Gene ERK-p2-2 (S.moellendorffii)

ERK-p2-2

Species: S.moellendorffii
Alias: ERK-p2-2
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK-p2-2.AA Protein None 435 None Fasta, JSON
ERK-p2-2.NA RNA None 1308 None Fasta, JSON
ERK-p2-2.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of ERK-p2-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK-p2-2.AA ERK 103-386 56 6.1e-191 640.63 In-house 4-307 (307) Show / Hide 
Range on Protein: 103-386
Range on HMM: 4-307/307
Sequence Identity: 56% (172 aa)

IRPIGRGAYGIVCSAVNSE-----TNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQ
| .||.||||.||||.. |     |.. |||||| ||||..|..|||||||||||| . ||||. ..||..| |....||.|.| |||.|||||||.| |
IKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQ

QLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLAR----TTSET-----DYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSV
.|.|||||||.||.|.||||.|||||.||||||||.|.| |||||||||||||    . .|       .|||||.||||||||..|. ..|| |.|.||.
ELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSC

GCIFMELLNREPLFPGRDYVQQLRLITELIGSP-EDADLGFLRNDNARRYVRQLQR--YPRQSFAHRFPN--VPPLAVDLVERMLVFNPQNRISVTEALA
|||| |.|.| |||||.||| |...|...||.|  . ||    ..||. |...|.   .| ...  .|||  . |.|.|| |.||||.|. ||.| |.|.
GCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLE

HPYL
|||.
HPYF
Kinase ERK-p2-2.AA MAPK 100-386 52 4.8e-190 637.64 In-house 1-328 (328) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

VPPIRPIGRGAYGIVCSAVNSETNEE------VAIKKIGNAFDNRIDAKRTLREIKLLRHM-DHENIVAIRDIIRP------PSKDEFNDVYIVYELMDT
  ...||| ||||.||||.  .||.       |||||| ..|.| ...|||.||||||||. .||||. ..||..|      .|..||||.||| |||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIRSNQQLTDDHCQYFLYQLLRG--LKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETD---------------YMTEYVVTRWYRAP
||||||.|.|.|.|||.|||.||.|||  ||| |||||.||||||||.|.| |||||||||||||..  ..               .|||||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLN--CSEYTAAIDVWSVGCIFMELLN-REPLFPGRDYVQQLRLITELIGSPEDADLGFLR-NDNARRYVRQL---QRYPRQSFAHRFPN----VPPL
|..||    .|| |.|.||||||| |.|. | |||||.||. |. ||.|..|.|.. .. ..  ...|| |...|   ..||...... |||    . |.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLVERMLVFNPQNRISVTEALAHPYL
|.||.|.||||.|. ||.| |||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK-p2-2.AA CMGC 100-386 27 5.5e-144 476.55 In-house 1-513 (513) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

VPPIRPIGRGAYGIVCSAVN--------------SETNEEVAIKKIGNAFDNRIDAK----------RTLREIKLLRHM-----------------DHEN
   |..||.|.||.|.....               ||||.|||||| |.| . ..||          |.|||||.|.|.                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVAIRDIIRPPSKD------------EFNDVYIVYELMDTDLHQIIRSNQ---------QLTDDH------------CQYFL------YQLLRGLK--YV
|| ..||....  |            .||..|.| |.||.||.|.|..||          |.. |            ..||.      ||.|||||  | 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPSNLLLNANCDL--------------------KICDFGLARTTSE----------------------TDYMTEYVVTRWYRAPELLL
||..  ..||||||.|.|.| ||.|                    ||||||||| ...                      .  .|.|||||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NCSEYT---------AAIDVWSVGCIFMELLNR--------EPLFP-----------GRDYVQQLRLITELIGSP----------------EDADLGFLR
....||          .||.||||||| |....        .||||           |.... || .| ...|.|                |. . ... 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NDNARRYVRQ---LQRYPRQSFAHRFPN-----------------------------------VPPLAVDLVERMLVFNP
                    .. ||.|...   ....|....   ||.                                    .|.|.||...||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

QNRISVTEALAHPYL
..||.. .||.|||.
DKRITAEQALQHPYF
Kinase ERK-p2-2.AA p38 100-386 46 2.6e-143 482.41 In-house 1-289 (289) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-289/289
Sequence Identity: 46% (136 aa)

VPPIRPIGRGAYGIVCSAVNSETNEE---VAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRP--PSKDEFNDVYIVYELMDTDLHQIIRS
   ..|.| |||| ||.|. ..|..    |||||.   |   |.|||| ||..||.||.|||.. . |.  |   | ..|.|||.| ..|..||..|...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NQQLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
 |.|.||| |. .||.||||||.|||.. ||||||||. .| .|.|.| ||||||  .  | ||.||.|||||||| .||  .|| ..|.||||||  ||
-QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAEL

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
. ...|||| |...||. |....|.|..  .  . ...|| |.. .  .||. |.| |..  |.|.|| |.||.  |  ||.. ||..|||.
ITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK-p2-2.AA ERK1 99-386 54 2.9e-132 445.7 In-house 1-289 (289) Show / Hide 
Range on Protein: 99-386
Range on HMM: 1-289/289
Sequence Identity: 54% (158 aa)

YVPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQQL
|.  .. || ||||.||||.   ... ||||||   |.     .|||||||.|    ||||. |.|||| .. ... ||||| .||.||| ..... |.|
YT-NLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHL

TDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLAR----TTSETDYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
  ||  |||||.||||||.||||||||||||||||||  ||||||||||||     .  | ..|||| ||||||||..||   || .||.||||||  |.
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
|   |.|||. |. || .|  ..|||  .||  . |. || |.. |   |....|. ||.  . |.||...|| |||..|| | ||||||||
LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK-p2-2.AA ERK5 102-386 51 6.30000000001e-132 444.59 In-house 3-295 (295) Show / Hide 
Range on Protein: 102-386
Range on HMM: 3-295/295
Sequence Identity: 51% (152 aa)

PIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPS-KDEFNDVYIVYELMDTDLHQIIRSNQQLTD
.|  || ||||.||||..  . ..|||||| ||||    ||||.||.|.|||  |.||.|||||..|     |. |||.|..||. |||||| ||| .| 
IIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFTL

DHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSE------TDYMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
.|  |||||.||||||.|||.|.|||||||||| | ||.||| |||.||  .         .||||| |||||||||..   .|| ||||||||||| |.
EHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEM

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQ-LQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
. |  .|||. |..||.|| . .| |  . .     |  . |. . .     . . . .|   . |.||. |||.| | .||.| .|| ||.|
IARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK-p2-2.AA nmo 100-386 47 1.7e-121 375.54 In-house 1-292 (292) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-292/292
Sequence Identity: 47% (140 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQQLT
. | |||| ||.|.| |         ||.||. | | | . .||  ||.|.|    |.|... .||..|| || |...|.| |||  |||.|| | |.|.
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

DDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETD--YMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMELLNR
 || . ||||.||||||.||||.||||.|| |||.|.|| ||||||||||.  . .   ||. ||| .|||||.|.    ||.|.|.||||||| ||| |
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

EPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPN---VPPLAVDLVERMLVFNPQNRISVTEALAHPYL
  ||  .  .||| .||.|.| |   |. .  .      .|. .. |  .   .          ||.|. |||.|.|. |||...|||||||
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK-p2-2.AA ERK7 103-386 44 1.1e-119 403.91 In-house 4-292 (292) Show / Hide 
Range on Protein: 103-386
Range on HMM: 4-292/292
Sequence Identity: 44% (130 aa)

IRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HENIVAIRDIIRPPSKDEFNDVYIVYELMDTDLHQIIRSNQQLTDD
.. .|.||||||  |.   | . ||.|||  || |..|| || ||| .|. .. |.||. . ..||    |   |.|.|.| |.|||| .||  . | | 
RKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETD-------YMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMEL
| || .||||| .||.||.||.||||||||.||...| .|.|||||||. ....        .|||| |||||||| ||   .|| ..| ||.|||  |.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

LNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALAHPYL
|   |.|||   . |. .| |.|. |  .|.  .  . |   . |... .|... . .|. .. |.||. |.|||||..|.....||.||| 
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK-p2-2.AA CDK 102-386 34 3.8e-102 327.62 In-house 3-284 (284) Show / Hide 
Range on Protein: 102-386
Range on HMM: 3-284/284
Sequence Identity: 34% (111 aa)

PIRPIGRGAYGIVCSAVNSETN-----EEVAIKKIGNAFD-NRID---AKR-TLREIKLLRHMDHENIVAIRDIIRPPSKD----EF--NDVYIVYELMD
 .  ||.|.||.|  | . .|.     . ||.|||    .  ...       ..|||.||... |.||| ..|..   ..|     .  | .|.| | ||
KLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMD

TDLHQIIRSNQQLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCD-----LKICDFGLARTTS-------ETDYMTEYVVTRWYRAPELLL
.|| ....         .. ...|||||| | || ...||||||.|.|.| |       ||| ||||||  .       ..  .|  |||.|||||||||
HDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLL

NCSEYT--AAIDVWSVGCIFMELLN---REPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLV
 ...|.   .||.||||||| |...   |.|||||.    || .| ...|.| . .            | .|. |                 || ..||.
GSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNW---------PGVTKLPDY-----------------DLLNKMLC

FNPQNRISVTEALAHPYL
..|..||| ..|| |||.
YDPKKRISAEQALQHPYF
Kinase ERK-p2-2.AA S_TKc 100-386 28 2.1e-100 340.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDT---DLHQIIRSNQ
   .|.||.||.| |. ... .|...||||.|          ....|||..|.. .|.||| . |...       ...|.| |..|.   ||...|....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

Q------LTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDYMTEYVVTRWYRAPELLLNCSEYTA-AIDVWSVGC
       ..  |.....||....|.| || ...||||||.|.||.    .|||||||||        | ...|.||.|||.|     |.  ..|.||.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

IFMELLNREPLFPGRDYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVTEALA-------
|. |.| ..|.||      |. .. ..||                                     .| | |.....|...|..|... |||.       
ILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

HPYL
||..
HPWF
Kinase ERK-p2-2.AA Pkinase 100-386 28 1.9e-94 324.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIGNAFDNRIDAKRTLR--EIKLLRHMDHENIVAIRDIIRPPSKDEFNDVYIVYELMDT-----DLHQII
   .|.||.|..| |. ...  |...||.|.|    ..    .. .|  ||.......|.||| ..|. .       ...|.| |...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

R--SNQQL--TDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDL----KICDFGLART--TSETDYMTEYVVTRWYRAPELLLNCSEYTAAI
.  ..  .  ....|. ..||.||||.| || ...||||||.|.|.. |...    ||||||||.   .     || ...|.||.|||... ...|. ..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSVGCIFMELLNREPLFPGR----DYVQQLRLITELIGSPEDADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVERMLVFNPQNRISVT
|.||.|||. |.|...|.|||.    . . |. .| .  | | . |   ...   .  .|. .    . .  . .|... . |.....| ..|. |.. .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EALAHPYL
..| ||..
QILQHPWF
Kinase ERK-p2-2.AA MAPK-Unclassified 102-249 52 5e-81 275.5 In-house 3-157 (575) Show / Hide 
Range on Protein: 102-249
Range on HMM: 3-157/575
Sequence Identity: 52% (81 aa)

PIRPIGRGAYGIVCSAVNSET-NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPSKDE--FNDVYIVYELMDT---DLHQIIRSN
..  || ||||.|| |. . . |  |||||.  .| | .|.||.|||| .||.. |.||..|.||... .     | |.||| ..| |   ||||||.||
YQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSN

Q-QLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLAR
|  . . | |||.||.|||||| |||...||||||||||.| .| ..|||||..|
QDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK-p2-2.AA MAPK-Unclassified 256-386 33 1.3e-53 184.44 In-house 404-575 (575) Show / Hide 
Range on Protein: 256-386
Range on HMM: 404-575/575
Sequence Identity: 33% (57 aa)

YMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMELLNR-----------EPLFPGRD--------------------YVQQLRLITELIGSPEDAD
.||.|||||||||||..|  .||....| ||.|||| |....            |||||.|                    .. |. .| .  |.|.  |
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

LGFLRNDNARRYVRQLQRYPRQSFA-HRFPNVP---------PLAVDLVERMLVFNPQNRISVTEALAHPYL
. | ..|.|| |.. . . ..  |    |...|         ... |.|  ||.|||. ||.  .|| ||| 
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK-p2-2.AA Pkinase_Tyr 103-286 29 2.2e-16 56.14 Pfam 4-199 (270) Show / Hide 
Range on Protein: 103-286
Range on HMM: 4-199/270
Sequence Identity: 29% (61 aa)

IRPIGRGAYGIVCSAVNS----ETNEEVAIKKIGNAFDNRID--AKRTLREIKLLRHM-DHENIVAIRDIIR---PPSKDEFNDVYIVYELMDT-DLHQI
.. .|.||.| |. ..      .|. .||.|.. .      .   .  .||.|..... .|.|||    ..     |.      .||| |.|   ||.  
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLLDY

IRS----NQQLTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDYMTEYVVT-------RWYRAPELLLNCSEYTA
 |.    .|.||  .   . .|  .|. | .| |  ||||   | |.. |   |||||||||.  ..||   |...       .|. ||| . ..  .| 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY--YRKRGGGKLPIKWM-APECINYGK-FTT

AIDVWS
. ||||
KSDVWS
Kinase ERK-p2-2.AA TyrKc 100-386 21 5e-16 36.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 100-386
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

VPPIRPIGRGAYGIVCSAVNSETNEEVAIKKIG-NAFDNRIDAKRTLREIKLLRHM--DHENIVAIRDIIRPPSKDEF---NDVYIVYELMDT-DLHQII
.  .. .|.||.|.|. .. .   ..||.|..  .|       .  .||......   .|.|||..  ... ..   |     ..|| |.|.  ||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

RSNQQ-LTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSET-------DYMT------EY--VVTRWYRAPELLLNCS
|...  |. ..  .| .|  .|  | || |. ||||   | |...|   ||.||||.|   .        || .      .   .  ||. ||| . | .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

EYTAAIDVWSVGCIFMELLNREPLFPGR-----DYVQQLRLITELI---GSPED----ADLGFLRNDNARRYVRQLQRYPRQSFAHRFPNVPPLAVDLVE
..| . |||| |    |.. .    .          |...   .       |..    .                            |.  |.   .. .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------FVCCPDEMYQIMK

RMLVFNPQNRISVTEALAHPYL
.   ..| .| . .|   | ..
QCWHEDPEDRPTFSEI--HECF