Gene CDC7_a (S.moellendorffii)
CDC7_a
Species: S.moellendorffii
Alias: CDC7_a
External Links:
Annotation:
Sequence
Protein domains of CDC7_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CDC7_a.AA | CDC7 | 160-188 | 68 | 1.1e-15 | 41.91 | In-house | 128-156 (522) | Show / Hide |
Range on Protein: 160-188 Range on HMM: 128-156/522 Sequence Identity: 68% (20 aa) NIIHRDVKPGNFLYSRKSKVGHLVDFNLA .||||||||.||||.|..| . |||| || GIIHRDVKPSNFLYNRRTKKFLLVDFGLA |
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| Kinase | CDC7_a.AA | Pkinase | 73-185 | 21 | 1.7e-13 | 48.78 | Pfam | 50-156 (293) | Show / Hide |
Range on Protein: 73-185 Range on HMM: 50-156/293 Sequence Identity: 21% (27 aa) EIKLLKLFGGKHSIIRLEEVIRDGEKKYLVLEHVEYD----SIQ-----SLKKDI--SMNDLRSYGFHLFKALNYMHQKVGLFFFFFVNTVFTFELLQNI ||...| .. .. |.|| .. .|. . |.|.|..| . . . .. . |......| ....|.|.|.. .| EIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-------------------GI IHRDVKPGNFLYSRKSKVG---HLVDF ||||.|| |.|.... .. .. || IHRDLKPENILIDNNGHIDACVKICDF |
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| Kinase | CDC7_a.AA | S_TKc | 10-254 | 19 | 2.1e-10 | -24.2 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-254
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)
YRIEGVEGSGAYSVVFKARRFGDGRLFAIKCALFLCIFFGPGLLLTILTGPLQGDKIAASVDKEIKLLKLFGGKHSIIRLEEVIRDGEKKYLVLEHVEY-
|.| . |.||...|.|.| ..||..|||. .. .||..|| . |..| .|..| .. |.|.|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGD
--DSIQSLKKD--------ISMNDLRSYGFHLFKALNYMHQKVGLFFFFFVNTVFTFELLQNIIHRDVKPGNFLYSRKSKVGHLVDFNLALVRFYSF---
| . .|| .. . |.| ...||.|.|. ..|||||.|| | | .. . . || || . ..|
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS-------------------HGIIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGT
-------IIWMLTF-------------VIARNRISLEGLKVSILLAIYSSNLWK--VLYVIRKTAK--PKQTDAMQ----SASRHYF
.. .. . . . .. | | | . .| . | .|.| .. .|
PWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | CDC7_a.AA | CK2 | 10-140 | 28 | 2.6e-10 | 26.2 | In-house | 1-114 (288) | Show / Hide |
Range on Protein: 10-140 Range on HMM: 1-114/288 Sequence Identity: 28% (38 aa) YRIEGVEGSGAYSVVFKARRFGDGRLF--AIKCALFLCIFFGPGLLLTILTGPLQGDKIAASVDKEIKLLKLFGGKHSIIRLEEVIRDGEKKYL--VLEH | .. |.| || ||... || || | . || ||| |. | ||.| ....| | | |. YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIK----------------ILK-PVKKKKIK----REIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEY VEYDSIQSLKKDISMNDLRSYGFHLFKALNYMHQK |. .. | . .. |.| | | | ||| | | . VNNTDFRQLYQTLTDYDIRYYMFELLKALDYCHSM |
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| Kinase | CDC7_a.AA | CMGC | 73-140 | 15 | 1.2e-08 | 23.53 | In-house | 71-201 (513) | Show / Hide |
Range on Protein: 73-140
Range on HMM: 71-201/513
Sequence Identity: 15% (20 aa)
EIKLLKLFG---------------GKHS-IIRLEEVIRDGE-----------------KKYLVLEHVEYDSIQSLKKD----------------------
|||.|| . .| |..| ..... . . ||| |....| | .|.
EIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHR
--------ISMNDLRSYGFHLFKALN--YMHQK
... . | | . ....|. |.|..
RPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSH
|
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| Kinase | CDC7_a.AA | CDC7 | 72-140 | 23 | 5.1e-08 | 18.48 | In-house | 57-127 (522) | Show / Hide |
Range on Protein: 72-140 Range on HMM: 57-127/522 Sequence Identity: 23% (17 aa) KEIKLLKLFGGKHSIIRLEEVIRDGEKKYLVLEHVEYDSIQSLKKDIS--MNDLRSYGFHLFKALNYMHQK .|. .| . ||.| .. . . .| .. .|... ...| | . . . | ..| ||.|| . ||. NELQCLTRMGGHHNVMGMCCCFRYNDHVHIVMPYFPHCSFQDFYFHMNRDMEEIKHYMYNLFYALRHVHQF |
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| Kinase | CDC7_a.AA | AGC | 10-40 | 21 | 1e-06 | 11.85 | In-house | 1-37 (395) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 1-37/395 Sequence Identity: 21% (8 aa) YRIEGVEGSGAYSVVFKARRF------GDGRLFAIKC ... | | |... |. .|. . |...|.|. FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV |
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| Kinase | CDC7_a.AA | CDK | 73-140 | 22 | 1e-06 | 16.93 | In-house | 58-127 (284) | Show / Hide |
Range on Protein: 73-140 Range on HMM: 58-127/284 Sequence Identity: 22% (18 aa) EIKLLKLFGGKHSIIRLEEVIRDG-----------EKKYLVLEHVEYD--SIQSLKKDISMNDLRSYGFHLFKALNYMHQK ||.||| . |..| .|. . | |.| |....| .. . ..| . | ..|.|.|.. EISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSN |
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| Kinase | CDC7_a.AA | CAMKK | 100-172 | 18 | 2e-06 | 15.69 | In-house | 105-228 (396) | Show / Hide |
Range on Protein: 100-172 Range on HMM: 105-228/396 Sequence Identity: 18% (23 aa) YLV-LEHVEYDSIQSLK--KD--------------------------ISMND---------------------LRSYGFHLFKALNYMHQKVG--LFFFF |.| .| .|. .|... | .| . ...| . |.| |.|.... . YMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYIII FVNTVFTFELLQNIIHRDVKPGNFL ..| | ||||| || | | YINEFI-IDHFQDIIHRDIKPQNIL |
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| Kinase | CDC7_a.AA | Ciliate-E2a | 10-39 | 30 | 3e-06 | 14.53 | In-house | 1-30 (275) | Show / Hide |
Range on Protein: 10-39 Range on HMM: 1-30/275 Sequence Identity: 30% (9 aa) YRIEGVEGSGAYSVVFKARRFGDGRLFAIK |... . |.|.. .|..|.. ..| ||.| YKFIKKIGKGNFGSVYLAQHKQTGKQFAMK |
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| Kinase | CDC7_a.AA | CMGC | 10-39 | 27 | 4e-06 | 15.03 | In-house | 1-44 (513) | Show / Hide |
Range on Protein: 10-39 Range on HMM: 1-44/513 Sequence Identity: 27% (12 aa) YRIEGVEGSGAYSVVFKARR--------------FGDGRLFAIK | | .. |.|.|.||.|.| .... ||| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIK |
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| Kinase | CDC7_a.AA | CAMK1 | 10-40 | 32 | 8e-06 | 12.9 | In-house | 1-34 (276) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 1-34/276 Sequence Identity: 32% (11 aa) YRIEGVEGSGAYSVVFKARRFG---DGRLFAIKC | . . |.|| |.|... . .|. .|||| YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKC |
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| Kinase | CDC7_a.AA | Pkinase | 10-40 | 35 | 1e-05 | 21.32 | Pfam | 1-31 (293) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 1-31/293 Sequence Identity: 35% (11 aa) YRIEGVEGSGAYSVVFKARRFGDGRLFAIKC |.|... |||....|.|... |.|...|.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI |
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| Kinase | CDC7_a.AA | RCK | 10-40 | 38 | 2.1e-05 | 12.81 | In-house | 1-31 (298) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 1-31/298 Sequence Identity: 38% (12 aa) YRIEGVEGSGAYSVVFKARRFGDGRLFAIKC | | | |.|..|.||... .| . |||. YQIIKQLGDGTYGCVMKAQNKETGEIVAIKK |
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| Kinase | CDC7_a.AA | TyrKc | 10-261 | 13 | 3.2e-05 | -138.13 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-261
Range on HMM: 1-280/280
Sequence Identity: 13% (45 aa)
YRIEGVEGSGAYSVVFKARRFGDGRLFAIKCALFLCIFFGPGLLLTILTGPLQGDKIAASVDKEIKLLKLFGGKH-SIIRLEEVIRDG-------EKKYL
. . . |.||. .|.|.. . |.|. . . .|..... .||.| |.|| |.... | ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI
VLEHVEY----DSIQSLKKDISMNDLRSYGFHLFKALNYMHQKVGLFFFFFVNTVFTFELLQNIIHRDVKPGNFLYSRK----------SKVGHLV----
|.|.... | ... .....| || |. . . .| |.| |.|||| | |.... |. ..
VMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG
---DFNLA----LVRFYSFIIWMLTFVIARNR------------------ISLEGLKVSILLA--IYSSNLWKVLYVIRKTAKPKQ---------TDAM-
| . .. | || .| . . .. . . . . . . . . .|. .|.|
ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY
---------QSASRHYFHRGTERL
. ..| | |..
QIMKQCWHEDPEDRPTFSEIHECF
|
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| Kinase | CDC7_a.AA | AGC | 159-182 | 42 | 3.5e-05 | 7.76 | In-house | 172-194 (395) | Show / Hide |
Range on Protein: 159-182 Range on HMM: 172-194/395 Sequence Identity: 42% (11 aa) Q-NIIHRD-VKPGNFLYSRKSKVGHL . .||||| .|| | | .. ||. HMGIIHRDYLKPENILLDED---GHI |
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| Kinase | CDC7_a.AA | Ciliate-E2 | 10-40 | 29 | 0.000347 | 10.25 | In-house | 1-31 (365) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 1-31/365 Sequence Identity: 29% (9 aa) YRIEGVEGSGAYSVVFKARRFGDGRLFAIKC | . . |.|....|.|... ....||||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKI |
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| Kinase | CDC7_a.AA | CK2 | 161-188 | 42 | 0.000495 | 7.09 | In-house | 116-143 (288) | Show / Hide |
Range on Protein: 161-188 Range on HMM: 116-143/288 Sequence Identity: 42% (12 aa) IIHRDVKPGNFLYSRKSKVGHLVDFNLA |.|||||| | . . .. |.| || IMHRDVKPHNIMIDHEKRKLRLIDWGLA |
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| Kinase | CDC7_a.AA | CAMK1 | 159-177 | 52 | 0.000976 | 6.67 | In-house | 127-145 (276) | Show / Hide |
Range on Protein: 159-177 Range on HMM: 127-145/276 Sequence Identity: 52% (10 aa) QNIIHRDVKPGNFLYSRKS ..| ||| || | ||. |. KGIVHRDLKPENLLYYDKD |
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| Kinase | CDC7_a.AA | RCK | 71-140 | 25 | 0.001167 | 7.16 | In-house | 45-124 (298) | Show / Hide |
Range on Protein: 71-140 Range on HMM: 45-124/298 Sequence Identity: 25% (21 aa) DKEIKLLKLFG-GKHSIIRLEEVIRDGE--KKYLVLEHVE---YDSIQS---LKKDISMND--LRSYGFHLFKALNYMHQK ..||| |. . .. || | ||||| . |.|.|... | ... .| .. | .... . ....|..|| . LREIKSLRKLNPHPN-IIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKH |
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| Kinase | CDC7_a.AA | Ciliate-E2 | 159-188 | 41 | 0.001934 | 7.65 | In-house | 179-203 (365) | Show / Hide |
Range on Protein: 159-188 Range on HMM: 179-203/365 Sequence Identity: 41% (13 aa) QN-IIHRDVKPGNFLYSRKSKVGHLVDFNLA .| ||||| || | |. ..|| |. KNNIIHRDIKPENILF------IKIIDFGLS |
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| Kinase | CDC7_a.AA | Ciliate-E2a | 159-178 | 42 | 0.002483 | 5.69 | In-house | 121-141 (275) | Show / Hide |
Range on Protein: 159-178 Range on HMM: 121-141/275 Sequence Identity: 42% (9 aa) QNIIHRDVKPGNFLYS-RKSK .||.||| || |.|. .... RNIMHRDLKPENILFKNCSKN |
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| Kinase | CDC7_a.AA | Ciliate-E2 | 86-140 | 16 | 0.003976 | 6.56 | In-house | 94-179 (365) | Show / Hide |
Range on Protein: 86-140 Range on HMM: 94-179/365 Sequence Identity: 16% (14 aa) IIRLEEVIR--DGEKKYLVLEHVEYDSIQS-LKKD-------------ISMNDLRSYGFHLFK---------------ALNYMHQK ||.. |. | .. |||.| ... . .. .|. .... . . .... ||.|.|.| IIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK |
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| Kinase | CDC7_a.AA | CAMKK | 10-39 | 29 | 0.008721 | 4.17 | In-house | 1-31 (396) | Show / Hide |
Range on Protein: 10-39 Range on HMM: 1-31/396 Sequence Identity: 29% (9 aa) YRIEGVEGSGAYSVVFKARRFGD-GRLFAIK |.. . |.|.. .| .|.. .| ....||| YELMKEIGQGQFGKVKLAYNEYDTQKHYAIK |
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| Kinase | CDC7_a.AA | CMGC | 159-170 | 57 | 0.013978 | 3.26 | In-house | 201-214 (513) | Show / Hide |
Range on Protein: 159-170 Range on HMM: 201-214/513 Sequence Identity: 57% (8 aa) QN--IIHRDVKPGN .. ||||| || | HWGNIIHRDLKPEN |
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| Kinase | CDC7_a.AA | CDK | 10-40 | 33 | 0.014192 | 3.87 | In-house | 1-36 (284) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 1-36/284 Sequence Identity: 33% (12 aa) YRIEGVEGSGAYSVVFKARRFGDG-----RLFAIKC | . | |.| ||.||| .| .. |.|. YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKK |
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| Kinase | CDC7_a.AA | CDK | 159-176 | 44 | 0.01884 | 3.47 | In-house | 127-144 (284) | Show / Hide |
Range on Protein: 159-176 Range on HMM: 127-144/284 Sequence Identity: 44% (8 aa) QNIIHRDVKPGNFLYSRK ..|.||| || | |.... NWIMHRDLKPQNILINNN |
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| Kinase | CDC7_a.AA | CDC7 | 10-27 | 38 | 0.048911 | 0.21 | In-house | 1-18 (522) | Show / Hide |
Range on Protein: 10-27 Range on HMM: 1-18/522 Sequence Identity: 38% (7 aa) YRIEGVEGSGAYSVVFKA |... |.| .|.|.|| YKVHDKIGEGTFSSVYKA |
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| Kinase | CDC7_a.AA | RCK | 159-174 | 37 | 0.109222 | 0.8 | In-house | 124-139 (298) | Show / Hide |
Range on Protein: 159-174 Range on HMM: 124-139/298 Sequence Identity: 37% (6 aa) QNIIHRDVKPGNFLYS ... |||.|| | ... HGFFHRDLKPENIMCT |
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