Gene IRAK-0_g-1 (S.moellendorffii)

IRAK-0_g-1

Species: S.moellendorffii
Alias: IRAK-0_g-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_g-1.AA Protein None 645 None Fasta, JSON
IRAK-0_g-1.NA RNA None 1938 None Fasta, JSON
IRAK-0_g-1.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_g-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_g-1.AA DUF26 75-127 32 7.3e-20 62.03 Pfam 1-55 (55) Show / Hide 
Range on Protein: 75-127
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

LYGLLQCRQDMSRDSCDQCARDIGQAV-KSRCSSSLGAKIQLYGCFLRYENHP-F
.||. ||| |.|...| .| ... . . ...|... |. |.. .|.|||...| |
VYGMAQCRPDLSPSDCRDCLATAVRQMLPQCCPNRQGGRIWYDWCYLRYSDYPNF
DUF26 IRAK-0_g-1.AA DUF26 178-230 32 5.6e-17 53.33 Pfam 1-55 (55) Show / Hide 
Range on Protein: 178-230
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

VFVLGECRGDLSSQQCDSCVRVAMRNM-TDRCIGNTSGSILLNSCYTRFDAFK-F
|.... ||.|||...| .|.. | |.|   .| ... | |.. .|| |..  . |
VYGMAQCRPDLSPSDCRDCLATAVRQMLPQCCPNRQGGRIWYDWCYLRYSDYPNF
Kinase IRAK-0_g-1.AA TKL 335-599 20 1.8e-61 210.56 In-house 1-364 (364) Show / Hide 
Range on Protein: 335-599
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

LGQGGFGVVYKGTLPD---------GRRIAIKRLTTQS---------------------------QKGKQEFLNEVKLVSSVQHRNLVKLYGCCTEESE-
.|.||||.||||..           |. .|.|.. ...                           .. .... .|... |. .| |.|...|.|....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYELLENNS-LSRVLFQGNLCLSWEQRYNVILGVARGLAYLHEDS-----QVKIIHRDIKAGNVLLDEKFE--------------
              .|.|. .. | |....        |.|| . .|..|||..||| .        .|||||.|  |.|.||...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKIADFGLARLYSDERS-------------------INTQIAGTLGYMAPEYAL----------------HGHLTDKADVFSFGILSLEIVSGRRSTDLN
.||.||||.|  | . .                    .  . ||...||||                   ..  . |.||.||||.  ||....|     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

QPIERQYLLEWAWKSHERNEQLDLVDARLNTVPPSF---------DKEQAV--RVVCVGLLCTQATPSQRPSMSRVVTMI
 | . .   .. .      |.   ...  .  ||            ..  .  ..      | .. |..|||.....  .
-PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_g-1.AA IRAK 329-595 30 6.5e-59 202.03 In-house 1-317 (317) Show / Hide 
Range on Protein: 329-595
Range on HMM: 1-317/317
Sequence Identity: 30% (98 aa)

FSDDNKLGQGGFGVVYKGTLPDGRR--IAIKRL----TTQSQKGKQEFLN---EVKLVSSVQHRNLVKLYGCCTEESERLLVYELLENNSLS-RVLFQGN
|. ||..|.||||.||.| . ..     |.|.|     ..  . .|.|.    |.|. .. .| |.| ||| |||...  |||... | ||  |   |..
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

---L-CLSWEQRYNVILGVARGLAYLHEDS-QVKIIHRDIKAGNVLLDEKFEAKIADFGLARL-----YSDERSI---NTQ-IAGTLGYMAPEYAL--HG
   .  ||| ||  . .| |.|. .||...  . |||.|||  |.|||. |..||.||||.|       .   ..    |. . ||. ||.||.     |
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

HLTDKADVFSFGILSLEIVSGRRSTDLNQPIERQYLLEWAWKSHERNEQ--------------------------LDLVDARLNTVPPSFDKEQAVRVVC
 || | ||.||||  ||...|.|  . ..| | .||..      |   .                           ...| | . .|| . || . . .|
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRP-EHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACC

VGLLCTQATPSQRPSMSRV
.|. ..   .. .. |.. 
CGHHRANRRCDMAWVMQQL
Kinase IRAK-0_g-1.AA Pkinase 329-524 28 3.4e-52 184.51 Pfam 1-209 (293) Show / Hide 
Range on Protein: 329-524
Range on HMM: 1-209/293
Sequence Identity: 28% (60 aa)

FSDDNKLGQGGFGVVYKGTLPDGRR-IAIKRLTTQSQKGKQE--FLN--EVKLVSSVQHRNLVKLYGCCTEESERLLVYELLENN----SLSRVLF---Q
.    |.|.|.||.|||..  . ..  |.|..  ...| ...   ..  |...  ...| | |.||........  .| |..|.     .|....    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GNLCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEA----KIADFGLARLY-SDERSINTQIAGTLGYMAPEYAL-HGHLTDKADV
|.. .|...  .... ..|||.|.|.    .|||||.|  |.|.|.. .     ||.|||||...     | .| ..||..|||||  . . . . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSFGILSLEIVSGR
.|.|..  | ..||
WSCGCILYEMLCGR
Kinase IRAK-0_g-1.AA TKL-Unique 331-515 32 9.4e-44 151.67 In-house 1-216 (290) Show / Hide 
Range on Protein: 331-515
Range on HMM: 1-216/290
Sequence Identity: 32% (71 aa)

DDNKLGQGGFGVVYKGTLPDGRRIAIKRLTT---QSQKGKQEFLNEVKLVSSVQ-HRNLVKLYGCCT----EESERLLVYELLENNSLSRVLF-------
. ||.|.||.|.||||. . |  .|||..     .| . .||| |||.. .  . | |.|...| |.     .... .| | .. .||  ||        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--QGNLCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEK-----FEAKIADFGLARLYSDE-RSINTQI--------AGTLGYMAPEYA
    |. |...||.. .. .|.|. |||  .   |||||.|  |.|.|..     . .||.||||... | . ...|. .         |.. .||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-

LHG---HLTDKADVFSFGI
| .   . . |.||.||||
LRMNFCQYSEKSDVYSFGI
Kinase IRAK-0_g-1.AA MLK 329-516 26 1.7e-43 148.73 In-house 1-225 (291) Show / Hide 
Range on Protein: 329-516
Range on HMM: 1-225/291
Sequence Identity: 26% (61 aa)

FSDDNKLGQGGFGVVYKGTLPDGRR-----IAIKRLT--TQSQKGK-----QEFLNEVKLVSSVQHRN----LVKLYGCCTEE-SERLLVYELLENNSLS
.    ..| |.||.|.||.   ...     .|.|| .  .   |..     ..|  |..... ..|.|     ...||.|... .. ..| | .|. ||.
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

RVLFQGN-------------LCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDE------KFEAKIADFGLAR-LYSDERSINTQIAGTL
.||  ..                . ..  |  | .|||..|||.. ...|||||.|  |.|.||      .  .||.|||..| ... . .  .  |||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYMAPEY---ALHGHLTDKADVFSFGIL
 .||||    . ..  . |.||.|.|..
AWMAPEVIQQFRCEKYSEKCDVWSWGVV
Kinase IRAK-0_g-1.AA Pkinase_Tyr 329-516 31 1.6e-40 137.84 Pfam 1-203 (270) Show / Hide 
Range on Protein: 329-516
Range on HMM: 1-203/270
Sequence Identity: 31% (65 aa)

FSDDNKLGQGGFGVVYKGTLP-----DGRRIAIKRL--TTQSQK-GKQEFLNEVKLVSSV-QHRNLVKLYGCCT-EESE--RLLVYELLENNSLSRVLFQ
 . . |||.| ||.|||||.      ..   |.| |  .. ..   ...|..|.|. ..  .| |.|.|||.|| ..     ..| |. .. .|   | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G---NLCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLY-SDERSINTQIAGTLG---YMAPEYALHGHLTDKAD
    .  |. ..  .  . .|.|..||..    ..||||. | |.|..|.. .||.||||||.  .|.    ..  |.      ||||   .|  | | |
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VFSFGIL
| |||.|
VWSFGVL
Kinase IRAK-0_g-1.AA STE 329-524 22 5.6e-40 138.88 In-house 1-265 (359) Show / Hide 
Range on Protein: 329-524
Range on HMM: 1-265/359
Sequence Identity: 22% (62 aa)

FSDDNKLGQGGFGVVYKGTLPD----------------GRRIAIKRLTTQSQKG-----------------KQEFLNEVKLVSSVQ--HRNLVKLYGCCT
. .  |.|.|.||.|||.   .                |...|||..  ....                  .|..|.|.|. .  .  | | || |||. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EE-------SERLLVYELLENNSLSRVLFQGNLCLS-------------WEQRYNVILGVARG-LAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFG
 |       .|  .. |.... ||. .. .   |.               .|   ..  . .| |.|||.     |||||||..|.||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLYSDE----------------RSINTQIAGTLGYMAPEYALH------GHLTDKADVFSFGILSLEIVSGR
..   .|.                 . .. ..||  .||||  .       .. . |.|. |.|.. .| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_g-1.AA TK 329-522 17 2.3e-38 125.68 In-house 1-389 (486) Show / Hide 
Range on Protein: 329-522
Range on HMM: 1-389/486
Sequence Identity: 17% (70 aa)

FSDDNKLGQGGFG---VVYKGTLPDGR--------------------------RIAIKRLT---TQSQKGKQE--------------FLNEVKLVSS--V
    .|||.| ||   .||||.. ...                          . |.| |.   ..||. ...              ...| |. ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVKLYGCCTEE------------SERLLVYELLENNS----LS------RVLFQGNLC--------------------------------------
.| |.|.|||.||..               ..| |. .. .    |       |  || ..                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWEQRYNVILGVARGLAYLHED--SQV--KIIHRDIKAGNVLLDEKFE-----------AKIADFGLA
                               |. .|.    . .|.|..|||.   .    ...|||. | |.|..|.             .|||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----LYSDERSINTQIAGTLGY-----------------------------MAPEYALHGH---------LTDKADVFSFGILSLEIVS
|     |  |  |     . . ..                             ||||  ....          | | ||.|||.|  ||..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_g-1.AA Dicty4-Unclassified 332-523 31 2.4e-38 128.89 In-house 4-204 (263) Show / Hide 
Range on Protein: 332-523
Range on HMM: 4-204/263
Sequence Identity: 31% (65 aa)

DNKLGQGGFGVVYKGTLPDGRRIAIKRLTTQSQKGK----QEFLNEVKLVSSVQHRNLVKLYGCCTEE----SERLLVYELLENNSLSRVLF----QGNL
|  .|.| |  |.||    |. .|.| .   . |      |.|. || .  |.|| ||||.|| |       |    | |..    |  |        . 
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

CLSWEQ--RYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDERSINTQIAGTLGYMAPEYALHGHLTDKADVFSFGILS
 .. .      . . .|.|...||    . .||||||. |.|.|  | .||||||..|  .      | ||||    .||   |   . |.||.|.... 
PIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM-TTIAGTPKWESPECLMHESYNQKSDVYSYAMML

LEIVSG
 | . |
YELATG
Kinase IRAK-0_g-1.AA Dicty4 329-516 30 6.5e-38 124.14 In-house 1-206 (277) Show / Hide 
Range on Protein: 329-516
Range on HMM: 1-206/277
Sequence Identity: 30% (63 aa)

FSDDNKLGQGGFGVVYKGTLPDGRRIAIKRL--TTQS--QKGKQEFLNEVKLVSSVQHRNLVKLYGCCT----EESERLLVYELLENNSLSRVLFQ----
   ....|.|.|| |||||   |   |.| |  . |   ..  .||..||.. .. .| |.....| ||    . .. . | |..   .| ..|      
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--GNLCLSWEQRYN---VILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDERSINT---QIAGTLGYMAPEYALHGHLTDKA
   .  |.|. .       . .|||...||. . . |||||.|. | | |. . .|..||||...   . . ..     .|| ..||||   |   . ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVFSFGIL
||.||||.
DVYSFGIV
Kinase IRAK-0_g-1.AA S_TKc 329-599 22 2e-37 131.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 329-599
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FSDDNKLGQGGFGVVYKGTLPD-GRRIAIKRLTTQSQKGKQEFLNEVKLVSSVQHRNLVKLYGCCTEESERLLVYELLEN--NSLSRVLFQGN-------
.   .|.|.|.||.|||..  . ||. |||..        . ...|... .. .| |.||||... . ..  .| |....   .| ... . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDERSINTQIAGTLGYMAPEYALHGHLTD-KADVFSFGILS
.   . ..|  .  ....|.|.|  |. .|||||.|  |.||||  . ||.||||||..       | . ||. |||||     . .  |.|. |.|.. 
FPE-HARFY--MYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIVSGRRSTDLNQPIERQYLLEWAWKSHERNEQLDLVDARLNTVPPSFDKEQAVRVVCVGLLCTQATPSQRPSMSRVVT---------MI
 | ..|.   . ..    . ..                             ..|      ..|.    |..||.   . .          .
YEMLCGYPPFP-QMQMMFKKIG----------------------------SPEAKD-FIRKCLQKD--PEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_g-1.AA LISK 334-525 28 2.8e-37 118.56 In-house 1-237 (296) Show / Hide 
Range on Protein: 334-525
Range on HMM: 1-237/296
Sequence Identity: 28% (69 aa)

KLGQGGFGVVYKGTLP-DGRRIAIKRLTT-----QSQKGKQEFLNEVKLVSSVQHRNLVKLYGCCTE-ESERLLVYELLENNSLSRVLFQGNL---CLSW
..|.|.|| |||||.  .|. .||| ...             .| ||..  . .|.| |. .| | . ...  .| |. .   | . |.  ..    |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEK----FEAKIADFGLARLYSDER------------------------SINTQ---------
.|| .  |..|.|..|||.    .||||| |. |.|..|.    ...|..|||.||. ..|.                        .|.           
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

-IAGTLGYMAPEYALHGHLTDKADVFSFGILSLEIVSGRR
 | ||   ||||  |    ....|||||||. .||. ...
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAK-0_g-1.AA TK-Unique 329-522 27 5.1e-36 121.74 In-house 1-234 (294) Show / Hide 
Range on Protein: 329-522
Range on HMM: 1-234/294
Sequence Identity: 27% (66 aa)

FSDDNKLGQGGFGVVYKGTLPD-------GRRIAIKRLT-TQSQKGKQEFLNEVKLVSSVQ-HRNLVKLYGCCTEES-ERLLVYELLENNSLSRVLFQGN
.  ....|.| || |..|..          ...|.| |    ..  ||.||.| .. ...  | |.|...||||. .   ....| ... .| . ... .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNL-QHYLRTC

LC--------------------------LSWEQRYNVILGVARGLAYLHEDSQ--VKIIHRDIKAGNVLLDEKFEAKIADFGLAR------LYSDERSIN
 .                          .| .. |. . ..|.|..||.   .   ||.|||. | |||| |....||.|||.||       || ..| .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLA---SQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

TQIAGTLGYMAPEYAL--HGHL-TDKADVFSFGILSLEIVS
. .   . .||||. .  ||.  | | || |||.|  ||..
RIP---IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_g-1.AA TyrKc 329-599 25 5.2e-31 110.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 329-599
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

FSDDNKLGQGGFGVVYKGTLPDGRRIAIKRLTTQSQKGKQEFLNEVKLVSSV--QHRNLVKLYGCCTEE-------SERLLVYELLENNSLSRVL-FQGN
 . . ||| | ||.|||||.   .  |.| |   .   ...|..| .. ...  .| |.|.|||.||..          ..| |. .. .|   |   ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

LCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDE-------RSINTQ---IA---GTLGYMAPEYALHGHLT
  |....  .  . .|.| .|||.    ..||||. | |.|..|.. .||.||||.|   |.         . ..    .     .  ||||   .|  |
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

DKADVFSFGILSLEIVSGRRSTDLN---QPIERQYLLEWAWKSHERNEQLDL----VDARLNTVPPSFDKEQAVRVVCVGLLCTQATPSQRPSMSRVVTM
 | ||.|||..  || .   .   .   |... | ..|.  |. .| .| .                |  .    .  . . | .. |..||..| ..  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMS----------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase IRAK-0_g-1.AA TK 579-599 23 0.001637 6.79 In-house 466-486 (486) Show / Hide 
Range on Protein: 579-599
Range on HMM: 466-486/486
Sequence Identity: 23% (5 aa)

LLCTQATPSQRPSMSRVVTMI
. | .. |..||..| .. ..
QQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_g-1.AA TK-Unique 581-599 31 0.015579 4.7 In-house 276-294 (294) Show / Hide 
Range on Protein: 581-599
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTQATPSQRPSMSRVVTMI
|.|  |..||| . .. ..
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_g-1.AA MLK 581-599 31 0.092136 2.05 In-house 273-291 (291) Show / Hide 
Range on Protein: 581-599
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CTQATPSQRPSMSRVVTMI
| .. |..|||.. .|.  
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_g-1.AA TKL-Unique 586-599 42 0.304329 0.36 In-house 277-290 (290) Show / Hide 
Range on Protein: 586-599
Range on HMM: 277-290/290
Sequence Identity: 42% (6 aa)

PSQRPSMSRVVTMI
|||||| . ... .
PSQRPSFDEIIHRL
Kinase IRAK-0_g-1.AA Pkinase_Tyr 579-599 23 0.477839 4.17 Pfam 250-270 (270) Show / Hide 
Range on Protein: 579-599
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LLCTQATPSQRPSMSRVVTMI
..| .. |..||..| .. ..
KQCWHYDPEDRPTFSEIHEQL