Gene CDK11_b-2 (S.moellendorffii)

CDK11_b-2

Species: S.moellendorffii
Alias: CDK11_b-2
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK11

Sequence

Name Sequence Type Origin Length Description Download
CDK11_b-2.AA Protein None 503 None Fasta, JSON
CDK11_b-2.NA RNA None 1512 None Fasta, JSON
CDK11_b-2.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of CDK11_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK11_b-2.AA PITSLRE 159-450 62 1.2e-202 679.49 In-house 1-295 (295) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-295/295
Sequence Identity: 62% (188 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMD--HEREGFPMTSLREIN-VLLSFHHPSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMDAMK---
|. ||.|.||||||||||.||. .|||||||.||.   |.|||| ||||||| .|    || || |||.|.|||.|.|.|||||.|||||.||. ||   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPFTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYTRMVVTLWYRAPELLLGSKKYNAAIDMWSLGCIMAEF
|||. .| ||||.||  ||...||||..||||||||||... | |||||||||| ||||.| || .||||||||||||||.|||  ..|||| |||.|||
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LAKEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVK-CN-FVRQPYNRLREKFPPVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
. ..|||.|||||||...||| .|||.||||| .  ||..|  | |  .||| ||..||     .   .|. |.||||..|||.| .||||..|| |.||
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFP-----AENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK11_b-2.AA CDK 159-450 46 5e-175 564.58 In-house 1-284 (284) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-284/284
Sequence Identity: 46% (151 aa)

FERLNKIDEGTYGVVYRARDKKSG-----EIVALKRVKMDH-----EREGFPMTSLREINVLLSFHHPSIVDVKEVVVGSNLD---------SIFMVMEY
.|.|.|| ||||||||.||||..|     .|||||...|..     |.||||.|..|||. |    || || ...|....|.|         ...||.||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MEHDLKGLMDAMKQPFTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGD-----LKICDFGLARQYGS------PLKTYTRMVVTLWYRAPE
|.||||..||           ||.|.|| .|. |.|.||..|||||..|.|.||.|      ||| |||||| .|.      |..|||  ||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGSKKYN--AAIDMWSLGCIMAEFLA---KEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNRLREKFPPVAFGGRPALSEKG
||||||.|.   .|||||.|||.||..    ..||| |.||||||.|||...|||.|..||... ||.                                
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------------

YDLLNKLLTYDPSKRITAEEALNHEWF
 |||||.|.|||.|||.||.||.|..|
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDK11_b-2.AA CDC2 159-450 45 1.4e-147 456.99 In-house 1-301 (301) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-301/301
Sequence Identity: 45% (137 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHEREG--FPMTSLREINVLLSFH-HPSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMD-AMK--
.....|| ||||||||...|.....|||||... ..| ||  .| |..|||  |     || ||  ..|..     ...|| ||...||| .||   .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPFTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYT--RMVVTLWYRAPELLLGSKKYNAAIDMWSLGCIMA
......  | .| |. .|| ..| . ..||||| .|.|... |..|| ||||||  | |..|||  . ||||||||||.|||.|.|. ..||||.|||.|
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EF---LAKEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNRLREKFPPVAFGGRP-ALSEKGYDLLNKLLTYDPSKRITAEEALN
|.     |.||| |.|||||| |||..||||||..||.  .||  |  | | . . |.. .|   ..     | ..| |||...| |||.|||.|.|||.
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HEWF
| .|
HPYF
Kinase CDK11_b-2.AA CMGC 159-450 27 2.3e-145 481.2 In-house 1-513 (513) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

FERLNKIDEGTYGVVYRARD--------------KKSGEIVALKRVK---MDH------EREGFPMTSLREINVLLSF-----------------HHPSI
.| ..|| ||||||||..||              ....||||.|..|   ...      |..|||...||||  |  .                 ||. |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VDVKEVVVGSNLD---------------SIFMVMEYMEHDLKGLMDAMK--------QPFTQSE------------AKCLM------LQLFEGVK--YLH
|  ..... .| |               ....|.|||.|||..... ..        .|... .             |..|       |...|.|  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--VLHRDLKTSNLLLNNRGDL--------------------KICDFGLARQYGSP---------------------LKTYTRMVVTLWYRAPELLLG
 .|  ..||||| .|.|.|....|                    |||||||||.|...                     ...||  |||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

S---------KKYNAAIDMWSLGCIMAEFLAK--------EPLFTGKSE-----------IDQLDKIFKTLGTPN---------------EKIWPNFVNL
.         ..|. .|||||.|||.|| . .        .||| |.||           ||||.||||.||||.               |..|||...|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PGV--------------------------KCNFVRQPYNRLREKFPPVAFGGRPA----------------------------LSEKGYDLLNKLLTYDP
|.                           ...| ..|.. ....||.  ....                              ..... |||.|.|.|||
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-NNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SKRITAEEALNHEWF
.||||||.||.|..|
DKRITAEQALQHPYF
Kinase CDK11_b-2.AA CDK10 159-450 54 2.1e-140 472.77 In-house 1-285 (285) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-285/285
Sequence Identity: 54% (161 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHEREGFPMTSLREINVLLSFHHPSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMDAMKQPFTQS
||.||.. |||||.|||||| .| ||||||.|.||.|..| |. .|||| .|.  .|. ||...|||||  |||||.||.| | ||  |.| | |||| .
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

EAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYTRMVVTLWYRAPELLLGSKKYNAAIDMWSLGCIMAEFLAKEPL
. ||.|||.  |.||||||...||||| ||||.  .| .|. ||||||.|| | |  |  .|||||||||||||...   ||||| .|||..| |.. ||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

FTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGV-KCNFVRQPYNRLREKFPPVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
. | ||| |.| | . ||||.|.||| | .|| | .    .|||| |..||        . ||. |  ||| |. |.| || ||||.|. ..|
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF--------HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK11_b-2.AA CRK7 159-450 41 4.8e-132 444.98 In-house 1-343 (343) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-343/343
Sequence Identity: 41% (145 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHE---REGFPMTSLREINVLLSFHHPSIVDVKEVVVG--------SNLDSIFMVMEYMEHDLKGL
.|... | ||||| || |..|. ||.||||.|.||.|   .|||| |. ||| .| ...|..||  ||.|.         .   |..|| ||| ||| ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MDAM-KQPFTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPL--KTYTRMVVTLWYRAPELLLGSKKY--------
..    . | ... ||.| || ||. |.|.. .||||.| ||.|.||.| .|| |||||| | |    . ||  |.|||||.|||||| ..|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------NAAIDMWSLGCIMAEFLAKEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNR-LR
                              . .||||| |||..| . |.|.| |. |..||.||.|  |.||   ||.   ||. .    .. ||| ||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

EKFP----PVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
| |     ||       ....  ||| |.|..||.||.||||.|.|.||
EEFYHHKKPV------FMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK11_b-2.AA CDK7 159-450 38 1.4e-131 352.87 In-house 1-288 (288) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-288/288
Sequence Identity: 38% (114 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVK----MDHEREGFPMTSLREINVLLSFHHPSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMDAMKQP
.| . .| ||....||.|.|...|.||| |..|     .  . |  .| .||| .|   .|. ...   .     ...| .|...|. ||       .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYTRMVVTLWYRAPELLLGSKKYNAAIDMWSLGCIMAEFLA
.|... |  |...  |. |.| ||.||||||  |||.|  |.||| ||||||.|||| . ||  ||| |||||||| | . |  ..|||| |||.|| . 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

KEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNRLREKFPP---VAFGGR-PALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
  | . | |.|||| .||.|||||.|. |||   ..          |. .. .||.   ...  .  | |.   ||. ...| .|.||.|. ..|... |
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMD---------YIKFK-DFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK11_b-2.AA CDK5 159-450 45 5.3e-126 400.3 In-house 1-287 (287) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-287/287
Sequence Identity: 45% (134 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHEREGFPMTSLREINVLLSFHHPSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMDAMKQPFTQS
.|...|| |||||.||.||.|...||||||||..| | || | | .||| .|    |. ||    |.   .   . .| |..  |||  || ..    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNGEMDMH

EAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYTRMVVTLWYRAPELLLGSKKYNAAIDMWSLGCIMAEFL-AKEP
 .| .|.||  |. . |.. |||||||  ||| | .| ||  |||||| .| | ..|.  |||||||.|  |.|||.|.  ||||| |||.||   |  |
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNRLREKFPPVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
|| | .. ||| .||| .|||.|  ||   .||  | | .  |   ... . ..     | |.||| |||.|.| ..| .||.|..||.| .|
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIV----PKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK11_b-2.AA S_TKc 159-450 31 1.2e-103 351.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-231/231
Sequence Identity: 31% (98 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHEREGFPMTSLREINVLLSFHHPSIVDVKEVVVGSNLDSIFMVMEYMEH---DLKGLMDAMKQP-
.| |.|| .|..|.||..|.||.|.|||.|..|          . .|||..| . ||| ||  ..| .    |...|||||...   ||. ... .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYTRMVVTLWYRAPELLLGSKKYNA-AIDMWSLGCIM
    |.  .|...| |......|.|.....||||| .|.||..   .||||||||||.       | ...|.||.|||.|    .|.  ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AEFLAKEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNRLREKFPPVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALN---
.|.|. .|.|       |....|| .|                                           |. . |...|.|..||.||.|| |||.   
YEMLCGYPPFP------QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----HEWF
    |.||
DIKCHPWF
Kinase CDK11_b-2.AA Pkinase 159-450 33 1.3e-99 342.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-293/293
Sequence Identity: 33% (103 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHEREGFPMTSLR--EINVLLSFHHPSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMDAM-----
.... || .|..|.||....|..|.|||.|..| .||......| .|  || ......|| ||  ....     |.| |||||.|..|. .|| .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--KQPF--TQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDL----KICDFGLARQY-GSPLKTYTRMVVTLWYRAPELLLGSKKYNAAIDM
  . .|  .  |.|. |.|...|..|.|.....||||| .|.|..|.|..    ||||||||.|.   .   .|  ..|.||.|||...|...|  ..||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGCIMAEFLAKEPLFTGK----SEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQPYNRLREKFPPVAFGGRPALSEKGYDLLNKLLTYDPSKR
||.|||..|.| ..|.| |.    . .||. .|....|.|..  ||.  . .  . .. . .         . .    ...|| . |.....|..||.||
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H---------F-HWTF-HNWSEECKDFIKWCLCKDPKKR

ITAEEALNHEWF
.|||..|.|.||
PTAEQILQHPWF
Kinase CDK11_b-2.AA MAPK 159-450 35 6.9e-89 301.62 In-house 1-328 (328) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-328/328
Sequence Identity: 35% (117 aa)

FERLNKIDEGTYGVVYRARDKK------SGEIVALKRVKMDHEREGFPMTSLREINVLLSF-HHPSIVDVKEVVVG------SNL---DSIFMVMEYMEH
.. | .| .| ||||  |.||.      .|..||.|..    . . .    .|||  |  | ||. |. ....         ..|   . | .|||.||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLKGLMDAMKQPFTQSEAKCLMLQLFEG--VKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGS-PLKTY-------------TRMVVTLWYRA
||  ..  .. | .    . .| |.  |  .||.|   |.||||| ||.|.|  .|||||||||||.  .   . .             |  |.| ||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLLG--SKKYNAAIDMWSLGCIMAEFLA-KEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPGVKCNFVRQ-----PYNR--LREKFPPVAFGGR
||..|.  ...|. |.||||.|||.||.|    ||| ||. |||. .|...|||| |  . .  . .    |....     .|..  ... ||   |   
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICM-SEHARNYIQSLGNLPKYPKKPWEKMFPNANF---

PALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
   . .  ||| |.|. ||.||||.||||.|. |
-NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK11_b-2.AA CDK4 159-390 45 3.4e-83 282.68 In-house 1-240 (290) Show / Hide 
Range on Protein: 159-390
Range on HMM: 1-240/290
Sequence Identity: 45% (110 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHERE--GFPMTSLREINV---LLSFHHPSIVDVKEVVVGSNLDS----IFMVMEYMEHDLKGLMD
.. .. | || || |||||| ..| .||||.|.   . |  | ||  .||| |   |  | || ||  ..|   .  |     | ||.|  . ||. ..|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

AMKQP-FTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSPLKTYTRMVVTLWYRAPELLLGSKKYNAAIDMWSLGCI
 . .|   .  .| .| ||  || .|| . . |||||  |.|..  | .|. |||||| |..  .  |  |||||||||| || |  ||  .||||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQS-YYNTPVDMWSVGCI

MAEFLAKEPLFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLP
.||     ||| |.|| |||.|||.  |.| |. ||  | ||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP
Kinase CDK11_b-2.AA Pkinase_Tyr 159-306 34 1.9e-16 56.34 Pfam 1-159 (270) Show / Hide 
Range on Protein: 159-306
Range on HMM: 1-159/270
Sequence Identity: 34% (57 aa)

FERLNKIDEGTYGVVYRARDK----KSGEIVALKRV--KMDHE---REGFPMTSLREINVLLSF-HHPSIVDVKEVVV--GS-NLDSIFMVMEYMEH-DL
 . . |. || .|.||... |    . .  || | .  . .||   || |    .||.... .. ||| ||    |..  |  |  .|..|||||.| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDL

KGLMDAM---KQPFTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLAR
.    .    |||.| ..  .  .|  .|  ||...   |||| . | |... .  |||||||||
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK11_b-2.AA TyrKc 159-450 23 2.9e-14 7.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-450
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

FERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMDHEREGFPMTSLREINVLLSF--HHPSIVDVKEVVVGS-----NLDSIFMVMEYMEH-DLKGLMDA
 . . |. || .|.||... |   . || | .| |. || |    .||.... ..  ||| ||    |.. .       . ...|||||.| |||    .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKQPFTQSEAKCLMLQLFEGVKYLHDNWVLHRDLKTSNLLLNNRGDLKICDFGLARQYGSP------LKTY-------TRMVVTLWYRAPELLLGSKKYN
 .  .. ..    ..|  .|  |||.. . |||| . | |.....  ||.||||.|  ..        ..|       ..... .   ||| .   .|..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

AAIDMWSLGCIMAEF--LAKEPLF------TGKSEIDQLDKIFKTLGTPNE----KIWPNFVNLPGVKCNFVRQPYNRLREKFPPVAFGGRPALSEKGYD
 . | || |  | |   . ..|           .|. .. |  . .  | .                                    |   .  ... |.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------F---VCCPDEMYQ

LLNKLLTYDPSKRITAEEALNHEWF
.  .   .||..| | .|   || |
IMKQCWHEDPEDRPTFSEI--HECF
Kinase CDK11_b-2.AA CDK4 417-450 41 4.6e-14 44.44 In-house 257-290 (290) Show / Hide 
Range on Protein: 417-450
Range on HMM: 257-290/290
Sequence Identity: 41% (14 aa)

PALSEKGYDLLNKLLTYDPSKRITAEEALNHEWF
| ... | |||.| |.|...||..|...|.| .|
PHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF