Caki_Dmel       MTE-----DEIVFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLS
CASK_Mmus       MAD-----DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS
lin-2_Cele      MRELDPDESNLLLDEQLSIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLG
CASK_Hsap       MAD-----DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS
CASK_Spur       ------------------------------------------------------------


Caki_Dmel       TADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSE
CASK_Mmus       TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE
lin-2_Cele      FEEIDEEIRICQNLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSE
CASK_Hsap       TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE
CASK_Spur       ------------------------------------------------------------


Caki_Dmel       AVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRET
CASK_Mmus       AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGES--G
lin-2_Cele      YVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIG-G
CASK_Hsap       AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGES--G
CASK_Spur       ---SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVKLGGFGIAIPLPSS--G
                   .** **:::** *** ..*:***::*   :**: :.***:** *** *  *

Caki_Dmel       IETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARG
CASK_Mmus       LVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKG
lin-2_Cele      SMACGRVGVPQFMAPEIVRKDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQT
CASK_Hsap       LVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKG
CASK_Spur       LIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKG
                  : **:* *::****:* :   .   *:*..**:*.:**:* *** *:   : : : :

Caki_Dmel       RLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKL-QRTHLADTVE
CASK_Mmus       KYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVE
lin-2_Cele      DVDVDGY-MPNISESARNLVRRMLNADPSKRISAKEALNHEWIRDKEHMASRKHMNDVID
CASK_Hsap       KYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVE
CASK_Spur       RYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWLRERDKFAPKVHLLETVE
                  ...      ** .*::*:  **  :* .*::  *.* * *::::::   : *: :.::

Caki_Dmel       ELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATD-------------------
CASK_Mmus       QLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEE-LPDFS--------------------
lin-2_Cele      QMRRYNESRKLKSNVLSAVNSGRFDETTPR-QDTPQTAFVDGSSPGGDCCHRGESSSNDA
CASK_Hsap       QLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEE-LPDFS--------------------
CASK_Spur       ELKKFNARRKLKGAVLAAVASHKFTSFYSDPNTKHITDFAD-------------------
                :::::*  ****. * : . . .:            .

Caki_Dmel       ---EWADEEAGIE----AV-----QRILDCLDDIYSLQDAH-V--DADVLRDM--LRDNR
CASK_Mmus       -EDPTSS---GLLAAERAV-----SQVLDSLEEIHALTDCSEK--DLDFLHSV--FQDQH
lin-2_Cele      AEPPADK---DLS----GA-----YKVLGSLDAINSLLDPNSYKPGSTTFQKI--HDDGS
CASK_Hsap       -EDPTSS---GLLAAERAV-----SQVLDSLEEIHALTDCSEK--DLDFLHSV--FQDQH
CASK_Spur       -EDPTSSRSRGIQTTERKRSYGANMNVIDSLLLSLAFVS----------MHSIRLFKCN-
                      .   .:             .::..*    :: .          ::.:

Caki_Dmel       LHQFLQLFDRIA-----ATVVTSN--GRAPA-AEAVGRC-RDVLEQLSSTSGGNSLGGKY
CASK_Mmus       LHTLLDLYDKIN-----T-KSSPQ--IRNPP-SDAVQRA-KEVLEEISCYP------ENN
lin-2_Cele      VRNLLRLYDKIK-----AL-PCEP--VVTE-V-DTSTLR-KETLNQIDGLLG-----PSP
CASK_Hsap       LHTLLDLYDKIN-----T-KSSPQ--IRNPP-SDAVQRA-KEVLEEISCYP------ENN
CASK_Spur       ---IIQALDFMACSSSTV-MSCPMLPLQNVPSLQSVHVTTEQVLELFRQHNQ-----DSQ
                   ::   * :      .               ::     .:.*: :           .

Caki_Dmel       AKEELMRLLAAPHMQALLHSHDVVARDVYGEE--------------AARHP-APDGALPQ
CASK_Mmus       DAKELKRILTQPHFMALLQTHDVVAHEVYSDE--------------ALRVTPPPTSPYLN
lin-2_Cele      EALELRQLLNSPHLASCVQALDVVVCEIRDPKNEASGSGDKEGNASLFCVSSDPAPAYLN
CASK_Hsap       DAKELKRILTQPHFMALLQTHDVVAHEVYSDE--------------ALRVTPPPTSPYLN
CASK_Spur       DAYELQAILSDPYFRALLQAHDVVAHEVYSDH--------------AIRVTPPPVMPYLN
                   **  :*  *:: : ::: ***. :: . .                  .  *  .  :

Caki_Dmel       WR-----------------------ELDNVEGG-E-LQHVTRVRLVHFQKNTDEPMGITL
CASK_Mmus       GDS-P----------------------ESANGDMD-MENVTRVRLVQFQKNTDEPMGITL
lin-2_Cele      GGVLPLGAQRAGTSFEHFNQSAVHTSYDEEEE--ELYDCMSRLRLVQFQKDTQEPMGITL
CASK_Hsap       GDS-P----------------------ESANGDMD-MENVTRVRLVQFQKNTDEPMGITL
CASK_Spur       GDS-E--------------------LMQPPNGNMDQTDQVTRVRLVQFQKNSEEPLGITL
                                           :  :   :  : ::*:***:***:::**:****

Caki_Dmel       KMTEDGRCIVARLMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTF
CASK_Mmus       KMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF
lin-2_Cele      KVNEDGRCFVARIMHGGMIHRQATLHVGDEIREINGMSVANRSVESLQEMLRDARGQVTF
CASK_Hsap       KMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF
CASK_Spur       KMNEDRRCIVARIMHGGMIHRQATLHVGDEIREINNASVANQTVDQLQKLLRELKGSITF
                *:.*  :*:***:*********.************. .* :::* .**.:**: :*.:**

Caki_Dmel       KIVPSYRSAPPPCE-----------------------------------IFVRAQFDYNP
CASK_Mmus       KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP
lin-2_Cele      KIIPSYRSAPPACE-----------------------------------IFVRAQFDYEP
CASK_Hsap       KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP
CASK_Spur       KIVPSYRSAPQPCE-----------------------------------IYVRAQFDYDP
                **:****: . .**                                   *:*****:*:*

Caki_Dmel       LDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLG-T--------------VGGSAGL
CASK_Mmus       AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLEN--------------SKNGTAGL
lin-2_Cele      SQDDLIPCPQAGIPFKTGDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVAGL
CASK_Hsap       AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLEN--------------SKNGTAGL
CASK_Spur       GQDDLIPCQQAGLSFRCGDILQIISKDDHNWWQARKEGE-------------PLNGTAGL
                 .*:**** :**: *: ***:*:******:***.:                      ***

Caki_Dmel       IPSPELQEWRIACQTVDKTKQE-QVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEV
CASK_Mmus       IPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEV
lin-2_Cele      IPSPELQEWRTACLAMERSKNTCNTHCMWFNKKKKYYTTKYLQKHSALFDQLDLVTYEEV
CASK_Hsap       IPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEV
CASK_Spur       IPSPELQEWRVACLAIERAKKEQQASCTWFGRRKKQYRDKYLAKHNAVFDQLDLVTYEEV
                ********** ** :::::*:  :. *  *.::**    *** **.*:** **:******

Caki_Dmel       VKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYVYPIPHTTRPAKPEEENGRS
CASK_Mmus       VKLP----AFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKN
lin-2_Cele      MRLS----QYRRKTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKH
CASK_Hsap       VKLP----AFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKN
CASK_Spur       VRLP----AFMRKTLVLLGAHGVGRRHIKNTLITSHPNKYAYPIPHTTRRCKSDEENGKN
                :::.     : **********************  :*:::.********  : :* :*:

Caki_Dmel       YYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRT
CASK_Mmus       YYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRT
lin-2_Cele      YYFVTNEQMMADIQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRT
CASK_Hsap       YYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRT
CASK_Spur       YFFVSHEEMMNDIANNKYLEYGTHEDAMYGTKLDTIREIHNRSLIAILDVEPQALKVLRC
                *:**::::** **  *:*****:**::******:***.**  . :***********:**

Caki_Dmel       AEFTPYVVFIAAPSLQNIAD-YDGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATL
CASK_Mmus       AEFAPFVVFIAAPTITPGLN-EDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHL
lin-2_Cele      AEYSPFVVFIAAPNLQGMQD-PDGSLEKLLNESDVLRQAFGHLFDFIITNSDIDDTIAQL
CASK_Hsap       AEFAPFVVFIAAPTITPGLN-EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHL
CASK_Spur       AEFAPFVVFIAAPTLTGMNDVHDSSLERLAKESELLRQAYGHFFDLTIVNNDIDDTIRTL
                **::*:*******.:    :  * **::* :**::*:: :.* **: * *.:*.:**  *

Caki_Dmel       ETAIDRVHTTPQWVPVSWLY
CASK_Mmus       EEAVELVCTAPQWVPVSWVY
lin-2_Cele      ERLVEKLPAYPQWLPVTWVY
CASK_Hsap       EEAVELVCTAPQWVPVSWVY
CASK_Spur       ENAMEEICTTPQWVPVSWVY
                *  :: : : ***:**:*:*