PDHK4_Hsap_PDHK MKAARFVLRSAG----------------SL---------------------NGA------
PDHK3_Hsap_PDHK MRLFRWLLKQ--------------------------------------------------
PDHK2_Hsap_PDHK MRWVWALLKNA-----------------SL------------------------------
PDHK1_Hsap_PDHK MRLARLLRGAALA----GPGPGLRAAGFSRSFSSDSG-----------SSPASE------
PDK_Dmel_PDHK MRLFPVRFSAA-----------------SL---------------------S-M------
PDHK4_Mmus_PDHK MKAARFVMRSAS----------------SL---------------------SSA------
PDHK3_Mmus_PDHK MRLFYRLLKQ--------------------------------------------------
PDHK2_Mmus_PDHK MRWVRALLKNA-----------------SL------------------------------
PDHK1_Mmus_PDHK MRLARLLRGGTSV----RPLCAVPCASRSLASASASG-----------SGPASE------
BCKDK_Mmus_BCKDK MILTSVLGSGPRSWSSLWPLLGSSLSLRARSTSATD---------THHVELARERSKTVT
BCKDK_Hsap_BCKDK MILASVLRSGPGGGLPLRPLLGPALALRARSTSATD---------THHVEMARERSKTVT
YIL042C_Scer_PDHK MWKIMRSWKCGGM-RWAHR-QRPSHE--LLSQLSFD----------QHYK-I-R------
BCKDK_Spur_BCKDK MALSTMKANQL-VFK---QALNFKSASYSRSIAITSYRPQSNYSAVHDYSPAKEKSRPVV
PDHK_Spur_PDHK MVRLTVRLLAM----------------------------------------A-K------
aSWK467_Cele_PDHK MRFSRKLLGPF------------------------------------------V------
pdhk-2_Cele_PDHK MRFSRKLLGPF------------------------------------------V------
CC1G_13956_Ccin_BCKDK MLLRHALRPLARR-RWYST------K--FQQP-------------------N-S------
CC1G_00337_Ccin_BCKDK MTTFMVGRRVFNL-TTTTPFLQSSLR--YSST-------------------F-N------
CC1G_15212_Ccin_PDHK MSAGFRITP---------------------------------------------------
*
PDHK4_Hsap_PDHK -GLVPREVEHFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRL---ANILKE
PDHK3_Hsap_PDHK --PVPKQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRL---ANTMRE
PDHK2_Hsap_PDHK -AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRL---ANIMKE
PDHK1_Hsap_PDHK -RGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRL---ANIMKE
PDK_Dmel_PDHK -ASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NAC--EKKSYIFLRKELPVRL---ANIMKE
PDHK4_Mmus_PDHK -SLVPREVELFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRL---ANILKE
PDHK3_Mmus_PDHK --PVPKQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRL---ANTMRE
PDHK2_Mmus_PDHK -AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRL---ANIMKE
PDHK1_Mmus_PDHK -LGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRL---ANIMKE
BCKDK_Mmus_BCKDK SFYNQSAIDVAAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRI---AHRIKG
BCKDK_Hsap_BCKDK SFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRI---AHRIKG
YIL042C_Scer_PDHK -SNIELLIQDYASKPIAPLNYEYFLQYRPPLTK---KEEYMLTIKTINLLLSLTCKRLNA
BCKDK_Spur_BCKDK SFYNQSAIDVAAKKPSVRLTPATLLYTGKSPDGNHLLRSAQYLHKELPVRV---AHRIAE
PDHK_Spur_PDHK -KNMQAQMEYYSKFSPSPLSIKQFMDFGQSKDV-DSAKSFVFLRQELPVRI---ANIMKE
aSWK467_Cele_PDHK -GSLAKKLDYYSQFQPSSLTIQQYLDFGRIGT--S-ANSYTFLKNELLVRL---ANIMQE
pdhk-2_Cele_PDHK -GSLAKKLDYYSQFQPSSLTIQQYLDFGRIGT--S-ANSYTFLKNELLVRL---ANIMQE
CC1G_13956_Ccin_BCKDK -AEVTALLAQYGTAAPRPLNLSQLLSFGRPVTPDSVLSSVSYVLYELPRRL---ATRVRY
CC1G_00337_Ccin_BCKDK -FYQNRQLEQYANREAKPLTLRQLVFFGRHLTEEKILKSANYVRSELPVRI---AHRLRD
CC1G_15212_Ccin_PDHK --ALWDKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLKASQFLSEELPVRL---AHRVKE
: . :. : : : . :
PDHK4_Hsap_PDHK IDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSP------------------------
PDHK3_Hsap_PDHK VNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSP------------------------
PDHK2_Hsap_PDHK INLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDP------------------------
