Gene CK1y_c-2 (S.moellendorffii)

CK1y_c-2

Species: S.moellendorffii
Alias: CK1y_c-2
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1y

Sequence

Name Sequence Type Origin Length Description Download
CK1y_c-2.AA Protein None 379 None Fasta, JSON
CK1y_c-2.NA RNA None 1140 None Fasta, JSON
CK1y_c-2.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of CK1y_c-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CK1y_c-2.AA CK1 9-267 71 9.3e-207 693.16 In-house 1-271 (271) Show / Hide 
Range on Protein: 9-267
Range on HMM: 1-271/271
Sequence Identity: 71% (195 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEE---VAIKLENVKTKHPQLLYESKLYRILQG------GTGIPNIRWYGVE--GDFNVMVIELLGPSLEDLFNFCG
.|.|||||.||||.||.| .. ||.|   ||||||  |.|||||.||.|.|.||||      . |||...|.| |  ||.|.||..|||||||||||||.
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

RKFSLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGL-GRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHLGIEQSRRDDL
||||||||||.|||.. |.| || |.||||||||||||||. |....|||||||||||.|||. | |||||.|||||||||||||||||||||||||||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ESLGYVLMYFLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLCKG-YPPEFASYFHYCRCLRFDDKPDYS
||||||||||||||||||||||.|||||||||.|||. ||.|.|||| .| ||| |. ||| |.|..|||| 
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase CK1y_c-2.AA CK1-Unclassified 9-241 67 3.5e-204 608.48 In-house 1-244 (244) Show / Hide 
Range on Protein: 9-241
Range on HMM: 1-244/244
Sequence Identity: 67% (165 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLYESKLYRILQGGT-------GIPNIRWYGVE--GDFNVMVIELLGPSLEDLFNFCGRK
.|...|||.|||||||.....|||||||||||  ..|||||.|| |....||.|        |||.. |.| |  ||.|.|| .|||||||||||.|.||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDP-TTYQHIPYKENKNLTGTARYASINTHLGIEQSRRDDLE
||||||||.|||.. |.|..| |.|||||||||||||| ||....|||||||||.|.|.|.  | .||||.|||||||||||||||.|||||||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SLGYVLMYFLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLC
||||||.|||.||||||..|| .||.||||| |.|. ||.| ||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase CK1y_c-2.AA CK1-D 9-269 78 1.9e-190 638.98 In-house 1-261 (261) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-261/261
Sequence Identity: 78% (204 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLYESKLYRILQGGTGIPNIRWYGVEGDFNVMVIELLGPSLEDLFNFCGRKFSLKTVLML
.|.||||||||||.||||   ||||||||||| .||||||| .|||.|...||| |||.|||.| |||.||||..|||||||||||.|.|||||||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

ADQLVNRVELVHAKSFIHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFLR
|||.. |.| .|...||||||||||||||||.| | ||||||||||.|||. | |||||.|||||||||||||||||.|||||||||||||||||||| |
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GSLPWQGLKAATKKQKYEKISEKKIATPIETLCKGYPPEFASYFHYCRCLRFDDKPDYSYL
|||||||||||||.||||.|.|||. |.|.||||||| ||. |. ||| |.|||||||.||
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase CK1y_c-2.AA CK1-A 9-269 72 1.4e-174 586.28 In-house 1-261 (261) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-261/261
Sequence Identity: 72% (189 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLYESKLYRILQGGTGIPNIRWYGVEGDFNVMVIELLGPSLEDLFNFCGRKFSLKTVLML
.|| |||||||||.|| |. ..  ||||||.|  | .||||.||.|.||||||. |||..|||| | |.||||..||||||||||||| |.|..||||||
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

ADQLVNRVELVHAKSFIHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFLR
|||.. |.| || |.||||||||||||||.||  |....|||||||||||. | |||||.| ||||||||||||| |||||||||||.||.|||.||| |
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GSLPWQGLKAATKKQKYEKISEKKIATPIETLCKGYPPEFASYFHYCRCLRFDDKPDYSYL
|.|||||.||.|||||||||||||..|||| ||||.| ||. |. ||| |||...||| ||
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase CK1y_c-2.AA CK1-G 9-269 56 2.2e-152 512.53 In-house 1-266 (266) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-266/266
Sequence Identity: 56% (149 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLYESKLYRILQGGT-GIPNIRWYGVEGDFNVMVIELLGPSLEDLFNFCGRKFSLKTVLM
.| |.||| |.|||.. |    .|| ||||.| .|.. |||  | . |.|| |   |||.. ..| .| .|.||..||||||||||..|.||||.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

