Gene ERK-p2-1 (S.moellendorffii)

ERK-p2-1

Species: S.moellendorffii
Alias: ERK-p2-1
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK-p2-1.AA Protein None 380 None Fasta, JSON
ERK-p2-1.NA RNA None 1143 None Fasta, JSON
ERK-p2-1.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of ERK-p2-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK-p2-1.AA ERK 48-331 56 6.1e-191 640.63 In-house 4-307 (307) Show / Hide 
Range on Protein: 48-331
Range on HMM: 4-307/307
Sequence Identity: 56% (172 aa)

IRPIGRGAYGIVCSAVNSE-----TNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQ
| .||.||||.||||.. |     |.. |||||| ||||..|..|||||||||||| . ||||. ..||..| |....||.|.| |||.|||||||.| |
IKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQ

QLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLAR----TTSET-----DYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSV
.|.|||||||.||.|.||||.|||||.||||||||.|.| |||||||||||||    . .|       .|||||.||||||||..|. ..|| |.|.||.
ELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSC

GCIFMELLNREPLFPGRDYVQQLRLITELIGSP-EDADLGFLRNDNARRYVRQLQR--YPRQSFAHRFPN--VPPLAVDLVERMLVFNPQNRISVTEALA
|||| |.|.| |||||.||| |...|...||.|  . ||    ..||. |...|.   .| ...  .|||  . |.|.|| |.||||.|. ||.| |.|.
GCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLE

HPYL
|||.
HPYF
Kinase ERK-p2-1.AA MAPK 45-331 52 4.8e-190 637.64 In-house 1-328 (328) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

VPPIRPIGRGAYGIVCSAVNSETNEE------VAIKKIGNAFDNRIDAKRTLREIKLLRHM-DHENIVAIRDIIRP------PSKDEFNDVYIVYELMDT
  ...||| ||||.||||.  .||.       |||||| ..|.| ...|||.||||||||. .||||. ..||..|      .|..||||.||| |||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIRSNQQLTDDHCQYFLYQLLRG--LKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETD---------------YMTEYVVTRWYRAP
||||||.|.|.|.|||.|||.||.|||  ||| |||||.||||||||.|.| |||||||||||||..  ..               .|||||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLN--CSEYTAAIDVWSVGCIFMELLN-REPLFPGRDYVQQLRLITELIGSPEDADLGFLR-NDNARRYVRQL---QRYPRQSFAHRFPN----VPPL
|..||    .|| |.|.||||||| |.|. | |||||.||. |. ||.|..|.|.. .. ..  ...|| |...|   ..||...... |||    . |.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLVERMLVFNPQNRISVTEALAHPYL
|.||.|.||||.|. ||.| |||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK-p2-1.AA CMGC 45-331 27 5.5e-144 476.55 In-house 1-513 (513) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

VPPIRPIGRGAYGIVCSAVN--------------SETNEEVAIKKIGNAFDNRIDAK----------RTLREIKLLRHM-----------------DHEN
   |..||.|.||.|.....               ||||.|||||| |.| . ..||          |.|||||.|.|.                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVAIRDIIRPPSKD------------EFNDVYIVYELMDTDLHQIIRSNQ---------QLTDDH------------CQYFL------YQLLRGLK--YV
|| ..||....  |            .||..|.| |.||.||.|.|..||          |.. |            ..||.      ||.|||||  | 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPSNLLLNANCDL--------------------KICDFGLARTTSE----------------------TDYMTEYVVTRWYRAPELLL
||..  ..||||||.|.|.| ||.|                    ||||||||| ...                      .  .|.|||||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NCSEYT---------AAIDVWSVGCIFMELLNR--------EPLFP-----------GRDYVQQLRLITELIGSP----------------EDADLGFLR
....||          .||.||||||| |....        .||||           |.... || .| ...|.|                |. . ... 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NDNARRYVRQ---LQRYPRQSFAHRFPN-----------------------------------VPPLAVDLVERMLVFNP
                    .. ||.|...   ....|....   ||.                                    .|.|.||...||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

QNRISVTEALAHPYL
..||.. .||.|||.
DKRITAEQALQHPYF
Kinase ERK-p2-1.AA p38 45-331 46 2.6e-143 482.41 In-house 1-289 (289) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-289/289
Sequence Identity: 46% (136 aa)

VPPIRPIGRGAYGIVCSAVNSETNEE---VAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRP--PSKDEFNDVYIVYELMDTDLHQIIRS
   ..|.| |||| ||.|. ..|..    |||||.   |   |.|||| ||..||.||.|||.. . |.  |   | ..|.|||.| ..|..||..|...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NQQLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
 |.|.||| |. .||.||||||.|||.. ||||||||. .| .|.|.| ||||||  .  | ||.||.|||||||| .||  .|| ..|.||||||  ||
-QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAEL

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
. ...|||| |...||. |....|.|..  .  . ...|| |.. .  .||. |.| |..  |.|.|| |.||.  |  ||.. ||..|||.
ITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK-p2-1.AA ERK1 44-331 54 2.9e-132 445.7 In-house 1-289 (289) Show / Hide 
Range on Protein: 44-331
Range on HMM: 1-289/289
Sequence Identity: 54% (158 aa)

YVPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQQL
|.  .. || ||||.||||.   ... ||||||   |.     .|||||||.|    ||||. |.|||| .. ... ||||| .||.||| ..... |.|
YT-NLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHL

TDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLAR----TTSETDYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
  ||  |||||.||||||.||||||||||||||||||  ||||||||||||     .  | ..|||| ||||||||..||   || .||.||||||  |.
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
|   |.|||. |. || .|  ..|||  .||  . |. || |.. |   |....|. ||.  . |.||...|| |||..|| | ||||||||
LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK-p2-1.AA ERK5 47-331 51 6.30000000001e-132 444.59 In-house 3-295 (295) Show / Hide 
Range on Protein: 47-331
Range on HMM: 3-295/295
Sequence Identity: 51% (152 aa)

PIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPS-KDEFNDVYIVYELMDTDLHQIIRSNQQLTD
.|  || ||||.||||..  . ..|||||| ||||    ||||.||.|.|||  |.||.|||||..|     |. |||.|..||. |||||| ||| .| 
IIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFTL

DHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSE------TDYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
.|  |||||.||||||.|||.|.|||||||||| | ||.||| |||.||  .         .||||| |||||||||..   .|| ||||||||||| |.
EHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEM

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQ-LQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
. |  .|||. |..||.|| . .| |  . .     |  . |. . .     . . . .|   . |.||. |||.| | .||.| .|| ||.|
IARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK-p2-1.AA nmo 45-331 47 1.7e-121 375.54 In-house 1-292 (292) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-292/292
Sequence Identity: 47% (140 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQQLT
. | |||| ||.|.| |         ||.||. | | | . .||  ||.|.|    |.|... .||..|| || |...|.| |||  |||.|| | |.|.
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

DDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETD--YMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMELLNR
 || . ||||.||||||.||||.||||.|| |||.|.|| ||||||||||.  . .   ||. ||| .|||||.|.    ||.|.|.||||||| ||| |
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

EPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPN---VPPLAVDLVERMLVFNPQNRISVTEALAHPYL
  ||  .  .||| .||.|.| |   |. .  .      .|. .. |  .   .          ||.|. |||.|.|. |||...|||||||
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK-p2-1.AA ERK7 48-331 44 1.1e-119 403.91 In-house 4-292 (292) Show / Hide 
Range on Protein: 48-331
Range on HMM: 4-292/292
Sequence Identity: 44% (130 aa)

IRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQQLTDD
.. .|.||||||  |.   | . ||.|||  || |..|| || ||| .|. .. |.||. . ..||    |   |.|.|.| |.|||| .||  . | | 
RKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETD-------YMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
| || .||||| .||.||.||.||||||||.||...| .|.|||||||. ....        .|||| |||||||| ||   .|| ..| ||.|||  |.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
|   |.|||   . |. .| |.|. |  .|.  .  . |   . |... .|... . .|. .. |.||. |.|||||..|.....||.||| 
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK-p2-1.AA CDK 47-331 34 3.8e-102 327.62 In-house 3-284 (284) Show / Hide 
Range on Protein: 47-331
Range on HMM: 3-284/284
Sequence Identity: 34% (111 aa)

PIRPIGRGAYGIVCSAVNSETN-----EEVAIKKIGNAFD-NRID---AKR-TLREIKLLRHMDHENIVAIRDIIRPPSKD----EF--NDVYIVYELMD
 .  ||.|.||.|  | . .|.     . ||.|||    .  ...       ..|||.||... |.||| ..|..   ..|     .  | .|.| | ||
KLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMD

TDLHQIIRSNQQLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCD-----LKICDFGLARTTS-------ETDYMTEYVVTRWYRAPELLL
.|| ....         .. ...|||||| | || ...||||||.|.|.| |       ||| ||||||  .       ..  .|  |||.|||||||||
HDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLL

NCSEYT--AAIDVWSVGCIFMELLN---REPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLV
 ...|.   .||.||||||| |...   |.|||||.    || .| ...|.| . .            | .|. |                 || ..||.
GSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNW---------PGVTKLPDY-----------------DLLNKMLC

FNPQNRISVTEALAHPYL
..|..||| ..|| |||.
YDPKKRISAEQALQHPYF
Kinase ERK-p2-1.AA S_TKc 45-331 28 2.1e-100 340.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDT---DLHQIIRSNQ
   .|.||.||.| |. ... .|...||||.|          ....|||..|.. .|.||| . |...       ...|.| |..|.   ||...|....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