PDHK1_Hsap_PDHK ISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSA------------------------
PDK_Dmel_PDHK IALLPDNLLHTRSVSEVSSWYVKSFEDVLVYEKAEP------------------------
PDHK4_Mmus_PDHK IDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHEKSP------------------------
PDHK3_Mmus_PDHK VNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSP------------------------
PDHK2_Mmus_PDHK INLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLDKDP------------------------
PDHK1_Mmus_PDHK ISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSA------------------------
BCKDK_Mmus_BCKDK FRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK-------------------------
BCKDK_Hsap_BCKDK FRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK-------------------------
YIL042C_Scer_PDHK IQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYE------------------------
BCKDK_Spur_BCKDK FRGLPFIVGCNPTILHVHELYIRAFHLLSEFPSIR-------------------------
PDHK_Spur_PDHK INLLPEKLLQMPSVRMVQGWYQQTFEELLEYVEKTE------------------------
aSWK467_Cele_PDHK FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASD-------------------------
pdhk-2_Cele_PDHK FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASD-------------------------
CC1G_13956_Ccin_BCKDK LESLPFIVGTNPYVAKTLKAFREGFWVLATHPPVTNL-----------------------
CC1G_00337_Ccin_BCKDK LQALPYVVVTQEGVEKVYKLYWTAFEKFRTYPPITS------------------------
CC1G_15212_Ccin_PDHK LDELPHNLSDMPSIKRVKNWYAQSFEELINFPHPQLPPEIRQALITSRSDELALPESKPN
. ** . : : .
PDHK4_Hsap_PDHK ------------------------------------------------DDQKALSDFVDT
PDHK3_Hsap_PDHK ------------------------------------------------EDPQVLDNFLQV
PDHK2_Hsap_PDHK ------------------------------------------------EDHRTLSQFTDA
PDHK1_Hsap_PDHK ------------------------------------------------EDAKAIYDFTDT
PDK_Dmel_PDHK -------------------------------------------------THDNLQKFVAD
PDHK4_Mmus_PDHK ------------------------------------------------EDQKALSEFVDT
PDHK3_Mmus_PDHK ------------------------------------------------EDPRVLDNFLNV
PDHK2_Mmus_PDHK ------------------------------------------------EDHRTLSQFTDA
PDHK1_Mmus_PDHK ------------------------------------------------EDAKTIYEFTDT
BCKDK_Mmus_BCKDK -------------------------------------------------DQADEAQYCQL
BCKDK_Hsap_BCKDK -------------------------------------------------DQADEAQYCQL
YIL042C_Scer_PDHK --------------------------------------------------LHNPPKIQAK
BCKDK_Spur_BCKDK -------------------------------------------------DMDTERQYCKM
PDHK_Spur_PDHK ------------------------------------------------EEDPVLLRYINQ
aSWK467_Cele_PDHK ------------------------------------------------SSPEQVARFNDQ
pdhk-2_Cele_PDHK ------------------------------------------------SSPEQVARFNDQ
CC1G_13956_Ccin_BCKDK ---------------------------------------------------EENEK----
CC1G_00337_Ccin_BCKDK --------------------------------------------------IEENTKFCKF
CC1G_15212_Ccin_PDHK PSLIDTIYGSSPSNGNGNGGNGFNKLRLRVPMERRYYANTSNITHWPPEVQDYNKRFTKL
PDHK4_Hsap_PDHK LIKVRNRHHNVVPTMAQG------------------------------------------
PDHK3_Hsap_PDHK LIKVRNRHNDVVPTMAQG------------------------------------------
PDHK2_Hsap_PDHK LVTIRNRHNDVVPTMAQG------------------------------------------
PDHK1_Hsap_PDHK VIRIRNRHNDVIPTMAQG------------------------------------------
PDK_Dmel_PDHK LDLIRNRHNDVVQTMAQG------------------------------------------
PDHK4_Mmus_PDHK LVKVRNRHHNVVPTMAQG------------------------------------------
PDHK3_Mmus_PDHK LINIRNRHNDVVPTMAQG------------------------------------------
PDHK2_Mmus_PDHK LVTIRNRHNDVVPTMAQG------------------------------------------
PDHK1_Mmus_PDHK VIRIRNRHNDVIPTMAQG------------------------------------------
BCKDK_Mmus_BCKDK VRQLLDDHKDVVTLLAEG------------------------------------------
BCKDK_Hsap_BCKDK VRQLLDDHKDVVTLLAEG------------------------------------------
YIL042C_Scer_PDHK FTELLDDHEDAIVVLAKG------------------------------------------
BCKDK_Spur_BCKDK VKTLLDDHKDVVTHLAEG------------------------------------------
PDHK_Spur_PDHK LTTIRNRHVNVVETMAQG------------------------------------------
aSWK467_Cele_PDHK LTVVLKRHAHVVETMAEG------------------------------------------
pdhk-2_Cele_PDHK LTVVLKRHAHVVETMAEG------------------------------------------
CC1G_13956_Ccin_BCKDK ------------------FQ----------------------------------------
CC1G_00337_Ccin_BCKDK VGSLLDDHAVVIPNLSLG------------------------------------------
CC1G_15212_Ccin_PDHK LEHIKSRHDPTVTTVAQGRSFRLPAFFGVLGVFWASGLGSVPLPSLYSRSMDPFVICEEH
PDHK4_Hsap_PDHK -----------------------------------------------------IIEYKDA
PDHK3_Hsap_PDHK -----------------------------------------------------VIEYKEK
PDHK2_Hsap_PDHK -----------------------------------------------------VLEYKDT
PDHK1_Hsap_PDHK -----------------------------------------------------VIEYKES
PDK_Dmel_PDHK -----------------------------------------------------VIEMKEN
PDHK4_Mmus_PDHK -----------------------------------------------------ILEYKDT
PDHK3_Mmus_PDHK -----------------------------------------------------VIEYKEK
PDHK2_Mmus_PDHK -----------------------------------------------------VLEYKDT
PDHK1_Mmus_PDHK -----------------------------------------------------VTEYKES
BCKDK_Mmus_BCKDK -----------------------------------------------------LRESRKH
BCKDK_Hsap_BCKDK -----------------------------------------------------LRESRKH
YIL042C_Scer_PDHK -----------------------------------------------------LQEIQSC
BCKDK_Spur_BCKDK -----------------------------------------------------FRECRKH
PDHK_Spur_PDHK -----------------------------------------------------ILEMRES
aSWK467_Cele_PDHK -----------------------------------------------------LIELRES
pdhk-2_Cele_PDHK -----------------------------------------------------LIELRES
CC1G_13956_Ccin_BCKDK ----------------------------------------------------------E-
CC1G_00337_Ccin_BCKDK -----------------------------------------------------LSLSS--
CC1G_15212_Ccin_PDHK ALTELSIPFTLPQCLHAPLLGFLSLSLTHALASRLPPTFLVTGPRLPRTDLLCVLEWKRS
PDHK4_Hsap_PDHK CT--VDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S---QTGN--PSHIGSIDP
PDHK3_Hsap_PDHK FG--FDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDT---NPVH--PKHIGSIDP
PDHK2_Hsap_PDHK YG--DDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST---NPAH--PKHIGSIDP
PDHK1_Hsap_PDHK FG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG-KGSPSH--RKHIGSINP
PDK_Dmel_PDHK EGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG-N---PHAG--GRHIGCLDP
PDHK4_Mmus_PDHK CT--VDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S---KTGN--PSHIGSIDP
PDHK3_Mmus_PDHK FG--FDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDT---NPAH--PKHIGSIDP
PDHK2_Mmus_PDHK YG--DDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST---NPAH--PKHIGSIDP
PDHK1_Mmus_PDHK FG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG---SPSH--RKHIGSINP
BCKDK_Mmus_BCKDK IQ------DEKLVRYFLDKTLTSRLGIRMLATHHLALHED--------K--PDFVGIICT
BCKDK_Hsap_BCKDK IE------DEKLVRYFLDKTLTSRLGIRMLATHHLALHED--------K--PDFVGIICT
YIL042C_Scer_PDHK -------YPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNK---GDTN--KRMIGILHR
BCKDK_Spur_BCKDK IT------DESLIHNFLDRILTSRLGIRMLAEHHLFLHQD--------K--NDSIGIIAT
PDHK_Spur_PDHK YK--VDQHEENNVQYFLDRFYISRISIRMLINQHTLMFGQ-I---PTTH--PLLVGSIDP
aSWK467_Cele_PDHK DG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V---LPES--PRHVGCIDP
pdhk-2_Cele_PDHK DG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V---LPES--PRHVGCIDP
CC1G_13956_Ccin_BCKDK -S--AKYMSFEDINAFLDGAIRNRISVRLIAEQHIAVTRALH--DPPQD--GKDVGVIDT
CC1G_00337_Ccin_BCKDK -----PFLSPDKLDSFMRRMLVSRISRRVLAEHHIALSKTYLAKDSPAHEAEPRVGIIYT
CC1G_15212_Ccin_PDHK QN--ARH-IGLDIQAWLDRFYMSRIGIRFLIGQHVALNTQ------QAH--EDYVGIICT
: :: .*: :.: :: : :* :
PDHK4_Hsap_PDHK N-----------------------------------------------------------
PDHK3_Hsap_PDHK T-----------------------------------------------------------
PDHK2_Hsap_PDHK N-----------------------------------------------------------
PDHK1_Hsap_PDHK N-----------------------------------------------------------
PDK_Dmel_PDHK A-----------------------------------------------------------
PDHK4_Mmus_PDHK N-----------------------------------------------------------
PDHK3_Mmus_PDHK T-----------------------------------------------------------
PDHK2_Mmus_PDHK N-----------------------------------------------------------
PDHK1_Mmus_PDHK N-----------------------------------------------------------
BCKDK_Mmus_BCKDK R-----------------------------------------------------------
BCKDK_Hsap_BCKDK R-----------------------------------------------------------
YIL042C_Scer_PDHK D-----------------------------------------------------------
BCKDK_Spur_BCKDK K-----------------------------------------------------------
PDHK_Spur_PDHK S-----------------------------------------------------------
aSWK467_Cele_PDHK A-----------------------------------------------------------
pdhk-2_Cele_PDHK A-----------------------------------------------------------
CC1G_13956_Ccin_BCKDK R-----------------------------------------------------------
CC1G_00337_Ccin_BCKDK A-----------------------------------------------------------
CC1G_15212_Ccin_PDHK KAVRVPPSPSPFDTLFHFFGTSSAIEPHTDETAFLFLFRMRLVVVVVDVIVMDTLVVVMR
PDHK4_Hsap_PDHK ------------------------------------------CDVVAVVQDAFECSRMLC
PDHK3_Hsap_PDHK ------------------------------------------CNVADVVKDAYETAKMLC
PDHK2_Hsap_PDHK ------------------------------------------CNVSEVVKDAYDMAKLLC
PDHK1_Hsap_PDHK ------------------------------------------CNVLEVIKDGYENARRLC
PDK_Dmel_PDHK ------------------------------------------CDLSDVVRDAYENARFLC
PDHK4_Mmus_PDHK ------------------------------------------CDVVAVVQDAFECAKMLC
PDHK3_Mmus_PDHK ------------------------------------------CNVADVVKDAYETAKMLC
PDHK2_Mmus_PDHK ------------------------------------------CSVSDVVKDAYDMAKLLC
PDHK1_Mmus_PDHK ------------------------------------------CDVVEVIKDGYENARRLC
BCKDK_Mmus_BCKDK ------------------------------------------LSPKKIIEKWVDFARRLC
BCKDK_Hsap_BCKDK ------------------------------------------LSPKKIIEKWVDFARRLC
YIL042C_Scer_PDHK ------------------------------------------LPIAQLIKHVSDYVNDIC
BCKDK_Spur_BCKDK ------------------------------------------MSLKKVIEKWVSFAREQC
PDHK_Spur_PDHK ------------------------------------------CDIVAVIRDAYDSAKYLC
aSWK467_Cele_PDHK ------------------------------------------CDVESVVYDAFENARFLC
pdhk-2_Cele_PDHK ------------------------------------------CDVESVVYDAFENARFLC
CC1G_13956_Ccin_BCKDK ------------------------------------------CSPKEMVDVCGSFVGDLC
CC1G_00337_Ccin_BCKDK ------------------------------------------LDVKRCIDRCSTILRDRP
CC1G_15212_Ccin_PDHK SRYLDSTRLGRCDVFGIWFCLDLGGYGAISRTFYTCAVISGLWNVHDIVQEAIENARFVC
:
PDHK4_Hsap_PDHK -------DQYYLS--SPELKLTQVNGKFP-DQPIHIVYVPSHLHHMLFELFKNAMRATVE
PDHK3_Hsap_PDHK -------EQYYLV--APELEVEEFNAKAP-DKPIQVVYVPSHLFHMLFELFKNSMRATVE
PDHK2_Hsap_PDHK -------DKYYMA--SPDLEIQEINAANS-KQPIHMVYVPSHLYHMLFELFKNAMRATVE
PDHK1_Hsap_PDHK -------DLYYIN--SPELELEELNAKSP-GQPIQVVYVPSHLYHMVFELFKNAMRATME
PDK_Dmel_PDHK -------DQYYLT--SPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVE
PDHK4_Mmus_PDHK -------DQYYLT--SPELNLTQVNGKFP-GQPIHIVYVPSHLHHMLFELFKNAMRATVE
PDHK3_Mmus_PDHK -------EQYYLV--APELEVEEFNAKAP-NKPIQVVYVPSHLFHMLFELFKNSMRATVE
PDHK2_Mmus_PDHK -------DKYYMA--SPDLEIQEVNATNA-NQPIHMVYVPSHLYHMLFELFKNAMRATVE
PDHK1_Mmus_PDHK -------DLYYVN--SPELELEELNAKSP-GQTIQVVYVPSHLYHMVFELFKNAMRATME
BCKDK_Mmus_BCKDK -------EHKYGN--APRVRINGHV-------AARFPFIPMPLDYILPELLKNAMRATME
BCKDK_Hsap_BCKDK -------EHKYGN--APRVRINGHV-------AARFPFIPMPLDYILPELLKNAMRATME
YIL042C_Scer_PDHK -------FVKFNTQRTPVLIHPP-------SQDITFTCIPPILEYIMTEVFKNAFEAQIA
BCKDK_Spur_BCKDK -------ELRFGY--APSVKINGHT-------GATFPYIIQPLDYMLPELLKNAMRATIE
PDHK_Spur_PDHK -------DQYYLA--SPDIDVRWIDARDG-SDSIRMVYVPSHLYHIMFELLKNAMRAVME
aSWK467_Cele_PDHK -------DRYYLT--SPSMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVE
pdhk-2_Cele_PDHK -------DRYYLT--SPSMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVE
CC1G_13956_Ccin_BCKDK -------RATLGS--APEIVVDG-------YPEATFAYIPVHLEYVLTELLKNSFRATVE
CC1G_00337_Ccin_BCKDK LWVHGNEDVRIDA--WPEVEVEG-------HLDTKFAYIRDHLEYIVFELLKNAMSATVL
CC1G_15212_Ccin_PDHK -------EEHYAMFKGPPVQLIC-------PPSLTFAYVPGHLSHICFELLKNSLRAVVE
* : : * :: *::**:: * :
PDHK4_Hsap_PDHK HQE-NQ--PSLTPIEVIVVLGKED-----------------LTIKISDRGGGVPLR----
PDHK3_Hsap_PDHK LYE-DR-KEGYPAVKTLVTLGKED-----------------LSIKISDLGGGVPLR----
PDHK2_Hsap_PDHK SHE-SS--LILPPIKVMVALGEED-----------------LSIKMSDRGGGVPLR----
PDHK1_Hsap_PDHK HHA-NR--GVYPPIQVHVTLGNED-----------------LTVKMSDRGGGVPLR----
PDK_Dmel_PDHK HHGHDN-NDTLPPLKVAICKGKED-----------------ICVKISDQGGGIPRS----
PDHK4_Mmus_PDHK HQE-NR--PSLTPVEATVVLGKED-----------------LTIKISDRGGGVPLR----
PDHK3_Mmus_PDHK LHE-DK-KEGYPAVKTLVTLGKED-----------------LSIKISDLGGGVPLR----
PDHK2_Mmus_PDHK SHE-SS--LTLPPIKIMVALGEED-----------------LSIKMSDRGGGVPLR----
PDHK1_Mmus_PDHK HHA-DK--GVYPPIQVHVTLGEED-----------------LTVKMSDRGGGVPLR----
BCKDK_Mmus_BCKDK SHL-DT-PYNVPDVVITIANNDID-----------------LIIRISDRGGGIAHK----
BCKDK_Hsap_BCKDK SHL-DT-PYNVPDVVITIANNDVD-----------------LIIRISDRGGGIAHK----
YIL042C_Scer_PDHK LG---KE--H-MPIEINLLKP----------------DDDELYLRIRDHGGGITPE----
BCKDK_Spur_BCKDK SHL-DT-PMNLPDVVITIASNEVDFIISFGWQNQLIEYDNDVLNRISDRGGGIPHS----
PDHK_Spur_PDHK HKG-PS-ASEFPPIGILVTKGKED-----------------VTIKVSDEGGGIPKS----
aSWK467_Cele_PDHK YHG-VD--DDLPDIKVYVVKGQED-----------------LSIKICDRGGGVSRT----
pdhk-2_Cele_PDHK YHG-VD--DDLPDIKVYVVKGQED-----------------LSIKICDRGGGVSRT----
CC1G_13956_Ccin_BCKDK HHARSKERGSLPPIQITLSPPPASSH--SG---HNVDRPNFFSIRIRDQGGGVSRQ----
CC1G_00337_Ccin_BCKDK KHHDS--GSSLPPIRVTIVAG-----------------EDDISLRISDQGGGLTSVNAPT
CC1G_15212_Ccin_PDHK RYGVDA-EDHFPPIKVIVVEG-----------------KEDITIKISDEGGGIARS----
: : . :: * ***:.
PDHK4_Hsap_PDHK -IIDRLFSYTYSTAPTPVMDNS--------------------------------------
PDHK3_Hsap_PDHK -KIDRLFNYMYSTAPRPSLEPT--------------------------------------
PDHK2_Hsap_PDHK -KIERLFSYMYSTAPTPQP-GT--------------------------------------
PDHK1_Hsap_PDHK -KIDRLFNYMYSTAPRPRVETS--------------------------------------
PDK_Dmel_PDHK -QTDQLFKYMYSTAPQPSKSDL--------------------------------------
PDHK4_Mmus_PDHK -ITDRLFSYTYSTAPTPVMDNS--------------------------------------
PDHK3_Mmus_PDHK -KIDRLFNYMYSTAPRPSLEPT--------------------------------------
PDHK2_Mmus_PDHK -KIERLFSYMYSTAPTPQP-GT--------------------------------------
PDHK1_Mmus_PDHK -KIDRLFNYMYSTAPRPRVETS--------------------------------------
BCKDK_Mmus_BCKDK -DLDRVMDYHFTTAEASTQDPR----------------INPLFGHL--------------
BCKDK_Hsap_BCKDK -DLDRVMDYHFTTAEASTQDPR----------------ISPLFGHL--------------
YIL042C_Scer_PDHK -VEALMFNYSYSTHTQQSADSES---------------T---------------------
BCKDK_Spur_BCKDK -LLKKVFQYHFTTANDDESVSDNGGALGTMIEAVNQPTAGPLCGISDRGGGIP---HSLL
PDHK_Spur_PDHK -EIDLLFNYMYSTAPAPPKPGV--------------------------------------
aSWK467_Cele_PDHK -ILERLYNYMYSTAPPPPRDG---------------------------------------
pdhk-2_Cele_PDHK -ILERLYNYMYSTAPPPPRDG---------------------------------------
CC1G_13956_Ccin_BCKDK -HLERIFSYAFTTVKTGDDEGPD---------------W---------------------
CC1G_00337_Ccin_BCKDK NDPMDLFSFSHIRNAS-RLEDSR---------------LG--ALRTASEEGLRATVDEQL
CC1G_15212_Ccin_PDHK -AIPLIWTYMYTTMEHQTSLDED-------------------------------------
: : .
PDHK4_Hsap_PDHK -------------------------------------RNAPLAGFGYGLPISRLYAKYFQ
PDHK3_Hsap_PDHK -------------------------------------RAAPLAGFGYGLPISRLYARYFQ
PDHK2_Hsap_PDHK -------------------------------------GGTPLAGFGYGLPISRLYAKYFQ
PDHK1_Hsap_PDHK -------------------------------------RAVPLAGFGYGLPISRLYAQYFQ
PDK_Dmel_PDHK -------------------------------------HTVPLAGYGYGLPISRLYARYFH
PDHK4_Mmus_PDHK -------------------------------------RNAPLAGFGYGLPISRLYAKYFQ
PDHK3_Mmus_PDHK -------------------------------------RAAPLAGFGYGLPISRLYARYFQ
PDHK2_Mmus_PDHK -------------------------------------GGTPLAGFGYGLPISRLYAKYFQ
PDHK1_Mmus_PDHK -------------------------------------RAVPLAGFGYGLPISRLYAQYFQ
BCKDK_Mmus_BCKDK --------------D-----------------MHSGGQSGPMHGFGFGLPTSRAYAEYLG
BCKDK_Hsap_BCKDK --------------D-----------------MHSGAQSGPMHGFGFGLPTSRAYAEYLG
YIL042C_Scer_PDHK --------------------------------DLPGEQINNVSGMGFGLPMCKTYLELFG
BCKDK_Spur_BCKDK KKVFQYHFTTA-NDDESVSDNGGA--LGTMIEAVNQPTAGPLCGFGFGLPVSKAYAEYLG
PDHK_Spur_PDHK ------------------------------------SIIPPLAGYGYGLPISRLYAKYFH
aSWK467_Cele_PDHK ------------------------------------T-QAPLAGYGYGLPLSRLYARYFL
pdhk-2_Cele_PDHK ------------------------------------T-QAPLAGYGYGLPLSRLYARYFL
CC1G_13956_Ccin_BCKDK --------------DT-SDSREDEPFLGVMTQRTLQTGLGTIAGLGYGLPMSKLYTKYFG
CC1G_00337_Ccin_BCKDK SRWQKHSYYQPKNRDK-LEEHGTA--------PSQEIMNIVRSRIGIGLPMSNIYATYFG
CC1G_15212_Ccin_PDHK --------------------------------FQASDFKAPMAGFGYGLPLSRLYARYFG
* *** .. * :
PDHK4_Hsap_PDHK GDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNL
PDHK3_Hsap_PDHK GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA
PDHK2_Hsap_PDHK GDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNT
PDHK1_Hsap_PDHK GDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDM
PDK_Dmel_PDHK GDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVPTGDWSNQVKYAKKK
PDHK4_Mmus_PDHK GDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNL
PDHK3_Mmus_PDHK GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA
PDHK2_Mmus_PDHK GDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNT
PDHK1_Mmus_PDHK GDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDM
BCKDK_Mmus_BCKDK GSLQLQSLQGIGTDVYLRLRHIDGRE----------------------------------
BCKDK_Hsap_BCKDK GSLQLQSLQGIGTDVYLRLRHIDGRE----------------------------------
YIL042C_Scer_PDHK GKIDVQSLLGWGTDVYIKLKGPSKTA-L--------------------------------
BCKDK_Spur_BCKDK GSISLETMQGIGTDVYLRLRHIDGKQ----------------------------------
PDHK_Spur_PDHK GDLTLSSMDGYGTDAVVYLKVLSSEASELLPIYNSAVSRYYKTPTPASDWSTPGYFIRNY
aSWK467_Cele_PDHK GDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHH--VPGQG
pdhk-2_Cele_PDHK GDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHH--VPGQG
CC1G_13956_Ccin_BCKDK GSLDLISLEGWGSDVYIKLRCLDEAG-D--------------------------------
CC1G_00337_Ccin_BCKDK GSLELVSLDGWGTDVFLRLPKLGTNL-E--------------------------------
CC1G_15212_Ccin_PDHK GDLRLIAMDGFGTDVYIHLNRLSSSR-E--------------------------------
*.: : : * *:*. : :
PDHK4_Hsap_PDHK AK----------EVAM
PDHK3_Hsap_PDHK SKYKAKQDKIKTNRTF
PDHK2_Hsap_PDHK ST----------YRVS
PDHK1_Hsap_PDHK TT----------FRSA
PDK_Dmel_PDHK KTS---------AVSQ
PDHK4_Mmus_PDHK AKE---------KLAV
PDHK3_Mmus_PDHK SKYKAKQDKIKSNRTF
PDHK2_Mmus_PDHK ST----------YRVS
PDHK1_Mmus_PDHK TT----------FRSS
BCKDK_Mmus_BCKDK -E----------SFRI
BCKDK_Hsap_BCKDK -E----------SFRI
YIL042C_Scer_PDHK ------------LSKK
BCKDK_Spur_BCKDK -E----------SFRI
PDHK_Spur_PDHK TTK---------RYGK
aSWK467_Cele_PDHK NR----------PAQS
pdhk-2_Cele_PDHK NR----------PAQS
CC1G_13956_Ccin_BCKDK -------------SNI
CC1G_00337_Ccin_BCKDK ------------GIEV
CC1G_15212_Ccin_PDHK -------------PLP