LADQLVNRVELVHAKSFIHRDIKPDNFLMGL--GRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMY
.| |...|.| ||... | ||.|||||| |    .... ..|||||.||.|.|| | ||||| | | ||||||| ||||||| |||||||.|.|| . ||
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLCKG--YPPEFASYFHYCRCLRFDDKPDYSYL
||||||||||||| . |..|.|| ..| .|.|| ||..  .| .|| |  | | | |...||| ||
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase CK1y_c-2.AA CK1 9-269 40 1.4e-138 466.65 In-house 1-339 (339) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-339/339
Sequence Identity: 40% (137 aa)

FRLGRKIGSGSFG-EIYHG-----VHTQTN-----EEVAIKLENVKTK--HPQLLYESKLYRILQGG-------------------TGIPNIRWYGVEGD
.....|||.|.|| .||..     . ...|     ||.|.|.| .|..  ||||..|...|..||||                    ..| ..||. |.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--FNVMVIELLGPSLEDLFN---FCGRKFSLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGL------GRRAN--------QVYIIDFGLAK-KY
  .|.||..||||.||||..   .|.||||.||.||.|.|.....| .| . |||||||||||.||.      |.. .        |||.||||.|. ||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

RDP-----------TTYQHIPYKE---NKNLTG-TARYASINTHLGIEQSRRDDLESLGYVLMYFLRGS--LPWQGLKAATK-------KQKYEKISEKK
||.            |.||.|..|   .|...| ||||.|||.|||.||.|||||.|..|.|...|.|.  ||||..|. .|       |.|||.|.|||
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

IATPIETLCKG-----YPPEFASYFHYCRCLRFDDKPDYSYL
  ||.. ||..     .|.||  .. |.| |...|.||| ..
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase CK1y_c-2.AA TTBKL 9-273 28 2.6e-57 192.08 In-house 1-288 (288) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-288/288
Sequence Identity: 28% (84 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKT-KHPQ--LLYESKLYRILQ--GGTGIPNIRWYGVEGDFNVMVIELLGPSLEDLFNFCGRK--FS
..  ..||.| ||..||.. ... ...|.. | ...  .    .  | ..   ||  | . .|.. ..| ..|.| || .|.||.| || .   .|  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGLG----RRANQVYIIDFGLAKKYRDP----------TTYQHIPYKE---NKNLTGTARYASINT
  |.. .. |..  . ..| . |||||.|| |. .|.     .|.  ||.||||.|..|...           .... . ..      . || ||.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLCKG------YPPEFASYFHYCRCLRFDDKPDYSYLKRIF
|.. ||.| ||| |. |...... | |||.... .      ..| ..| ..  |.|.|.       |.||.. . . | ||. | |||...  .|
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDK------MEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase CK1y_c-2.AA Worm6 9-269 29 1.9e-53 183.91 In-house 1-279 (279) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-279/279
Sequence Identity: 29% (82 aa)

FRLGRKIGSGSFGEIYHGVHTQTNE--EVAIKLEN--VKTKHPQLLYESKLYRILQGGT--GIPNIRWYG-VEGD-FNVMVIELLGPSLEDLFNFC-GRK
. ...|||.|.|| .|   ......  ..|.|.|.   . |...|  |      .  .   . ..|  .| |. . || .|..|.|..|.||  .. .||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGL-----GRRANQVYIIDFGLAK--KYRDPTTYQHIPYK-ENKNLTGTARYASINTHLGIEQS
||. | | .| |  ...| .|   |||||.|| ||  |       .   ..|..|||...  ||..  . . .. . ..    || |||... | |.||.
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGN-ELRTPRWTACGFRGTVRYAPLACHKGQEQC

RRDDLESLGYVLMYFLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLCKG-YPP-EFASYFHYCRCLRFDDKPDYSYL
|.||.||  |..  ...| |||...|.   ..|. |   ...  |....  |  |. ||   . |   ... |.||| ..
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase CK1y_c-2.AA TTBK 9-269 36 2.7e-52 180.05 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-257/257
Sequence Identity: 36% (96 aa)

FRLGRKIGSGSFGEIYHGVHTQTN-EEVAIKLENVKTKHPQLLYESKLYRILQGGTGIPNIRWYGVEGDFNVMVIELLGPSLEDLFNFCGR-KFSLKTVL
 .  .||| | ||||| .   ... |.||||.| ....   |  |    . |||   .      | . .|| || .|.| .| ||     | .||| | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MLADQLVNRVELVHAKSFIHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMY
 |  |... .| .|   | |||||| || || .  . ...|..||||| .|   .. .  |  |     ||.|||||| |.  |  |.||| || |.|  
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

FLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLCKGYPPEFASYFHYCRCLRFDDKPDYSYL
|. | |||  .|        ... | |       | |  |.||  . .  . | . |.|||  .
FVQGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase CK1y_c-2.AA Pkinase 9-250 22 1.8e-40 144.22 Pfam 1-268 (293) Show / Hide 
Range on Protein: 9-250
Range on HMM: 1-268/293
Sequence Identity: 22% (62 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLY------ESKLYRILQGGTGIPNIRWYGVEGDFNVMVIELLGPSLEDLFNFC------
...||||||||||. |...|  |...||.|  ........ ..      | .. . |.    .  ..|.   .|   || |...  |. ..  .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

-GRKF--SLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHL-GIEQS
 ...|  | ... . . |..  .|  |....||||.||.|.|.   |  .  | |.||||||...      . ..  .. ..|| .|..   .. | . .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RRDDLESLGYVLMYFLRGSLPWQGL----KAATKKQKYEKISEKKIATPIETLCKGY----------------PPEFAS
.. |  |.| .| ..| | .|..|     . ....|....| ....  .....| ..                ..|. .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD
Kinase CK1y_c-2.AA VRK 80-222 36 3.4e-26 81.23 In-house 106-251 (284) Show / Hide 
Range on Protein: 80-222
Range on HMM: 106-251/284
Sequence Identity: 36% (55 aa)

MVIELLGPSLEDLFN-FCGRKFSLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPTTY-QHIPYKENKNLT--G
||.. .| .|. .    .| .|| |||| || .. .  |  | .   | |||  | | |.   ..||| .|.||| .|   ..   | .|||..     |
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRY---CPNGKHRQYKEDPRRCHNG

TARYASINTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKA--ATKK
|  . |.  |.|   ||| |||.||| .|. | |.|||  ..    ..|
TCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEK
Kinase CK1y_c-2.AA S_TKc 9-278 21 2.9e-15 46.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-278
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLYESKLYRILQGGTGIPNIRWYGVEGDFNVMVIELLGP---SLEDLFNFCGRK-----F
....||||.|.||. | ..|. |...||||  .      ... | .. .   .   | ..  . .. |.  || |...    .| |.   .||.     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPTTYQHIPYKENKNLTGTARYASINTHLGIEQSR-RDDLESL
.  ..  .. |... .|  | . .||||.||.| |.       .. |.|||||...              . . ||  | .         .. . |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVLMYFLRGSLPWQGLKAATKKQKYEKISEKKIATPIETLCKGYPPEFASYFHYCRCLRFDDK--PDYSYLKR----IFRDLFI
| .|  .| |  |..     . .. ..||                .||. .    ..||..| .  |    . .    |  . ..
GCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFI--RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CK1y_c-2.AA Pkinase_Tyr 9-38 38 6.1e-09 30.91 Pfam 1-34 (270) Show / Hide 
Range on Protein: 9-38
Range on HMM: 1-34/270
Sequence Identity: 38% (13 aa)

FRLGRKIGSGSFGEIYHGVHT----QTNEEVAIK
 ..|.|.|.|.|||.|.|. .    .|. .||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase CK1y_c-2.AA VRK 9-35 40 2.5e-07 20.01 In-house 1-26 (284) Show / Hide 
Range on Protein: 9-35
Range on HMM: 1-26/284
Sequence Identity: 40% (11 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEV
.|||..||.| ||.||    . |....
WRLGKPIGQGGFGCIYLASPN-TCKPC
Kinase CK1y_c-2.AA TyrKc 9-273 20 3e-06 -120.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

FRLGRKIGSGSFGEIYHGVHTQTNEEVAIKLENVKTKHPQLLYESKLYRIL--QGGTGIPNI-RWYGVEGDF--------NVMVIELLGP--SLEDLFNF
 .||.|.|.| |||.|.|. .   ..||.|  .  . .  .. | .. . |  .     ||| | |||  .          .|..  . |  .| |    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHH----PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGRKFSLKTVLMLADQLVNRVELVHAKSFIHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDP------TTYQHIPYKENKNLTGTARYASINTHLGIE
...|...|. |  . |  .  |  | | .||||.   | | | ..   .| | ||||...  |       . | .   .....     |  ..       
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP-------

QSRRDDLESL-GY------------VLMY--FLRGSLPWQGLKA--ATKKQKYEKISEKKIATPIETLCKG-----YPPEFASYFHYCRCLRFDDKPDYS
       |..  .            |.|.  | .|  |. |      . .. .|.. . .   . .  .        |.|  .    |     .| |  |
-------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

YLKRIF
 ....|
EIHECF