Q------LTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDYMTEYVVTRWYRAPELLLNCSEYTA-AIDVWSVGC
       ..  |.....||....|.| || ...||||||.|.||.    .|||||||||        | ...|.||.|||.|     |.  ..|.||.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

IFMELLNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALA-------
|. |.| ..|.||      |. .. ..||                                     .| | |.....|...|..|... |||.       
ILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

HPYL
||..
HPWF
Kinase ERK-p2-1.AA Pkinase 45-331 28 1.9e-94 324.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLR--EIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDT-----DLHQII
   .|.||.|..| |. ...  |...||.|.|    ..    .. .|  ||.......|.||| ..|. .       ...|.| |...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

R--SNQQL--TDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDL----KICDFGLART--TSETDYMTEYVVTRWYRAPELLLNCSEYTAAI
.  ..  .  ....|. ..||.||||.| || ...||||||.|.|.. |...    ||||||||.   .     || ...|.||.|||... ...|. ..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSVGCIFMELLNREPLFPGR----DYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVT
|.||.|||. |.|...|.|||.    . . |. .| .  | | . |   ...   .  .|. .    . .  . .|... . |.....| ..|. |.. .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EALAHPYL
..| ||..
QILQHPWF
Kinase ERK-p2-1.AA MAPK-Unclassified 47-194 52 5e-81 275.5 In-house 3-157 (575) Show / Hide 
Range on Protein: 47-194
Range on HMM: 3-157/575
Sequence Identity: 52% (81 aa)

PIRPIGRGAYGIVCSAVNSET-NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDE--FNDVYIVYELMDT---DLHQIIRSN
..  || ||||.|| |. . . |  |||||.  .| | .|.||.|||| .||.. |.||..|.||... .     | |.||| ..| |   ||||||.||
YQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSN

Q-QLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLAR
|  . . | |||.||.|||||| |||...||||||||||.| .| ..|||||..|
QDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK-p2-1.AA MAPK-Unclassified 201-331 33 1.3e-53 184.44 In-house 404-575 (575) Show / Hide 
Range on Protein: 201-331
Range on HMM: 404-575/575
Sequence Identity: 33% (57 aa)

YMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMELLNR-----------EPLFPGRD--------------------YVQQLRLITELIGSPEDAD
.||.|||||||||||..|  .||....| ||.|||| |....            |||||.|                    .. |. .| .  |.|.  |
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

LGFLRNDNARRYVRQLQRYPRQSFA-HRFPNVP---------PLAVDLVERMLVFNPQNRISVTEALAHPYL
. | ..|.|| |.. . . ..  |    |...|         ... |.|  ||.|||. ||.  .|| ||| 
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK-p2-1.AA Pkinase_Tyr 48-231 29 2.2e-16 56.14 Pfam 4-199 (270) Show / Hide 
Range on Protein: 48-231
Range on HMM: 4-199/270
Sequence Identity: 29% (61 aa)

IRPIGRGAYGIVCSAVNS----ETNEEVAIKKIGNAFDNRID--AKRTLREIKLLRHM-DHENIVAIRDIIR---PPSKDEFNDVYIVYELMDT-DLHQI
.. .|.||.| |. ..      .|. .||.|.. .      .   .  .||.|..... .|.|||    ..     |.      .||| |.|   ||.  
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLLDY

IRS----NQQLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDYMTEYVVT-------RWYRAPELLLNCSEYTA
 |.    .|.||  .   . .|  .|. | .| |  ||||   | |.. |   |||||||||.  ..||   |...       .|. ||| . ..  .| 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY--YRKRGGGKLPIKWM-APECINYGK-FTT

AIDVWS
. ||||
KSDVWS
Kinase ERK-p2-1.AA TyrKc 45-331 21 5e-16 36.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-331
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIG-NAFDNRIDAKRTLREIKLLRHM--DHENIVAIRDIIRPPSKDEF---NDVYIVYELMDT-DLHQII
.  .. .|.||.|.|. .. .   ..||.|..  .|       .  .||......   .|.|||..  ... ..   |     ..|| |.|.  ||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

RSNQQ-LTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSET-------DYMT------EY--VVTRWYRAPELLLNCS
|...  |. ..  .| .|  .|  | || |. ||||   | |...|   ||.||||.|   .        || .      .   .  ||. ||| . | .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

EYTAAIDVWSVGCIFMELLNREPLFPGR-----DYVQQLRLITELI---GSPED----ADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVE
..| . |||| |    |.. .    .          |...   .       |..    .                            |.  |.   .. .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------FVCCPDEMYQIMK

RMLVFNPQNRISVTEALAHPYL
.   ..| .| . .|   | ..
QCWHEDPEDRPTFSEI--HECF