Gene Aur-1 (S.moellendorffii)

Aur-1

Species: S.moellendorffii
Alias: Aur-1
External Links:
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
Aur-1.AA Protein None 288 None Fasta, JSON
Aur-1.NA RNA None 864 None Fasta, JSON
Aur-1.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
Aur-1.AA Protein None 288 None Fasta, JSON
Aur-1.NA RNA None 867 None Fasta, JSON

Protein domain

The gene does not contain any known protein domains.

Protein domains of Aur-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Aur-1.AA Aur 19-270 59 8e-214 571.0 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-257/257
Sequence Identity: 59% (154 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQSQVEHQLRREIEIQSHLRHPNILRLYGYFYDQNRVYLILEYAAKGELYKELQRC--KVFSE
|.||||||.||||||||||.| ... .||||.||.|......||||||||.|||||.|||||..||||.|..|.|||||||  ||||||||.   | |.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

KRAATYIASLARALMYCHEKHVIHRDIKPENLLIG-MKGELKIADFGWSVHTF-N-RRRTMCGTLDYLPPEMVENKEHDASVDVWSLGVLCYEFLFGTPP
.|||.|.. .. || |||.|..|||||||||.|..  .|..||.|||||||.  | ||.|.||||||.||||||...|| .||.|.|||||||.. | ||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FEA-QKLSDTYRRIV-RVDLKFPIKPVISTAAKDLICQLLCKDSSQRLPLKELLAHPWI
||. .. . ||.||  .||..||  . ||  |||||...| .|..||..|.. ..||||
FESNENHDETYDRIKNKVDIQFP--SHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase Aur-1.AA AGC 19-270 25 5.6e-114 295.59 In-house 1-395 (395) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-395/395
Sequence Identity: 25% (100 aa)

FDIGKPLGRGKFGNVYLAREK------RSKYVVALKVLFKNQ---------LQQSQVEHQ------LRREIEIQSHLR----------HPNILR-LYGYF
|.. |..|.| || |||.|.|       .. . |.||| |           ... ..||       ...| .| ....          ||.| . |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YDQNR--VYLILEYAA---------KG-ELYKELQ---RCKVFSEKRAATYIAS-------LARALMYCHE-KHVIHRD-IKPENLLIGMKGELKIADFG
 |...  .|...||.           | ||.  ||   ....|.|.||  |.|        .. || | |. ...|||| .||||.|.  .| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSVHTFNRR-----------------------------------------------------RTMCG--TLDYLPPEMVENKEHDASVDVWS--LGVLCY
 .    |..                                                      |.||  | .|..||..    .. ..| ||  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFLFGTPPFEAQKLS----------DTYRRIV------RVDLKFPIK--------PVISTAAKDLICQLLCKDSSQRLP----------LKELLAHPWI
|.|.| ||| ..             ... .|         ..||| .        . .|  ||||| .||||| ..||            .|. .||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Aur-1.AA S_TKc 19-270 32 9.60000000001e-102 345.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-231/231
Sequence Identity: 32% (86 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQSQVEHQLRREIEIQSHLRHPNILRLYGYFYDQNRVYLILEYAAK--GELYKELQRCKV---
..|....|.| || ||..|.|... .||.|..            ..||||.| .. .|||| .||..|.| ...|...||.    |.|.. .....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMVENKEHDA-SVDVWSLGVLCYEFLF
   |.| .|. |.. ...|| |||....||||.||||.|.    ..||.||| . .     .|.|||..|..||..    ..  ..|.||.|.. ||.| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GTPPFEAQKLSDTYRRIVRVDLKFPIKPVISTAAKDLICQLLCKDSSQRLPLKELLA-------HPWI
| |||.   .  ....|.            |  |||.|...|.|| ..|.   |.|.       |||.
GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Aur-1.AA CAMK 24-270 21 1.8e-93 301.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 24-270
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

