MNK2_Hsap_MNK MVQKKPAELQ-G--------FH----RSF-------------------------------
MNK1_Hsap_MNK MVSSQKLEK---------------------------------------------------
MAPKAPK5_Hsap_MK5 MSEESDM-----------------------------------------------------
MAPKAPK3_Hsap_MK2 MDGETAEEQG--------------------------------------------------
MAPKAPK2_Hsap_MK2 MLSNSQGQSP--------------------------------------------------
MAPk-Ak2_Dmel_MK2 MLSLQN------------------------------------------------------
Lk6_Dmel_MNK MVEPKSGTAA-S--------AA-----AA-------------------------------
MNK2_Mmus_MNK MVQKRTAELQ-G--------FH----RSF-------------------------------
MNK1_Mmus_MNK MGSS--------------------------------------------------------
MAPKAPK5_Mmus_MK5 MSEDSDM-----------------------------------------------------
MAPKAPK3_Mmus_MK2 MDGETAGEKG--------------------------------------------------
MAPKAPK2_Mmus_MK2 MLSGSPGQTP--------------------------------------------------
R166.5_Cele_MNK MTILHAGYPQ-S-------P-V----VHF-----GRHHNVNINQLNLNHLGQVDNIPNNS
K08F8.1_Cele_MK2 MMFEYEEDED-P--------MEQQKHEEFKHHSTD-------------------------
C44C8.6_Cele_MK2 MQIRVLCVST----------------ADFS------------------------------
MAPKAPK2_Spur_MK2 MIR---------------------------------------------------------
MAPKAPK5a_Spur_MK2 MDFRTGF-----------------------------------------------------
MAPKAPK5b_Spur_MK5 MSLFTPITNLRL--------------GG--------------------------------
Mnk_Spur_MNK MGNDRGKQAI-VYKKQVLQPVM----RSF-------------------------------
AqueK073_Aque_MK2 MSSHPLTGKA--------------------------------------------------
AqueK074_Aque_MK5 MRRVSGAIDF----------------VY--------------------------------
AqueK075_Aque_MNK MEGTASRAAS--------------------------------------------------
*
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK --------------KASNNN-----------NNN--------------HPRG-SGDSGIR
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK AVGGGGAAFHHLHTSAATPRHVATSEFYDDEEAT--------------SPRG-GIEIGAG
K08F8.1_Cele_MK2 --------------HSGS------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ------------VFPTVCPQ------------DS--------------YPS---------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------TKMEDREEIRDLLQFKHDFTLGLVSENGSSKTNGSI
MNK2_Hsap_MNK ------------------------KGQNPFELAFSL----------D-------------
MNK1_Hsap_MNK ----------------------------PI------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 --------------------------G-P----------------VP-------------
MAPKAPK2_Hsap_MK2 --------------------------PVPFP--------------AP------------A
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK SGSGISCSNTDNSCSQSQS-----DGQNELTRYSS-------------------------
MNK2_Mmus_MNK ------------------------KGQNPFELAFSL----------D-------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 --------------------------S-L----------------VP-------------
MAPKAPK2_Mmus_MK2 --------------------------PAPFP--------------SP-------------
R166.5_Cele_MNK GGKMM---------ANLRRHRQ--RERETYEDEDVL----------S-------------
K08F8.1_Cele_MK2 ------------------------PQENPFRFSYDTGKRAASMFVTPSSEDLIAYGTKHL
C44C8.6_Cele_MK2 --------------------------PKNLL--------------GP------------S
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 --------------------------STPIA--------------PD------------N
Mnk_Spur_MNK ------------------------QETTPIT---------------K-------------
AqueK073_Aque_MK2 --------------------------PPDFA-----------------------------
AqueK074_Aque_MK5 --------------------------KLPFW--------------SY------------S
AqueK075_Aque_MNK DGKMG---------AAEKRNDESIKSLKEFQKSFKL----------G-------------
MNK2_Hsap_MNK ------------------------------------------------------QPD---
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------PPVA--
MAPKAPK2_Hsap_MK2 ------------------------------------------------------PPPQ--
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK ------------------------------------------------------------
MNK2_Mmus_MNK ------------------------------------------------------LAQ---
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------PPGA--
MAPKAPK2_Mmus_MK2 ------------------------------------------------------PPPA--
R166.5_Cele_MNK ------------------------------------------------------SSD---
K08F8.1_Cele_MK2 -----------------LD-----------------------------------SPTAVQ
C44C8.6_Cele_MK2 SLIFRVFFGGFLYANVKLE-----------------------------------APEA--
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 Q---------------AVYITEVDAQKRFARCGEPLIAMVCSDHTIKLVGKETMSSAG--
Mnk_Spur_MNK ------------------------------------------------------MPT---
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ---------------------------RLQRREEALLT----------------LPVA--
AqueK075_Aque_MNK ------------------------------------------------------KSE---
MNK2_Hsap_MNK -----------------HGDSDF-----GL---QCSAR--PD-----------M------
MNK1_Hsap_MNK -----------------------------------------E-----------M------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 -----------------------------P---GGP-----------------G------
MAPKAPK2_Hsap_MK2 -----------------------------P---PTP-----------------A------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK --------------------EDV----SGN---ESSEA--PN-----------M------
MNK2_Mmus_MNK -----------------HRDSDF-----SP---QCEAR--PD-----------M------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 -----------------------------L---GGS-----------------A------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK -----------------E----------------SSGRPIPR-----------YVGRDTD
K08F8.1_Cele_MK2 RSLVLNATTSLNIDCDLSSDDDL-----SP---TTQRK--ICF----------C------
C44C8.6_Cele_MK2 -----------------------------Q--KSTR------GSFFSRIGCCLS------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 -----------------------------QLKGHGGP----------------V------
Mnk_Spur_MNK ------------------GD--------KM---TVSQR--P-------------------
AqueK073_Aque_MK2 -----------------------------A------------------------------
AqueK074_Aque_MK5 -----------------------------SL-LFGS-----------------I------
AqueK075_Aque_MNK -----------------QSNSVLSPHVNGS---DCSQREVPR-----------SLD----
MNK2_Hsap_MNK -------------------------------PA--------------------S---QP-
MNK1_Hsap_MNK -------------------------------GS--------------------S---EP-
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 -------------------------------LG--------------------G------
MAPKAPK2_Hsap_MK2 -------------------------------LP--------------------H---PP-
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK -------------------------------TE--------------------V---ERQ
MNK2_Mmus_MNK -------------------------------PS--------------------S---QP-
MNK1_Mmus_MNK ---------------------------------------------------------EP-
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 -------------------------------LG--------------------G---AP-
MAPKAPK2_Mmus_MK2 ----------------------------------------------------------P-
R166.5_Cele_MNK HVFGEFEMDDEDVVMRREDGYGEDETDEDYFDE--------------------E---EP-
K08F8.1_Cele_MK2 -------------------------------AS--------------------Q---NP-
C44C8.6_Cele_MK2 -------------------------------TK--------------------S---SP-
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 -------------------------------SGVKFAHRNPFTVFSSSRDGTVRCWDTR-
Mnk_Spur_MNK -------------------------------PA--------------------T---AA-
AqueK073_Aque_MK2 -----------------------------------------------------H---VP-
AqueK074_Aque_MK5 -------------------------------TG--------------------N--LIN-
AqueK075_Aque_MNK -------------------------------IT--------------------A---QP-
MNK2_Hsap_MNK IDI-P-----------------------------------------DAKKRGKK-KK-RG
MNK1_Hsap_MNK LPI-A-----------------------------------------DGDRRRKK-KR-RG
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 -----------------------------------------------A---------P-G
MAPKAPK2_Hsap_MK2 AQP-P----------------------------------------PPPPQQFPQ-FHV-K
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK AEL-N----------------------------------------RHKEEMQKK-RR-KK
MNK2_Mmus_MNK IDI-P-----------------------------------------DAKKRGRK-KK-RC
MNK1_Mmus_MNK LPI-V-----------------------------------------DSDKRRKK-KR-KT
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 -----------------------------------------------A---------P-G
MAPKAPK2_Mmus_MK2 AQP-P----------------------------------------PP----FPQ-FHV-K
R166.5_Cele_MNK VAE-L-------------------------------------LPLGGGTRRVPR-TP-GR
K08F8.1_Cele_MK2 AET-Q----------------------------------------EQGL--RPA-KSTLA
C44C8.6_Cele_MK2 AEK-I----------------------------------------K-P---------P-D
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 MKRNK----------------------------------------APQV--F--TG----
Mnk_Spur_MNK VQM-PDCKATAENYANNNIADETCLLSEQMDLMMSISSVEDFHSGLDDSRRKRK-KK-KK
AqueK073_Aque_MK2 -----------------------------------------------S---------A-Q
AqueK074_Aque_MK5 RKR-S----------------------------------------KPQN--LSLMSKY-E
AqueK075_Aque_MNK VSR-G-------------------------------------QANTSKKKKQKK-KR-LK
MNK2_Hsap_MNK RATDS-FSGRFEDV--YQLQ----------------------------------------
MNK1_Hsap_MNK RATDS-LPGKFEDM--YKLT----------------------------------------
MAPKAPK5_Hsap_MK5 -DKA-IKETSILEE--YSINW---------------------------------------
MAPKAPK3_Hsap_MK2 GRRE-PKKYAVTDD--YQLS----------------------------------------
MAPKAPK2_Hsap_MK2 SGLQ-IKKNAIIDD--YKVT----------------------------------------
MAPk-Ak2_Dmel_MK2 -QRQ-PKTTPLTDD--YVTS----------------------------------------
Lk6_Dmel_MNK RISSSLHSSTFQEL--YKLT----------------------------------------
MNK2_Mmus_MNK RATDS-FSGRFEDV--YQLQ----------------------------------------
MNK1_Mmus_MNK RATDS-LPGKFEDV--YQLT----------------------------------------
MAPKAPK5_Mmus_MK5 -EKA-IKETSILEE--YSINW---------------------------------------
MAPKAPK3_Mmus_MK2 VRRE-PKKYAVTDD--YQLS----------------------------------------
MAPKAPK2_Mmus_MK2 SGLQ-IRKNAITDD--YKVT----------------------------------------
R166.5_Cele_MNK -K-NS-SKCGFFDY--YKLT----------------------------------------
K08F8.1_Cele_MK2 ISFP-CHQHQITED--YTIS----------------------------------------
C44C8.6_Cele_MK2 EIMA-FHEYPVTQD--YRIS----------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 -----FETVSILED--YTIDW---------------------------------------
MAPKAPK5b_Spur_MK5 -----YEGN-SFTSFDINSTDDILSAGTEAVDNDAYLMFWDRRSTNLLGTYKESHSDDIT
Mnk_Spur_MNK RTSGI-VPNRFEDV--YDLT----------------------------------------
AqueK073_Aque_MK2 KPLI-PKKHAITGD--YTIL----------------------------------------
AqueK074_Aque_MK5 RDPE-FKKTSILDD--YEIKW---------------------------------------
AqueK075_Aque_MNK PIPDD-IDYSFNDL--YELT----------------------------------------
MNK2_Hsap_MNK --------EDVLGEGAH-ARVQTCINLITSQEYAVKIIEKQPG-HIRSRVFREVEM----
MNK1_Hsap_MNK --------SELLGEGAY-AKVQGAVSLQNGKEYAVKIIEKQAG-HSRSRVFREVET----
MAPKAPK5_Hsap_MK5 --------TQKLGAGIS-GPVRVCVKKSTQERFALKILLDRP------KARNEVRL----
MAPKAPK3_Hsap_MK2 --------KQVLGLGVN-GKVLECFHRRTGQKCALKLLYDSP------KARQEVDH----
MAPKAPK2_Hsap_MK2 --------SQVLGLGIN-GKVLQIFNKRTQEKFALKMLQDCP------KARREVEL----
MAPk-Ak2_Dmel_MK2 --------NTVLGYGIN-GKVVQCTHRRTQQNYALKVLLDSE------RARREVDL----
Lk6_Dmel_MNK --------GEILGEGAY-ASVQTCVNIYTDLEYAVKVIDKIPG-HARARVFREVET----
MNK2_Mmus_MNK --------EDVLGEGAH-ARVQTCVNLITNQEYAVKIIEKQLG-HIRSRVFREVEM----
MNK1_Mmus_MNK --------SELLGEGAY-AKVQGAVNLQSGKEYAVKIIEKQAG-HSRSRVFREVET----
MAPKAPK5_Mmus_MK5 --------TQKLGAGIS-GPVRVCVKKSTQERFALKILLDRP------KARNEVRL----
MAPKAPK3_Mmus_MK2 --------KQVLGLGVN-GKVLECYHRRSGQKCALKLLYDSP------KARQEVDH----
MAPKAPK2_Mmus_MK2 --------SQVLGLGIN-GKVLRIFDKRTQQKFALKMLQDCP------KARREVEL----
R166.5_Cele_MNK --------DEHLGSGAY-GSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNI----
K08F8.1_Cele_MK2 --------AEIIGIGES-GKVMACYQKVTGEKFALKVLRDSQ------KARREVEL----
C44C8.6_Cele_MK2 --------RKVLGVGIN-GKVVECEHRQSGDKFALKVLRDTQ------KARREVEL----
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 --------TQKLGTGIN-GPVRPCQHKRSEDRFALKLLLDKP------GARAEVNL----
MAPKAPK5b_Spur_MK5 QVKFHPTKSSSLATGSTDGLVCVFDTSQTNEEDALVTTLNSE------SSVSHIDWCGTN
Mnk_Spur_MNK --------GELLGSGSY-ASVRTCRQISSGKEYAVKMMEKRPG-NSRTKIFREVET----
AqueK073_Aque_MK2 --------TRSLGVGVN-GKVLECIHKATGERRALKILRENP------KSRRELDL----
AqueK074_Aque_MK5 --------NRSLGTGVS-GPVRLCIHRATGKEYALKLLLDRSD---RKKAEIEATL----
AqueK075_Aque_MNK --------SEILGSGAR-ATVITCIKRTTRQQYAAKIINNSGP-EVRDRVLKEVEI----
MNK2_Hsap_MNK --LYQCQGHRNVLELIEFFEEE------------------------------DRFYLVFE
MNK1_Hsap_MNK --LYQCQGNKNILELIEFFEDD------------------------------TRFYLVFE
MAPKAPK5_Hsap_MK5 --HMMCATHPNIVQIIEVFANSV--QFPH------------------ESSPRARLLIVME
MAPKAPK3_Hsap_MK2 --HWQASGGPHIVCILDVYENMH--H------------------------GKRCLLIIME
MAPKAPK2_Hsap_MK2 --HWRASQCPHIVRIVDVYENLY--A------------------------GRKCLLIVME
MAPk-Ak2_Dmel_MK2 --HWRVSGCRYIVNIIDVYENTF--K------------------------DRKCLLVVME
Lk6_Dmel_MNK --FHHCQGHLGILQLIEFFEDD------------------------------EKFYLVFE
MNK2_Mmus_MNK --LYQCQGHRNVLELIEFFEEE------------------------------DRFYLVFE
MNK1_Mmus_MNK --LYQCQGNRNILELIEFFEDD------------------------------TRFYLVFE
MAPKAPK5_Mmus_MK5 --HMMCATHPNIVQIIEVFANSV--QFPH------------------ESSPRARLLIVME
MAPKAPK3_Mmus_MK2 --HWQASGGPHIVRILDVYENMH--H------------------------GKRCLLIVME
MAPKAPK2_Mmus_MK2 --HWRASQCPHIVHIVDVYENLY--A------------------------GRKCLLIVME
R166.5_Cele_MNK --FKTCKDHPNIVQLLDWFEDE------------------------------TNFYLVME
K08F8.1_Cele_MK2 --HWLTNAHENVVSILDIYENTF--D------------------------NVKCLLMVVE
C44C8.6_Cele_MK2 --HVMASGHGHVVSVHDVYKNSY--N------------------------GVDCLLVVME
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 --HSRCSGHANIVKIIEVFSNEV--QFPG------------------EPAPKSRLLVVME
MAPKAPK5b_Spur_MK5 SEYLYCLTHTETIRIFDAVESSEITKFDSVRESLKEDRCKVDYLVDCFYHSGLKSLVVLG
Mnk_Spur_MNK --LYHCQGHNNILQLIEYFEDD------------------------------DRFYLIFE
AqueK073_Aque_MK2 --HWRSCSHENIVNICDVYENVF--M------------------------GHRSLLVVME
AqueK074_Aque_MK5 --HWRCSGGDHIVRIVDIYRNEI--QQPG------------------ELSPKKRILLVME
AqueK075_Aque_MNK --LYSCSSCDNFLKIEDFFETS------------------------------EKFYLVFE
MNK2_Hsap_MNK KMRGGSILS--HIHKR--RHFNELEASVVVQDVASALDFLHNK-----------------
MNK1_Hsap_MNK KLQGGSILA--HIQKQ--KHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSG
MAPKAPK5_Hsap_MK5 MMEGGELFH--RISQH--RHFTEKQASQVTKQATLALRHCHLL-----------------
MAPKAPK3_Hsap_MK2 CMEGGELFS--RIQERGDQAFTEREAAEIMRDIGTAIQFLHSH-----------------
MAPKAPK2_Hsap_MK2 CLDGGELFS--RIQDRGDQAFTEREASEIMKSIGEAIQYLHSI-----------------
MAPk-Ak2_Dmel_MK2 CMEGGELFQ--RIQDKADGAFTEREAAQIMHEICAAVDYLHSR-----------------
Lk6_Dmel_MNK KINGGPLLS--RIQEH--ICFSEHEASQIIKEIASGLDFLHKK-----------------
MNK2_Mmus_MNK KMRGGSILS--HIHRR--RHFNELEASVVVQDVASALDFLHNK-----------------
MNK1_Mmus_MNK KLQGGSILA--HIQKR--KHFNEREASRVVRDVATALDFLHTK-----------------
MAPKAPK5_Mmus_MK5 MMEGGELFH--RISQH--RHFTEKQASQVTKQIALALQHCHLL-----------------
MAPKAPK3_Mmus_MK2 CMEGGELFS--RIQERGDQAFTEREAAEIMRDIGTAIQFLHSR-----------------
MAPKAPK2_Mmus_MK2 CLDGGELFS--RIQDRGDQAFTEREASEIMKSIGEAIQYLHSI-----------------
R166.5_Cele_MNK KMRGGPLLQ--HILQR--KYFTEEEARRVTKDISLALKFMHDR-----------------
K08F8.1_Cele_MK2 FLEGGDLLS--QFESQGSIPYTEKKVGEIIRQIGNAVMYLHDM-----------------
C44C8.6_Cele_MK2 NMKGGELFN--RIQERGQKAFTEREAAGIVNEICSAVAHLHRM-----------------
MAPKAPK2_Spur_MK2 ----------------------LTEAAEIVRSIGQAVHHLHVM-----------------
MAPKAPK5a_Spur_MK2 LMDGGELFD--RISKQ--KRFTERQAVILTKQIASAVLQCHSL-----------------
MAPKAPK5b_Spur_MK5 GTVGGDLHLLTVGKDR--------------------LHFVHSL-----------------
Mnk_Spur_MNK KMYGGALLQ--HIEQR--GTFTEQEASQVIRDIASALSFLHNK-----------------
AqueK073_Aque_MK2 CMEGGELFD--RIQDK--GHFTEREAAEVVRCISLAVAHLHHM-----------------
AqueK074_Aque_MK5 LMEGKELFD--YISKR--HHFTEHEASKYILQIVRGVQFCHRL-----------------
AqueK075_Aque_MNK KMEG-PLLE--LIQKR--ERFTEREASEVTREVAAALSFLHRQ-----------------
: *
MNK2_Hsap_MNK ------------------------GI--------AHRDLKPENILCEHP---NQVSPVKI
MNK1_Hsap_MNK LTAAPTSLGSSDPPTSASQVAGTTGI--------AHRDLKPENILCESP---EKVSPVKI
MAPKAPK5_Hsap_MK5 ------------------------NI--------AHRDLKPENLLFKDN---SLDAPVKL
MAPKAPK3_Hsap_MK2 ------------------------NI--------AHRDVKPENLLYTSK---EKDAVLKL
MAPKAPK2_Hsap_MK2 ------------------------NI--------AHRDVKPENLLYTSK---RPNAILKL
MAPk-Ak2_Dmel_MK2 ------------------------DI--------AHRDLKPENLLYTTT---QPNATLKL
Lk6_Dmel_MNK ------------------------GI--------AHRDLKPENILCVKT---DSLCPIKI
MNK2_Mmus_MNK ------------------------GI--------AHRDLKPENILCEHP---NQVSPVKI
MNK1_Mmus_MNK ------------------------GI--------AHRDLKPENILCESP---EKVSPVKI
MAPKAPK5_Mmus_MK5 ------------------------NI--------AHRDLKPENLLFKDN---SLDAPVKL
MAPKAPK3_Mmus_MK2 ------------------------NI--------AHRDVKPENLLYTSK---EKDAVLKL
MAPKAPK2_Mmus_MK2 ------------------------NI--------AHRDVKPENLLYTSK---RPNAILKL
R166.5_Cele_MNK ------------------------GI--------AHRDVKPENVLCTDP---NHVSPVKL
K08F8.1_Cele_MK2 ------------------------NI--------AHRDIKLENILCSGT---GDNCVYKL
C44C8.6_Cele_MK2 ------------------------SI--------AHRDLKPENLLYVTT---ASNAALKL
MAPKAPK2_Spur_MK2 ------------------------NI--------AHRDLKPENLLYRDR---TPNSLLKL
MAPKAPK5a_Spur_MK2 ------------------------NI--------AHRDLKPENLLLKDN---SEDSPVKL
MAPKAPK5b_Spur_MK5 ------------------------KGTHKGVVRCLHWDNQTETLVTGGEDSI---VSAWQ
Mnk_Spur_MNK ------------------------GI--------AHRDLKPENILCESM---YSISPIKI
AqueK073_Aque_MK2 ------------------------DI--------AHRDLKPENLLYSDK---TPSAKLKL
AqueK074_Aque_MK5 ------------------------NI--------AHRDIKPENLLLLKPASNPEDVVIKL
AqueK075_Aque_MNK ------------------------GI--------AHRDLKPENILCQTK---DEVVPIKV
* * : *.::
MNK2_Hsap_MNK CDFDL--------GSGIKLNGD-CS----PISTPELLTPCGSAEYMAP-EVVEAFS----
MNK1_Hsap_MNK CDFDL--------GSGMKLNNS-CT----PITTPELTTPCGSAEYMAP-EVVEVFT----
MAPKAPK5_Hsap_MK5 CDFGF--------AKID---------------QGDLMTPQFTPYYVAP-QVLEAQRRHQK
MAPKAPK3_Hsap_MK2 TDFGF--------AKETT--------------QNALQTPCYTPYYVAP-EVLG-------
MAPKAPK2_Hsap_MK2 TDFGF--------AKETTS-------------HNSLTTPCYTPYYVAP-EVLG-------
MAPk-Ak2_Dmel_MK2 TDFGF--------AKETFT-------------SYTLQTPCYTPYYVAP-EVLG-------
Lk6_Dmel_MNK CDFDL--------GSGIKFTTDISS----PAATPQLLTPVGSAEFMAP-EVVDLFV----
MNK2_Mmus_MNK CDFDL--------GSGIKLNGD-CS----PISTPELLTPCGSAEYMAP-EVVEAFS----
MNK1_Mmus_MNK CDFDL--------GSGVKLNNS-CT----PITTPELTTPCGSAEYMAP-EVVEVFR----
MAPKAPK5_Mmus_MK5 CDFGF--------AKVD---------------QGDLMTPQFTPYYVAP-QVLEAQRRHQK
MAPKAPK3_Mmus_MK2 TDFGF--------AKETT--------------QNALQTPCYTPYYVAP-EVLG-------
MAPKAPK2_Mmus_MK2 TDFGF--------AKETTS-------------HNSLTTPCYTPYYVAP-EVLG-------
R166.5_Cele_MNK CDLDL--------ASQRPPQHE-RHPLSQVASEPDLASPVGSAEFMAP-EVVDAYV----
K08F8.1_Cele_MK2 GDYGF--------AKRPER-------------NVLMESPCCTPFYAPP-EVLG-------
C44C8.6_Cele_MK2 TDFGF--------AKKTDES-----------EPQGLKTACFTPYYCAP-EVLG-------
MAPKAPK2_Spur_MK2 TDFGF--------AKETT--------------TTNLQTPCYTPYYVAP-EVLG-------
MAPKAPK5a_Spur_MK2 SDFGF--------AKVD---------------DGTLMTPHFTPYYVAP-QVSTSLT----
MAPKAPK5b_Spur_MK5 PDRNANQSSSKKGSPAQ---------------TSRIRQGRRAEKRGSPVKVLEAQKRQRR
Mnk_Spur_MNK CDFGL--------GSGIHLSSQYNT----PVTTPELLTPVGSAEFMAP-EIVEAFIY---
AqueK073_Aque_MK2 TDFGF--------AKENHG-------------SKALTTPCYTPYYVAP-EVLG-------
AqueK074_Aque_MK5 SDFGF--------AKVD---------------NGDLKTPQFTPYYVAP-QVLEAQKRQKE
AqueK075_Aque_MNK CDFDL--------SSMMSQH----T----PATTPNLFTPVGSAEYMAP-EVLDTFT----
* . . : : .* ::
MNK2_Hsap_MNK ---------EEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGS-DCGWDRGEACPACQN
MNK1_Hsap_MNK ---------DQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGA-DCGWDRGEVCRVCQN
MAPKAPK5_Hsap_MK5 EKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS-----------RTIPK
MAPKAPK3_Hsap_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG------------QAISP
MAPKAPK2_Hsap_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG------------LAISP
MAPk-Ak2_Dmel_MK2 -----------PEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHG------------LAISP
Lk6_Dmel_MNK ---------GEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGE-DCGWNRGENCRTCQE
MNK2_Mmus_MNK ---------EEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGS-DCGWDRGEACPACQN
MNK1_Mmus_MNK ---------DEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGA-DCGWDRGEVCRMCQN
MAPKAPK5_Mmus_MK5 EKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS-----------RTIPK
MAPKAPK3_Mmus_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG------------QAISP
MAPKAPK2_Mmus_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG------------LAISP
R166.5_Cele_MNK ---------GDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQ
K08F8.1_Cele_MK2 -----------RERYDKSCDMWSLGVAMYILLCGYPPFYSMKG------------VALSP
C44C8.6_Cele_MK2 -----------TEKYDKSCDLWSIGVIMYILLCGYPPFYSQHG------------QPMSP
MAPKAPK2_Spur_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGFPPFYSNHG------------MAISP
MAPKAPK5a_Spur_MK2 ---------PI-------------------------------------------------
MAPKAPK5b_Spur_MK5 EQKNLIQTSPRPYTYDKGCDMWSLGVIIYIMLCGYPPFYPDTPS-----------RQLSK
Mnk_Spur_MNK --------DLQATVYDKRCDLWSLGVILYILLCGHPPFVGSCGE-DCGWDRGEACQDCEE
AqueK073_Aque_MK2 -----------PEKYDTSCDMWSIGVITYILLCGFPPFYSYGG------------APISP
AqueK074_Aque_MK5 SLSGY--KHRTPYYYDKSCDIWSIGVIMYIMLCGYPPFYSEVPH-----------QALSN
AqueK075_Aque_MNK ---------GEIFSYDKKCDLWSLGVLVYMMLSGSPPFTGGCRT-DCGWEKGEECEKCQA
MNK2_Hsap_MNK MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLS------------------
MNK1_Hsap_MNK KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS------------------
MAPKAPK5_Hsap_MK5 DMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT------------------
MAPKAPK3_Hsap_MK2 GMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLT------------------
MAPKAPK2_Hsap_MK2 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT------------------
MAPk-Ak2_Dmel_MK2 GMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLR------------------
Lk6_Dmel_MNK LLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLS------------------
MNK2_Mmus_MNK MLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLS------------------
MNK1_Mmus_MNK KLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLS------------------
MAPKAPK5_Mmus_MK5 DMRKKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT------------------
MAPKAPK3_Mmus_MK2 GMKRRIRLGQYSFPNPEWLDVSEDAKQLIRLLLKTDPTERLT------------------
MAPKAPK2_Mmus_MK2 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT------------------
R166.5_Cele_MNK DLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVNPFANRIRLTLVA
K08F8.1_Cele_MK2 GMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLT------------------
C44C8.6_Cele_MK2 GMKAKIKSGQYTFPSPEWDCVSEAAKDLIRKLLRTEPTERIT------------------
MAPKAPK2_Spur_MK2 GMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLS------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 DMRHKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLT------------------
Mnk_Spur_MNK LLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYT------------------
AqueK073_Aque_MK2 GMKKRIRQGQYGFPDPEWTNVSSQAKDLIKGLLKTNPADRFT------------------
AqueK074_Aque_MK5 RMKQKIMSADFDFPENDWKAVTDEAKDLIRKMLCVEPSERLS------------------
AqueK075_Aque_MNK ILLEKIGKGQYSFPQEIWASISSEAKDLISSLLQRDVRKRLS------------------
MNK2_Hsap_MNK --------------------------------------AAQVLQHPWVQGC--APE----
MNK1_Hsap_MNK --------------------------------------AAQVLQHPWVQGQ--APE----
MAPKAPK5_Hsap_MK5 --------------------------------------IEGVLDHPWLNST-EALD----
MAPKAPK3_Hsap_MK2 --------------------------------------ITQFMNHPWINQSMVVPQ----
MAPKAPK2_Hsap_MK2 --------------------------------------ITEFMNHPWIMQSTKVPQ----
MAPk-Ak2_Dmel_MK2 --------------------------------------IQDVISNKWIAQYNAVPQ----
Lk6_Dmel_MNK --------------------------------------AEAVLNHPWIRMCEQEPPASKH
MNK2_Mmus_MNK --------------------------------------AAQVLQHPWVQGC--APE----
MNK1_Mmus_MNK --------------------------------------AAQVLQHPWVQGQ--APE----
MAPKAPK5_Mmus_MK5 --------------------------------------IEGVLDHPWLNST-EALD----
MAPKAPK3_Mmus_MK2 --------------------------------------IMQFMNHPWINQSMVVPQ----
MAPKAPK2_Mmus_MK2 --------------------------------------ITEFMNHPWIMQSTKVPQ----
R166.5_Cele_MNK QSVACAIPTQPIVGSIPSYPALSLFIDCGAWKWRRKFNADQILSHRWLQQS--AAS----
K08F8.1_Cele_MK2 --------------------------------------IHELMATPLVTGEPIVPG----
C44C8.6_Cele_MK2 --------------------------------------IEQTMEHKWISHYRRVPD----
MAPKAPK2_Spur_MK2 --------------------------------------IQEFMNSPWVRQCSAVPA----
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 --------------------------------------IEELCSHPWLREN-SAPN----
Mnk_Spur_MNK --------------------------------------AGMVLNHPWVKQ---PPS----
AqueK073_Aque_MK2 --------------------------------------IDDVLRHRWIAGYQEVPQ----
AqueK074_Aque_MK5 --------------------------------------IEEVLHHPWLAQN-ASPN----
AqueK075_Aque_MNK --------------------------------------ADEVLAHPWIKTE--VPD----
MNK2_Hsap_MNK ----NTLPTPMVLQRNS-------------------------------------------
MNK1_Hsap_MNK ----KGLPTPQVLQRNS-------------------------------------------
MAPKAPK5_Hsap_MK5 ----NVLPSAQLMM-DK-------------------------------------------
MAPKAPK3_Hsap_MK2 ----TPLHTARVLQEDK-------------------------------------------
MAPKAPK2_Hsap_MK2 ----TPLHTSRVLKEDK-------------------------------------------
MAPk-Ak2_Dmel_MK2 ----TPLCTGRMLKEAE-------------------------------------------
Lk6_Dmel_MNK GRRHKALQTPSNIRRNH-------------------------------------------
MNK2_Mmus_MNK ----NTLPTPLVLQRNS-------------------------------------------
MNK1_Mmus_MNK ----RGLPTPQVLQRNS-------------------------------------------
MAPKAPK5_Mmus_MK5 ----NVLPSAQLMM-DK-------------------------------------------
MAPKAPK3_Mmus_MK2 ----TPLYTARVLQEDK-------------------------------------------
MAPKAPK2_Mmus_MK2 ----TPLHTSRVLKEDK-------------------------------------------
R166.5_Cele_MNK ----TILQTPSNLINRK-------------------------------------------
K08F8.1_Cele_MK2 ----KHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVAEILPVPKSVRFLRDGVKA
C44C8.6_Cele_MK2 ----TPLFTSSNLNDQR-------------------------------------------
MAPKAPK2_Spur_MK2 ----TPLHTSSVMKEEGV------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ----TELHSPAIML-DK-------------------------------------------
Mnk_Spur_MNK ----TPLLTPAIIKRNN-------------------------------------------
AqueK073_Aque_MK2 ----TPLACIQVLQDDK-------------------------------------------
AqueK074_Aque_MK5 ----RDLNSPYLIS-DK-------------------------------------------
AqueK075_Aque_MNK ----TPLKTPGVLRLNP-------------------------------------------
MNK2_Hsap_MNK -CAKDLTSFAAEAIAMNRQLAQHD----E-------------------------------
MNK1_Hsap_MNK -STMDLTLFAAEAIALNRQLSQHE----E-------------------------------
MAPKAPK5_Hsap_MK5 AVVAGIQQAHAEQLANMRIQDLKVSL----------------------------------
MAPKAPK3_Hsap_MK2 DHWDEVKEEMTSALATMRVDYDQVKI----------------------------------
MAPKAPK2_Hsap_MK2 ERWEDVKEEMTSALATMRVDYEQIKI----------------------------------
MAPk-Ak2_Dmel_MK2 ETWPEVQEEMTRSLATMRVDYDQMQI----------------------------------
Lk6_Dmel_MNK QSAREISQFAESAMAVKRVVLQHF----SMRYDYMKERPNIYQPSQAYMDAYSDENYNPK
MNK2_Mmus_MNK -CAKDLTSFAAEAIAMNRQLAQCE----E-------------------------------
MNK1_Mmus_MNK -STMDLTLFAAEAIALNRQLSQHE----E-------------------------------
MAPKAPK5_Mmus_MK5 AVVAGIQQAHAEQLANMRIQDLKVSL----------------------------------
MAPKAPK3_Mmus_MK2 DHWDDVKEEMTSALATMRVDYDQVKI----------------------------------
MAPKAPK2_Mmus_MK2 ERWEDVKEEMTSALATMRVDYEQIKI----------------------------------
R166.5_Cele_MNK DSARDVQQMSEHFNLMNRLADTRLSARFD-------------------------------
K08F8.1_Cele_MK2 PRLHSIQEEVGRAMEIMRMGTDQVYI----------------------------------
C44C8.6_Cele_MK2 EQWTDMQDEMEATLASMRVGPENIQI----------------------------------
MAPKAPK2_Spur_MK2 NQWADIQDEMTNALATMRVDYDQIKI----------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 NMLDDAKQIHSEQLTAMRIPDKKVML----------------------------------
Mnk_Spur_MNK -SAKDLSQFAADAVACNRLVAQKE----E-------------------------------
AqueK073_Aque_MK2 ELWPDIQDEMSHALATMRVADEPSKI----------------------------------
AqueK074_Aque_MK5 DALVEVQGAHAKLLQNFRRDDTGFYL----------------------------------
AqueK075_Aque_MNK SITDELSQVAASCLKCNRRLSTHF----E-------------------------------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK PPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLN
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ------------------------------------------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ------------------------------------------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK VHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDEDGE
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ------------------------------------------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ------------------------------------------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK -----------DL-AEE----------------------------E--------------
MNK1_Hsap_MNK -----------NELAEE----------------------------P--------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK NEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEEEFEDEPKEETQADNLKLSKAYVE
MNK2_Mmus_MNK -----------DA-GQ--------------------------------------------
MNK1_Mmus_MNK -----------NELAEE----------------------------Q--------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK -----------NKMTMS----------------------------EC-------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK -----------DEIQEE----------------------------V--------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK -----------KSFK---------------------------------------------
MNK2_Hsap_MNK ---------------------------------------AAGQ------GQP--------
MNK1_Hsap_MNK ---------------------------------------E--------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK QVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQSEFAKLTIMRNDAQTEE------
MNK2_Mmus_MNK -------------------------------------------------DQP--------
MNK1_Mmus_MNK ---------------------------------------E--------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ---------------------------------------GSDLGTATIHG--DGSFLSMG
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ---------------------------------------IEEDVDTEDDGGI--------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK -NKIMQQQ---DEEKKEEKQQDDVDGAKKQGPSSDISATTITDNNKLQTPVMTTTHINNW
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK GEPFGTFPRKKSVGIAIEKSR----SGEF-------------------TP----------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ------------------------------------------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ----------V-------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK QTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPAASATRPPTDNPEE
MNK2_Mmus_MNK ----------V-------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ----------P-------------------------------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ----------C-------------------------------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK -------------------------------LVR--------------------------
MNK1_Hsap_MNK -------------------------------ALA--------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK DDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTVNFAPDAYQNDEDA
MNK2_Mmus_MNK -------------------------------VIR--------------------------
MNK1_Mmus_MNK -------------------------------ALA--------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK -------------------------------ISR--------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK -------------------------------IIR--------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK DIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLADQVPQRQHTENWRY
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ------------------------------------------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK -----------------------------------------PSG----------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK RTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNQQRNYLGSFSHSGGAAGYKIAPMPPPMQ
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ------------------------------------------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ------------------------------------------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 ------------------------------------------------------------
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK PPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQGPEQQRHNRSSGQR
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 ------------------------------------------------------------
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ------------------------------------------------------------
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 ------------------------------------------------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ------------------------------------------------------------
Mnk_Spur_MNK ------------------------------------------Q-----------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 ------------------------------------------------------------
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ----------------------A-TSRCLQLSPPS--------QSKLAQRRQRASLSS--
MNK1_Hsap_MNK ----------------------D-GLCSMKLSPPC--------KSRLARRRALAQAGR--
MAPKAPK5_Hsap_MK5 ----------------------------KPLHSVN--------NPILRKRKLLGTKPKDS
MAPKAPK3_Hsap_MK2 ----------------------------KDLKTSN--------NRLLNKRRKKQAGSSSA
MAPKAPK2_Hsap_MK2 ----------------------------KKIEDAS--------NPLLLKRRKKARALEA-
MAPk-Ak2_Dmel_MK2 ----------------------------KALDKSN--------NPLLTKRRKKIEEMELY
Lk6_Dmel_MNK VQQQPRIGSGRFAHLQAAQLMDELPDMRIGLSPPS--------ESVLLQRRLRQQQRA--
MNK2_Mmus_MNK ----------------------A-TSRCLQLSPPS--------QSKLAQRRQRASLSA--
MNK1_Mmus_MNK ----------------------E-GLCSMKLSPPS--------KSRLARRRALAQAGR--
MAPKAPK5_Mmus_MK5 ----------------------------KPLHSVN--------NPILRKRKLLGTKPKDG
MAPKAPK3_Mmus_MK2 ----------------------------KDLKTSN--------NRLLNKRRKKQAGSSSA
MAPKAPK2_Mmus_MK2 ----------------------------KKIEDAS--------NPLLLKRRKKARAVED-
R166.5_Cele_MNK ----------------------A----SPTTPPPSMLNLSEDLTDSPVKRRSADDSGT--
K08F8.1_Cele_MK2 ----------------------------KNPTASC--------NNLFERRRAVHLS----
C44C8.6_Cele_MK2 ----------------------------KSLGDSN--------NKLLAKRRKGGASPKDD
MAPKAPK2_Spur_MK2 ----------------------------KEVNVST--------NPLLAKRRKKELA----
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 ----------------------------KPVAKAN--------NPIVRKRILTRGQSIDN
Mnk_Spur_MNK -------------------LNNG-GLNNFGLSPPG--------QSALAKRRAAMH-SQ--
AqueK073_Aque_MK2 ----------------------------KKVADAN--------NPILARRAKKN------
AqueK074_Aque_MK5 ----------------------------KPLGQAK--------NPVLASRMKKQEEKKES
AqueK075_Aque_MNK ------------------------------LSPPG--------SSELALRRGG-------
MNK2_Hsap_MNK ------------------------------------------------------------
MNK1_Hsap_MNK ------------------------------------------------------------
MAPKAPK5_Hsap_MK5 VYIHDHENGA--EDSNVALEKLRDVIAQCILPQAGKGENEDEK-----LNEVMQEAWKYN
MAPKAPK3_Hsap_MK2 ------------------------------------------------------------
MAPKAPK2_Hsap_MK2 ------------------------------------------------------------
MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------
Lk6_Dmel_MNK ------------------------------------------------------------
MNK2_Mmus_MNK ------------------------------------------------------------
MNK1_Mmus_MNK ------------------------------------------------------------
MAPKAPK5_Mmus_MK5 IYIHDHENGT--EDSNVALEKLRDVIAQCILPQAGKGENEDEK-----LNEVMQEAWKYN
MAPKAPK3_Mmus_MK2 ------------------------------------------------------------
MAPKAPK2_Mmus_MK2 ------------------------------------------------------------
R166.5_Cele_MNK ---------------------------FSLFSPAS--SNGDDSICSPPMVFVDMPSIQLF
K08F8.1_Cele_MK2 ------------------------------------------------------------
C44C8.6_Cele_MK2 PMDDIK----EEE-----------------------K-----------------------
MAPKAPK2_Spur_MK2 ------------------------------------------------------------
MAPKAPK5a_Spur_MK2 ------------------------------------------------------------
MAPKAPK5b_Spur_MK5 KIGEEQPPKKQNRENSEGVTCLRNIIAHCIVPPK--DANGEDA-----LCELMKRACQYN
Mnk_Spur_MNK ------------------------------------------------------------
AqueK073_Aque_MK2 ------------------------------------------------------------
AqueK074_Aque_MK5 GGAG-NESEP---SSSKAVQSLKSLMDVCNMPPPPPSLSSESSLSSSFLSESVKNALVLN
AqueK075_Aque_MNK ------------------------------------------------------------
MNK2_Hsap_MNK ---------------------------------APVV------LVGDHA
MNK1_Hsap_MNK ---------------------------------GEDR------SPPTAL
MAPKAPK5_Hsap_MK5 RECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIE--EQTTSHESQ
MAPKAPK3_Hsap_MK2 ------------------------------------------SQGCNNQ
MAPKAPK2_Hsap_MK2 --------------------------------------------AALAH
MAPk-Ak2_Dmel_MK2 ------------------------------------------MANATRN
Lk6_Dmel_MNK ---------------------------------NDLSE--YCEPATASG
MNK2_Mmus_MNK ---------------------------------TPVV------LVGDRA
MNK1_Mmus_MNK ---------------------------------SRDAN--PC-LTPAGL
MAPKAPK5_Mmus_MK5 RECKLLRDALQSFSWNGRGFTDKVDRLKLAEVVKQVIE--EQTLPHEPQ
MAPKAPK3_Mmus_MK2 ------------------------------------------SQGCNNQ
MAPKAPK2_Mmus_MK2 --------------------------------------------AALAH
R166.5_Cele_MNK GTGALLTSVQMTPRHTTEDDASLKSFEDE----QENANPIHRIETQVNV
K08F8.1_Cele_MK2 -------------------------------------------IPRVYC
C44C8.6_Cele_MK2 ----------------------------------------DDEEEKMIS
MAPKAPK2_Spur_MK2 ---------------------------------------------MQAE
MAPKAPK5a_Spur_MK2 ----------------------------------------AQLEYKLHF
MAPKAPK5b_Spur_MK5 RDCPSLDKALNNLSWNGEQFCDKVDRSELALLLKDIV---DQKERHEKC
Mnk_Spur_MNK ---------------------------------GRDQ------CITIQA
AqueK073_Aque_MK2 ----------------------------------------------SGK
AqueK074_Aque_MK5 EHNASLLKALEQESWNGNEFIHQVNCKRLASSLQ-------ELIEQLEP
AqueK075_Aque_MNK --------------------------------------------DHKFP