Kinase Subfamily CDK16

Kinase Classification: Group CMGC: Family CDK

Evolution

CDK16 is found in most animals and choanoflagellates, but is lost in Drosophila. Three members (CDK16, 17, 18 or PCTAIRE1, 2, 3; PCTK1, PCTK2, PCTK3) are found in mammals. Within the CDK subfamilies it is most closely related to the animal-specific CDK14 (PFTAIRE) subfamily.

Domain Structure

The kinase domain is in the middle with typically 100-150 AA of sequence N-terminal and about 40 AA C-terminal without known domains.

Function

CDK16 is activated by Cyclin Y to which it binds both in the kinase domain and N-terminal unique region. CDK16 members are not associated with cell cycle and are expressed in post-mitotic tissues like brain and testis