TYK2_Hsap LKKIRDLGEGHFGKVSLYCYDPT------------------NDG--TGEMVAVKALKADC
TYK2~b_Hsap ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPS-
JAK3_Hsap LKYISQLGKGNFGSVELCRYDPL------------------GDN--TGALVAVKQLQHS-
JAK3~b_Hsap LEWHENLGHGSFTKIYRGCRHEVVD------------------GEARKTEVLLKVMDAK-
JAK2_Hsap LKFLQQLGKGNFGSVEMCRYDPL------------------QDN--TGEVVAVKKLQHS-
JAK2~b_Hsap LIFNESLGQGTFTKIFKGVRREVGDY-----------------GQLHETEVLLKVLDKA-
JAK1_Hsap LKRIRDLGEGHFGKVELCRYDPE------------------GDN--TGEQVAVKSLKPES
JAK1~b_Hsap LVQGEHLGRGTRTHIYSGTLMDYKDDE--------------GTSEEKKIKVILKVLDPS-
hop_Dmel YPDSI--SLSDDGMMFTMRGDWIQQS------------------PVKDVSVTMKMLKS--
hop~b_Dmel YNMENMIGRGHYGTVYKGHLEFN-D----------------KDQ--PREQVAIKMLNTM-
JAK3_Mmus LKYISLLGKGNFGSVELCRYDPL------------------GDN--TGPLVAVKQLQHS-
JAK3~b_Mmus LEWHENLGHGSFTKIFRGRRREVVD------------------GETHDSEVLLKVMDSR-
JAK2_Mmus LKFLQQLGKGNFGSVEMCRYDPL------------------QDN--TGEVVAVKKLQHS-
JAK2~b_Mmus LIFNESLGQGTFTKIFKGVRREVGDY-----------------GQLHKTEVLLKVLDKA-
JAK1_Mmus LKRIRDLGEGHFGKVELCRYDPE------------------GDN--TGEQVAVKSLKPES
JAK1~b_Mmus IIQGEHLGRGTRTHIYSGTLLDYKDEE--------------GIAEEKKIKVILKVLDPS-
TYK2_Mmus LKKIRDLGEGHFGKVSLYCYDPT------------------NDG--TGEMVAVKALKEGC
TYK2~b_Mmus ITQLSHLGQGTRTNVYEGLLRVGGPDE---GKVDNGCPPEPGGTSGQQLRVVLKVLDPS-
JAK1_Spur LKKEERLGSGHFGMVFRGVLMPR------------------QGI--PAE-IVAKVIKNDS
JAK1~b_Spur -------GEGAFATIYLVACLDALDMT---------------DLDCDFRRVALKIQHPPC
JAK2_Spur RTNWRHLDDGDFTEVWAADLRKKVG------------------NRPRKMRVAIKCPKMDA
JAK2~b_Spur ------------------------------------------------------------
TYK2_Hsap GPQHRSGW-KQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPR---
TYK2~b_Hsap HHDIALAF-YETASLMSQVSHTHLAFVHGVCVR-GPE-NIMVTEYVEHGPLDVWLRR---
JAK3_Hsap GPDQQRDF-QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR---
JAK3~b_Hsap HKNCMESF-LEAASLMSQVSYRHLVLLHGVCMA-G-D-STMVQEFVHLGAIDMYLRK---
JAK2_Hsap TEEHLRDF-EREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK---
JAK2~b_Hsap HRNYSESF-FEAASMMSKLSHKHLVLNYGVCVC-GDE-NILVQEFVKFGSLDTYLKK---
JAK1_Hsap GGNHIADL-KKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPK---
JAK1~b_Hsap HRDISLAF-FEAASMMRQVSHKHIVYLYGVCVR-DVE-NIMVEEFVEGGPLDLFMHR---
hop_Dmel DGN-FMEF-FRLAQTWSLIQSPQFLKLYGLT---LADPYTMVMEYSRYGPLNKFLHS---
hop~b_Dmel --QVSTDF-HREIGIMRTLSHPNIVKFKYWA----EKSHCIIMEYLQSGSFDIYLRF---
JAK3_Mmus GPDQQRDF-QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR---
JAK3~b_Mmus HRNCMESF-LEAASLMSQVSYPHLVLLHGVCMA-G-D-SIMVQEFVYLGAIDMYLRK---
JAK2_Mmus TEEHLRDF-EREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQK---
JAK2~b_Mmus HRNYSESF-FEAASMMSQLSHKHLVLNYGVCVC-GEE-NILVQEFVKFGSLDTYLKK---
JAK1_Mmus GGNHIADL-KKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPK---
JAK1~b_Mmus HRDISLAF-FEAASMMRQVSHKHIVYLYGVCVR-DVE-NIMVEEFVEGGPLDLFMHR---
TYK2_Mmus GPQLRSGW-QREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPR---
TYK2~b_Mmus HHDIALAF-YETASLMSQVSHMHLAFLHGVCVR-GSE-NIIVTEFVEHGPLDVWLRR---
JAK1_Spur ---RSDQF-QQEIRAMSYCDHKNIVKVLGYCED-NSNRLSLVMEYFPLGSLEKYLRE---
JAK1~b_Spur PRE-IKELHARLSRLPSQIDVRQSIMT-AECAHIYQDKSCMVTEYKSKGILLNLFNK---
JAK2_Spur PQSVQQKF-SQSVDLMSSWVHKHIIRFEGI----GAG-YMLVMEYASEGPLDHYLRSLLE
JAK2~b_Spur ----QQKF-SQSVDLMSSWVHKHIIRFEGI----GAG-YMLVMEYASEGPLDHYLRSLLE
. :: *: * : :
TYK2_Hsap -H------SI--GLAQLLLFAQQICEGMAYLHA-QHYIHRDLAARNVLLDNDR-------
TYK2~b_Hsap -ERG----HV--PMAWKMVVAQQLASALSYLEN-KNLVHGNVCGRNILLARLGLA-EGTS
JAK3_Hsap -HRA----RL--DASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEA-------
JAK3~b_Hsap -RGH----LV--PASWKLQVVKQLAYALNYLED-KGLPHGNVSARKVLLAREGAD--GSP
JAK2_Hsap -HKE----RI--DHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENEN-------
JAK2~b_Hsap -NKN----CI--NILWKLEVAKQLAWAMHFLEE-NTLIHGNVCAKNILLIREEDRKTGNP
JAK1_Hsap -NKN----KI--NLKQQLKYAVQICKGMDYLGS-RQYVHRDLAARNVLVESEH-------
JAK1~b_Hsap -KSD----VL--TTPWKFKVAKQLASALSYLED-KDLVHGNVCTKNLLLAREGID-SECG
hop_Dmel -MPN-----V--TLHCLLDLMHGLVRGMHYLED-NKIIHNYIRCSNLYVTKYDPN--SYV
hop~b_Dmel -TAP----NL--NNPRLVSFALDIANGMKYLSD-MGLIHRDLAARNILVDHNGD-----G
JAK3_Mmus -HRA----RL--HTDRLLLFAWQICKGMEYLGA-RRCVHRDLAARNILVESEA-------
JAK3~b_Mmus -RGH----LV--SASWKLQVTKQLAYALNYLED-KGLPHGNVSARKVLLAREGGD--GNP
JAK2_Mmus -HKE----RI--DHKKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENEN-------
JAK2~b_Mmus -NKN----SI--NILWKLGVAKQLAWAMHFLEE-KSLIHGNVCAKNILLIREEDRRTGNP
JAK1_Mmus -NKN----KI--NLKQQLKYAIQICKGMDYLGS-RQYVHRDLAARNVLVESEH-------
JAK1~b_Mmus -KSD----AL--TTPWKFKVAKQLASALSYLED-KDLVHGNVCTKNLLLAREGID-SDIG
TYK2_Mmus -H------CV--GLAQLLLFAQQICEGMAYLHA-QHYIHRDLAARNVLLDNDR-------
TYK2~b_Mmus -QRG----QV--PMTWKMVVAQQLASALSYLED-KNLVHGNVCGRNILLARLGLE-EGTN
JAK1_Spur -KKD----RV--SHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNEN-------
JAK1~b_Spur -VKAVNKKDLSHSEDWVMFFAIKILQVVEYMHR-CKIIHGDVKPDNFL------------
JAK2_Spur NERK----RL--GLNSQLHAAFQLIDALEYLES-RRIVHGNVSAHNTLVLRPAP-----N
JAK2~b_Spur NERK----RL--GLNSQLHAAFQLIDALEYLES-RRIVHGNVSAHNTLVLRPAP-----N
: : : :: * : :
TYK2_Hsap -LVKIGDFGLAKAVPEGHEYYRVREDG-DSPVFWYAPE---CLKEY-K-FYYASDVWSFG
TYK2~b_Hsap PFIKLSDPGVGLGALSREE-------R-VERIPWLAPE---CLPGGANSLSTAMDKWGFG
JAK3_Hsap -HVKIADFGLAKLLPLDKDYYVVREPG-QSPIFWYAPE---SLSDN-I-FSRQSDVWSFG
JAK3~b_Hsap PFIKLSDPGVSPAVLSLEM-------L-TDRIPWVAPE---CLREA-QTLSLEADKWGFG
JAK2_Hsap -RVKIGDFGLTKVLPQDKEYYKVKEPG-ESPIFWYAPE---SLTES-K-FSVASDVWSFG
JAK2~b_Hsap PFIKLSDPGISITVLPKDI-------L-QERIPWVPPE---CIENP-KNLNLATDKWSFG
JAK1_Hsap -QVKIGDFGLTKAIETDKEYYTVKDDR-DSPVFWYAPE---CLMQS-K-FYIASDVWSFG
JAK1~b_Hsap PFIKLSDPGIPITVLSRQE-------C-IERIPWIAPE---CVEDS-KNLSVAADKWSFG
hop_Dmel LDAKISDPGYPRPY-------RESD------SPWIPVKYYRNLQAA-K-TDQFAQLWAFA
hop~b_Dmel DCVKISDFGLAQFANSD-GYYYAKSKR-DIPIRWYSPE---AISTC-R-FSSYSDVWSYG
JAK3_Mmus -HVKIADFGLAKLLPLGKDYYVVREPG-QSPIFWYAPE---SLSDN-I-FSRQSDVWSFG
JAK3~b_Mmus PFIKLSDPGVSPTVLSLEM-------L-TDRIPWVAPE---CLQEA-QTLCLEADKWGFG
JAK2_Mmus -RVKIGDFGLTKVLPQDKEYYKVKEPG-ESPIFWYAPE---SLTES-K-FSVASDVWSFG
JAK2~b_Mmus PFIKLSDPGISITVLPKDI-------L-QERIPWVPPE---CIENP-KNLNLATDKWSFG
JAK1_Mmus -QVKIGDFGLTKAIETDKEYYTVKDDR-DSPVFWYAPE---CLIQC-K-FYIASDVWSFG
JAK1~b_Mmus PFIKLSDPGIPVSVLTRQE-------C-IERIPWIAPE---CVEDS-KNLSVAADKWSFG
TYK2_Mmus -LVKIGDFGLAKAVPEGHEYYRVREDG-DSPVFWYAPE---CLKEC-K-FYYASDVWSFG
TYK2~b_Mmus PFIKLSDPGVGQGALSREE-------R-VERIPWTAPE---CLSGGTSSLGTATDMWGFG
JAK1_Spur -EVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPE---WLRHQ-K-YQKESDVWSLG
JAK1~b_Spur ------------------------------------------------------------
JAK2_Spur MHIKLADPMLGVYYHSLEM---TSRPK-LERVRWTAPE---LLATN-SEPTLAGDKFSYA
JAK2~b_Spur MHIKLADPMLGVYYHSLEM---TSRPK-LERVRWTAPE---LLATN-SEPTLAGDKFSYA
TYK2_Hsap VTLYELLTHCDSSQSPPTKFLELIGIA-QGQMTVLRLTELLERGERLPRPDKCPCEVYHL
TYK2~b_Hsap ATLLEICFDGEAPLQSRS---------------PSEKEHFYQRQHRLPEPS-C-PQLATL
JAK3_Hsap VVLYELFTYCDKSCSPSAEFLRMMGCER-DVPALCRLLELLEEGQRLPAPPACPAEVHEL
JAK3~b_Hsap ATVWEVFSGVTMPISALD---------------PAKKLQFYEDRQQLPAPK-W-TELALL
JAK2_Hsap VVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMI
JAK2~b_Hsap TTLWEICSGGDKPLSALD---------------SQRKLQFYEDRHQLPAPK-W-AELANL
JAK1_Hsap VTLHELLTYCDSDSSPMALFLKMIGPT-HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQL
JAK1~b_Hsap TTLWEICYNGEIPLKDKT---------------LIEKERFYESRCRPVTPS-C-KELADL
hop_Dmel TTIYEIFSRCKEDLSTLRQE------------QLLRQKNLDGNILKMLDQDICPAPIFET
hop~b_Dmel VTLFEMFSRGEEPNLVPIQT------------SQEDFLNRLQSGERLNRPASCPDFIYDL
JAK3_Mmus VVLYELFTYCDKSCSPSAEFLSMMGPER-EGPPLCRLLELLAEGRRLPPPPTCPTEVQEL
JAK3~b_Mmus ATTWEVFSGGPAHITSLE---------------PAKKLKFYEDQGQLPALK-W-TELAGL
JAK2_Mmus VVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVI
JAK2~b_Mmus TTLWEICSGGDKPLSALD---------------SQRKLQFYEDKHQLPAPK-W-TELANL
JAK1_Mmus VTLHELLTYCDSDFSPMALFLKMIGPT-HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQL
JAK1~b_Mmus TTLWEICYNGEIPLKDKT---------------LIEKERFYESRCRPVTPS-C-KELADL
TYK2_Mmus VTLYELLTYCDSNQSPHMKFTELIGHT-QGQMTVLRLTELLERGERLPRPDRCPCEIYHL
TYK2~b_Mmus ATLLEICFDGEAPLQGRG---------------PSEKERFYTKKHQLPEPS-S-PELATL
JAK1_Spur IVLWEMFSYGQDPIYQDSKGR---------RVEHIELLDFFEKGMRLTHPPSCPAAIETM
JAK1~b_Spur ------------------------------------------------------------
JAK2_Spur ITLWQIMSHGAIPAENLS---------------DExxxxxYRHGVRLDAPPGCPQELLKI
JAK2~b_Spur ITLWQI------------------------------------------------------
TYK2_Hsap MKNCWETEASFRPT-----------------------F
TYK2~b_Hsap TSQCLTYEPTQRPSFRTILRD----------------L
JAK3_Hsap MKLCWAPSPQDRPSFSALGPQL--------------DM
JAK3~b_Hsap IQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTP
JAK2_Hsap MTECWNNNVNQRPSFRDLALRVD-------------QI
JAK2~b_Hsap INNCMDYEPDFRPSFRAIIRDLNS------------LF
JAK1_Hsap MRKCWEFQPSNRTSFQNLIEGFE-------------AL
JAK1~b_Hsap MTRCMNYDPNQRPFFRAIMRDIN--------------K
hop_Dmel IMDGWSDDETKRFSHHDIFS----------------RL
hop~b_Dmel MQLCWHATPRSRPSFATIV-----------------DI
JAK3_Mmus MQLCWAPSPHDRPAFGTLSPQL--------------DA
JAK3~b_Mmus ITQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTP
JAK2_Mmus MTECWNNNVSQRPSFRDLSLRVD-------------QI
JAK2~b_Mmus INNCMDYEPDFRPAFRAVIRDLNS------------LF
JAK1_Mmus MRKCWEFQPSNRTTFQNLIEGFE-------------AL
JAK1~b_Mmus MTRCMNYDPNQRPFFRAIMRDIN--------------K
TYK2_Mmus MKNCWETEASFRPT-----------------------F
TYK2~b_Mmus TRQCLTYEPAQRPSFRTILRD----------------L
JAK1_Spur MNDCWEMDPLKRPKFQSMIVRLG-------------IL
JAK1~b_Spur -------------------------------------I
JAK2_Spur MEACWSHNPRNRPSCRGVLRDVNSF-----------LS
JAK2~b_Spur -------------------------------------M