Gene STE11-p2_b-1 (S.moellendorffii)
STE11-p2_b-1
Species: S.moellendorffii
Alias: STE11-p2_b-1
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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STE11-p2_b-1.AA | Protein | None | 243 | None | Fasta, JSON |
STE11-p2_b-1.NA | RNA | None | 732 | None | Fasta, JSON |
STE11-p2_b-1.kin_dom | Protein Kinase Domain | None | 243 | None | Fasta, JSON |
Protein domains of STE11-p2_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | STE11-p2_b-1.AA | STE11 | 1-242 | 41 | 6.9e-118 | 397.94 | In-house | 15-296 (303) | Show / Hide |
Range on Protein: 1-242 Range on HMM: 15-296/303 Sequence Identity: 41% (117 aa) VFAGLNQTTGELMAVKQLKIEPTD---GQSRAVYLA-----SLEREIDLYKQLRHRHIVGYIAMEQDE-ANNLLYIFLEYVSGGSIQSMLE-RFGR--FS |....| ||||||||| .|.... .. . | . .. || |.|.|.| .|| |. .... .|. ..||.||..|||. |||. ..|. |. VYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFD ESLVRIYTRQLLLGLEYLHANKIVHRDIKGGNVLVDADGV-VKLADFGASKAFH-DPTITDG-------CKSIRGSVF--------WMAPEVIKGDG--- |...|.||.|.| || |||...|.|||||| |.|.|.||. .||||||..| . . | |.. |||..|... ||||||||. | EMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDG YGRRADIWSVGCTVIEMLTATHPWPGIDN-TWTAIFHIAKA-SSGPPVPADAS------ECAKDFLQQCFNLEARSRPTASQ |||.|||||.|||||||.|. .||...|. ...|.|.|... . || | . | | ..|||..|| . ||||.| YGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQ |
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Kinase | STE11-p2_b-1.AA | STE11-Unclassified | 1-242 | 37 | 5e-116 | 391.78 | In-house | 15-301 (308) | Show / Hide |
Range on Protein: 1-242 Range on HMM: 15-301/308 Sequence Identity: 37% (109 aa) VFAGLNQTTGELMAVKQLKIEPTD--GQSRAVY-LASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGGSIQSMLERFGRFSESLVRIYTR |. ..| .|||.|||||..|. .. . .. . |.. |. ..|||.| .|| |. | ..... ..||.||..|||| |||...|.|.|.. ..||. VYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNKYGCFDEMVIKKYTK QLLLGLEYLHANKIVHRDIKGGNVLVDADGVVKLADFGASK---------------------AFHDPT--ITDGCKSIRGSVF---WMAPEVIK---GDG |.| ||.|||...|.||||||.|.|.|.||..||.|||..| . .. . |||..|... |||||||| .| QILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPFWMAPEVIKNSTQTG YGRRADIWSVGCTVIEMLTATHPWPGIDN--TWTAIFHIAKASSGPPVPADAS-----------ECAKDFLQQCFNLEARSRPTASQ ..|..||||.||||||| |. |||....| ||..|... . |. | . | . .||||..|| . ||||.| HCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTANQ |
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Kinase | STE11-p2_b-1.AA | STE | 1-242 | 26 | 2.7e-80 | 273.06 | In-house | 15-350 (359) | Show / Hide |
Range on Protein: 1-242 Range on HMM: 15-350/359 Sequence Identity: 26% (91 aa) VFAGLNQT---------------TGELMAVKQLKIEPTDGQSRA------------VYLASLEREIDLYKQLR--HRHIVGYIAMEQDE-----ANNLLY |. ..| |||.||.||...|. . . . ....||.. |... | .|| |. .. .| ... |. VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELW IFLEYVSGGSIQSMLE-RF-------------GRFSESLVRIYTRQLLLG-LEYLHANKIVHRDIKGGNVLVDADGVVKLADFGASKAFHD--------- |..||..|||. .... .. .||.||......||.| | |.||| ..|.|||||..|.|. |||.||| .. . | ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNN -----PTITDGCKSIRGSVFWMAPEVIKG------DGYGRRADIWSVGCTVIEMLTATHPWPGIDNT---WTAIFHIAKAS----------SGPPVPADA |. .... |. |||||||.. .||....||||.|||.|||.| .|| .. . ..| ..... || | . IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHL S-------------------ECAKDFLQQCFNLEARSRPTASQ | .. |||...|.. . . |||||| SQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ |
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Kinase | STE11-p2_b-1.AA | MEKK2 | 9-240 | 46 | 2.6e-76 | 259.82 | In-house | 23-253 (262) | Show / Hide |
Range on Protein: 9-240 Range on HMM: 23-253/262 Sequence Identity: 46% (109 aa) TGELMAVKQLKIEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGGSIQSMLERFGRFSESLVRIYTRQLLLGLEYLHA || .|||| ...| . ..| .|| ||.| | |.| || | .|... | ||.||..|||.. | .| |. | ||||.| |..||| TGRELAVKQVQFDPDNPETRKE-VQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGALTETVTRKYTRQILEGMHYLHD NKIVHRDIKGGNVLVDADGVVKLADFGASKAFHDPTITD-GCKSIRGSVFWMAPEVIKGDGYGRRADIWSVGCTVIEMLTATHPWPGIDNTWTAIFHIAK . |||||||| |.| |. | |||.|||||| . | ||. | .||.|||| |.||||.||.||.||||.|||| || . ||| || HMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVEMLTEKPPWAEYE-AMAAIFKIAT ASSGPPVPADASECAKDFLQQCFNLEARS-RPTA | .| |. |.|||..|| |.. || | QPTNPQLPQHVSQHARDFLKRCF-VEIKQDRPSA |
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Kinase | STE11-p2_b-1.AA | MEKK15 | 1-243 | 42 | 2.8e-68 | 233.15 | In-house | 15-258 (264) | Show / Hide |
Range on Protein: 1-243 Range on HMM: 15-258/264 Sequence Identity: 42% (106 aa) VFAGLNQTTGELMAVKQLKIEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGGSIQSMLERFGRFSESLVRIYTRQLL |. || . || |.|||| ... | . | |.|| | |.|. ||.|. . .. | . ||...| |||| |.. ||| | ||.|.| VYCGLTN-TGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLED--NVVNIFMQFVPGGSISSIINRFGPLDEMVFCKYTKQIL LGLEYLHANKIVHRDIKGGNVLVDADGVVKLADFGASK--AFH--DPTITDGCKSIRGSVFWMAPEVIKGDGYGRRADIWSVGCTVIEMLTATHPWPGID | .||| | .||||||| ||.. . |..|| ||| | .. . | .| ||.|| .|||||||. ||||..||||.|||| || | || .| QGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEMATRKPPWADMD NTWTAIFHIAKA-SSGPPVPADASECAKDFLQQCFNLEARSRPTASQV |.| | |..|. || |..| . | . ||||||. R-MAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQL |
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Kinase | STE11-p2_b-1.AA | S_TKc | 1-243 | 29 | 4.9e-67 | 229.95 | SMART | 15-218 (231) | Show / Hide |
Range on Protein: 1-243 Range on HMM: 15-218/231 Sequence Identity: 29% (74 aa) VFAGLNQTTGELMAVKQLKIEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSG--GSIQSMLERFGR------FSESLV |. . . ||...|.|..| ...|||.. |. .| .|| .. . || . ||...||..| |. ..... || |.| . VYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA RIYTRQLLLGLEYLHANKIVHRDIKGGNVLVDADGVVKLADFGASKAFHDPTITDGCKSIRGSVFWMAPEVIKGDGYGR-RADIWSVGCTVIEMLTATHP | |..|....|||.| ..|.|||.| |.|.| ..|..||| .. . ... |. ..|||||. |||. ..|.||.||...|||. | RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP WPGIDNTWTAIFHIAKASSGPPVPADASECAKDFLQQCFNLEARSRPTASQV .| . ..|.. . |. ||||...|.. . . |||| .. FP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EA |
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Kinase | STE11-p2_b-1.AA | Pkinase | 1-243 | 30 | 8e-65 | 226.47 | Pfam | 15-287 (293) | Show / Hide |
Range on Protein: 1-243 Range on HMM: 15-287/293 Sequence Identity: 30% (84 aa) VFAGLNQTTGELMAVKQLKIEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGG----SIQSMLE--RFGRF--SESLV |. . .. ||.. |||..| . .. . .... | .|| . | |.| .|| .. . .| .. .|. .||. || . .... | |.| || . VYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWEC RIYTRQLLLGLEYLHANKIVHRDIKGGNVLVDADGVV----KLADFGASKAFHDPTITDGCKSIRGSVFWMAPEVIK-GDGYGRRADIWSVGCTVIEMLT . | .|.| ||||.|...|.|||.| |.|.| .|.. |..||| .| | . ...... |. ..||||||. | .||...|.||.||...|||. KFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC ATHPWPGI-----DNTWTAIFHIAKASSGPPVPADAS-------------------ECAKDFLQQCFNLEARSRPTASQV |.|| .. |. | .. . | . | | .|||. |... .|||| |. GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI |
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Kinase | STE11-p2_b-1.AA | ASK | 1-243 | 38 | 1.2e-59 | 196.94 | In-house | 10-248 (254) | Show / Hide |
Range on Protein: 1-243 Range on HMM: 10-248/254 Sequence Identity: 38% (96 aa) VFAGLNQTTGELMAVKQLKIEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGGSIQSMLE-RFGRFS--ESLVRIYTR |.|| .. | .|.| .. | | || |.|||||| || |. . |. . ||.| | |||. ..|. ..| . |. .. ||. VYAGRDMHTQVRIAIKEIPERDSR------YVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTK QLLLGLEYLHANKIVHRDIKGGNVLVDA-DGVVKLADFGASKAFHDPTITDGCKSIRGSVFWMAPEVI-KGD-GYGRRADIWSVGCTVIEMLTATHPWPG |.| ||.||| |.|||||||| |||| ||||..||| .| |. .. .| . .|||||| .| |||. |||||.|||..|| |. |. QILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLA--GINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHE IDNTWTAIFHIAKASSGPPVPADASECAKDFLQQCFNLEARSRPTASQV ... |.|.. |..| . |. .|.|. .||. ... |..|... LGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDL |
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Kinase | STE11-p2_b-1.AA | STE20 | 1-242 | 32 | 1.1e-53 | 184.65 | In-house | 15-281 (288) | Show / Hide |
Range on Protein: 1-242 Range on HMM: 15-281/288 Sequence Identity: 32% (89 aa) VFAGLNQTTGEL----MAVKQLKIEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEAN--NLLYIFLEYVSGGSIQSMLERFG--------- |. . . |||. |.|....|. | .. . ... ||. ||..| .|| |. . . . . |.| || .|||.. ..... VYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ--DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGH RFSESLVRIYTRQLLLGLEYLHANKIVHRDIKGGNVLVDADGVVKLADFG-ASKAFH--DPTITDGCK--SIRGSVFWMAPEVIKG-----DGYGRRADI ...|. . .|..| ||.|||.|.|.|||||..|.|.. || ||||||| ... . . |...| .. |. .|||||||.. ||. ..|| PMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDI WSVGCTVIEMLTATHPWPGID-NTWTAIFHIAKASSGPP---V--PADASECAKDFLQQCFNLEARSRPTASQ ||.| | |||.. | | . |.|.|.| . .|| | | . .||. .| . . |||||| WSLGITAIEMAEGE--PPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQ |
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Kinase | STE11-p2_b-1.AA | CAMK | 1-243 | 18 | 1.1e-52 | 167.67 | In-house | 10-419 (425) | Show / Hide |
Range on Protein: 1-243 Range on HMM: 10-419/425 Sequence Identity: 18% (75 aa) VFAGLNQ-TTG-----------ELMAVKQLKIEPTDGQS----------------------RAVYLASLEREIDLYKQ-------LRHRHIVGYIAMEQD |. . . ||| . |.| .. . .... |.. .....|||.. |. |.|..|. . . .| VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED EA-----------------NNLLYIFL---EYVSGG----SIQSMLERF---------------GRFSESLVRIYTRQLLLGLEYLHANKIVHRDIKGGN . .. .|... ||.||| . ... . |||.|. .| | ||.. ...|.| ..|||||.| | PHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPEN VLVDAD-----------------GVVKLADFGASKAFHD-------------------PTITDG--CKSIRGSVFWMA-PEVIKG--------------D .|.| . . .|..||| .. | . .| |.| .| |. || |||..| . ILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKP GYGRRADIWSVGCTVIEMLTATHPWPGI---------------DNTWTAIFHIAKASSGPPVP----------AD---------ASECAKDFLQQCFNLE .||. .|.||.|. ||. . |. | ... | |... | |. .||..... . . YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVD ARSRPTASQV |.|..|. PEKRMTIEQC |
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Kinase | STE11-p2_b-1.AA | MEKK1 | 9-238 | 36 | 1.7e-45 | 157.49 | In-house | 23-255 (266) | Show / Hide |
Range on Protein: 9-238 Range on HMM: 23-255/266 Sequence Identity: 36% (87 aa) TGELMAVKQLK-IEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGGSIQSMLERFGRFSESLVRIYTRQLLLGLEYLH || |||||| . . . | . . .|| . . | ||. . ..... .| | |||. .| .| |..| | |. |...|| ||| TGTLMAVKQITYCRNNSSDQEDV-MEEIRKEIRMMAHFNHPHIIRMMGATCHDSH--YNVFIEWMPGGSVAHLLKDYGAFKNSVVINYIHQVCRGLSYLH ANKIVHRDIKGGNVLVDADGV-VKLADFG-ASKAFHDPTITDGCK-SIRGSVFWMAPEVIKGDGYGRRADIWSVGCTVIEMLTATHPW--PGIDNTWTAI |.|.|||.|| | |.| | |||| | . | | || . . | . ||||| |. ||| ||||||| .||| .. || . | | DNQIIHRDVKGANLLMDSTGHHLRIADFGTAARMNSDITRTDEFQGQFLGTIAFMAPEVLRGQQYGRSCDIWSVGCCIIEMCCTKPPWNNEKHSNHYQLI FHIAKASSGPPVPADASECAKDFLQQCFNLEARSRP | || | ||.| | | | .. || FKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRP |
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Kinase | STE11-p2_b-1.AA | Dicty2 | 1-135 | 41 | 4.5e-43 | 147.84 | In-house | 16-151 (264) | Show / Hide |
Range on Protein: 1-135 Range on HMM: 16-151/264 Sequence Identity: 41% (58 aa) VFAGLNQTTGELMAVKQLK-IEPTDGQSRAVYLASLEREIDLYKQLRHRHIVGYIAMEQDEANNLLYIFLEYVSGGSIQSMLERFGRFSESLVRIYTRQL |. ||. .||. | || . . . .| . |. ||.| | |.| || || .. |.. |||.|||. .|| ...|| |.|||. || .| VYKGLHIETGDFVAIKQINIMKKKTKISEEQ-HQSIMQEIHLLKKLNHHNIVKYIEHIETENH--LYIILEYIENGSLSKIIKKFGCFPESLCCIYIYQV LLGLEYLHANKIVHRDIKGGNVLVDADGV---VKLADFG | ||.||| ....|||||. | |. .|. .|||||| LKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFG |
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Kinase | STE11-p2_b-1.AA | Pkinase_Tyr | 14-198 | 29 | 5.5e-24 | 81.85 | Pfam | 32-222 (270) | Show / Hide |
Range on Protein: 14-198 Range on HMM: 32-222/270 Sequence Identity: 29% (57 aa) AVKQLKIEPTDGQSRAVYLASLEREIDLYKQL-RHRHIVGYIA--MEQDEANNLLYIFLEYVSGGSIQSMLER----FGRFSESLVRIYTRQLLLGLEYL ||| || .. | ..... ||. . ||| .| .|| ... ..|.| | .|| .||. .|. . | . .... . . .| |.||| AVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYL HANKIVHRDIKGGNVLVDADGVVKLADFGASKAF-HDPTI-TDGCKSIRGSVFWMAPEVIKGDGYGRRADIWSVGCTVIEMLT-ATHP-WPGIDNT ......|||. |.||. ..||| .||| ... .| . . . .. ..|||||.|. . |.|| | . |..| | .||..|. ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE |
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Kinase | STE11-p2_b-1.AA | Dicty2 | 157-242 | 44 | 4.5e-21 | 70.23 | In-house | 172-257 (264) | Show / Hide |
Range on Protein: 157-242 Range on HMM: 172-257/264 Sequence Identity: 44% (39 aa) FWMAPEVIKGDG--YGRRADIWSVGCTVIEMLTATHPWPGIDNTWTAIFHIAKASSGPPVPADASECAKDFLQQCFNLEARSRPTASQ .||||||| .| ||||.|||.||.|| . | . |. | | . || | | | ||||.|||. . |.||.| YWMAPEVIQMSGNHCCTACDIWSLGCTIIELLTGNPPYWDL-NPMHAMFRMVQDDH-PPLPNDISPECKDFLMQCFCKDPNQRMTAKQ |
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Kinase | STE11-p2_b-1.AA | TyrKc | 1-243 | 23 | 1.8e-15 | 27.48 | SMART | 15-276 (280) | Show / Hide |
Range on Protein: 1-243 Range on HMM: 15-276/280 Sequence Identity: 23% (65 aa) VFAGLNQTTGELMAVKQLKIEPTDGQSRAVYLASLEREIDLYKQL--RHRHIVGYIAMEQDEAN-----NLLYIFLEYVSGGSIQSMLERFGR-FSESLV |. | . ||| || . .. . ||. . ..| .| .|| .. .. |.| .||...|. .. | . .. .. . VYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDL RIYTRQLLLGLEYLHANKIVHRDIKGGNVLVDADGVVKLADFGASKAFHDP------TITDGCK---SIR--GSVFWMAPEVIKGDGYGRRADIWSVGCT . | | |||| ....|||. |.||.....|| .||| |.. .| . . | . . . |||||.|. . |.|| | . LSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVC VIEMLT-ATHPWPG-ID--NTWTAIFHIAKASSGPPVPAD---------ASECAKDFLQQCFNLEARSRPTASQV |..| |.|| | ... ... |. .| |.. .| . .|| . .. .||| |.. MWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI |