Gene NEK_a (S.moellendorffii)

NEK_a

Species: S.moellendorffii
Alias: NEK_a
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
NEK_a.AA Protein None 633 None Fasta, JSON
NEK_a.NA RNA None 1902 None Fasta, JSON
NEK_a.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of NEK_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK_a.AA NEK 10-265 37 6.5e-115 388.06 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-286/286
Sequence Identity: 37% (107 aa)

YEIMEQVGRGAFGSAILVNHKIEKKK-----YVLKKIRLARQTDRCRRSAH-QEMALIAGITHPYIVDHKESWVEKG-CYVCIVTGYCE-GGDMAEM---
||| ...|.|.||.. .| .|. .|.     ||.||| . . ... .. |  .|  . . . ||.||  ..|..|..  . |||  ||| |||....   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRRSN--GTFFPEEKLCRWFTQLLLAVEYLHSN-----HVLHRDLKCSNIFLTKDQD----IRLAGDFGLAKLLKAD-DLASS-VVGTPNYMCPELLADI
| .    |..|.||.  .||.|..||. |.|..     ..||||.|..||||||.      ... ||||..|.|. . |.|.. .|||| ||.||.. . 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKI-GDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

PYGFKSDIWSLGCCMYEMAAH--RPAFKAF--DMQGLISKINKS-TVGPLPNN--YSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
||..|||||||||. |||..   ...|.|   .| .|. || |  .  |.| .  ||. |...|..||.|.||.||.. ..| .| .
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK_a.AA NEK4 10-265 43 6.9e-99 334.83 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESW-VEKGCYVCIVTGYCEGGDMAEMIRRSNGTFFP
|..| .||.| .|   || |.. ||.||.||. | .   | |. | .|  |     || ||  ||||  | | . .|| |.|||||. .  ..  . | .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLLK-ADDLASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAHR
|.    || |  .|  |.|  |.||||||  ||||||   |.. ||||... |    |.|. ..||| || ||. .  || .||||||||||.|||.  .
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKI-GDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

PAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
 || | ||  || .| .    |.| |||  |. ... || | |. || . |... | .
HAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK_a.AA NEK1 10-265 38 1.5e-83 283.86 In-house 1-276 (276) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-276/276
Sequence Identity: 38% (106 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGC--YVCIVTGYCEGGDMAEMIRRS--NGT
|..  |.| |.|| |.|| || . . ||.| |.. .. .  |  .  | |. |   || ||  ||| .| ||  .. ||  ||.|||..  | |    | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILY-IVMEYCDGGDLMQKINRQKRKGK

FFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLT--KDQ---------------DIRLAGDFGLAKLL-KADDLASSVVGTPNYMCPELLADIPY
 |.|     ||.|. ||. . |.  .||||.| .|||||  |.                 ..| |||| |..|   ...|. ..||| |  ||.    ||
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKL-GDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPY

GFKSDIWSLGCCMYEMAAHRPAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
  |||||||||  ||  .   .| |  .. |. || ..|. |.|. ||. |.| . .|...||.||| | ..|  | .
NNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK_a.AA S_TKc 10-265 32 2.7e-79 270.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEG--GDMAEMIRRSNGTF-
|||....|.||||.  .. ||  .... .|.|.         ... .|...     ||.||  ......   ....|. ||.|  ||. ..|.. ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLLKADDLASSVVGTPNYMCPELLADIPYGF-KSDIWSLGCCMYE
   |||   .... |...|.||.||....||||| .||.|..   | .. |||||..|      ....|||.|| ||.|   .||. |.|.||.||..||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKIC-DFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MAAHRPAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLR-------HPHL
|.. .| |   .|| .. ||            |  .|..|| .|.|.||.|||. ..|.       || .
MLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK_a.AA NEK8 10-265 31 7.8e-74 210.14 In-house 1-278 (278) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-278/278
Sequence Identity: 31% (87 aa)

YEIMEQVGRGAFGSAILVNHKIEK--KKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGGDMAEMIRRSNGTFF
||    |||||||...|   |     .. ..| | . | . . |..|  |  . . . || |.   ..  | .    |.  |..||  ..|| .  .. |
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNT-LMIEMEYADGGTLYQMIQHQQNKLF

PEEK-----------------LCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLLKADDLAS-S--VVGTPNYMCPELLADIPY
 ||.                     |.| ..|| ..|.. .||||||  |||.|... .   ||||..| .  . ... .  |||||.|| ||.    ||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

GFKSDIWSLGCCMYEMAAHRPAFKAFDMQGLISKINKS-TVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
 .|||.|.|||  |||.  . || |     |. ||  . .  |..  ||| ... ... | . || ||..  ..  | .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK_a.AA AGC 10-265 21 1.3e-72 186.14 In-house 1-395 (395) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-395/395
Sequence Identity: 21% (87 aa)

YEIMEQVGRGAFGSAILVNHK------IEKKKYVLKKIRLAR--------QTDRCRRS--------AHQEMALIAGIT----------HPYIVD-HKESW
.|.   .|.|.||  .|| .|        .| | .|... ..        . ..  .           .|    . .           ||.||   . |.
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

VEKGC-YVCIVTGYCE--------GGDMAEMIRRSN--GTF-FPEEKLCRWFTQ-------LLLAVEYLHS-NHVLHRD-LKCSNIFLTKDQDIRLAGDF
  |   |...|  |..        ||..  ...  .  . . |.||  . .. .       ..||.||||| ... ||| ||  || |..|  |.|. ||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT-DF

GLAKLLKAD---------------------------------------------------DLASSVVG--TPNYMCPELLADIPYGFKSDIWS--LGCCM
||.| .. |                                                   |.... .|  ||.|| || |    ||.  |.||  |||.|
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEMAAHRPAFKAFDMQ----------GLISKINK-----STVGPLP----------NNYSNTLKSIIRSMLRKNPEHRPT----------VGDLLRHPHL
||| . .| | . . |           .  || .     .   ..|           . |. .|..|. .| |.||.|..          . .. .||  
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase NEK_a.AA Pkinase 10-265 27 2.7e-70 244.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQ--EMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGG----DMAEMIR-RS
|.| ...|.|.||.  .  || . |....|.|.. .. . .....    | .. . . ||.||  .... . . ....|. |||||    | ...|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

NGTF-FPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDI----RLAGDFGLAKL--LKADDLASSVVGTPNYMCPELLA-DIPYGFKSDIW
.|.| |.|. ......|.| ..||.||. ..||||| .||.. .. .|    ... ||||||.  .  .  .....|||.|| ||..  . .|| |.|.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC-DFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGCCMYEMAAHRPAFKAF----DMQGLISKINKSTVGPLPNNYS-----------------------NTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
|.|| .|||.  || |.      .    . .|..   .||. ...                        ..|..|...|.|.|. |||  ..| || .
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK_a.AA STE 10-265 22 6.7e-62 211.97 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

YEIMEQVGRGAFGSAILVNHK----IE-----------KKKYVLKKIRLARQT---------------DRCRRSAHQEMALIAGIT--HPYIVDHKESWV
.|..|..|.||||.  .  ..    |.           .. .  |...| ...               .  . .  .|. .       ||.||    . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKG------CYVCIVTGYCEGGDMAEMIRRSNGTFFP------------EEKLCRWFTQLLLA-VEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLA
 .|       ...|.  |..||   ..|..  |...|            |. ...   |.| .  .||||.|. |||.|..||.|     . |. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC-DFGVC

KLLKA-----------------DDLASSVVGTPNYMCPELLA------DIPYGFKSDIWSLGCCMYEMAAHRPAFKA-FDMQGLISKINK----------
. |                   .    ..|||| .| || .       | .|..|.|||||||.. |||  .| .    .|. .  ....          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----STVGPLPN-------------------NYSNTLKSIIRSMLRKNPEHRPTVGDLLR--HPHL
     .  |||.                   ..|  .|  |.  |.|.|..|||. .||.  || .
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK_a.AA NEK-Unclassified 10-265 31 2.3e-61 201.79 In-house 1-258 (258) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-258/258
Sequence Identity: 31% (83 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGGDMAEMIRRSNGT--FF
|. .  .| |  |   || |.| |.  | .  .  ..  |  .     . ... . || ||   .|. |    .     ||.||.. . |..  .    |
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKRKKKKKRQNK-----IIILSQLRHPHIVTYHDSFFEN-AKLFYTQDYCDGGNLDRRIQKHRKKNEPF

PEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLL-KADDLASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAH
 |  . .|. |.  || | |.  ..||||| .|||||.|  . . |||| .. .  . | |   |||...| || . | ||  .||.||||| .|||.. 
DEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSM-GDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC

RPAFKAFDMQGLISKINKSTV------GPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
 |.| .  |  .  || .          |    ||  |  .|| |||.|.. ||   ...  .  
EPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK_a.AA CAMK 15-265 19 4.7e-60 191.9 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-265
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

QVGRGAFGSAILVNHKIEK------------KKYVLKKIRLARQT--------------------------DRCRRSAHQEMALIAG-------ITHPYI
. |||.||   |. ||  .            .|.  | |   . .                          .. |..  .|...          . || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VDHKESWVEKGC------------------YVCIVT---GYCEGG----DMAEMIRRSNG-------------TFFPEEKLCRWFTQLLLAVEYLHSNHV
.   | .  . .                  ....|.    ||.||    |. ..|..  .               |.|.  .|.| |.. ||.|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKCSNIFLTKDQ-----------------DIRLAGDFGLAKLLKA------------------------DDLASSVVGTPNYMC-PELLAD-----
 |||||. || |...                  .| .. |||.|. ..                         ... . ..||| ||. ||.|       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII-DFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------IPYGFKSDIWSLGCCMYEMAAHRPAFKAF-------------DMQGLISKINKSTVGPLPNN---------------YSNT--------LK
          .||.|.|.||.|. .| |   .| | .              ... |  || |      |                  |.          |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SIIRSMLRKNPEHRPTVGDLLRHPHL
. ||.||...||.|.|. . |.|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK_a.AA NEK2 89-265 31 2.6e-54 181.25 In-house 81-319 (319) Show / Hide 
Range on Protein: 89-265
Range on HMM: 81-319/319
Sequence Identity: 31% (76 aa)

YCEGGDMAEMIR--RSNGTFFPEEKLCRWFTQLLLAVEYLHS-------------------N--HVLHRDLKCSNIFLTKDQD-----------------
|||||| . ||   |.  ....||   | ..||..|    |                    .   .||||.|  ||||  |.                  
YCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSN

----------------------IRLAGDFGLAKLLKADDL-ASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAHRPAFKAFDMQGLISKINKS
                      . | ||||||. |. | . | . |||| || ||.. . .|  ||||||.||  |||.| .| |.|.  . | .|| . 
YYRDHRVNSGKRGSPMDYSQVVVKL-GDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQG

TVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
   ..|  ||  |  || .|.  ...||| .  .|.|| .
HFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase NEK_a.AA NEK11 10-265 38 3.4e-54 186.38 In-house 1-259 (259) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-259/259
Sequence Identity: 38% (102 aa)

YEIMEQVGRGAFGSAILVNHKIEKKK---YVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGGDMAEMIR--RSNG
| .  ..| |.||   ||  |  |.     ||| |            |  |  |.. . || ||    |..|.  . ||.| |||| |. . |   .  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNF-CIITEYCEGRDLDYRIQEYKQAG

TFFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLLKAD-DLASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEM
  ||| ..  || |||| |.|.|   .||||||  |||| |   ... |||| ..||    |||  . ||| || || |    |  ||||||| | .|||
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKI-GDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEM

AAHRPAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
     ||   .   .. .|       ||. |   | .|. .|| |||  ||   |.|. | .
CCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK_a.AA TyrKc 10-265 20 2.3e-14 9.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YEIMEQVGRGAFG---SAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGI--THPYIVDHKESWVEKG-------CYVCIVTGYCEGGDMAE
 .  .. |.||||    ...        .   |...        |.  ..|. .   .   || ||      . ..         ..||. |...||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIV-RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

MIRRSNGTFFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLLKAD-------DLASSVV--GTP-----NYMCPELLA
 .|.. .. .. ..|. . .|     |||||... |||| . |. ..... .. . ||||.. .. |       |  ..    |.        | || . 
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS-DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

DIPYGFKSDIWSLGCCMYEMA--AHRPAFKA----FDMQGLISKINKSTVGPLPNN--------YSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
.  . .|||.|| | ||.|.      |         . | .| .. .    | | |         .  . .|...  . .|| |||  ..  |  .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase NEK_a.AA Pkinase_Tyr 82-203 27 5.5e-13 44.61 Pfam 81-207 (270) Show / Hide 
Range on Protein: 82-203
Range on HMM: 81-207/270
Sequence Identity: 27% (36 aa)

YVCIVTGYCEGGDMAEMIRRS--NGTFFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLAGDFGLAKLLKADDLASSVVGT-----P
...||. |...||. .  |.   ..  .. . |. . .|   . |||.|..  |||| . |. .|..  .. . |||||...  ||   .....      
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKIC-DFGLARDIYNDDYY-YRKRGGGKLPI

NYMCPELLADIPYGFKSDIWSLGCCMYEM
  | || ...  .  |||.|| | .|.|.
KWMAPECINYGKFTTKSDVWSFGVLMWEI
Kinase NEK_a.AA NEK2 10-41 37 0.000723 8.77 In-house 1-32 (319) Show / Hide 
Range on Protein: 10-41
Range on HMM: 1-32/319
Sequence Identity: 37% (12 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKI
||. .  |.| ||.   | .|  .|  | | |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEI
Kinase NEK_a.AA Pkinase_Tyr 10-23 35 5.992044 0.45 Pfam 1-14 (270) Show / Hide 
Range on Protein: 10-23
Range on HMM: 1-14/270
Sequence Identity: 35% (5 aa)

YEIMEQVGRGAFGS
 ..... |.||||.
ITFGKKLGEGAFGE