Gene CR4L_e-2 (S.moellendorffii)

CR4L_e-2

Species: S.moellendorffii
Alias: CR4L_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: CR4L

Sequence

Name Sequence Type Origin Length Description Download
CR4L_e-2.AA Protein None 822 None Fasta, JSON
CR4L_e-2.NA RNA None 2469 None Fasta, JSON
CR4L_e-2.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of CR4L_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CR4L_e-2.AA IRAK 501-710 37 3.2e-64 219.66 In-house 1-223 (317) Show / Hide 
Range on Protein: 501-710
Range on HMM: 1-223/317
Sequence Identity: 37% (87 aa)

FSDDNRIGTGSFGTVYRGVLPDGRE--VAIKRGGVGSSGMDAIAKKKFQDKESAFQS---ELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPNGTQQE
|. ||||| | ||.||||.. .. .  .|.|.         . |. ..  ..  ||.   ||. ..|..| ..| | |.|.| ..  |||..||||. . 
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKK-------LKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLED

RIFAIN-LNS-----WQMRIGIALQAARGIEYLHTYA-VPPIIHRDIKSSNILIDAECSARVSDFGLSLMG-PSDGESHLSL------TAAGTVGYMDPE
|  . .  ..     |..|. |.. .|.||..||.     ||||.||||.||| |.   .  .||||   | |  .  . ..      .  ||  || ||
RLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPE

YYR--LQQLTTKSDVYSFGVVLLEILTGKRA
. |    |||.|.||||||.||||.||| ||
FIRDPQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase CR4L_e-2.AA TKL 507-790 23 6.6e-62 211.99 In-house 1-364 (364) Show / Hide 
Range on Protein: 507-790
Range on HMM: 1-364/364
Sequence Identity: 23% (91 aa)

IGTGSFGTVYRGVLPD---------GREVAIKRGGVGS------------------SGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDD
|| |.||.||.|..           |..||.|.  . .                    |  .  .. .  .  .  |.  . ||.| ..| ..|.| . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSD-M-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

E-------------RLLVYDFMPNGTQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAV-----PPIIHRDIKSSNILID--------------AECS
                .|....|.|.  ...       |. |. .||..|||..|||.        |||||||.||.|||.|              |.. 
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

ARVSDFGLSL-MGPSDGESHLSLT----------------AAGTVGYMDPEYYRLQ----------------QLTTKSDVYSFGVVLLEILTGKRAIIVE
. ..|||||  | .| . .. . |                  || ..| ||  | |                . ..|.||||||.|| ||||..|     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

NRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIG-VPEE----ADEMEAVLIVAELAEECVRLEGKERPSMGEIVSRL
     ...|  |. . |  .  .... .   | | |  ....     ..  .   ...|...|   . ..|||. ||..||
---PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CR4L_e-2.AA TKL-Unique 503-709 29 5.7e-40 138.67 In-house 1-226 (290) Show / Hide 
Range on Protein: 503-709
Range on HMM: 1-226/290
Sequence Identity: 29% (70 aa)

DDNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLH-HRHLVTLVGFCA----EDDERLLVYDFMPNGTQQERI
. | ||.|..|.||.|. . | .||||.  .  ..   . ...       | .|.  . .|| |  .|...|.|.       .. .| ...| |.  . .
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQE-------FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL

F----------AINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAE-----CSARVSDFGLSLMGPSDGESHLS-------LTAAGTV
             . ...|.|. .|...|.| .|||..  | |||||.||||.|.| .      .....|||||    .. .. ..        |  |. 
HQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSF

GYMDPEYYRL--QQLTTKSDVYSFGVVLLEILTGKR
 .| ||  |    | ..||||||||.|| ||.|.|.
RWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase CR4L_e-2.AA Pkinase 501-708 27 1.3e-36 130.53 Pfam 1-209 (293) Show / Hide 
Range on Protein: 501-708
Range on HMM: 1-209/293
Sequence Identity: 27% (61 aa)

FSDDNRIGTGSFGTVYRGVLPDGRE-VAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPNG----TQQE
.    .|| ||||.||...  . .. ||.|.  . .  ..    .          ||.. . ||.| . |.| ... ..|.  .| .....|       .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

RIF--AINLN--SWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSA----RVSDFGLSLMGPSDGESHLSLTAAGTVGYMDPEYYR-LQ
.|   . .    |..  . ...| .||.||.|      |||||.|..||||| ..      ...||||.        ..   | .|| .|| ||  |  |
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQ

QLTTKSDVYSFGVVLLEILTGK
  ..|.|..|.|..| | |.|.
YYGPKVDMWSCGCILYEMLCGR
Kinase CR4L_e-2.AA MLK 501-708 28 1.7e-33 113.65 In-house 1-233 (291) Show / Hide 
Range on Protein: 501-708
Range on HMM: 1-233/291
Sequence Identity: 28% (70 aa)

FSDDNRIGTGSFGTVYRGVLPDGRE-----VAIKRGGVGSSGMDAIAKKKFQDKESA------FQSELEFLTRLHHRH----LVTLVGFCAEDDE-RLLV
.     || |||| |..|.   ...     ||.||          ..  .| || ..      |. | . | .| |.      . ..| |...    ..|
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKR----------VRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIV

YDFMPNGTQQERIFAINL--------------NSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDA------ECSARVSDFGLSLMGPSDGE
  ....|   . . ...                . .  . .||| |||..|||  |..||||||.||.|||||.      .  ....|||.| .  . . 
MEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-

S-HLSLTAAGTVGYMDPEYY---RLQQLTTKSDVYSFGVVLLEILTGK
. . |  .|||. .| ||     | .. . |.||.|.|||| |.||..
TNMMS--NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase CR4L_e-2.AA TK 501-706 15 6.3e-32 103.74 In-house 1-389 (486) Show / Hide 
Range on Protein: 501-706
Range on HMM: 1-389/486
Sequence Identity: 15% (61 aa)

FSDDNRIGTGSFG---TVYRGVLPDGR--------------------------EVAIKRGGVGSSGMDAIAKK-KFQDKESA--------FQSELEFLT-
    . .| | ||   .||.| . ...                          .||.|    |..  ..  .   ..|            . .|.. .  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD---RDGGEDFLEEAEEMKMMCH

-RLHHRHLVTLVGFCAEDDE------------RLLVYDFMPNGT---------QQERIFAINLNS-----------------------------------
  .|| ..| |.| | ....             ..|  .||.|          .. |  ...  .                                   
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE

------------------------------------WQMRIGIALQAARGIEYLHTYAV---PPIIHRDIKSSNILIDAECS-----------ARVSDFG
                                     . .. ...|.|.| ||||   .   . ..|||.   |.|.. .             ....|||
QDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

LSLMGP----SDGESHLSLTAAGTVG----------------------------YMDPEYYRLQQ---------LTTKSDVYSFGVVLLEILT
|| .|      | .|.   ..... |                            .| ||  . ..          ||||||.||||.. ||.|
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase CR4L_e-2.AA LRRK 501-710 25 6e-31 106.71 In-house 1-282 (351) Show / Hide 
Range on Protein: 501-710
Range on HMM: 1-282/351
Sequence Identity: 25% (74 aa)

FSDDNRIGTGSFG-TVYRGVLPD---------------------------GREVAIKRGGVG----------SSG-----------------MDAIAKKK
.   . || |.|| .|||. . .                           . .||||   ..          |..                  .. . ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPNGTQQERIFAIN---L-----N-SWQMRIGIALQAARGIEYLHTYAVPPIIHRDIK
|.     |. |.  . .|.| ..| |.||| .   . .| ...|.|. ......     .     . ||.... |||| |.|.||||  . ||||||| |
FRE----FRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLK

SSNILI---D---------AECSARVSDFGLSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQ---QLTTKSDVYSFGVVLLEILTGK-RA
| |||.   .         |.  | ..|||.| |  .   . .  .  |. |.| ||  |     . |.|.|.||||..| |.||.. ..
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase CR4L_e-2.AA RIPK 507-710 26 4.4e-30 99.7 In-house 1-227 (290) Show / Hide 
Range on Protein: 507-710
Range on HMM: 1-227/290
Sequence Identity: 26% (62 aa)

IGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDE------RLLVYDFMPNGTQQE-RIFA
.| |.||.|.. .  . .....|     . .   ...   . .. .   | . . .| ..| | . ||| . .         .|  .|.||   . ..  
VGGGGFGEVFKARHRHWGDWVAKKC---KPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTK

INL----NSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLS-LMGPS--DG--------ESHLSLTAAGTVGYMDPEYYR
.        |  |  .  . ..|  |||    ||||||| | .|||.|..  . ..||||.  |. |   .         |  |.   ||  ||.|| .|
WPYQHHPDPWPLRCRMIHEISCGMCYLHSMN-PPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

--LQQL----TTKSDVYSFGVVLLEILTGKRA
  .       |.|.|||||..|. |.||.| .
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase CR4L_e-2.AA Dicty4 604-708 44 1.1e-28 92.89 In-house 107-214 (277) Show / Hide 
Range on Protein: 604-708
Range on HMM: 107-214/277
Sequence Identity: 44% (49 aa)

SWQMRIG---IALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSL-MGPSDGESHLS--LTAAGTVGYMDPEYYRLQQLTTKSDVYSF
.|  ..    .|. ||||. .||.   | |||||.||.|.|.|.   . |.|||||  | .  .|.|     ||.||...| ||  . |  . |.|||||
DWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK--HEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSF

GVVLLEILTGK
| || ||||..
GIVLWEILTRQ
Kinase CR4L_e-2.AA Dicty4-Unclassified 504-707 30 3.8e-28 93.47 In-house 4-204 (263) Show / Hide 
Range on Protein: 504-707
Range on HMM: 4-204/263
Sequence Identity: 30% (67 aa)

DNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAED----DERLLVYDFMPNGTQQERIF-
|  || | |  |..|.   |..||.|      .. .       ||    |  | | |  . |  ||.. | |            |  ||. |.  | |  
DQFIGKGHFSKVHKGNW-KGKDVAVK---KFNENKFKFREEMIQD----FKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHS

-------AINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSDGESHLSLTAAG-TVGYMDPEYYRLQQLTT
        | |..  . | .|.  |.|. .|||     .|||||||||||.|    ... |||.|       .    .|. . |.    ||  .    . 
KPSEQQQPIKLDD-TLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRV----IDFNFNMTTIAGTPKWESPECLMHESYNQ

KSDVYSFGVVLLEILTG
||||||....| | .||
KSDVYSYAMMLYELATG
Kinase CR4L_e-2.AA TyrKc 501-790 22 3e-27 97.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 501-790
Range on HMM: 1-280/280
Sequence Identity: 22% (74 aa)

FSDDNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRL--HHRHLVTLVGFCAED-------DERLLVYDFMPNG
 . .  .| | ||.||.|..   ..||.|    ..              . .| .|.. ...|  || ..| |.| | ..       .  ..|  .||.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

TQQERI-FAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSD---GESHLSLTA----AGT----VGYMD
  ....    .  ...  . ...|.|.| ||||     ..||||.   |.|....  ...||||||  . .|   |||.   ..     |     .  | 
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEYYRLQQLTTKSDVYSFGVVLLEILT-------G-----KRAIIVENRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIGVPEEADEMEAVLIVAE
||  .    ||||||.||||.. ||.|       |     . .. | ...| .  .  | |.     | .                      ..   . .
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P-MS-----------------F--VCCPDEMYQ

LAEECVRLEGKERPSMGEIVSRL
. ..| . . ..||.. ||....
IMKQCWHEDPEDRPTFSEIHECF
Kinase CR4L_e-2.AA S_TKc 501-794 19 2.1e-23 84.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 501-794
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

FSDDNRIGTGSFGTVYRGVLPD-GREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPN--GTQQERI
.   . || |.||.||...  . ||.||||.                      ...|.. | . || ..|.| ... . |.  .| .....  |.  ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

FAIN-------LNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQQLTT
   .       ..  . |  .. | ....||.|      |||||.| .|||.|      ..||||.             |  ||  || ||     . ..
KKRGRHGLRFPFPE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-KSDVYSFGVVLLEILTGKRAIIVENRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIGVPEEADEMEAVLIVAELAEECVRLEGKERPSMGEIVS-
 |.|..|.|..| | |.|.      .  .. ..                                          . .. . | . . ..||.  |.   
CKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

----RLESAV
    ..   .
EWDIKCHPWF
Kinase CR4L_e-2.AA DRK 604-706 39 1.4e-22 73.31 In-house 96-197 (258) Show / Hide 
Range on Protein: 604-706
Range on HMM: 96-197/258
Sequence Identity: 39% (41 aa)

SWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQQLTTKSDVYSFGVVLLE
.|  .. ... .|.|. |||    | ||||| || | |.|      |.|||||       .     |. || .   ||  | |  | | |||||..|| |
DWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE

ILT
..|
CVT
Kinase CR4L_e-2.AA Pkinase_Tyr 501-591 23 8e-12 40.66 Pfam 1-92 (270) Show / Hide 
Range on Protein: 501-591
Range on HMM: 1-92/270
Sequence Identity: 23% (24 aa)

FSDDNRIGTGSFGTVYRGVLP-----DGREVAIKRGGVGSSGMDAIAKKKFQDKE---SAFQSELEFLTRL-HHRHLVTLVGFCA-EDDE--RLLVYDFM
 . .  .| |.||.||.|..      .. .||.|           . | .  ...    .| .|.. .. | || ..| |.| |  ...    ..|  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK-----------MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM

PNG
|.|
PHG
Kinase CR4L_e-2.AA ABC1 507-529 45 1.1e-05 21.41 Pfam 19-42 (126) Show / Hide 
Range on Protein: 507-529
Range on HMM: 19-42/126
Sequence Identity: 45% (11 aa)

IGTGSFGTVYRGVLPD-GREVAIK
|...| . |.|..|.| |.|||.|
IAAASIAQVHRARLKDDGEEVAVK
Kinase CR4L_e-2.AA Pkinase_Tyr 604-656 30 1.4e-05 19.52 Pfam 109-158 (270) Show / Hide 
Range on Protein: 604-656
Range on HMM: 109-158/270
Sequence Identity: 30% (16 aa)

SWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLS
. .. .....| |.| |||.      .||||.   |.|.. .  ....||||.
TMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA
Kinase CR4L_e-2.AA Pkinase_Tyr 689-706 72 7.4e-05 17.08 Pfam 192-209 (270) Show / Hide 
Range on Protein: 689-706
Range on HMM: 192-209/270
Sequence Identity: 72% (13 aa)

TTKSDVYSFGVVLLEILT
||||||.||||.. ||.|
TTKSDVWSFGVLMWEIFT
Kinase CR4L_e-2.AA DRK 766-792 37 7.6e-05 12.38 In-house 232-258 (258) Show / Hide 
Range on Protein: 766-792
Range on HMM: 232-258/258
Sequence Identity: 37% (10 aa)

AELAEECVRLEGKERPSMGEIVSRLES
. |  .|   .   |||| |.. |||.
IQLMNDCWNEDPQHRPSMQECLERLEA
Kinase CR4L_e-2.AA Dicty4 501-529 51 8.1e-05 12.2 In-house 1-28 (277) Show / Hide 
Range on Protein: 501-529
Range on HMM: 1-28/277
Sequence Identity: 51% (15 aa)

FSDDNRIGTGSFGTVYRGVLPDGREVAIK
   ..|||.||||.||.|    | |||.|
INIEQRIGKGSFGEVYKGTWR-GKEVAVK
Kinase CR4L_e-2.AA TK 757-790 14 8.5e-05 11.18 In-house 453-486 (486) Show / Hide 
Range on Protein: 757-790
Range on HMM: 453-486/486
Sequence Identity: 14% (5 aa)

DEMEAVLIVAELAEECVRLEGKERPSMGEIVSRL
.. ..  ....|  .| ... ..||.. .....|
PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CR4L_e-2.AA Dicty4 778-792 47 0.000141 11.38 In-house 261-277 (277) Show / Hide 
Range on Protein: 778-792
Range on HMM: 261-277/277
Sequence Identity: 47% (8 aa)

KERPSMGEIVSR--LES
. |||. ||..|  ||.
QHRPSFEEIIQRRILEH
Kinase CR4L_e-2.AA DRK 504-530 48 0.000691 9.09 In-house 4-29 (258) Show / Hide 
Range on Protein: 504-530
Range on HMM: 4-29/258
Sequence Identity: 48% (13 aa)

DNRIGTGSFGTVYRGVLPDGREVAIKR
 |||| |..| |.||    | .||.|.
GNRIGRGNYGEVFRGTW-RGTQVAVKM
Kinase CR4L_e-2.AA LRRK 778-792 46 0.004271 6.78 In-house 337-351 (351) Show / Hide 
Range on Protein: 778-792
Range on HMM: 337-351/351
Sequence Identity: 46% (7 aa)

KERPSMGEIVSRLES
|.||.. .||.||..
KKRPHFSQIVKRLSQ
Kinase CR4L_e-2.AA MLK 766-790 32 0.005162 6.45 In-house 267-291 (291) Show / Hide 
Range on Protein: 766-790
Range on HMM: 267-291/291
Sequence Identity: 32% (8 aa)

AELAEECVRLEGKERPSMGEIVSRL
..| ..|   . ..|||. .||. |
KKLMKQCWNQDPHKRPSFRQIVQHL
Kinase CR4L_e-2.AA Dicty4-Unclassified 778-790 38 0.036933 3.15 In-house 251-263 (263) Show / Hide 
Range on Protein: 778-790
Range on HMM: 251-263/263
Sequence Identity: 38% (5 aa)

KERPSMGEIVSRL
. ||.| .|. .|
NKRPTMNQIIQYL
Kinase CR4L_e-2.AA TKL-Unique 770-790 38 0.090581 2.24 In-house 270-290 (290) Show / Hide 
Range on Protein: 770-790
Range on HMM: 270-290/290
Sequence Identity: 38% (8 aa)

EECVRLEGKERPSMGEIVSRL
..| . .  .|||  ||..||
QQCWHHDPSQRPSFDEIIHRL
Kinase CR4L_e-2.AA IRAK 768-790 21 0.093684 2.2 In-house 295-317 (317) Show / Hide 
Range on Protein: 768-790
Range on HMM: 295-317/317
Sequence Identity: 21% (5 aa)

LAEECVRLEGKERPSMGEIVSRL
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CACCCGHHRANRRCDMAWVMQQL
Kinase CR4L_e-2.AA Pkinase_Tyr 778-790 38 0.491012 4.13 Pfam 258-270 (270) Show / Hide 
Range on Protein: 778-790
Range on HMM: 258-270/270
Sequence Identity: 38% (5 aa)

KERPSMGEIVSRL
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EDRPTFSEIHEQL