Gene CDK11_a-2 (S.moellendorffii)

CDK11_a-2

Species: S.moellendorffii
Alias: CDK11_a-2
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK11

Sequence

Name Sequence Type Origin Length Description Download
CDK11_a-2.AA Protein None 478 None Fasta, JSON
CDK11_a-2.NA RNA None 1437 None Fasta, JSON
CDK11_a-2.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of CDK11_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK11_a-2.AA PITSLRE 167-383 56 1.5e-124 420.08 In-house 1-219 (295) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-219/295
Sequence Identity: 56% (126 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMH-NQETEGFPVTSLREIN-LLISLRHPAIVDVREVVIGKDMDSVFMVMEYIERNLKDVMAALP---
|..| | .||.|||||.|.||||.||||||..||   .| ||||.||||||| .|  |.|| || |.|.|.|..||...|||||.|  ||..|       
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPWEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVS-GGELKICDFGMARRYDSPIKAYTHKVVTMWYRAPELLASTQEEQYHYTAAVDVWSLGCI
||     .| .||||| .|...| ||..||||| ||.| |  | ||||||| ||.| ||||.||  |||.||||||||  ...    |. .||.|| |||
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKK----YSTPVDMWSVGCI

MAELILNETLFQGTSEIDQLRRI
.||.|. . |||| |||||. .|
FAEFITMKPLFQGKSEIDQINCI
Kinase CDK11_a-2.AA CDK 167-383 46 2.7e-117 376.88 In-house 1-237 (284) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-237/284
Sequence Identity: 46% (117 aa)

FEKLGRLGEGAYGVVYKARDKRTE-----EIVALKKIKMHNQ----ETEGFPVTSLREINLLISLRHPAIVDVREVVIGKDMD---------SVFMVMEY
.||| ..|||.||||||||||.|      .|||||||.| |.    | |||| |..|||.||  | || || ...|...|.||         ...||.||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IERNLKDVMAALPQPWEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVS-GGE-----LKICDFGMARRYDS------PIKAYTHKVVTMWYRAPE
..  || .|           .|..|.|||....|.| ||..||||||.|||..  ||     ||| ||| || . .      |...|||.|||.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLA-STQEEQYHYT--AAVDVWSLGCIMAELIL---NETLFQGTSEIDQLRRI
||  |.     ||.   ..|.||.|||.||...   .. ||.|.|||||| .|
LLLGSK-----HYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKI
Kinase CDK11_a-2.AA CMGC 167-383 28 4.1e-103 339.75 In-house 1-366 (513) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-366/513
Sequence Identity: 28% (105 aa)

FEKLGRLGEGAYGVVYKARDKRTE--------------EIVALKKIK---MHNQ-----ETEGFPVTSLREINLLISLR----------------HPA-I
.|.....|||.||||||.|||||.              ||||.||||   ...|     | .||| ..|||| .|  |.                |.  |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VDVREVVIGKDMD---------------SVFMVMEYIERNLKDVMAALP--------QPWEHAV------------VKHMM------QQLLDAVA--YLH
|  ....  |..|               ....|.||.. .|....   .        .| .. .            .|..|      .|.| ...  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ANW--VLHRDLKPSNILVSG---------------------GELKICDFGMARRYDSP---------------------IKAYTHKVVTMWYRAPELLAS
 .|  ..||||||.|||..                      |.|||||||.|| |...                      ..||| |||.||||||.| .
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

TQ-----EEQYHYTAAVDVWSLGCIMAELILN--------ETLFQGTSE-----------IDQLRRI
 .     .   ||| ..|.||.|||.||....        ..||.| ||           |||| .|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKI
Kinase CDK11_a-2.AA CDC2 167-383 43 2.2e-101 312.36 In-house 1-221 (301) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-221/301
Sequence Identity: 43% (99 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQETE-GFPVTSLREINLLISLR-HPAIVDVREVVIGKDMDSVFMVMEYIERNLKDVMA-ALP--
..|. ..||| ||||||..|..| .|||||||.  ... . |.| |..||| .|  |. || ||  ..|..     ...|| ||....||  |   .|  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPWEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVSG-GELKICDFGMARRYDSPIKAYT--HKVVTMWYRAPELLASTQEEQYHYTAAVDVWSLG
.. . ..||  | |.|..|...|.. ..||||||.|||..  |..|| ||| ||    ||..||  | ||| ||||||.|   .    .|. .||.||.|
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCK----RYSTPVDMWSIG

CIMAEL---ILNETLFQGTSEIDQLRRI
||.||.   . .. ||.| |||||| .|
CIFAEMFMDVTKKPLFHGDSEIDQLFKI
Kinase CDK11_a-2.AA CDK10 167-454 43 4.3e-99 335.52 In-house 1-285 (285) Show / Hide 
Range on Protein: 167-454
Range on HMM: 1-285/285
Sequence Identity: 43% (128 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQETEGFPVTSLREINLLISLRHPAIVDVREVVIGKDMDSVFMVMEYIERNLKDVMAALPQPWEH
|||| |.|||.||.||.||| |..|||||||..| ..| .| |. .|||| ||| .||. ||...|||.|. .||.|.||.| |  |  ..  .|||.  
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRM-DKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTE

AVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVSG-GELKICDFGMARRYDSPIKAYTHKVVTMWYRAPELLASTQEEQYHYTAAVDVWSLGCIMAELI
. || .| |.| .. ||| |...||||| ||.|..  | .|. |||.||.|  |.|  | |.||.||||||||  ....    | |.|.| .|||..||.
TQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQ----TTAIDMWAVGCILGELL

LNETLFQGTSEIDQLRRIKKMVWTAQLE-KPGFI-FPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
..  |. |.||| |.  | ... |   .  |||   |. .  .|. .  |   ..  ..||. |. ||  |. |.| ||  |  .|   .|
VHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLK-KQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK11_a-2.AA S_TKc 167-454 29 9.1e-96 325.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 167-454
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQETEGFPVTSLREINLLISLRHPAIVDVREVVIGKDMDSVFMVMEYIER---NLKDVMAALPQP
.|.|  .|.||.|.|||.|.|.| .|||.|.||           . .|||..| . .|| ||   .|      |...|||||..    .|.|..   . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----WEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVSGGELKICDFGMARRYDSPIKAYTHKVVTMWYRAPELLASTQEEQYHYTA-AVDVWSL
         .....|.|...|..|.| ....||||||.|||..  ..||||||.||..       |. ..| ||.|||.|        .|.  ..|.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GCIMAELILNETLFQGTSEIDQLRRIKKMVWTAQLEKPGFIFPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISASAALA-------
|||..|..  ...|.   .   ...|.                                       |. ..|.. ..| .||.||..|  ||.       
GCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

HPWF
||||
HPWF
Kinase CDK11_a-2.AA CDK5 167-454 41 2.4e-93 295.29 In-house 1-287 (287) Show / Hide 
Range on Protein: 167-454
Range on HMM: 1-287/287
Sequence Identity: 41% (122 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQETEGFPVTSLREINLLISLRHPAIVDVREVVIGKDMDSVFMVMEYIERNLKDVMAALPQPWEH
.||. ..||| ||.|||||.| |.||||||.... ..| || | | .||| ||  |.|. ||    |.         .| |..   ||  |  .    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRL-DSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKK--LTLVFEFCDQDLKKYMDSCNGEMDM

AVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVS-GGELKICDFGMARRYDSPIKAYTHKVVTMWYRAPELLASTQEEQYHYTAAVDVWSLGCIMAELI
...| .| |||  .|. |.. |||||||| | |..  ||||  |||.|| .  |.. |.| |||.|||.|  |   .    ||.  .|.|| |||.||..
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSK----HYSTSIDMWSCGCIFAEMA

-LNETLFQGTSEIDQLRRIKKMVWTAQLEK-PGFI-FPAHK--LSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
     || |... ||| || |.. |   .| |.    |  |    ..  . . .. |   | |.|||.||| ..| ..|..|||| ||| ||.|
NAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK11_a-2.AA CDK7 167-383 42 2.8e-90 240.57 In-house 1-215 (288) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-215/288
Sequence Identity: 42% (93 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIK---MHNQETEGFPVTSLREINLLISLRHPAIVDVREVVIGKDMDSVFMVMEYIERNLKDVMAALPQP
.||.  .||| ...||||.|. |..||| ||||     ..   |   | .||| .|  ..|. ... . .   |  ... .|.....  |  |       
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHK--SNIQLVFDFMDWDLEVVIKDKSII

WEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVSG-GELKICDFGMARRYDSPIKAYTHKVVTMWYRAPELLASTQEEQYHYTAAVDVWSLGCIMA
   | .|  | ..|  . |.|.||.||||||| | |..  |.||| ||| || | || ..|||.||| ||||||||        ||. .||.|| |||.|
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGAR----HYGTGVDMWSVGCIFA

ELILNETLFQGTSEIDQLRRI
||.|    . |.|.||||.||
ELMLRVPYLPGDSDIDQLTRI
Kinase CDK11_a-2.AA Pkinase 167-454 29 1.3e-81 282.25 Pfam 1-293 (293) Show / Hide 
Range on Protein: 167-454
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQETEGFPVTSLR--EINLLISLRHPAIVDVREVVIGKDMDSVFMVMEYIER-----NLKDVMA-
.......|.|..|.|||...| |..|||.|.|| .  | .....| .|  || .. .|.|| ||  ....     |.. ||||| |       |.|..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

ALPQPW--EHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVS-GGEL----KICDFGMARRY-DSPIKAYTHKVVTMWYRAPELLASTQEEQYHYTA
    .   .  ..|..| |.| ...|.|.....||||||.|||..  |..    |||||| |. .   .   .|. ..| ||.|||..     .. .|. 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGP

AVDVWSLGCIMAELILNETLFQGT----SEIDQLRRIKKMVWTAQLEKPGFIFPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISAS
.||.||.|||..|... ...|.|     . .||. .|..  ..   .      .    . .|.    . ..   . .|| ..|..  .|..|| ||..| 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

AALAHPWF
 .| ||||
QILQHPWF
Kinase CDK11_a-2.AA CRK7 167-383 36 3.3e-78 266.12 In-house 1-265 (343) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-265/343
Sequence Identity: 36% (97 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQ--ETEGFPVTSLREINLLISLRHPAIVDVREVVIGK--------DMDSVFMVMEYIERNLKDV
.|...  ||| || ||||..|.|.|.|||||..| |     ||||.|. ||| .| .| |. ||  .|.|. |        .  |..|| ||.   |   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MAAL-PQPWEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVS-GGELKICDFGMARRYDSPI--KAYTHKVVTMWYRAPELLASTQEEQYHY----
.     .   |  .|..| |||. ..|.| . .||||.| ||||.   ||.|| ||| || | |    . || .|.| |||.||||  ..    .|    
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEE----RYTEQH

----------------------------------TAAVDVWSLGCIMAELILNETLFQGTSEIDQLRRI
                                  . ..|.|| |||..||   ...|||  |..||  |
ILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKI
Kinase CDK11_a-2.AA MAPK 167-383 33 2.3e-68 233.44 In-house 1-247 (328) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-247/328
Sequence Identity: 33% (86 aa)

FEKLGRLGEGAYGVVYKARDKR------TEEIVALKKIK---MHNQETEGFPVTSLREINLLISL-RHPAIVDVREVVIG------KD---MDSVFMVME
.. | ..|.|||||| .|.|||      ....||.|||     . . .       .||| ||  . .|. |. ....         ..   .. . .|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK----RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVME

YIERNLKDVMAALPQPWEHAVVKHMMQQLLDA--VAYLHANWVLHRDLKPSNILV-SGGELKICDFGMARRYDS-PIKAY-------------THKVVTM
. | .|  ..   . |...  ..  | |.| .  . |.|   |.||||||||||| . ..|||||||.||  |.   . .             |  |.| 
LMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPELLAS--TQEEQYHYTAAVDVWSLGCIMAELIL-NETLFQGTSEIDQLRRI
||||||.. .  ..    ||| |||.||.|||.||..  . .||.|.. |||. .|
WYRAPEIMLNWIWM----HYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLI
Kinase CDK11_a-2.AA CDK4 167-383 42 1.5e-67 230.72 In-house 1-221 (290) Show / Hide 
Range on Protein: 167-383
Range on HMM: 1-221/290
Sequence Identity: 42% (98 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQET-EGFPVTSLREINLLISLR---HPAIVDVREVVIGKDMDS----VFMVMEYIERNLKDVMA
....  .|||||| ||.|||  |  .||||...  ..|   | |.  .||| ..  |    || ||   .|    | |     . ||.| ..  |.. . 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

ALPQP-WEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILV-SGGELKICDFGMARRYDSPIKAYTHKVVTMWYRAPE-LLASTQEEQYHYTAAVDVW
 .|.|      .|||| ||| .| .||.. . |||||| |||| | |..|. ||| || | .   | |  |||.|||||| ||.|.      |   || |
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLLQSY------YNTPVDMW

SLGCIMAELILNETLFQGTSEIDQLRRI
|.|||.||.     || |.|| ||| .|
SVGCIFAEMYCRRPLFCGQSEKDQLHKI
Kinase CDK11_a-2.AA CDC2 422-454 60 1.4e-17 50.14 In-house 269-301 (301) Show / Hide 
Range on Protein: 422-454
Range on HMM: 269-301/301
Sequence Identity: 60% (20 aa)

MLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
.| ..|.||| |.|.||| ||||| .||.||.|
CLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDK11_a-2.AA CMGC 422-454 51 3.7e-16 48.71 In-house 481-513 (513) Show / Hide 
Range on Protein: 422-454
Range on HMM: 481-513/513
Sequence Identity: 51% (17 aa)

MLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
.......||| ..| |||||||.|. ||.||.|
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDK11_a-2.AA Pkinase_Tyr 167-314 31 1.8e-15 53.04 Pfam 1-159 (270) Show / Hide 
Range on Protein: 167-314
Range on HMM: 1-159/270
Sequence Identity: 31% (51 aa)

FEKLGRLGEGAYGVVYKARDK----RTEEIVALKKI--KMHNQE--TEGFPVTSLREINLLISL-RHPAIVDVREVVIGKDMDS--VFMVMEYIER-NLK
 ...  |||||.|.|||.. |     |.  || |..  . . ..   | |    .||.... .| .|| ||    |.. .. ..  ...|||| .  .|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLL

DVMAAL---PQPWEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVS-GGELKICDFGMAR
|   .    .||  .    .| .|  .. .||...   ||||   |.||. ..  ||||||.||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK11_a-2.AA PITSLRE 423-454 59 3.6e-15 51.82 In-house 264-295 (295) Show / Hide 
Range on Protein: 423-454
Range on HMM: 264-295/295
Sequence Identity: 59% (19 aa)

LSEKGLDLLAQLLAYDPDKRISASAALAHPWF
.|. |.||| |.| |.| .||.||.|| ||||
ISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK11_a-2.AA CDK 429-454 65 6.8e-15 43.92 In-house 259-284 (284) Show / Hide 
Range on Protein: 429-454
Range on HMM: 259-284/284
Sequence Identity: 65% (17 aa)

DLLAQLLAYDPDKRISASAALAHPWF
||| ..|.|||.|||||..|| ||.|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDK11_a-2.AA TyrKc 167-454 21 4.7e-14 4.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 167-454
Range on HMM: 1-280/280
Sequence Identity: 21% (71 aa)

FEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHNQETEGFPVTSLREINLLISL--RHPAIVDVREVVIGK-----DMDSVFMVMEYIER-NLKDVMA
 ...  |||||.|.|||.. |   . || |..| .    | |    .||.... .|  .|| ||    |.. .       . ...|||| .  .|||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ALPQPWEHAVVKHMMQQLLDAVAYLHANWVLHRDLKPSNILVSGGE-LKICDFGMARRYDSP------IKAYTHKV--VTM------WYRAPELLASTQE
.      ..   ... |  .  .||| . . ||||   |.||. .   ||.|||..|  ..        . |..|    .       |. ||| .     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-----

EQYHYTAAVDVWSLGCIMAEL---------------ILNETLFQGTSEIDQLRRIKK---MVWTAQLEKPGFIFPAHKLSALRDRILYPAAQAGRPMLSE
  . .| . |||| |  | |.               . |. ...   . . ... .    |                                  .  ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------F--VCCPD

KGLDLLAQLLAYDPDKRISASAALAHPWF
.  ..  |  ..||..| . |.   |  |
EMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CDK11_a-2.AA CDK4 421-454 44 1.7e-13 42.43 In-house 257-290 (290) Show / Hide 
Range on Protein: 421-454
Range on HMM: 257-290/290
Sequence Identity: 44% (15 aa)

PMLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
| ... |.||| . | |...||.|| ..| ||.|
PHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK11_a-2.AA CRK7 422-454 42 1.7e-12 39.2 In-house 311-343 (343) Show / Hide 
Range on Protein: 422-454
Range on HMM: 311-343/343
Sequence Identity: 42% (14 aa)

MLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
..... |||| ..|..||.||..|. .| |.||
FMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK11_a-2.AA MAPK 412-454 39 5.2e-12 37.59 In-house 289-328 (328) Show / Hide 
Range on Protein: 412-454
Range on HMM: 289-328/328
Sequence Identity: 39% (17 aa)

LYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISASAALAHPWF
..| |     . . . .||| ..|. ||||||..  ||.|| |
MFPNANF---NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK11_a-2.AA CDK7 424-454 32 5.3e-11 25.1 In-house 258-288 (288) Show / Hide 
Range on Protein: 424-454
Range on HMM: 258-288/288
Sequence Identity: 32% (10 aa)

SEKGLDLLAQLLAYDPDKRISASAALAHPWF
|.  |||.. ... .| ||.... .| .| |
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF