Gene NEK_c (S.moellendorffii)

NEK_c

Species: S.moellendorffii
Alias: NEK_c
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
NEK_c.AA Protein None 558 None Fasta, JSON
NEK_c.NA RNA None 1677 None Fasta, JSON
NEK_c.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of NEK_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK_c.AA NEK 9-263 38 9.90000000001e-118 397.43 In-house 1-286 (286) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-286/286
Sequence Identity: 38% (111 aa)

YEIIGQVGKGAFGSAILVNHKLEKKK-----YVLKKIRLARQSDRCRRSAH-QEMALVSRVKHPHIVEYKEAWVEKG-CYVCIVTGYCE-GGDMADI---
|||| ..|.|.||.. .| .|  .|.     ||.||| . . |.. .. |  .|  . .. |||.||.|.....|..  . |||  ||| |||...    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRKAN--GTYFPEERLCRWFVQLLLGVEYLHAN-----HILHRDVKCSNIFLTKDHD----IRLGDFGLAKMLKSD-DLACS-VVGTPNYMCPELLADIP
| |    |.||.||   .||.|..|.. |.| .     .||||| |..||||||..     ...||||..|.|... |.|.. .|||| ||.||.. . |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YGFKSDIWSLGCCMYEMSAH--RPAFKAF--DIQGLINKINKS-SIGPLPTC--YSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
|..|||||||||. ||| .   ...|.|   .. .|..|| |     |.|    ||.  ..||..||.|.||.||.. ..| .| .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK_c.AA NEK4 9-263 43 3.6e-99 335.78 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAW-VEKGCYVCIVTGYCEGGDMADIIRKANGTYFP
|... .|||| .|   || |.  ||.||.||. | . | | |. | .|  | |. ||| |||||| |  | | . .|| |.|||||.    ..  .   .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLK-SDDLACSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMSAHRP
|.    ||||  ..  |.|  |||||| |  ||||||   |..||||... |  . |.|  ..||| || ||. .  || .||||||||||.|||   . 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
|| | |.  || .| .    |.|  ||   . |.. || | |. ||   .... | .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK_c.AA NEK1 9-263 38 1.8e-88 300.25 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-276/276
Sequence Identity: 38% (106 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGC--YVCIVTGYCEGGDMADIIRKA--NGT
|..| |.|.|.|| |.|| || . . ||.| |.. ....  |  .  | |. .. ||| ||.|||. .| ||  .. ||  ||.|||..  | ..   | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILY-IVMEYCDGGDLMQKINRQKRKGK

YFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLT--KDH---------------DIRLGDFGLAKMLKS-DDLACSVVGTPNYMCPELLADIPYG
 |.|     ||.|. |.. . |   ||||| | .|||||  |.                 ..||||| |.|| . ...|| ..||| |  ||.    || 
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

FKSDIWSLGCCMYEMSAHRPAFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
 |||||||||  ||  .   .| |   . |..|| .... |.|  ||   .||. .|...||.||| .  .|  | .
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK_c.AA S_TKc 9-263 33 5.4e-88 299.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEG--GDMADIIRKANG---
|||. ..||||||.  .. ||  .... .|.|.         ... .|... .. .||.|| .......   ....|. ||.|  ||. |.|.| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-TYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLKSDDLACSVVGTPNYMCPELLADIPYGF-KSDIWSLGCCMYEM
  .||| . .... |.....||.| ..|.|||.| .||.|..   | ..|||||. |       ...|||.|| ||.|   .||. |.|.||.||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

SAHRPAFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLR-------HPHL
 . .| |   ..| ...||            |...|..|| .|.|.||.|||| |.|.       || .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK_c.AA NEK8 9-263 32 6.8e-80 227.76 In-house 1-278 (278) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-278/278
Sequence Identity: 32% (90 aa)

YEIIGQVGKGAFGSAILVNHKLEK--KKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGGDMADIIRKANGTYF
|| |  ||.||||...|   |     .. ..| | . | | . |..|  |  . |.. || |..| .   | .    |.  |..||  ...| .  .. |
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNT-LMIEMEYADGGTLYQMIQHQQNKLF

PEER-----------------LCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKD-HDIRLGDFGLAKMLKSDDLAC-S--VVGTPNYMCPELLADIPY
 |||                     |.| ...| ..| . ||||| |  |||.|..   . .||||..| . .. ..  .  |||||.|| ||.    ||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

GFKSDIWSLGCCMYEMSAHRPAFKAFDIQGLINKINKS-SIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
 .|||.|.|||  |||   . || |     |..||  .    |..  ||.  ..|... | . || ||.|....  | .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK_c.AA AGC 9-263 22 2.9e-78 201.11 In-house 1-395 (395) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-395/395
Sequence Identity: 22% (89 aa)

YEIIGQVGKGAFGSAILVNHK------LEKKKYVLKKIRLAR--------QSDRCRRS--------AHQEMALVSRVK----------HPHIVE-YKEAW
.|..  .|||.||  .|| .|        .| | .|... ..        . ..  .           .|    ....          || ||   . ..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

VEKGC-YVCIVTGYCE---------GG-DMADIIRKA-NGTYFPEERLCRWFVQ-------LLLGVEYLHA-NHILHRD-VKCSNIFLTKDHDIRLGDFG
  |   |...|  |..         || ..  ....  .  .|.||| . .. .       ..|..||||  ..| ||| .|  || |..|  |.| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKMLKSD---------------------------------------------------DLACSVVG--TPNYMCPELLADIPYGFKSDIWS--LGCCMY
|.|....|                                                   |.. . .|  ||.|| || |    ||.  |.||  |||.||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMSAHRPAFKAFDIQ----------GLINKINK-----SSIGPLP----------TCYSSSFKSLIRSMLRKNPEHRPT----------AAELLRHPHL
|| . .| | . . |           . .|| .     .   ..|             |.  |.||. .| |.||.|..          | |. .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase NEK_c.AA Pkinase 9-263 29 3.4e-75 260.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQ--EMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGG----DMADIIR-KA
|.|....|.|.||.  .  || . |....|.|.. .... .....    | ..  |..||.||...... . . ....|. |||||    | .|.|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

NGTY-FPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDI----RLGDFGLAKM--LKSDDLACSVVGTPNYMCPELLA-DIPYGFKSDIWS
.|.. |.|. ..... |.| |.||.|.. |.|||.| .||.. .. .|    ...||||||   . ..  . ...|||.|| ||..  . .|| |.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCCMYEMSAHRPAFKAF------DIQGLINKINK---SSIGPLPTCYS-----------------SSFKSLIRSMLRKNPEHRPTAAELLRHPHL
.|| .|||   || |.        | . .|..| .   ..  | . . |                 ...|..|...|.|.|. ||||...| || .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK_c.AA CAMK 14-263 19 4.1e-68 218.33 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-263
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

QVGKGAFGSAILVNHKLEK------------KKYVLKKIRLARQS--------------------------DRCRRSAHQEMALVSR-------VKHPHI
. |.|.||   |. ||. .            .|.  | |   . .                          .. |..  .|... ..       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEYKEAWVEKGC------------------YVCIVT---GYCEGG----DMADIIRKANG-------------TYFPEERLCRWFVQLLLGVEYLHANHI
.   |..  . .                  ....|.    ||.||    |. | |..  .              .|.|.  .|.| |.. .|.|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDVKCSNIFLTKDH-----------------DIRLGDFGLAKMLKS------------------------DDLACSVVGTPNYMC-PELLAD------
 ||| |. || |....                 .| . |||.|.....                        ...   ..||| ||. ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------IPYGFKSDIWSLGCCMYEMSAHRPAFKAF-------------DIQGLINKINKSSIGPLPTCYSS-----------------------SFKS
         .||.|.|.||.|. .| |   .| | .              ... |  || |      |   |                        . |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRSMLRKNPEHRPTAAELLRHPHL
|||.||...||.|.|... |.|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK_c.AA STE 9-263 23 2.7e-67 229.9 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YEIIGQVGKGAFGSAILVNHK----LE-----------KKKYVLKKIRLARQS---------------DRCRRSAHQEMALVSRVK--HPHIVEYKEAWV
.|.|...||||||.  .  ..    ..           .. .  |...| ...               .  . .  .|. . .. .  ||.||.|  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKG------CYVCIVTGYCEGGDMADIIR---KANG---------TYFPEERLCRWFVQLLLG-VEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAK
 .|       ...|.  |..||   |||.   . ..         ..|||. ...  .|.| |  .||| .|| |||.|..||.|     . | |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MLKSD----------------DLAC-SVVGTPNYMCPELLA------DIPYGFKSDIWSLGCCMYEMSAHRPAFKA-FDIQGLINKINK-----------
 | ..                .  . ..|||| .| || .       | .|..|.|||||||.. ||   .| .    . . . .....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---SSIGPLPTC-------------------YSSSFKSLIRSMLRKNPEHRPTAAELLR--HPHL
     . |||.                    .|..||  |.  |.|.|..|||| .||.  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK_c.AA NEK-Unclassified 9-263 33 2.2e-64 212.0 In-house 1-258 (258) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-258/258
Sequence Identity: 33% (89 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQE-MALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGGDMADIIRKANGT--Y
|. |  .|.|  |   || |.. |.  | ..|     | | ..   |  . ..| ..||||| | ... |    .     ||.||..   |.|  .    
YDKITTLGQGGGGAVYLVRHQISKRHLV-QQI-----SKRKKKKKRQNKIIILSQLRHPHIVTYHDSFFEN-AKLFYTQDYCDGGNLDRRIQKHRKKNEP

FPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKML-KSDDLACSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMSAH
| | |. .|..|.   | | |   |.||| | .|||||.|  . .|||| .. .    | |   |||...| || . | ||  .||.||||| .||| . 
FDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC

RPAFKAFDIQGLINKINKSSI------GPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
 |.| .  .  .  || .          |    ||     .|| |||.|.. || | |..  .  
EPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK_c.AA Ciliate-E2 9-263 23 1.9e-61 209.67 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

YEIIGQVGKGAFG-----SAILVNH------------------KLEKKKYVLKKI-----RLARQSDRCRRSAH------QEMALVSRVKHPHIVEYKEA
|..| . |.|.||     . ..|..                  |  .|.| .| .     .   | ..  |  .      .|. . ....||.|....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WVE-KGCYVCIVTGYCEGGDMADIIR-----------KANGTYFPEERLCRWFVQLLL---------------GVEYLHANH-ILHRDVKCSNIFLTKDH
. | .  .. .|. ||.|||. |.|.           |    || |.  .. . |.|                ..|||| .. |.||| | .||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

DIRLGDFGLAKMLKSD--------------------------------DLACSVVGTPNYMCPELLADIP---------YGFKSDIWSLGCCMYEMSAHR
 | . ||||.| .. |                                ... ...|||.||.|| |   .         |..|.||||||...|||   .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PAFKAFDIQGLINKINKSSIGPLPTC-----------------YSSSFKSLIRS----MLRKNPEHRPT-AAELLRHPHL
| |        ...| .  |   . .                  | . | ||.     || |.|| |.| . ..| || .
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK_c.AA NEK11 9-263 39 3e-59 203.16 In-house 1-259 (259) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-259/259
Sequence Identity: 39% (103 aa)

YEIIGQVGKGAFGSAILVNHKLEKKK---YVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGGDMADIIR--KANG
| .  ..| |.||   ||  |  |.     ||| |            |  |  |.||..|| || .  ...|.  . ||.| |||| |. . |   |  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNF-CIITEYCEGRDLDYRIQEYKQAG

TYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLK-SDDLACSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMS
  |||  .  ||.||||||.|.|   |||||.|  |||| |   ...|||| ...|  | |||  . ||| || || |    |  ||||||| | .||| 
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

AHRPAFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
    ||   .   .. .|       ||  |     ... .|| |||  || |...|. | .
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK_c.AA Pkinase_Tyr 55-201 27 1.2e-16 57.02 Pfam 52-207 (270) Show / Hide 
Range on Protein: 55-201
Range on HMM: 52-207/270
Sequence Identity: 27% (43 aa)

QEMALVSRV-KHPHIVEYKEAWVEKGCY--VCIVTGYCEGGDMADIIRKA--NGTYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIR
.|... .   .||.|| .  . ...|    ..||. |...||. |  ||   ..  .. ..|. . .|   | |||..... |||. . |. .|... ..
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFGLAKMLKSDDLACSVVGT-----PNYMCPELLADIPYGFKSDIWSLGCCMYEM
 .|||||. . .||   .....        | || ...  .  |||.|| | .|.|.
ICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI
Kinase NEK_c.AA TyrKc 9-263 20 8.8e-16 32.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YEIIGQVGKGAFG---SAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRV--KHPHIVEYKEAWVEKG-------CYVCIVTGYCEGGDMAD
 . . . | ||||    ...        .   |...        |.  ..|. . ...  .||.||    . . ..         ..||. |...||  |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

IIRKANGTYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLKSD--------DLACSV-VGTP-----NYMCPELLAD
 .||  .. .. . |. . .|   | |||| ... |||  . |. ....| .. .||||.. ...|            .   |.        | || . .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

IPYGFKSDIWSLGCCMYEM--SAHRPA-------FKAFDIQGLINKINKSSIGPL------PTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
  . .|||.|| | ||.|.      |         .....  .. . .   . |       ..| .  .. ....  . .|| ||| .|.  |  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF