PKD3_Hsap MSANNS--PPSA--QKSV-----LPTA-IPAVLPA-------------------------
PKD2_Hsap MATAPSY--PA--------------------GLPGS------------------------
PKD1_Hsap MSAPPVLRPPSP--LLPVAAA--AAAA-AAALVPGS------------------------
CG7125_Dmel MEGP--------------------------------------------------------
PKD3_Mmus MSANNS--PPSA--QKSV-----FPAT-VSAVLPA-------------------------
PKD2_Mmus MAAAPSH--PA--------------------GLPGS------------------------
PKD1_Mmus MSVPPLLRPPSP--LLPAAAA--VAAA-AAALVPGS------------------------
T25E12.4_Cele MDANDY--PRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSE
W09C5.5_Cele MDGSQG------------------------------------------------------
PKD_Spur MGEEL---PP--------------------------------------------------
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap ------------------------------------------------------------
PKD2_Hsap ------------------------------------------------------------
PKD1_Hsap ------------------------------------------------------------
CG7125_Dmel ------------------------------------------------------------
PKD3_Mmus ------------------------------------------------------------
PKD2_Mmus ------------------------------------------------------------
PKD1_Mmus ------------------------------------------------------------
T25E12.4_Cele SEKSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSR
W09C5.5_Cele ------------------------------------------------------------
PKD_Spur ------------------------------------------------------------
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap --------------------------------------------------ASPCSSPKTG
PKD2_Hsap --------------------------------------------------PGPGSPPPPG
PKD1_Hsap ---------------------------------------------------GPG------
CG7125_Dmel ------------------------------------------------------------
PKD3_Mmus --------------------------------------------------PSPCSSPKTG
PKD2_Mmus --------------------------------------------------PGPGSPPPPG
PKD1_Mmus ---------------------------------------------------GP-------
T25E12.4_Cele RVSANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPG
W09C5.5_Cele ------------------------------------------------------------
PKD_Spur ------------------------------------------------------------
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap LSARLSNGSFSAPSLTNSR----------------------------GSVHTVSFLLQIG
PKD2_Hsap GL-EL---QSPPPLLPQIP----------------------------APGSGVSFHIQIG
PKD1_Hsap ----------PAPFLAPVA----------------------------APVGGISFHLQIG
CG7125_Dmel ---------------------------------------------------EVTFLFQFG
PKD3_Mmus LSARLSNGSFSAPSLTNSR----------------------------GSVHTVSFLLQIG
PKD2_Mmus GL-DL---QSPPPLLPQIP----------------------------APGSGVSFHIQIG
PKD1_Mmus -----------APFPAPGA----------------------------APAGGISFHLQIG
T25E12.4_Cele AH-QF---QLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSG
W09C5.5_Cele -----------------------------------------------STDYGDHVVLRYG
PKD_Spur -----------LPPM-TRP----------------------------GLVHGVSFAVQIG
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap LTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYD-KILLFRHDMNSENILQ
PKD2_Hsap LTREFVLLPAAS----ELAHVKQLACSIVDQKFPECGFYGLYD-KILLFKHDPTSANLLQ
PKD1_Hsap LSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYD-KILLFRHDPTSENILQ
CG7125_Dmel SVRDAVCVPAN---SLTLKTLKDLACDFINTKIPDSGLTYLSE-RILLFVHDYSTPNVLH
PKD3_Mmus LTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYD-KILLFRHDMNSENILQ
PKD2_Mmus LTREFVLLPAAS----ELAHVKQLACSIVDQKFPECGFYGLYD-KILLFKHDPTSANLLQ
PKD1_Mmus LSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYD-KILLFRHDPASDNILQ
T25E12.4_Cele IHKKSIAVEGT---EIALRDLRNEALQFIKEIYPEKGCSSLED-YILLYKHDLRSINILQ
W09C5.5_Cele GTREMVPLIRH---EQMLDMLMERARQIV------QGFGNLDTRNMYLFRHEYNSPTLLY
PKD_Spur FVRENFQIPPE-GGDPSIPLIKEIVTSMVRQRFPEHDFYGVYD-KLLLFKHNPGTSYSLT
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap LITSADEIHEGDLVEVVLSA----------------------------------------
PKD2_Hsap LVRSSGDIQEGDLVEVVLSA----------------------------------------
PKD1_Hsap LVKAASDIQEGDLIEVVLSA----------------------------------------
CG7125_Dmel IINSAAEVVDETLVEIVLTA----------------------------------------
PKD3_Mmus LITSADEIHEGDLVEVVLSA----------------------------------------
PKD2_Mmus LVRSAADIQEGDLVEVVLSA----------------------------------------
PKD1_Mmus LVKIASDIQEGDLIEVVLSA----------------------------------------
T25E12.4_Cele LITTSSDVTDGTLVEVVIGS----------------------------------------
W09C5.5_Cele PITSASQITSGSILEIILVD----------------------------------------
PKD_Spur PVTSVSDVTEGALIEAVLSDQWDGSRMNDLVSQNPSSGKYIYLVKKYDFYCRLLTSLFFS
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap --------------LA----TVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKC
PKD2_Hsap --------------SA----TFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKC
PKD1_Hsap --------------SA----TFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKC
CG7125_Dmel --------------SPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC
PKD3_Mmus --------------LA----TVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKC
PKD2_Mmus --------------SA----TFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKC
PKD1_Mmus --------------SA----TFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKC
T25E12.4_Cele --------------CP----QNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKC
W09C5.5_Cele --------------R-------TEAAVIPHVVEPESYMRPTFCDFCGEMLTGLMRQGVKC
PKD_Spur TIMNSNAGLQFCFSSA----TVEDRQIRPHTLYVHSYKSPTFCDFCGQMLFGLVRQGLKC
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap EGCGLNYHKRCAFKIPNNCSGVRKRRL-SNVSLPGPGLSV---------PR-------PL
PKD2_Hsap DGCGLNYHKRCAFSIPNNCSGARKRRL-SSTSLASGH-SVRLGTSESLPCTAEE-LSRST
PKD1_Hsap EGCGLNYHKRCAFKIPNNCSGVRRRRL-SNVSLTGVS-TIRTSSAELSTSAPDEPLLSPV
CG7125_Dmel DGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPR-SPSGSSQQSLVSTEDST-GR--
PKD3_Mmus EGCGLNYHKRCAFKIPNNCSGVRKRRL-SNVSLPGPGLSV---------PR-------PL
PKD2_Mmus DGCGLNYHKRCAFSIPNNCSGARKRRL-SSTSLASGH-SVRLGSSESLPCTAEE-LSRST
PKD1_Mmus EGCGLNYHKRCAFKIPNNCSGVRRRRL-SNVSLTGLG-TVRTASAEFSTSVPDEPLLSPV
T25E12.4_Cele FGCGLNYHKRCASKIPNNCNGSKQRRP-SAIPLSPSN-SNILNLNERRHSRRES-C----
W09C5.5_Cele KNCNGNFHKRCSNAARNNCGAPGAPGAQ------------------------------PS
PKD_Spur DGCGGNYHKRCAFKIPNDCTLSKRRRS--SLAISS--SSIPWSPSETSLSSEDSQ-QQQQ
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap QP-----EYVALPSEES-----------------------HVHQEPSKRIPSWSGRPIWM
PKD2_Hsap TE-----LLPRRPPSSS----------------------------SSSSASSYTGRPIEL
PKD1_Hsap SP-----GFEQKSPSES-----------------------FIGREKRSNSQSYIGRPIHL
CG7125_Dmel ---------NDSSSSLN-----------------------IPGRHQRTHSS--G------
PKD3_Mmus QP-----ECVPLLSEES-----------------------HTHQEPSKRIPSWSGRPIWM
PKD2_Mmus TD-----LLPRRPPSSS---------------------------SSSSSSSFYTGRPIEL
PKD1_Mmus SP-----GFEQKSPSES-----------------------FIGREKRSNSQSYIGRPIQL
T25E12.4_Cele LE-----ALDAARPSSTLGGAATPNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWM
W09C5.5_Cele RP-----PILPPIP------------------------------------TTPTGFPV--
PKD_Spur QQLAVFVTHSQQTPLVK------------------------SDSYKERRSPSWGNRPLWV
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap EKMVMCR--VKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP
PKD2_Hsap DKMLLSK--VKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVP
PKD1_Hsap DKILMSK--VKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP
CG7125_Dmel SRNGLMV--LRIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGLQCRDCQYNTHKKCMDKVP
PKD3_Mmus EKMVMCR--VKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP
PKD2_Mmus DKMLMSK--VKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVP
PKD1_Mmus DKLLMSK--VKVPHTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP
T25E12.4_Cele EIAEATRVKLQVPHTFQVHSYKLPTVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVA
W09C5.5_Cele -AALSTP--TGLPHTLIEHSYRQFTVCKVCDHLLVGLVKQGLKCRDCGVNVHRKCAMELA
PKD_Spur ERAVASR--IKVPHTFVVHNYTKPTICQYCKRLLVGLFRQGLQCKDCKFNCHKRCADKVP
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap RDCLG-EVTFNGEPSSLGT-DTDIPMDIDNNDINSDS-SR----G-LDDTEEPSPPEDKM
PKD2_Hsap NDCLG-EALING----------DVPMEEATDFSEADK-SA-----LMDESEDSGVIPGS-
PKD1_Hsap NNCLG-EVTINGDLLSPGA-ESDVVMEEGSDDNDSER-NS----GLMDDMEEAMVQDAEM
CG7125_Dmel HDCTG-EAQLSQLQIQAGAKERDNFFREEFDDSDGDD-GSEEAPKALTNAHNSPPELVNG
PKD3_Mmus RDCLG-EVTFNGEPCSVGT-DADMPMDIDSSDVNSDG-SR----G-LDDSEEPSPPEDKM
PKD2_Mmus NDCLG-EALING----------DVPMEEAADYSEADK-SS-----ISDELEDSGVIPGS-
PKD1_Mmus NNCLG-EVTINGELLSPGA-ESDVVMEEGSDDNDSER-NS----GLMDDMDEAMVQDTEM
T25E12.4_Cele KDCSG-NTKASQFF--LGS-QADDGASEDRDDDLSLRSGS----GAHKKAQN-T----PS
W09C5.5_Cele SNCVLSENAISR------------------------------------------------
PKD_Spur KDCLG-ETPLQE-----GD-NDDQERLIESDENEAEE-NE----------------NGS-
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap F------------FLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMV
PKD2_Hsap --------------HSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTL
PKD1_Hsap AMAECQN---D--SGEMQDP-DPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVM
CG7125_Dmel GLVDDSS--VSGGETSKSSS-DGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQAL
PKD3_Mmus F------------FLDPTDLDVERDEETVKTISPSTSNNIPLMRVVQSIKHTKRRSSTVV
PKD2_Mmus --------------HSESALHASEEEEGEGHKAQSSLGYIPLMRVVQSVRHTTRKSSTTL
PKD1_Mmus ALAEGQS---G--GAEMQDP-DADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVM
T25E12.4_Cele APLQGSEGSGSPGPVVSFAANA-LSNMPDDDVISSESANIPLMRVVMSKKQTKRKNNKLL
W09C5.5_Cele ----------------------VNFTDPEG-PGSSSSDNIPLFRLPGQVG--TRATEKKK
PKD_Spur -NRD------S--IGDETL---PDSPVNENPLSPVQSNNIPLMRIVQSVKHTKRRGSQVL
AqueK080_Aque ------------------------------------------------------------
PKD3_Hsap KEGWMVHYTSRDNL-RKRHYWRLDSKCLTLFQNES------GSKYYKEIPLSEILRISSP
PKD2_Hsap REGWVVHYSNKDTL-RKRHYWRLDCKCITLFQNNT------TNRYYKEIPLSEILTVESA
PKD1_Hsap KEGWMVHYTSKDTL-RKRHYWRLDSKCITLFQNDT------GSRYYKEIPLSEILSLEPV
CG7125_Dmel KEGWLVHYTSLDKA-VKRYYWRLDSKTITLFVSEQ------GSKYHKELPLAELLSIESH
PKD3_Mmus KEGWMVHYTSRDNL-RKRHYWRLDSKCLTLFQNES------GSKYYKEIPLSEILRVSSP
PKD2_Mmus REGWVVHYSNKDTL-RKRHYWRLDCKCITLFQNNT------TNRYYKEIPLSEILAVEPA
PKD1_Mmus KEGWMVHYTSKDTL-RKRHYWRLDSKCITLFQNDT------GSRYYKEIPLSEILCLEPA
T25E12.4_Cele KEGWIVHYTDQQNM-RKKHYWRLDTKGITMYQDEN------TTRYYKEIPLNEILNVSMS
W09C5.5_Cele LEGWMMHFILSDPERRLKHYWMMQSNAIHLYNEYSEGIGVNPNRVYRIIPLAEITSVVQN
PKD_Spur KEGWMVHYTDKDSM-RKRHYWRIDTKAITLYQSES------STRYYKEIPLSEILSVRMV
AqueK080_Aque ---------------RKKHFWRLDTKTLTLYKDSE------SSHYYKEIQLADIMAVDPM
:::* :: : : :: . .: :: : * :: :
PKD3_Hsap RDFTNIS------------------QGSNPHCFEIITD-TMVYFVGENNGDSSHNP----
PKD2_Hsap QNFSLVP------------------PGTNPHCFEIVTA-NATYFVGEMPGGTPG------
PKD1_Hsap KTSALIP------------------NGANPHCFEITTA-NVVYYVGENVVNPSSPSPN--
CG7125_Dmel LG---DP------------------RPECNYCFELRLP-NLSYFVGQDPQVGAKEEQA--
PKD3_Mmus QDFTSIS------------------QGSNPHCFEIITD-TVVYFVGENNGSSSHNP----
PKD2_Mmus QNFSLVP------------------PGTNPHCFEIITA-NVTYFVGETPGGAPG------
PKD1_Mmus KPSALTP------------------VGATPHCFEITTA-NVVYYVGENVVNPSSSPPN--
T25E12.4_Cele P-----P------------------DKTADYLFEIRTG-VCVYFISGSPSD---------
W09C5.5_Cele NGKSV-L------------------AKHPPHCFEIRTTTNTVFCVGEDYHAFSGGPPK--
PKD_Spur KPSQDGSGSGSSSSGMGISGLVGGDGFNSTHCFEIQTA-KTNYYVGERASLGDSSSEKGS
AqueK080_Aque VNHALYP-------------------LSPPHVFEIVTS-SCTYYVGVDMAGAVPEDLNPP
: **: : :.
PKD3_Hsap -----------------------VL-AATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP
PKD2_Hsap --------------------------GPSGQGAEAARGWETAIRQALMPVILQDAP-SAP
PKD1_Hsap ----------------------NSV-LTSGVGADVARMWEIAIQHALMPVIPKGSS-VGT
CG7125_Dmel --------------------VRLPP-PDSGIGSDIAKSWETSIRQAFMHVTNTQC-----
PKD3_Mmus -----------------------VL-AATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP
PKD2_Mmus --------------------------GPSGQGTEAVRGWETAIRQALMPVILQDAP-SAP
PKD1_Mmus ----------------------NSV-LPSGIGPDVARMWEVAIQHALMPVIPKGSS-VGS
T25E12.4_Cele ---------------------------EKGSSLD-AQSWTTAIQSALMPVTPQSSVV-GG
W09C5.5_Cele ----------------------KIPRSMSVRPSSNTTMWFQFIKESLQPPSR--------
PKD_Spur G---GSTTSSSKLPVPSSSSVDEEP-EQSWVGADVARDWEQKIRQALMPVTPQQSGTSIT
AqueK080_Aque KQTEGALG--PNILCNVSHMSLNQL-EEIGVGLTVALSWEEGLHSALMPITPQASMGSLA
. * :: ::
PKD3_Hsap GQG------------KDHKD----------------------------------------
PKD2_Hsap GH-------------APHRQ----------------------------------------
PKD1_Hsap GT-------------NLHRD----------------------------------------
CG7125_Dmel ------------------------------------------------------------
PKD3_Mmus GQG------------KDHKD----------------------------------------
PKD2_Mmus GH-------------TPHRQ----------------------------------------
PKD1_Mmus GS-------------NSHKD----------------------------------------
T25E12.4_Cele -KR------------IDKLK----------------------------------------
W09C5.5_Cele ------------------------------------------------------------
PKD_Spur STS------------SPRNDSVIQIP-RG---------YNPHHRQERKEGPVNATENGDD
AqueK080_Aque DIGVPGAAIVRPSSFRGRRGSSLKGSFRGTKGSFRNASRPPHHTSTGRGSFRGSFRAVKQ
PKD3_Hsap LSTSIS---VSNCQIQEN-VDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID
PKD2_Hsap ASLSIS---VSNSQIQEN-VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVID
PKD1_Hsap ISVSIS---VSNCQIQEN-VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID
CG7125_Dmel ------------CESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVID
PKD3_Mmus LATSIS---VSNCQVQEN-VDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID
PKD2_Mmus ASLSIS---VSNSQIQEN-VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVID
PKD1_Mmus ISVSIS---VSNCQIQEN-VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID
T25E12.4_Cele VPTEGE-TGHLGAKIQTE-HEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLID
W09C5.5_Cele ----------NEDNAEQA-LEFANLYQVLSDKTLGSGQFGTVYSAIQRHSGKEVAVKVIS
PKD_Spur FPAKVS--EPSFLNKREN-NDISQHYQIFPDEILGSGQFGIVYGGVHRTSGRQVAIKVID
AqueK080_Aque SPPAIPVRAAMKPKIETK-MDVSQMYQIFPEEILGSGQFGTVFGGQNRTTGKSVAIKVID
: . :.. **::.:: ******* *:.. :: . : **:*:*.
PKD3_Hsap KMRFPTKQE--SQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSS
PKD2_Hsap KLRFPTKQE--SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS
PKD1_Hsap KLRFPTKQE--SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSS
CG7125_Dmel KLRFPTKQE--AQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSH
PKD3_Mmus KMRFPTKQE--SQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSS
PKD2_Mmus KLRFPTKQE--SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS
PKD1_Mmus KLRFPTKQE--SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSS
T25E12.4_Cele KLKFPPNKE--DLLRAEVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSS
W09C5.5_Cele KERFSKKGSGAESMRAEVAILQQTCHPGIVCLEFMCETKDKIFVVMEKMNGDMLEMILSQ
PKD_Spur KFRFPTKQE--TQLKNEVAILHKVRHPGVVNLEQMFETPERVFVVMEKLKGDMLEMILSS
AqueK080_Aque KLRFPHKQD--TALRQEVTILQFLDHPGIIYLEQMFETPEKIYIAMEKMNGDMLEMILSS
* :*. : . :: ** **. * *:: : * ** :::::.***::*********
PKD3_Hsap EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS-AEPFPQVKLCDFGFAR
PKD2_Hsap EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
PKD1_Hsap EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
CG7125_Dmel ARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSS-DAEFPQVKLCDFGYAR
PKD3_Mmus EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS-AEPFPQVKLCDFGFAR
PKD2_Mmus EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
PKD1_Mmus EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
T25E12.4_Cele EKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNS-NSDFPQVKLCDFGFAR
W09C5.5_Cele ELGRLNSRATKFLLVQILCALKYLHDQGIAHCDLKPENVLLSDMGSNFPQTKICDFGYAR
PKD_Spur VHGRLFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSS-DGDFPQVKLCDFGFAR
AqueK080_Aque PNSRLSERVTKFLVYQILAALQYLHKKDIVHCDLKPENVLLTS-ESGMPQVKLCDFGFAR
.** .: *:*:: *** **: ** .*.********:** . :**.*:****:**
PKD3_Hsap IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQ
PKD2_Hsap IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ
PKD1_Hsap IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ
CG7125_Dmel IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQ
PKD3_Mmus IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQ
PKD2_Mmus IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ
PKD1_Mmus IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ
T25E12.4_Cele IIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQ
W09C5.5_Cele FIPESQFRKTVVGTPAYLPPEVLQRKGYNKSLDMWSVGVIIYVTLSGTFPFNEGEEISEQ
PKD_Spur IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEEITDQ
AqueK080_Aque IIGEKSFRKSIVGTPAYLAPEVLKNEGYNRSLDLWSVGVIIYVSLSGTFPFNEDEEISDQ
:* *..**:::*******.**** :*:*:***:******:**:********* *:* :*
PKD3_Hsap IQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE
PKD2_Hsap IQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELE
PKD1_Hsap IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELE
CG7125_Dmel IQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLRNLE
PKD3_Mmus IQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE
PKD2_Mmus IQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELE
PKD1_Mmus IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELE
T25E12.4_Cele IQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQIWMQNYTLWSDLRVLE
W09C5.5_Cele IQNASFMFPTEPWSEVEPLAVDLIQKLLKVEIEARMSIEQCLDHGWLKGEQLYRDLRDLE
PKD_Spur IHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWLQDYQVWLDLRDLE
AqueK080_Aque IHNAAFMYPPDPWAAITQEAIDLVSKLLQINRRSRFKTTQALNHIWLRDIRLYEDVCELE
*:** **:*. ** : *:::: **::: * . : : *:: : *: :*
PKD3_Hsap TRIGE-RYITHESDDARWEIHAYT-HNLV----YPK------------------------
PKD2_Hsap GKMGE-RYITHESDDVRWEQFAAE-HPLP----G--------------------------
PKD1_Hsap CKIGE-RYITHESDDLRWEKYAGE-QGLQ----YPT------------------------
CG7125_Dmel AQVGAGRYLTHEADDLRW------------------------------------------
PKD3_Mmus TRIGE-RYITHESDDARWEIHAYT-HNLE----YPK------------------------
PKD2_Mmus GKMGE-RYITHESDDARWDQFVAE-RH---------------------------------
PKD1_Mmus CRIGE-RYITHESDDSRWEQYAGE-QGLQ----YPA------------------------
T25E12.4_Cele KAVGQ-RFVTHESDDQQDPQRNFS-YFLHLLVTYPFKFYF---VFSCFII-FF-------
W09C5.5_Cele VRLNTPRYLTSPQDDILYGTLV--------------------------------------
PKD_Spur TIVGS-RYLTHESDDERWSAYQQA-QLGA-------------------------------
AqueK080_Aque GRLDI-RYLTHETEDAWWAQQGAKPHPLV----LKKEKKFSHHVYKNIQILDDPHRSNVP
:. *::* :*
PKD3_Hsap -----------------------HFI--M---------APNPDDM---------------
PKD2_Hsap -----------------------SGL--P--TDRDLGGACPPQDHD--------------
PKD1_Hsap -----------------------HLI--N--PSASHSDTPETEETE--------------
CG7125_Dmel ------------------------------------------------------------
PKD3_Mmus -----------------------HFI--M---------APNPDDM---------------
PKD2_Mmus ------------------------GT--P--AEGDLGGACLPQDHE--------------
PKD1_Mmus -----------------------HLI--S--LSASHSDSPEAEERE--------------
T25E12.4_Cele ---------------------------PN--FLTHIPCVP--------------------
W09C5.5_Cele ------------------------------------------------------------
PKD_Spur -------------------------G--N--DPAPGGNSPDNNSTH--------------
AqueK080_Aque SIATTVAVAKPPPPPSSNPPPSSTLVNPGPPAPTNNRSSKDKDSTDLKAGRKEKEGVAIK
PKD3_Hsap --------------EEDP
PKD2_Hsap ---MQ----GLAERISVL
PKD1_Hsap ---MK----ALGERVSIL
CG7125_Dmel -----------------D
PKD3_Mmus --------------EEDP
PKD2_Mmus ---MQ----GLAERISIL
PKD1_Mmus ---MK----ALSERVSIL
T25E12.4_Cele --------------TPIS
W09C5.5_Cele ----------------NP
PKD_Spur ---LQLSPVRHMDRVSTL
AqueK080_Aque LSDIEAHAKRVGYTVSTV