus YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP
PKN1_Mmus YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP
F46F6.2_Cele YAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTP
PKN_Spur YSACVVLGLQYLHENKIVYRDLKLDNLLLDQDGFLKIADFGLCKEGMGYGDRTSTFCGTP
AqueK022_Aque YAACVVLGLQYLHENGIVYRDLKLDNLLLDVDGFVKVADFGLCKEGMWYGSRTSTFCGTP
* *******::**:: *:***:******** :*::*:********.: .:*.******
PKN3_Hsap EFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLS
PKN2_Hsap EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS
PKN1_Hsap EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS
CG2049_Dmel EFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS
PKN3_Mmus EFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVSADVPCPHFLS
PKN2_Mmus EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS
PKN1_Mmus EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS
F46F6.2_Cele EFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLS
PKN_Spur EFLAPEVLTEPYYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS
AqueK022_Aque EFLAPEVLTDVSYTRAVDWWGLGVLIYEMLVGESPFPGEDEEEVFDSIVNDDVRYPRFLS
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PKN3_Hsap VQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTN--WQALLARTIQPPFVPTLCG
PKN2_Hsap TEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLID--WSALMDKKVKPPFIPTIRG
PKN1_Hsap AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLG--WEALLARRLPPPFVPTLSG
CG2049_Dmel LEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIV--WDDLLLRKVKPPFVPTINH
PKN3_Mmus VQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTN--WQALLARTVQPPFVPTLCG
PKN2_Mmus TEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTD--WSALMDKKVKPPFVPTIRG
PKN1_Mmus AEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRSLG--WDVLLARRLPPPFVPTLSG
F46F6.2_Cele VESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFFRHISWEWDKLLNREIRPPFQPQIRN
PKN_Spur TEAVAIMRRLLRRNPMRRLGSSQRDAEDIKMQGFFRNIN--WDDLLMRRVTPAFVPKIAN
AqueK022_Aque SEAISIMRKLLRRNPERRLGAGERDAEDIKRQPFFKHID--WEKLLRREVKPPFKPKLEG
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PKN3_Hsap PADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
PKN2_Hsap REDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADW---C
PKN1_Hsap RTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGG---C
CG2049_Dmel LEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEW---C
PKN3_Mmus PADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQFLES
PKN2_Mmus REDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFHDFDYVADW---C
PKN1_Mmus RTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVAGG---Y
F46F6.2_Cele PEDVSNFDLEFTQEKARFSAASSTRPITEADQRLFNNFDFSI-V---P
PKN_Spur SEDVSNFDEEFTAEHPVLTPAKDPRELTDEEQEHFKDFNYIADW---C
AqueK022_Aque RLDISNFDDEFTREDPIFTPPKNPRPLKAKEQKLFRGFEYSADWS-VI
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