Gene CDC2-S1_b (S.moellendorffii)

CDC2-S1_b

Species: S.moellendorffii
Alias: CDC2-S1_b
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe1

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S1_b.AA Protein None 287 None Fasta, JSON
CDC2-S1_b.NA RNA None 864 None Fasta, JSON
CDC2-S1_b.kin_dom Protein Kinase Domain None 222 None Fasta, JSON

Protein domain

Protein domains of CDC2-S1_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S1_b.AA CAMK 3-224 18 2.2e-30 94.53 In-house 80-425 (425) Show / Hide 
Range on Protein: 3-224
Range on HMM: 80-425/425
Sequence Identity: 18% (65 aa)

REVELMKECK-------HENIMRVLD---------------IGQE-----EDGDYMVL---EHLCDA------RDLQYERFYY------------KLSDV
||.|.|| ..       |.|| . ..                 .      ..  |||.   |.           |   |. .|            .  . 
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

GLIKETIRQLLVGLASLHEREVVHQDIVPACIRFELNHSN--------------FVVKLGDFHCSRRLST------------------------PPNVDT
   .  .||.. ... .|.. .|| |. |  | .  |...              . .|. ||  ....                           .   |
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT

MGGSMGFTA-PEVISRE------------TEKIGKGVDMWGVGAVLANMLLGENPFLEG-------------IDLSLSCDANKAKVMDNMKKFL------
. |. .. | |||....             . .|. .||| .| .|  || |. || .               |  |     |.|     ..|       
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY

KRDWYEMIEDE-------DAVDLLRCLLVWDPDKRITAEQALKSMYF
. .|   | ||       .. ||.|..|. ||.||.|.||.|.   .
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC2-S1_b.AA Ciliate-E2 3-224 16 2.6e-23 76.84 In-house 71-365 (365) Show / Hide 
Range on Protein: 3-224
Range on HMM: 71-365/365
Sequence Identity: 16% (55 aa)

REVE----------LMKECKHENIMRVLDIGQ--EEDGDYMVLEHLCDARDLQY---------------ERFYYKLSDVG-LIKETIR-----------Q
||..          .... .| ||..  .  |   ..  |.|.| .|.  ||..               .  |...  .. ..|. ..           .
REINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVME-YCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIAC

LLVGLASLHERE-VVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPNVDT----MG----------------------------GSMGFTAPEVIS
....| .||..  ..| || |  | |        .|. ||  |...... .  |    ..                            |. |. |||...
IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN

RETEK-------IGKGVDMWGVGAVLANMLLGENPFLEGIDLSLSCDANKAKVMDNMKKFLKRDWY-------------------EMIEDEDAVDLLRC-
.. .         .. .|.| .| .|  || |. ||                    ... .. ..                        .... ||..  
GKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF

---LLVWDPDKRIT-AEQALKSMYF
   .|. ||.|||| .||.|.  .|
GKRMLQKDPEKRITGWEQILNHPWF
Kinase CDC2-S1_b.AA Pkinase 92-224 25 3.4e-23 83.09 Pfam 142-293 (293) Show / Hide 
Range on Protein: 92-224
Range on HMM: 142-293/293
Sequence Identity: 25% (40 aa)

HSNFVV----KLGDFHCSRR--LSTPPNVDTMGGSMGFTAPEVISRETEKIGKGVDMWGVGAVLANMLLGENPFLEGIDLSLSCDANKAKVMDNMKKFLK
..| ..    |..|| ...   .   .  .|  |. .. |||||  . ...|. ||||..| .|. ||.|. || . .  . . .  ....  .|.. |.
DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLH

RDWYEMIED------------------EDAVDLLRCLLVWDPDKRITAEQALKSMYF
.||.. ..                   |.. |.....| .|| ||.||||.|.. .|
FDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC2-S1_b.AA Ciliate-E2-Unclassified 57-224 22 8.3e-22 72.43 In-house 140-352 (352) Show / Hide 
Range on Protein: 57-224
Range on HMM: 140-352/352
Sequence Identity: 22% (51 aa)

IK-----ETIRQLLVGLASLHERE-VVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPN----------------VDTMGGSMGFT----APEVIS
.|       ..|.|.|| .||.   ..| || |  | |  |..|. .|. ||  |... ...|                 .|. |. ..     ||||. 
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ

R-ETEKIG-KGVDMWGVGAVLANMLLGENPFL--EGID---------------LSLSCDANK-------------AKVMDNMKKFLKRDWYEMIEDEDAV
. . ..   . .|.|..| .|  || |. ||     ..                 ..   .|              .. .. | |..             
GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN-------------

DLLRCLLVWDPDKRITAEQALKSMYF
|||...|...|.||||.||.|.  .|
DLLQKMLKKNPNKRITFEQILNHPWF
S_TKc CDC2-S1_b.AA S_TKc 1-224 21 4.8e-20 73.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-224
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

MV-----------------------------------REVELMKECKHENIMRVLDIGQEEDGDYMVLEHLCDA--RDLQYERFYYKL------SDVGLI
                                     ||....|. .|.|| . .|. |. |  |||.| .||    ||      ..        .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVME-YCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

KETIRQLLVGLASLHEREVVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPNVDTMGGSMGFTAPEVISRETEKIGK-GVDMWGVGAVLANMLLGE
.  ..|.. .|. .|.. ..| |. |. | .       ..|..||  .|.|      .|. |.  . ||||.     . ||  .|.| .| .|. || |.
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGY

NPFLEGIDLSLSCDANKAKVMDNMKKFLKRDWYEMIEDEDAVDLLRCLLVWDPDKRITAEQALK-------SMYF
 ||            . ........            ...| |..| .|..||.||.|| .||.         .|
PPFP-----------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S1_b.AA MSK 61-224 24 1.1e-16 52.9 In-house 107-277 (277) Show / Hide 
Range on Protein: 61-224
Range on HMM: 107-277/277
Sequence Identity: 24% (42 aa)

IRQLLVGLASLHEREVVHQDIVPACIRFELNHSNFVVKLGDFHCSRRLSTPPNVDTMG--GSMGFTAPEVISR---ETEKIGKGVDMWGVGAVLANMLLG
.|.| . . ..|.. ..| |. |  | |. . .|  ||| ||  .| . . ..  .    ... . |||.. |   . .  .. .|.|..|..|  || |
MRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTG

ENPFL---EGIDLSLSCDANKAKVMDNMKKFLK-RDWYEMIEDEDAVDLLRCLLVWDPDKRITAEQALKSMYF
  ||    .....| .  .  .| .   .  .    | .|  ..|| ||.. ||  || || ...  ....  
QVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNM--SPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase CDC2-S1_b.AA STE 3-224 18 2.1e-16 54.52 In-house 77-359 (359) Show / Hide 
Range on Protein: 3-224
Range on HMM: 77-359/359
Sequence Identity: 18% (55 aa)

REVELMKECK--HENIMRVLDIGQEE-------DGDYMVLEHLC--DARDLQYERFYYKLSD-----------VGLIKETIRQLLVG-LASLHEREVVHQ
.|...||.|.  |.|| . ..    |       |  ....|..    ..|.  ...  . ..             .|.  .||.| | |. ||.  ..| 
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHR

DIVPACIRFELNHSNFVVKLGDFHCSRRLST-----------------PPNVDTMGGSMGFTAPEVISRETEK----IGKGVDMWGVGAVLANMLLGENP
|| || | .        ||| || .. .|.                    . .|. |.  . |||||......     .  .|.| .| ..  |. |. |
DIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

FLEGIDLSLSCDAN--KAKV--MDNMKKFLKRDWYEMIED---------------------EDAVDLLRCLLVWDPDKRITAEQALK--SMYF
. .. ...    ..  ....  .. . . .. .     ..                     ..  | ..  |. ||.|| ||.| ||     .
WHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CDC2-S1_b.AA CMGC 193-224 62 2.6e-14 42.53 In-house 482-513 (513) Show / Hide 
Range on Protein: 193-224
Range on HMM: 482-513/513
Sequence Identity: 62% (20 aa)

EDEDAVDLLRCLLVWDPDKRITAEQALKSMYF
.|..|.|||  .|..||||||||||||.  ||
CDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDC2-S1_b.AA MAPK 185-224 45 7.4e-14 44.08 In-house 283-328 (328) Show / Hide 
Range on Protein: 185-224
Range on HMM: 283-328/328
Sequence Identity: 45% (21 aa)

KRDWYEMIED------EDAVDLLRCLLVWDPDKRITAEQALKSMYF
|..|..|. .       .|.|||  .||.|||||||.|.||   ||
KKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDC2-S1_b.AA Ciliate-E2a 194-224 45 1.6e-11 30.18 In-house 245-275 (275) Show / Hide 
Range on Protein: 194-224
Range on HMM: 245-275/275
Sequence Identity: 45% (14 aa)

DEDAVDLLRCLLVWDPDKRITAEQALKSMYF
. .. ||.. .|. || |||||.|||.. .|
SKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase CDC2-S1_b.AA ERK7 195-224 60 5.1e-10 30.12 In-house 263-292 (292) Show / Hide 
Range on Protein: 195-224
Range on HMM: 263-292/292
Sequence Identity: 60% (18 aa)

EDAVDLLRCLLVWDPDKRITAEQALKSMYF
.||.|||. |||  |.||.||||||.  | 
DDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDC2-S1_b.AA CDK 199-224 61 5.3e-10 28.02 In-house 259-284 (284) Show / Hide 
Range on Protein: 199-224
Range on HMM: 259-284/284
Sequence Identity: 61% (16 aa)

DLLRCLLVWDPDKRITAEQALKSMYF
|||  .|. ||.|||.|||||.. ||
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S1_b.AA Ciliate-E2a 3-159 24 5.4e-10 25.64 In-house 48-216 (275) Show / Hide 
Range on Protein: 3-159
Range on HMM: 48-216/275
Sequence Identity: 24% (42 aa)

REVELMKECKHENIMRVLDIGQEEDGDYMVLEHLCDARDLQYERFYYKL-SDVG--LIKETIRQLL-VGLASLHEREVVHQDIVPACIRFE-LNHSN---
.|. .|.. .| ||..  .. . |.  |.|.| .|. ..| |... ..   .     |.. ..|||  ||. .| | ..| |. |  | |. .. ..   
NEINIMRQLDHPNIIKLYEVYEDENNYYLVME-YCEGGEL-YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQN

FVVKLGDFHCSRRLSTPPN--VDTMGGSMGFTAPEVISRETE----KIGKGVDMWGVGAVLANMLLGENPF
. .|. ||  ... ..  .  . .. |. |. ||||.  . .    . .. .||| .|...  .| |. ||
SDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPF
Kinase CDC2-S1_b.AA ERK7 3-155 28 5.5e-08 23.06 In-house 47-203 (292) Show / Hide 
Range on Protein: 3-155
Range on HMM: 47-203/292
Sequence Identity: 28% (47 aa)

REVELMKECK-HENIMRVLDIGQ-EEDGD-YMVLEHLCDARDLQYERF-YYKLSDVGLIKETIRQLLVGLASLHEREVVHQDIVPACIRFELNHSNFVVK
||. ...| . |.||.|.... . . | | |.| |..    ||         | |.   . .. |||  .  .|  .|.| |. |. |   |  |. .||
REIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFM--ETDLHAVIRKGNILKDI-HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNI---LLDSECMVK

LGDFHCSRRLSTPPNVDTMGGSMG-------FTAPEVISRETEKIGKGVDMWGVGAVLANMLLG
. ||   | ..  ...|   . .        . |||.     ..  ||||||..| .|. || |
VCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLG-SHRYTKGVDMWSIGCILGEMLRG
Kinase CDC2-S1_b.AA CDK 2-81 26 9e-07 17.52 In-house 56-134 (284) Show / Hide 
Range on Protein: 2-81
Range on HMM: 56-134/284
Sequence Identity: 26% (25 aa)

VREVELMKECKHENIMRVLDIGQEEDGD-----------YMVLEHLCDARD----LQYERFYYKLSDVGLIKETIRQLLVGLASLHEREVVHQDI
.||. |.||. |.|| ...|.   .. |           ||| |..    |    .              ||  ..||| ||. .|.. ..| |.
IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYM--DHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDL
Kinase CDC2-S1_b.AA CMGC 3-81 17 4.1e-05 11.72 In-house 70-210 (513) Show / Hide 
Range on Protein: 3-81
Range on HMM: 70-210/513
Sequence Identity: 17% (25 aa)

REVELMKECK-----------------HENIMRVLDIGQEEDGD-----------------YMVLEHLCDARDLQYERFYYKL----SDVGL--------
||....|. .                 |.|| . .|| . .. |                 |.| | ..|   .|| . . ..      ..|        
REIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFE-YMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHP

-------IKETI------RQLLVGLA--SLHERE--VVHQDI
       ||  .      .|.| ||.   .| .   ..| |.
HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDL
Kinase CDC2-S1_b.AA CMGC 125-162 24 6.6e-05 11.05 In-house 293-345 (513) Show / Hide 
Range on Protein: 125-162
Range on HMM: 293-345/513
Sequence Identity: 24% (13 aa)

APEVISRET--------EKIGKGVDMWGVGAVLANMLLG-------ENPFLEG
|||.. . .         . ....|||.|| ..| |..|         |.  |
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPG
Kinase CDC2-S1_b.AA MAPK 3-22 47 0.000422 9.82 In-house 53-73 (328) Show / Hide 
Range on Protein: 3-22
Range on HMM: 53-73/328
Sequence Identity: 47% (10 aa)

REVELMKEC-KHENIMRVLDI
||. |.... .||||...|||
REIKLLRHFHHHENIIKLLDI
Kinase CDC2-S1_b.AA CDK 137-159 34 0.001493 7.05 In-house 200-225 (284) Show / Hide 
Range on Protein: 137-159
Range on HMM: 200-225/284
Sequence Identity: 34% (9 aa)

GKGVDMWGVGAVLANMLL---GENPF
| ..|||.|| ..| |..   ..  |
GTPIDMWSVGCIFAEMFTDVTRKPLF
Kinase CDC2-S1_b.AA Pkinase 2-81 29 0.002868 12.64 Pfam 46-134 (293) Show / Hide 
Range on Protein: 2-81
Range on HMM: 46-134/293
Sequence Identity: 29% (27 aa)

VR--EVELMKECKHENIMRVLDIGQEEDGDYMVLEHLCDAR----DLQ------YERFYYKLSDVGLIKETIRQLLVGLASLHEREVVHQDI
.|  |...||...|.|| | .|. ...|  |||.| .|.      ||       ... .| .|.   .|  ..|.| ||. .|.. ..| |.
RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVME-YCEGGLYVMDLFDYISTWRHGCFY-FSE-WECKFYMYQILRGLEYCHSMGIIHRDL
Kinase CDC2-S1_b.AA MAPK 138-155 52 0.116182 1.25 In-house 213-231 (328) Show / Hide 
Range on Protein: 138-155
Range on HMM: 213-231/328
Sequence Identity: 52% (10 aa)

KGVDMWGVGAVLANMLL-G
|.|||| ||  .| ||  .
KAVDMWSVGCIFAEMLTDR