PLGRGKFGNVYLAREKRSK------------YVVALKVLFKNQLQ-------------------------QSQVEHQLRREIEIQSH-------LRHPNI
 |||| || |.|...|...              || |.. |..|.                         . . ....|||||| ..       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLYGYFYD-------------------QNRVYLIL---EYAAKGELYKEL------QRC-------------KVFSEKRAATYIASLARALMYCHEKHV
..|| .. |                   ....|...   ||.  |||. .|      ..|             . |.|. |..|.  .. |. |||....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLI-GMK----------------GELKIADFGWSVHTFN--------------------------RRRTMCGTLDYLP-PEMVENKE----
.|||.||||.|.   .                . .||.||| . . .                             .|.|||. | . ||... |     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------HDASVDVWSLGVLCYEFLFGTPPFEAQ-------------KLSDTYRRIVRVDLKFPIKPV--------------ISTA--------AKD
          .. ..|.||.||..|  | |.|||..               .......| . .  || ...              ||          .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LICQLLCKDSSQRLPLKELLAHPWI
||...|..| ..|. ... |.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Aur-1.AA Pkinase 19-270 32 2.6e-87 301.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQSQVEHQLR-REIEIQSHLRHPNILRLYGYFYDQNRVYLILEYAAKG----ELYKELQ--RC
. ||...|.| || ||....| .  .||.|.. |     .. .. .| .||.|  .|.||||.|||..|.| ...|...||. .|    .|.  ..  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KVF--SEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKGEL----KIADFGWSV---HTFNRRRTMCGTLDYLPPEMVE-NKEHDASVDVWSLG
..|  ||. .  |.  ..|.| |||.. .||||.||||.||  .|..    ||.||| .    .  |.  | |||..|..|| .  ..... .||.||.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

VLCYEFLFGTPPFEAQ------KLSDTYRRIVRVDLKFPIKPVIS-------------------TAAKDLICQLLCKDSSQRLPLKELLAHPWI
...||.|.| |||  .           ..|| . .|.|..   .|                    ..||.|. .|||| ..|.  ...| |||.
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Aur-1.AA CAMKL 19-270 29 7.3e-87 277.22 In-house 1-297 (297) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-297/297
Sequence Identity: 29% (88 aa)

FDIGKPLGRGKFGNVYLARE-KRSKYVVALKVLFKNQLQ-QSQVEHQ-----------LRREIEIQSHLR---HPNILRLYGYFYDQNR------VYLIL
..||| ||.| || | ||.  .  .  || |.. |. ..   ...             .||||.|...|.   |||| .||  .....       .||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAAKGE--LYKELQRC----KVFSEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKG--ELKIADFGWS-------VHTFNRRRTMCGTLDYL
||.  ||  |.  ...     . ..|. |  |   .  |. |||.....||||||||.|.  .|   .||.||| |       . . .  .| ||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEMVEN--KEHD-ASVDVWSLGVLCYEFLFGTPPFEAQKLS-------DTYRRIVRVDLKFPIKPVISTAAKDLICQLLCKDSSQRLPLKELLAHPWI
.||...   |..|   ||.||.||. |  ..|. ||... ..         |..| .   ..|| . .|  ..||| ..| .. ..|  ..... ||| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase Aur-1.AA Ciliate-E2 19-270 25 9.2e-80 271.29 In-house 1-365 (365) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

FDIGKPLGRGKFGNVYLAREKRSKY-----------------------VVALKVLFKNQLQQSQVEHQLRREIE----------IQSHLRHPNILRLYGY
... | .|.| || ||... .. ..                        .|.|.. |||..|   | .. |||.          |...| ||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY--DQNRVYLILEYAAKGELYKELQ------------RCKVFSEKRAATYIASLAR---------------ALMYCHEKH-VIHRDIKPENLLIGMKGE
|.  |.| .||..||.  |.|.. ..              | |.|| ...... ...               || |.|.|. .|||||||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKIADFGW--SVHTFNRRRTM--------------------------------CGTLDYLPPEMVENKE---------HDASVDVWSLGVLCYEFLFGTP
.||.|||    ....| .||.                                |||. |..||....|.         .| ..|.|||||. ||.||| |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEAQKLSDTYRRIVRVDLKFP----------------IKPVISTAAKDLICQ----LLCKDSSQRLP-LKELLAHPWI
||        .. |   ...||                ..  .|  .|||| .    .|.|| ..|.   ...| |||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Aur-1.AA PLK 19-270 34 7.3e-79 256.47 In-house 1-258 (258) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-258/258
Sequence Identity: 34% (90 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQSQVEHQLRREIEIQSHLRHPNILRLYGYFYDQNRVYLILEYAAKGELYKELQRC-KVFSEK
. .|..||.| |  .| ...  .|.|.| ||  |  .| .     ...||||.. |.||||.... .| |.. ||. |||. ...|   . |  |...| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

RAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKGELKIADFGWSVHTFN---RRRTMCGTLDYLPPEMVENKE--HDASVDVWSLGVLCYEFLFGTP
 .  |.  .. .| | |.. .||||.|. ||..  . ..||.||| ..   .   |..|||||  |  || .....  |.  ||.||||.  | .|.|.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFEAQKLSDTYRRIVRVDLKFPIKPVISTAAKDLICQLLCKDSSQRLPLKELLAHPWI
|||.. . .||.||.  .  ||  . || .||||| ..| .. ..|. ....| ||. 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase Aur-1.AA RSK 22-270 34 1.6e-76 260.49 In-house 1-278 (278) Show / Hide 
Range on Protein: 22-270
Range on HMM: 1-278/278
Sequence Identity: 34% (96 aa)

GKPLGRGKFGNVYLAREK---RSKYVVALKVLFKNQLQQSQV-EHQLRREIEIQSHLR-HPNILRLYGYFYDQNRVYLILEYAAKGELYKELQRCKV---
 | ||.| .| |.| |..    .. . | ||| |. . |.|.     ..|..| .. . ||.| .|.  | ..  .|||.||   |||.. ||. |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGM---KGELKIADFGWSVH-TFN---RRRTMCGTLDYLPPEMVE----NKEHDASVDVWSLGV
|||..|. |.| .. |. . |....||||.|||| |       |..|. ||| .     .   .  | |.|..|..|||.     .. ||...|.|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LCYEFLFGTPPFEA---QKLSDTYRRIVRVD--LKFPIKPVISTAAKDLICQLLCKDSSQRLP-----LKELLAHPWI
| || |.| ||| .   .  ... .|| . .  |..|. . .|..||||| ..|..| ..||      ..|...|||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Aur-1.AA MARK 19-270 34 8.4e-75 243.97 In-house 1-262 (262) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-262/262
Sequence Identity: 34% (92 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQSQVEHQLRREIEIQSHLRHPNILRLYGYFY--DQNR-VYLILEYAAKGELYKELQRC--KV
. ..| .| | .. |.||. |...  ||.|.. |..|.  |    ..||||| ..| |||| .|. ..   . .. .|||.||| .||||  ..      
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FSEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKG--ELKIADFGWSVHT--FNRRRTMCGTLDYLPPEMVENKEHD-ASVDVWSLGVLCYEFL
 .|. | ..   .  |. |||.|...||||||||.||  .|    ||.|||.|..    ..  | |||. | .||... |. |   ||.|||||. |  .
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

FGTPPFEAQK--LSDTYRRIVRVDLKFPIKPVISTAAKDLICQLLCKDSSQRLPLKELLAHPWI
 |. ||...   . . |..|.| . ..| .  .|. ...||..||  . ..|  ..|.. |||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase Aur-1.AA AktR 19-270 35 2.3e-70 240.05 In-house 1-268 (268) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-268/268
Sequence Identity: 35% (95 aa)

FDIGKPLGRGKFGNVYLAREK-RSKYVVALKVLFKNQLQQSQVEHQLRREIEIQS-HLRHPNILRLYGYFYDQNRVYLILEYAAKGELYKELQRCKVFSE
|.. |.||.|.||.|||...|  .. ..|.|.. |  ... . .|....|  |   . .|| | .|.  | ...  ..|.|| . |||.  |...| |||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

KRAATYIASLARALMYCHEK-HVIHRDIKPENLLIGMKGELKIADFGWSV-----HTFNRRRTMCGTLDYLPPEMVEN-KEHDASVDVWSLGVLCYEFLF
..|  |.|    || | |.. ..| ||.||||.|... | .||.||| |      |   . .. |||  |..|||. . | |. ||| |..|.. || ..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GTPPFEAQKLSDTYRRIVRVD-LKFPIKPVISTAAKDLIC-QLLCKDSSQRLP-----LKELLAHPWI
| |||....  . . .|   . .|||. . .| ..||||. .||||.  .||       .|.  ||| 
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Aur-1.AA Ciliate-E2-Unclassified 19-270 25 7.5e-70 238.37 In-house 1-352 (352) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQ-SQVEHQ---LRREIEIQSH----------------LRHPNILRLYGYFYDQNR--VYLIL
. |.| .|.| || ||....|  |.. |.| . |.| .   |....   .. ..|....                | ||...... ....|..  .|...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAA-----------------KGELYKELQRCKVFSEKRAA-----TYIASLARALMYCHEKH-VIHRDIKPENLLIGMKG---ELKIADFGWS------
||.                  ...|.. ... | |.|. |.     .|.| .  .| |.|.|. .|||||||||.|.  .|   ..||.||| |      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------VHTFNRRRTMCGTLDYL----PPEMVENKEHDAS----VDVWSLGVLCYEFLFGTPPFEAQKLSD----------------TYRRIVR
            .  ...  |.|||. |.    .||. .....| |    .|.|||||..||.|||..||....  .                 |. |  
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

VDLKFPIKP------VISTAAKDLIC----QLLCKDSSQRLPLKELLAHPWI
 ...||  |       .|  |||.|     ..| |. ..|. ....| |||.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Aur-1.AA Pkinase_Tyr 19-162 31 1.7e-25 87.01 Pfam 1-156 (270) Show / Hide 
Range on Protein: 19-162
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

FDIGKPLGRGKFGNVYLAREK----RSKYVVALKVLFKNQLQQSQ-VEHQLRREIEIQSHL-RHPNILRLYGYFY-DQNR--VYLILEYAAKGELYKELQ
  .|| ||.| ||.||... |      |. || |.| |..  ..|     . ||..| ..| .||||.||||  . ..    .|...||...| |.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RC----KVFSEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKGELKIADFG
.     . .. |.   . .  |... | ..|. ||||.   | |.. ..  ||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase Aur-1.AA TyrKc 19-270 22 4e-18 67.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-270
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FDIGKPLGRGKFGNVYLAREKRSKYVVALKVLFKNQLQQSQVEHQLRREIEIQSHL--RHPNILRLYGYFYDQ-------NRVYLILEYAAKGELYKELQ
   || ||.| || ||... |   . || |.| ..       .  ..||..| ..|  .||||.||||.  .|         .....||...| | . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RCKV-FSEKRAATYIASLARALMYCHEKHVIHRDIKPENLLIGMKGELKIADFGWSVHTFNR-------RRTMCGT---LD------YLPPEMVENKEHD
...  .. |    .    |.   | |.|..||||.   | |.| ..  ||.||| |    .           .  .    .       ..||    ..  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

ASVDVWSLGVLCYEFL-FGTPPFEA-----QKLSDTYRRIVRVDLKFPIKPV-------ISTAAKDLICQLLCKDSSQRLPLKELLAHPWI
   |||| ||...| . .| .| .       . .. .... . .   . . .        ...  ... |    | ..|   .|.  |  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Aur-1.AA Pkinase_Tyr 196-226 36 0.296891 4.87 Pfam 196-228 (270) Show / Hide 
Range on Protein: 196-226
Range on HMM: 196-228/270
Sequence Identity: 36% (12 aa)

DVWSLGVLCYEFLF-GTPP-FEAQKLSDTYRRI
|||| |||..| .  |  | ..  . .. |..|
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI